Long-living optical gain induced by solvent viscosity in a push-pull molecule

The combination of continuum and ultrafast pump-probe spectroscopy with DFT and TDDFT calculations, in viscous and non-viscous environments, is effective in unraveling important features of the twisted intramolecular charge transfer mechanism in a new push-pull molecule that possesses aggregation induced emission properties. Long-living optical gain is found when this mechanism is inhibited, highlighting the importance of the environment rigidity in the design of materials for photonic applications

Social Mobility And Struggle For Women’s Right To Choose Spouses In Jane Austen’s Persuasion

This research aims at: (1) finding out the effects of social mobility in the novel to the changing of human thoughts and attitudes; (2) scrutinizing the female main character’s struggle for her right to choose her spouse; and (3) revealing the relation of British social background in nineteenth century and Jane Austen’s Persuasion’s story. The qualitative research is carried out by making use of the descriptive method. The researcher analyzes the data by using feminist and sociology of literature. The analysis is used for: describing the extrinsic elements of the novel including the background of the novel’s production and Jane Austen’s life; analyzing the psychological motivations of changing thought and attitudes of each character of the novel. Based on the result of the data analysis, the research findings are: (1) The social mobility happens in Austen’s Persuasion. brings about some influences to the characters’ attitudes and thought; (2) the female main character do some struggles for obtaining her right to choose her spouse; (3) there is a close relation between the Jane Austen’s Persuasion and its context of production in the nineteenth century. The result of this research implies that the there are some significant changing on human thought and attitudes in Jane Austen’s Persuasion; there some efforts done by the female main character to struggle for her right to choose her spouse and the last, there is a close relation between Jane Austen’s Persuasion and its context of productio

Creating Promotional Text and Video as Media to Promote Tourism at Department of Youth and Sport and Tourism of Wonogiri Regency

ABSTRACT Deas Aliska Andari, 2017, Creating Promotional Text and Video as Media to Promote Tourism at Department of Youth and Sport and Tourism of Wonogiri Regency, English Diploma Program, Faculty of Cultural Sciences, Sebelas Maret University. The aims of this final project report are to describe (1) the internship activities that I have done during the internship at the Department of Youth and Sport and Tourism of Wonogiri Regency from 30 January to 1 March 2017; (2) the difficulties that I encountered during conducting the internship; (3) and the solutions to solve those difficulties. There were two activities which I have performed during the internship. The first activity was making promotional texts about tourism attractions, local dishes and cultural events. The second activity was making a promotional video. In making promotional texts, I collected data and information by doing observation, doing interview with local people, staffs, tour guides and caretakers of the tourist attractions and doing documentation review to leaflets and data from the department . I also obtained additional activities such as attending morning briefing at the department, reporting my tasks, and making an internship report. There were some difficulties that I faced such as finding a location of tourist attractions, translating cultural terms, selecting pictures of tourist attractions, and finding technical problems of the video.The solutions that I had done to solve the difficulties were using Longman Dictionary, discussing with the supervisor, and rearranging the video

The Influence of Online Customer Reviews and Online Customer Ratings on Purchasing Decisions Product electronics in the Shopee marketplace for the Karawang Regency Community

This research aims/objectives of this research are to find out, analyze, explain online customer reviews about selling electronic products in the shoppee marketplace, online customer ratings about selling electronic products in the shoppee marketplace, purchasing decisions of electronic products in the shoppee marketplace, the relationship between online customer reviews with online customer ratings on selling electronic products in the shoppee marketplace, the effect of partial online customer reviews on purchasing decisions of electronic products in the shopee marketplace, the effect of stimulants between online customer reviews and online customer ratings on buying electronic product decisions in the shoppee marketplace. This research was conducted using quantitative methods with descriptive and verification approaches and sampling using the Malhotra sampling technique which resulted in a sample of 115 respondents. The analysis technique used is the Likert scale analysis technique and path analysis with the help of the sequential interval method (MSI), Microsoft Office, and SPSS version 26. 0. Based on the results of the analysis that has been carried out, this research proves that. The correlation coefficient between the variables Online Customer Review and Online Customer Rating obtained a value of 0.661 which means that it is quite strong, positive and significant between online customer reviews and online customer ratings. the partial effect of online customer reviews on purchasing decisions has a value of 27.8%. The effect of online customer ratings on purchasing decisions has a value of 42.0%. The simultaneous effect of online customer review and online customer rating is 69.8% while the remaining 30.2% is another variable not examined.Penelitian ini bertujuan/tujuan dari penelitian ini adalah untuk mengetahui, menganalisis, menjelaskan ulasan pelanggan online tentang penjualan produk elektronik di marketplace shoppee, penilaian pelanggan online tentang penjualan produk elektronik di marketplace shoppee, keputusan pembelian produk elektronik di marketplace shoppee, hubungan antara review pelanggan online dengan penilaian pelanggan online pada penjualan produk elektronik di marketplace shopee, pengaruh review pelanggan online parsial terhadap keputusan pembelian produk elektronik di marketplace shopee, pengaruh perangsang antara review pelanggan online dan penilaian pelanggan online pada keputusan membeli produk elektronik di marketplace shoppee. Penelitian ini dilakukan dengan menggunakan metode kuantitatif dengan pendekatan deskriptif dan verifikatif serta pengambilan sampel menggunakan teknik Malhotra sampling yang menghasilkan sampel sebanyak 115 responden. Teknik analisis yang digunakan adalah teknik analisis skala Likert dan analisis jalur dengan bantuan metode sequential interval (MSI), Microsoft Office, dan SPSS versi 26.0. Berdasarkan hasil analisis yang telah dilakukan, penelitian ini membuktikan itu. Koefisien korelasi antara variabel Online Customer Review dan Online Customer Rating diperoleh nilai sebesar 0,661 yang artinya cukup kuat, positif dan signifikan antara online customer review dan online customer rating. pengaruh parsial ulasan pelanggan online terhadap keputusan pembelian memiliki nilai sebesar 27,8%. Pengaruh peringkat pelanggan online terhadap keputusan pembelian memiliki nilai sebesar 42,0%. Pengaruh simultan antara online customer review dan online customer rating adalah sebesar 69,8% sedangkan sisanya sebesar 30,2% merupakan variabel lain yang tidak diteliti

Картирование микроструктуры головного мозга при большом депрессивном расстройстве: пилотное МР-исследование

INTRODUCTION: Major depressive disorder is a common mental health disorder. Alterations in cortical structures have been identified in this disease, but findings have been variable and inconsistent. Previous studies have illustrated that the cingulate and prefrontal gyrus, along with the amygdala, are involved in emotional processing and the development of abnormal emotional responses in depression.OBJECTIVE: Our research aims to investigate the neurological structural differences and alterations in ACC, bilateral amygdala, and dmPFC regions in patients with MDD using quantitative MRI (MPF and Diffusion parameters mapping (DPM), including diffusion kurtosis).MATERIALS AND METHODS: In this study, we utilized advanced quantitative MRI techniques, specifically Diffusion Tensor Imaging, Diffusion Kurtosis Imaging, and Мacromolecular Proton Fraction Mapping, to investigate microstructural differences and alterations in the specific regions in patients diagnosed with major depressive disorder. RESULTS: Our findings revealed no significant interaction between Мacromolecular proton fraction Mapping with depressive disorder. However, patients with major depressive disorder exhibited a statistically significant increase in apparent mean, axial and radial diffusivity (F=6.3, p=0.01, F=5.0, p=0.03, F=7.08, p=0.01, respectively) in the bilateral amygdala compared to healthy controls, as well as in mean and radial diffusivity in the anterior cingulate cortex (F=5.61, p=0.02, F=7.08, p=0.01, respectively).DISCUSSION: These findings suggest that altered molecular diffusion characteristics in the amygdala and the anterior cingulate cortex may be specifically associated with major depressive disorder.CONCLUSIONS: The importance of using new quantitative MRI methods to assess structural changes at the molecular level in the brain is shown, which, ultimately, expands the fundamental understanding of the pathophysiology of depression.ВВЕДЕНИЕ: Большое депрессивное расстройство является распространенным нарушением психического здоровья. Изменения в структуре коры головного мозга при этом заболевании сегодня остаются малоизученными, а результаты исследований неоднозначны и противоречивы. Ранее было показано, что поясная и префронтальная извилины, а также миндалина участвуют в обработке эмоциональных сигналов и развитии аномальных эмоциональных реакций при депрессии.ЦЕЛЬ: Изучение неврологических структурных различий и изменений в передней поясной коре, миндалине и области дорсомедиальной префронтальной коры у пациентов с БДР с помощью количественной МРТ (МПФ и картирование диффузионных параметров, включая куртозис диффузии). МАТЕРИАЛЫ И МЕТОДЫ: В работе использовались современные количественные методы магнитно-резонансной томографии (МРТ), а именно диффузионно-тензорная томография, томография куртозиса диффузии и картирование макромолекулярной протонной фракции для изучения микроструктурных различий и изменений в специфических областях мозга у пациентов с большим депрессивным расстройством.РЕЗУЛЬТАТЫ: Полученные в данной работе результаты не выявили значимой взаимосвязи между содержанием макромолекулярной протонной фракции и депрессивным расстройством. Однако у пациентов с депрессивным расстройством наблюдалось статистически значимое увеличение измеряемого коэффициента средней, осевой и радиальной диффузии (F=6,3, p=0,01, F=5,0, p=0,03, F=7,08, p=0,01 соответственно) билатерально в миндалинах по сравнению с контрольной группой здоровых людей, а также измеряемого коэффициента средней и радиальной диффузии в передней поясной коре (F=5,61, p=0,02, F=7,08, p=0,01 соответственно).ОБСУЖДЕНИЕ: Полученные результаты дают основание полагать, что изменение характеристик молекулярной диффузии в миндалине и передней поясной коре может быть специфически связано с большим депрессивным расстройством.ЗАКЛЮЧЕНИЕ: Показана важность использования новых количественных методов МРТ для оценки структурных изменений на молекулярном уровне в головном мозге, что расширяет фундаментальные представления о патофизиологии депрессии

Summit, 1972

Rosary Hill College yearbook for Class of 1972.https://digitalcommons.daemen.edu/summit/1021/thumbnail.jp

Investigation of PTC124-mediated translational readthrough in a retinal organoid model of AIPL1-associated Leber congenital amaurosis

Leber congenital amaurosis type 4 (LCA4), caused by AIPL1 mutations, is characterized by severe sight impairment in infancy and rapidly progressing degeneration of photoreceptor cells. We generated retinal organoids using induced pluripotent stem cells (iPSCs) from renal epithelial cells obtained from four children with AIPL1 nonsense mutations. iPSC-derived photoreceptors exhibited the molecular hallmarks of LCA4, including undetectable AIPL1 and rod cyclic guanosine monophosphate (cGMP) phosphodiesterase (PDE6) compared with control or CRISPR-corrected organoids. Increased levels of cGMP were detected. The translational readthrough-inducing drug (TRID) PTC124 was investigated as a potential therapeutic agent. LCA4 retinal organoids exhibited low levels of rescue of full-length AIPL1. However, this was insufficient to fully restore PDE6 in photoreceptors and reduce cGMP. LCA4 retinal organoids are a valuable platform for in vitro investigation of novel therapeutic agents

DESIGNING A VIDEO TO PROMOTE SENTRAL KAMPUNG PEMPEK AS A CULINARY TOURISM DESTINATION IN PALEMBANG

The final report aims to know how to design a video of Sentral Kampung Pempek as one of culinary tourism destination in Palembang. The writer used Research and Development (R&D) method modified by Sukmadinata. This method consists of three steps, they are (1) Preliminary Study, (2) Model Development, (3) Final Product Testing. The video can be used as a medium to promote sentral kampung pempek as one of culinary tourism destinations. The video can be used as a guideline for tourists to find the information about Sentral Kampung Pempek. This video consists of the location of Sentral Kampung Pempek, the environment of Sentral Kampung Pempek, the kinds of food that were sold in Sentral Kampung Pempek and the range of prices of the foods

El Mustang, April 8, 1949

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.https://digitalcommons.calpoly.edu/studentnewspaper/1577/thumbnail.jp