331 research outputs found
Renal pericytes: regulators of medullary blood flow
Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli. DVR are composed of a continuous endothelium, intercalated with smooth muscle-like cells called pericytes. Pericytes have been shown to alter the diameter of isolated and in situ DVR in response to vasoactive stimuli that are transmitted via a network of autocrine and paracrine signalling pathways. Vasoactive stimuli can be released by neighbouring tubular epithelial, endothelial, red blood cells and neuronal cells in response to changes in NaCl transport and oxygen tension. The experimentally described sensitivity of pericytes to these stimuli strongly suggests their leading role in the phenomenon of MBF autoregulation. Because the debate on autoregulation of MBF fervently continues, we discuss the evidence favouring a physiological role for pericytes in the regulation of MBF and describe their potential role in tubulo-vascular cross-talk in this region of the kidney. Our review also considers current methods used to explore pericyte activity and function in the renal medulla
Length of the weaning period affects postweaning growth, health, and carcass merit of ranch-direct beef calves weaned during the fall
Bovine respiratory disease (BRD) is the most economically devastating feedlot disease. Risk factors associated with incidence of BRD include (1) stress associated with maternal separation, (2) stress associated with introduction to an unfamiliar environment, (3) poor intake associated with introduction of novel feedstuffs into the animal\u27s diet, (4) exposure to novel pathogens upon transport to a feeding facility and commingling with unfamiliar cattle, (5) inappropriately administered respiratory disease vaccination programs, and (6) poor response to respiratory disease vaccination programs. Management practices that are collectively referred to as preconditioning are thought to minimize damage to the beef carcass from the BRD complex. Preconditioning management reduces the aforementioned risk factors for respiratory disease by (1) using a relatively long ranch-of-origin weaning period following maternal separation, (2) exposing calves to concentrate-type feedstuffs, and (3) producing heightened resistance to respiratory disease-causing organisms through a preweaning vaccination program. The effectiveness of such programs for preserving animal performance is highly touted by certain segments of the beef industry. Ranch-of-origin weaning periods of up to 60 days are suggested for preconditioning beef calves prior to sale; however, optimal length of the ranch-of-origin weaning period has not been determined experimentally. The objective of this study was to test the validity of beef industry assumptions about appropriate length of ranch-of-origin weaning periods for calves aged 160 to 220 days and weaned during the fall
Deterministic delivery of externally cold and precisely positioned single molecular ions
We present the preparation and deterministic delivery of a selectable number
of externally cold molecular ions. A laser cooled ensemble of Mg^+ ions
subsequently confined in several linear Paul traps inter-connected via a
quadrupole guide serves as a cold bath for a single or up to a few hundred
molecular ions. Sympathetic cooling embeds the molecular ions in the
crystalline structure. MgH^+ ions, that serve as a model system for a large
variety of other possible molecular ions, are cooled down close to the Doppler
limit and are positioned with an accuracy of one micrometer. After the
production process, severely compromising the vacuum conditions, the molecular
ion is efficiently transfered into nearly background-free environment. The
transfer of a molecular ion between different traps as well as the control of
the molecular ions in the traps is demonstrated. Schemes, optimized for the
transfer of a specific number of ions, are realized and their efficiencies are
evaluated. This versatile source applicable for broad charge-to-mass ratios of
externally cold and precisely positioned molecular ions can serve as a
container-free target preparation device well suited for diffraction or
spectroscopic measurements on individual molecular ions at high repetition
rates (kHz).Comment: 11 pages, 8 figure
Recommended from our members
A New Method for Making Shallow P-Type Junctions
In this paper the authors present a new method for making shallow p-type junctions in silicon by molecular ion implantation. Unlike current molecular ion implantation methods which use boron and fluorine molecules, this new method uses an element which is completely miscible in silicon. Note that fluorine is an element that saturates at a very low concentration in silicon. The compounds used in this new method are boron silicides and boron germanium molecules. These compounds have several distinct advantages including the facts that the co-element silicon (or germanium) has a very high saturation value in the silicon matrix, the co-element is massive and therefore creates more damage during implantation, and the co-element has a larger projected range than the boron. Note that the Rp for fluorine is shallower than that of Boron for a BF{sub 2} implant. Recent experiments indicate that BSi ion beams can be generated in a sputter ion source with efficiencies of 0.5% with respect to the generated Si beam. A plan to develop a new ion source that is compatible with current ion implantation systems is presented
Cosmic histories of star formation and reionization: An analysis with a power-law approximation
With a simple power-law approximation of high-redshift () star
formation history, i.e., , we
investigate the reionization of intergalactic medium (IGM) and the consequent
Thomson scattering optical depth for cosmic microwave background (CMB) photons.
A constraint on the evolution index is derived from the CMB optical
depth measured by the {\it Wilkinson Microwave Anisotropy Probe} (WMAP)
experiment, which reads ,
where the free parameter is the number of the escaped
ionizing ultraviolet photons per baryon. Moreover, the redshift for full
reionization, , can also be expressed as a function of as well as
. By further taking into account the implication of the
Gunn-Peterson trough observations to quasars for the full reionization
redshift, i.e., , we obtain
and .
For a typical number of of ionizing photons released per baryon of
normal stars, the fraction of these photons escaping from the stars, , can be constrained to within the range of .Comment: 10 pages, 4 figures, accepted for publication in JCA
Spin Glass Ordering in Diluted Magnetic Semiconductors: a Monte Carlo Study
We study the temperature-dilution phase diagram of a site-diluted Heisenberg
antiferromagnet on a fcc lattice, with and without the Dzyaloshinskii-Moriya
anisotropic term, fixed to realistic microscopic parameters for (IIB=Cd, Hg, Zn). We show that the dipolar Dzyaloshinskii-Moriya anisotropy
induces a finite-temperature phase transition to a spin glass phase, at
dilutions larger than 80%. The resulting probability distribution of the order
parameter P(q) is similar to the one found in the cubic lattice
Edwards-Anderson Ising model. The critical exponents undergo large finite size
corrections, but tend to values similar to the ones of the
Edwards-Anderson-Ising model.Comment: 4 pages plus 3 postscript figure
Pairing in two-dimensional boson-fermion mixtures
The possibilities of pairing in two-dimensional boson-fermion mixtures are
carefully analyzed. It is shown that the boson-induced attraction between two
identical fermions dominates the p-wave pairing at low density. For a given
fermion density, the pairing gap becomes maximal at a certain optimal boson
concentration. The conditions for observing pairing in current experiments are
discussedComment: 10 pages, 5 figs, revtex
Intra-annual patterns of tracheid size in the Mediterranean tree Juniperus thurifera as an indicator of seasonal water stress
Because climate can affect xylem cell anatomy, series of intra-annual cell anatomical features have the potential to retrospectively supply seasonal climatic information. In this study, we explored the ability to extract information about water stress conditions from tracheid features of the Mediterranean conifer Juniperus thurifera L. Tracheidograms of four climatic years from two drought-sensitive sites in Spain were compared to evaluate whether it is possible to link intra-annual cell size patterns to seasonal climatic conditions. Results indicated site-specific anatomical adjustment such as smaller and thicker tracheids at the dryer site but also showed a strong climatic imprint on the intra-annual pattern of tracheid size. Site differences in cell size reflected expected structural adjustments against cavitation failures. Differences between intra-annual patterns, however, indicated a response to seasonal changes in water availability whereby cells formed under drought conditions were smaller and thicker, and vice versa. This relationship was more manifest and stable at the dryer sit
Potential Added Value of Psychological Capital in Predicting Work Attitudes
Meeting the challenge of effectively managing human resources requires new thinking and approaches. To extend the traditional perspective of economic capital, increasing recognition is being given to human capital and more recently social capital, this article proposes and empirically tests the potential added value that psychological capital may have for employee attitudes of satisfaction and commitment. After first providing the background and theory of PsyCap, this article reports a study of manufacturing employees (N = 74) that found a significant relationship between PsyCap and job satisfaction (r=.373) and organization commitment (r=.313). Importantly, the employees’ PsyCap had a significant added impact over human and social capital on these work attitudes. Future research and practical implications conclude the article
N-body simulations of gravitational dynamics
We describe the astrophysical and numerical basis of N-body simulations, both
of collisional stellar systems (dense star clusters and galactic centres) and
collisionless stellar dynamics (galaxies and large-scale structure). We explain
and discuss the state-of-the-art algorithms used for these quite different
regimes, attempt to give a fair critique, and point out possible directions of
future improvement and development. We briefly touch upon the history of N-body
simulations and their most important results.Comment: invited review (28 pages), to appear in European Physics Journal Plu
- …