5,873 research outputs found
Application Of Continuous Positive Airway Pressure In The Delivery Room: A Multicenter Randomized Clinical Trial.
This study evaluated whether the use of continuous positive airway pressure (CPAP) in the delivery room alters the need for mechanical ventilation and surfactant during the first 5 days of life and modifies the incidence of respiratory morbidity and mortality during the hospital stay. The study was a multicenter randomized clinical trial conducted in five public university hospitals in Brazil, from June 2008 to December 2009. Participants were 197 infants with birth weight of 1000-1500 g and without major birth defects. They were treated according to the guidelines of the American Academy of Pediatrics (APP). Infants not intubated or extubated less than 15 min after birth were randomized for two treatments, routine or CPAP, and were followed until hospital discharge. The routine (n=99) and CPAP (n=98) infants studied presented no statistically significant differences regarding birth characteristics, complications during the prenatal period, the need for mechanical ventilation during the first 5 days of life (19.2 vs 23.4%, P=0.50), use of surfactant (18.2 vs 17.3% P=0.92), or respiratory morbidity and mortality until discharge. The CPAP group required a greater number of doses of surfactant (1.5 vs 1.0, P=0.02). When CPAP was applied to the routine group, it was installed within a median time of 30 min. We found that CPAP applied less than 15 min after birth was not able to reduce the need for ventilator support and was associated with a higher number of doses of surfactant when compared to CPAP applied as clinically indicated within a median time of 30 min.47259-6
Double-beta decay of Te to the first 0 excited state of Xe with CUORICINO
The CUORICINO experiment was an array of 62 TeO single-crystal
bolometers with a total Te mass of kg. The experiment finished
in 2008 after more than 3 years of active operating time. Searches for both
and double-beta decay to the first excited state in
Xe were performed by studying different coincidence scenarios. The
analysis was based on data representing a total exposure of
N(Te)t=y. No evidence for a signal was
found. The resulting lower limits on the half lives are y (90% C.L.), and
y (90%
C.L.).Comment: 6 pages, 4 figure
Low oxygen tension primes aortic endothelial cells to the reparative effect of tissue-protective cytokines
Erythropoietin (EPO) has both erythropoietic and tissue-protective properties. The EPO analogues carbamylated EPO (CEPO) and pyroglutamate helix B surface peptide (pHBSP) lack the erythropoietic activity of EPO but retain the tissue-protective properties that are mediated by a heterocomplex of EPO receptor (EPOR) and the β common receptor (βCR). We studied the action of EPO and its analogues in a model of wound healing where a bovine aortic endothelial cells (BAECs) monolayer was scratched and the scratch closure was assessed over 24 h under different oxygen concentrations. We related the effects of EPO and its analogues on repair to their effect on BAECs proliferation and migration (evaluated using a micro-Boyden chamber). EPO, CEPO and pHBSP enhanced scratch closure only at lower oxygen (5%), while their effect at atmospheric oxygen (21%) was not significant. The mRNA expression of EPOR was doubled in 5% compared to 21% oxygen, and this was associated with increased EPOR assessed by immunofluorescence and Western blot. By contrast βCR mRNA levels were similar in 5% and 21% oxygen. EPO and its analogues increased both BAECs proliferation and migration, suggesting that both may be involved in the reparative process. The priming effect of low oxygen tension on the action of tissue-protective cytokines may be of relevance to vascular disease, including atherogenesis and restenosis
CUORE and beyond: bolometric techniques to explore inverted neutrino mass hierarchy
The CUORE (Cryogenic Underground Observatory for Rare Events) experiment will
search for neutrinoless double beta decay of Te. With 741 kg of TeO
crystals and an excellent energy resolution of 5 keV (0.2%) at the region of
interest, CUORE will be one of the most competitive neutrinoless double beta
decay experiments on the horizon. With five years of live time, CUORE projected
neutrinoless double beta decay half-life sensitivity is y
at ( y at the 90% confidence level), which
corresponds to an upper limit on the effective Majorana mass in the range
40--100 meV (50--130 meV). Further background rejection with auxiliary light
detector can significantly improve the search sensitivity and competitiveness
of bolometric detectors to fully explore the inverted neutrino mass hierarchy
with Te and possibly other double beta decay candidate nuclei.Comment: Submitted to the Proceedings of TAUP 2013 Conferenc
Exploring the Neutrinoless Double Beta Decay in the Inverted Neutrino Hierarchy with Bolometric Detectors
Neutrinoless double beta decay (0nubb) is one of the most sensitive probes
for physics beyond the Standard Model, providing unique information on the
nature of neutrinos. In this paper we review the status and outlook for
bolometric 0nubb decay searches. We summarize recent advances in background
suppression demonstrated using bolometers with simultaneous readout of heat and
light signals. We simulate several configurations of a future CUORE-like
bolometer array which would utilize these improvements and present the
sensitivity reach of a hypothetical next-generation bolometric 0nubb
experiment. We demonstrate that a bolometric experiment with the isotope mass
of about 1 ton is capable of reaching the sensitivity to the effective Majorana
neutrino mass (|mee|) of order 10-20 meV, thus completely exploring the
so-called inverted neutrino mass hierarchy region. We highlight the main
challenges and identify priorities for an R&D program addressing them.Comment: 22 pages, 15 figures, submitted to EPJ
Search for 14.4 keV solar axions from M1 transition of Fe-57 with CUORE crystals
We report the results of a search for axions from the 14.4 keV M1 transition
from Fe-57 in the core of the sun using the axio-electric effect in TeO2
bolometers. The detectors are 5x5x5 cm3 crystals operated at about 10 mK in a
facility used to test bolometers for the CUORE experiment at the Laboratori
Nazionali del Gran Sasso in Italy. An analysis of 43.65 kg d of data was made
using a newly developed low energy trigger which was optimized to reduce the
detectors energy threshold. An upper limit of 0.63 c kg-1 d-1 was established
at 95% C.L.. From this value, a lower bound at 95% C.L. was placed on the
Peccei-Quinn energy scale of fa >= 0.76 10**6 GeV for a value of S=0.55 for the
flavor-singlet axial vector matrix element. Bounds are given for the interval
0.15 < S < 0.55.Comment: 14 pages, 6 figures, submitted to JCA
Validation of techniques to mitigate copper surface contamination in CUORE
In this article we describe the background challenges for the CUORE
experiment posed by surface contamination of inert detector materials such as
copper, and present three techniques explored to mitigate these backgrounds.
Using data from a dedicated test apparatus constructed to validate and compare
these techniques we demonstrate that copper surface contamination levels better
than 10E-07 - 10E-08 Bq/cm2 are achieved for 238U and 232Th. If these levels
are reproduced in the final CUORE apparatus the projected 90% C.L. upper limit
on the number of background counts in the region of interest is 0.02-0.03
counts/keV/kg/y depending on the adopted mitigation technique.Comment: 10 pages, 6 figures, 6 table
Search for Neutrinoless Double-Beta Decay of Te with CUORE-0
We report the results of a search for neutrinoless double-beta decay in a
9.8~kgyr exposure of Te using a bolometric detector array,
CUORE-0. The characteristic detector energy resolution and background level in
the region of interest are FWHM and ~counts/(keVkgyr), respectively. The
median 90%~C.L. lower-limit sensitivity of the experiment is and surpasses the sensitivity of previous searches. We find
no evidence for neutrinoless double-beta decay of Te and place a
Bayesian lower bound on the decay half-life, ~ at 90%~C.L. Combining CUORE-0 data with the 19.75~kgyr
exposure of Te from the Cuoricino experiment we obtain at 90%~C.L.~(Bayesian), the most stringent
limit to date on this half-life. Using a range of nuclear matrix element
estimates we interpret this as a limit on the effective Majorana neutrino mass,
-- .Comment: 6 pages, 5 figures, updated version as published in PR
CUORE-0 results and prospects for the CUORE experiment
With 741 kg of TeO2 crystals and an excellent energy resolution of 5 keV
(0.2%) at the region of interest, the CUORE (Cryogenic Underground Observatory
for Rare Events) experiment aims at searching for neutrinoless double beta
decay of 130Te with unprecedented sensitivity. Expected to start data taking in
2015, CUORE is currently in an advanced construction phase at LNGS. CUORE
projected neutrinoless double beta decay half-life sensitivity is 1.6E26 y at 1
sigma (9.5E25 y at the 90% confidence level), in five years of live time,
corresponding to an upper limit on the effective Majorana mass in the range
40-100 meV (50-130 meV). Further background rejection with auxiliary bolometric
detectors could improve CUORE sensitivity and competitiveness of bolometric
detectors towards a full analysis of the inverted neutrino mass hierarchy.
CUORE-0 was built to test and demonstrate the performance of the upcoming CUORE
experiment. It consists of a single CUORE tower (52 TeO2 bolometers of 750 g
each, arranged in a 13 floor structure) constructed strictly following CUORE
recipes both for materials and assembly procedures. An experiment its own,
CUORE-0 is expected to reach a sensitivity to the neutrinoless double beta
decay half-life of 130Te around 3E24 y in one year of live time. We present an
update of the data, corresponding to an exposure of 18.1 kg y. An analysis of
the background indicates that the CUORE performance goal is satisfied while the
sensitivity goal is within reach.Comment: 10 pages, 3 figures, to appear in the proceedings of NEUTRINO 2014,
26th International Conference on Neutrino Physics and Astrophysics, 2-7 June
2014, held at Boston, Massachusetts, US
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