21 research outputs found
Eficacia y seguridad del tratamiento con lenalidomida y dexametasona en pacientes con mieloma mĂșltiple no candidatos a trasplante en recaĂda
PO-019
IntroducciĂłn: En la actualidad existe una amplia diversidad de tratamientos en pacientes con Mieloma MĂșltiple (MM) refractarios a tratamiento en primera lĂnea y no candidatos a trasplante de progenitores hematopoyĂ©ticos. El tratamiento de estos pacientes con lenalidomida y dexametasona ha sido una de las opciones terapeĂșticas mĂĄs utilizadas en los Ășltimos años. El objetivo de este estudio es evaluar la eficacia y tolerabilidad de este tratamiento en un centro hospitalario de tercer nivel.
Material Y MĂ©todos: Estudio descriptivo, observacional y retrospectivo en el que se incluyeron todos los pacientes no candidatos a TPH que iniciaron un esquema con lenalidomida entre Enero 2012 a Marzo 2019 y ademĂĄs recibieron al menos una lĂnea previa de quimioterapia. Fuentes: historia clĂnica electrĂłnica, registro de dispensaciĂłn de pacientes ambulatorios y externos (FarmaTools) del Servicio de Farmacia.
Resultados: En total 22 pacientes (50% mujeres) fueron incluidos en el estudio. La mediana de numero de lĂneas que recibieron previamente fue de 1(rango entre 1-2). 17 pacientes (77%) recibieron RD como 2Âș lĂnea y para 5 pacientes (33%) fue la 3ÂȘ lĂnea. Como tratamiento en 1ÂȘ lĂnea, solo 1 paciente recibiĂł tratamiento con QT convencional (VAD), ..
Astrophysical Origins of Ultrahigh Energy Cosmic Rays
In the first part of this review we discuss the basic observational features
at the end of the cosmic ray energy spectrum. We also present there the main
characteristics of each of the experiments involved in the detection of these
particles. We then briefly discuss the status of the chemical composition and
the distribution of arrival directions of cosmic rays. After that, we examine
the energy losses during propagation, introducing the Greisen-Zaptsepin-Kuzmin
(GZK) cutoff, and discuss the level of confidence with which each experiment
have detected particles beyond the GZK energy limit. In the second part of the
review, we discuss astrophysical environments able to accelerate particles up
to such high energies, including active galactic nuclei, large scale galactic
wind termination shocks, relativistic jets and hot-spots of Fanaroff-Riley
radiogalaxies, pulsars, magnetars, quasar remnants, starbursts, colliding
galaxies, and gamma ray burst fireballs. In the third part of the review we
provide a brief summary of scenarios which try to explain the super-GZK events
with the help of new physics beyond the standard model. In the last section, we
give an overview on neutrino telescopes and existing limits on the energy
spectrum and discuss some of the prospects for a new (multi-particle)
astronomy. Finally, we outline how extraterrestrial neutrino fluxes can be used
to probe new physics beyond the electroweak scale.Comment: Higher resolution version of Fig. 7 is available at
http://www.angelfire.com/id/dtorres/down3.html. Solicited review article
prepared for Reports on Progress in Physics, final versio
An upper limit to the photon fraction in cosmic rays above 10^19 eV from the Pierre Auger Observatory
An upper limit of 16% (at 95% c.l.) is derived for the photon fraction in cosmic rays with energies above 10^19 eV, based on observations of the depth of shower maximum performed with the hybrid detector of the Pierre Auger Observatory. This is the first such limit on photons obtained by observing the fluorescence light profile of air showers. This upper limit confirms and improves on previous results from the Haverah Park and AGASA surface arrays. Additional data recorded with the Auger surface detectors for a subset of the event sample, support the conclusion that a photon origin of the observed events is not favoured
Long-term safety of in utero exposure to anti-tumor necrosis factor for the treatment of inflammatory bowel diseases: results from the multicenter European TEDDY study
Mollusc and brachiopod skeletal hard parts: Intricate archives of their marine environment
Properties and performance of the prototype instrument for the Pierre Auger Observatory
Copyright © 2003 Elsevier B.V. All rights reserved.Construction of the first stage of the Pierre Auger Observatory has begun. The aim of the Observatory is to collect unprecedented information about cosmic rays above 1018 eV. The first phase of the project, the construction and operation of a prototype system, known as the engineering array, has now been completed. It has allowed all of the sub-systems that will be used in the full instrument to be tested under field conditions. In this paper, the properties and performance of these sub-systems are described and their success illustrated with descriptions of some of the events recorded thus far.Auger Collaboration, ..., J. A. Bellido, ..., R. W. Clay, ..., B. R. Dawson, ..., G. J. Thornton, ..., N. R. Wild, et al.http://www.elsevier.com/wps/find/journaldescription.cws_home/505701/description#descriptio
An upper limit to the photon fraction in cosmic rays above 10^19 eV from the Pierre Auger Observatory
31 pages, 11 figures, 2 tables. Minor changes, appendix expanded, conclusions unchanged; accepted by Astroparticle PhysicsAn upper limit of 16% (at 95% c.l.) is derived for the photon fraction in cosmic rays with energies greater than 10^19 eV, based on observations of the depth of shower maximum performed with the hybrid detector of the Pierre Auger Observatory. This is the first such limit on photons obtained by observing the fluorescence light profile of air showers. This upper limit confirms and improves on previous results from the Haverah Park and AGASA surface arrays. Additional data recorded with the Auger surface detectors for a subset of the event sample, support the conclusion that a photon origin of the observed events is not favored
Correlation of the highest-energy cosmic rays with nearby extragalactic objects
Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above 6 Ă 1019 electron volts and the positions of active galactic nuclei (AGN) lying within âŒ75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest-energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar spatial distribution are possible sources