71 research outputs found
Storm-water infiltration and focused recharge modeling with finite-volume two-dimensional Richards equation: application to an experimental rain garden
Rain gardens are infiltration systems that provide volume and water quality control, recharge enhancement, as well as landscape, ecological, and economic benefits. A model for application to rain gardens based on Richards equation coupled to a surface water balance was developed, using a two-dimensional finite-volume code. It allows for alternating upper boundary conditions, including ponding and overflow, and can simulate heterogeneous soil-layering or more complex geometries to estimate infiltration and recharge. The algorithm is conservative, and exhibits good performance compared to standard models for several test cases (less than 0.1% absolute mass balance error); simulations were also performed for an experimental rain garden and comparisons to collected data are presented. The model accurately simulated the matrix flow, soil water distribution, as well as deep percolation (potential recharge) for a natural rainfall event in the controlled experimental setup.
Read More: http://ascelibrary.org/doi/abs/10.1061/%28ASCE%29HY.1943-7900.0000111?prevSearch=authors%3A%28Dussaillant%2C%29&searchHistoryKey
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Geomorphologic impact of outburst flood cycle in braided gravel-bed rivers: confluence of Colonia and Baker rivers, Patagonia, Chile
Colonia River, as other glacial streams influenced by global warming, is affected by Glacial Lake Outburst Floods (OF). We present a study on geomorphologic features of Colonia River to comprehend the impact of OFs in sedimentary processes, analysing erosion and deposition linked to OF phenomena and frequency (since April 2008, more than 12 OFs have occurred). Interpolation analysis is carried out to create an elevation surface (DTM) from a set of sample measurements, given by contour line (2007 LiDAR) and rtkGPS point (2011 and 2012) data. These were used to create DTMs applying Delaunay triangulation. A comparisons between morphology during the current OF cycle that started on 8 April 2008, and the previous morphology (after 40 years without OFs, since end of previous cycle in 1968), is carried out through the creation of DEMs of Difference (DoDs) based on TINs. We created two DoDs, respectively between 2011-2007 (before/after the OFs cycle) and 2012-2011 (during the cycle, after the events of January and April 2012) to provide a high-resolution, spatially distributed surface model of topographic and volumetric change through time. The floodplain has been classified on the basis of the morphological characteristics: main and secondary channel(s), bars, braided area, island and delta fan features. The changes evidenced in the DoD are segregated according to these categories plus the geomorphic change taking place in each category (using GCD; Wheaton et al 2014). Issues regarding data quantity and quality will be discussed, and implications for the planned mega-dam that would flood the confluence
Rapid glucocorticoid inhibition of vasoactive intestinal peptide-induced cyclic AMP accumulation and prolactin release in rat pituitary cells in culture.
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Magnitude and timing of Holocene glacial lake outburst floods in the Baker River, Northern Patagonian Icefield, Chile / Magnitud y frecuencia de inundaciones Holocenas generadas por vaciamiento de lagos glaciares en el Rio Baker, Campo de Hielo, Patagonico Norte, Chile
The Baker River (Southern Chile) drains a catchment of 27,000 km2 and has a mean annual discharge of 1100 m3s-1. Since last deglaciation, the morpho-sedimentology of the Baker valley has been controlled by Outburst Floods (OFs) of different scales. We apply geomorphic mapping, stratigraphy (including radiocarbon and OSL dating) and palaeoflood hydrology to reconstruct the frequency, timing and magnitude of Holocene OFs. Geomorphic mapping reveals evidence of two Holocene alluvial terraces. The oldest (highest) contains basal gravels capped by a well-developed buried Podzolic Luvisol that was radiocarbon dated to 6160±40 BP. In this alluvial sequence, at least two major floods occurred between then and 5300 BP and at least eight major floods between 5300-2500 BP. At least three Late Holocene (post 610±30 BP) GLOF event(s) inundated upper terrace surfaces along the reach downstream the confluence of the Colonia River into the Baker River. We report on the implications of this palaeoflood research in relation to the proposed HydroAysén hydroelectric scheme
Hydrological regime of remote catchments with extreme gradients under accelerated change: the Baker basin in Patagonia
The Baker basin (27 000 km2) is located in one of the most pristine and remote areas of the planet. Its hydrological regime is poised to undergo dramatic changes in the near future due to hydropower development and climate change. The basin contains the second-largest lake in South America, and part of a major icefield. This study documents the natural baseline of the Baker River basin, discusses the main hydrological modes and analyses the potential for sustainable management. Annual precipitation varies several-fold from the eastern Patagonian steppes to the North Patagonian Icefield. The westernmost sub-basins are strongly governed by glacier melt with a peak discharge in the austral summer (January–March). The easternmost sub-basins have a much more seasonal response governed by quicker snowmelt in spring (November–December), while they exhibit low flows typical for semi-arid regions during summer and autumn. Topography, vegetation and wetlands may also influence streamflow. The strong spatio-temporal gradients and variability highlight the need for further monitoring, particularly in the headwaters, especially given the severe changes these basins are expected to undergo. The great diversity of hydrological controls and climate change pose significant challenges for hydrological prediction and management
APOA5 Q97X Mutation Identified through homozygosity mapping causes severe hypertriglyceridemia in a Chilean consanguineous family
BACKGROUND:
Severe hypertriglyceridemia (HTG) has been linked to defects in LPL, APOC2, APOA5, LMF1 and GBIHBP1 genes. However, a number of severe HTG cases are probably caused by as yet unidentified mutations. Very high triglyceride plasma levels (>112 mmol/L at diagnosis) were found in two sisters of a Chilean consanguineous family, which is strongly suggestive of a recessive highly penetrant mutation. The aim of this study was to determine the genetic locus responsible for the severe HTG in this family.
METHODS:
We carried out a genome-wide linkage study with nearly 300,000 biallelic markers (Illumina Human CytoSNP-12 panel). Using the homozygosity mapping strategy, we searched for chromosome regions with excess of homozygous genotypes in the affected cases compared to non-affected relatives.
RESULTS:
A large homozygous segment was found in the long arm of chromosome 11, with more than 2,500 consecutive homozygous SNP shared by the proband with her affected sister, and containing the APOA5/A4/C3/A1 cluster. Direct sequencing of the APOA5 gene revealed a known homozygous nonsense Q97X mutation (p.Gln97Ter) found in both affected sisters but not in non-affected relatives nor in a sample of unrelated controls.
CONCLUSION:
The Q97X mutation of the APOA5 gene in homozygous status is responsible for the severe hypertriglyceridemia in this family. We have shown that homozygosity mapping correctly pinpointed the genomic region containing the gene responsible for severe hypertriglyceridemia in this consanguineous Chilean famil
Observing glacier elevation changes from spaceborne optical and radar sensors – an inter-comparison experiment using ASTER and TanDEM-X data
Observations of glacier mass changes are key to understanding the response of glaciers to climate change and related impacts, such as regional runoff, ecosystem changes, and global sea level rise. Spaceborne optical and radar sensors make it possible to quantify glacier elevation changes, and thus multi-annual mass changes, on a regional and global scale. However, estimates from a growing number of studies show a wide range of results with differences often beyond uncertainty bounds. Here, we present the outcome of a community-based inter-comparison experiment using spaceborne optical stereo (ASTER) and synthetic aperture radar interferometry (TanDEM-X) data to estimate elevation changes for defined glaciers and target periods that pose different assessment challenges. Using provided or self-processed digital elevation models (DEMs) for five test sites, 12 research groups provided a total of 97 spaceborne elevation-change datasets using various processing approaches. Validation with airborne data showed that using an ensemble estimate is promising to reduce random errors from different instruments and processing methods but still requires a more comprehensive investigation and correction of systematic errors. We found that scene selection, DEM processing, and co-registration have the biggest impact on the results. Other processing steps, such as treating spatial data voids, differences in survey periods, or radar penetration, can still be important for individual cases. Future research should focus on testing different implementations of individual processing steps (e.g. co-registration) and addressing issues related to temporal corrections, radar penetration, glacier area changes, and density conversion. Finally, there is a clear need for our community to develop best practices, use open, reproducible software, and assess overall uncertainty to enhance inter-comparison and empower physical process insights across glacier elevation-change studies
Natural disasters and indicators of social cohesion
Do adversarial environmental conditions create social cohesion? We provide new answers to this question by exploiting spatial and temporal variation in exposure to earthquakes across Chile. Using a variety of methods and controlling for a number of socio-economic variables, we find that exposure to earthquakes has a positive effect on several indicators of social cohesion. Social cohesion increases after a big earthquake and slowly erodes in periods where environmental conditions are less adverse. Our results contribute to the current debate on whether and how environmental conditions shape formal and informal institutions
Nod2 Mediates Susceptibility to Yersinia pseudotuberculosis in Mice
Nucleotide oligomerisation domain 2 (NOD2) is a component of the innate immunity known to be involved in the homeostasis of Peyer patches (PPs) in mice. However, little is known about its role during gut infection in vivo. Yersinia pseudotuberculosis is an enteropathogen causing gastroenteritis, adenolymphitis and septicaemia which is able to invade its host through PPs. We investigated the role of Nod2 during Y. pseudotuberculosis infection. Death was delayed in Nod2 deleted and Crohn's disease associated Nod2 mutated mice orogastrically inoculated with Y. pseudotuberculosis. In PPs, the local immune response was characterized by a higher KC level and a more intense infiltration by neutrophils and macrophages. The apoptotic and bacterial cell counts were decreased. Finally, Nod2 deleted mice had a lower systemic bacterial dissemination and less damage of the haematopoeitic organs. This resistance phenotype was lost in case of intraperitoneal infection. We concluded that Nod2 contributes to the susceptibility to Y. pseudotuberculosis in mice
CARD15/NOD2 Is Required for Peyer's Patches Homeostasis in Mice
BACKGROUND: CARD15/NOD2 mutations are associated with susceptibility to Crohn's Disease (CD) and Graft Versus Host Disease (GVHD). CD and GVHD are suspected to be related with the dysfunction of Peyer's patches (PP) and isolated lymphoid follicles (LFs). Using a new mouse model invalidated for Card15/Nod2 (KO), we thus analysed the impact of the gene in these lymphoid formations together with the development of experimental colitis. METHODOLOGY/PRINCIPAL FINDINGS: At weeks 4, 12 and 52, the numbers of PPs and LFs were higher in KO mice while no difference was observed at birth. At weeks 4 and 12, the size and cellular composition of PPs were analysed by flow cytometry and immunohistochemistry. PPs of KO mice were larger with an increased proportion of M cells and CD4(+) T-cells. KO mice were also characterised by higher concentrations of TNFalpha, IFNgamma, IL12 and IL4 measured by ELISA. In contrast, little differences were found in the PP-free ileum and the spleen of KO mice. By using chamber experiments, we found that this PP phenotype is associated with an increased of both paracellular permeability and yeast/bacterial translocation. Finally, KO mice were more susceptible to the colitis induced by TNBS. CONCLUSIONS: Card15/Nod2 deficiency induces an abnormal development and function of the PPs characterised by an exaggerated immune response and an increased permeability. These observations provide a comprehensive link between the molecular defect and the Human CARD15/NOD2 associated disorders: CD and GVHD
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