3,044 research outputs found
Optical vernier technique for in-situ measurement of the length of long Fabry-Perot cavities
We propose a method for in-situ measurement of the length of kilometer size
Fabry-Perot cavities in laser gravitational wave detectors. The method is based
on the vernier, which occurs naturally when the laser incident on the cavity
has a sideband. By changing the length of the cavity over several wavelengths
we obtain a set of carrier resonances alternating with sideband resonances.
From the measurement of the separation between the carrier and a sideband
resonance we determine the length of the cavity. We apply the technique to the
measurement of the length of a Fabry-Perot cavity in the Caltech 40m
Interferometer and discuss the accuracy of the technique.Comment: LaTeX 2e, 12 pages, 4 figure
Theory of mechanical unfolding of homopolymer globule: all-or-none transition in force-clamp mode vs phase coexistence in position-clamp mode
Equilibrium mechanical unfolding of a globule formed by long flexible
homopolymer chain collapsed in a poor solvent and subjected to an extensional
force f (force-clamp mode) or extensional deformation D (position-clamp mode)
is studied theoretically. Our analysis, like all previous analysis of this
problem, shows that the globule behaves essentially differently in two modes of
extension. In the force-clamp mode, mechanical unfolding of the globule with
increasing applied force occurs without intramolecular microphase segregation,
and at certain threshold value of the pulling force the globule unfolds as a
whole ("all-or-none" transition). The value of the threshold force and the
corresponding jump in the distance between the chain ends increase with a
deterioration of the solvent quality and/or with an increase in the degree of
polymerization. In the position-clamp mode, the globule unfolding occurs via
intramolecular microphase coexistence of globular and extended microphases
followed by an abrupt unraveling transition. Reaction force in the microphase
segregation regime demonstrates an "anomalous" decrease with increasing
extension. Comparison of deformation curves in force and position-clamp modes
demonstrates that at weak and strong extensions the curves for two modes
coincide, differences are observed in the intermediate extension range. Another
unfolding scenario is typical for short globules: in both modes of extension
they unfold continuously, without jumps or intramolecular microphase
coexistence, by passing a sequence of uniformly elongated configurations.Comment: 19 pages, 13 figures, 1 tabl
An economic survey of New Zealand wheatgrowers : survey no. 2
This is survey number 2. No. 1 was know as "National wheatgrowers' survey"This Report is the second in an annual series of economic
surveys of New Zealand wheatgrowing farms. These surveys have been undertaken by the Agricultural Economics Research Unit
at Lincoln College on behalf of Wheat Growers Sub-Section of
Federated Farmers of New Zealand Inc.
Specific attention has been focused on the physical
characteristics of wheatgrowing farms, the area of wheat and
other crops sown, wheat yields, cultural practices and costs and
returns for the 1977/78 wheat crop. An attempt has also been
made to allocate plant and machinery overhead costs to the wheat
enterprise on both an historical and current cost basis.
The need for current and detailed information from the
Survey involved two visits to the farms in the sample; one in
the spring following drilling and the second in the autumn after
harvest
Early risk factors for adolescent antisocial behaviour: an Australian longitudinal study
Objective: This investigation utilizes data from an Australian longitudinal study to identify early risk factors for adolescent antisocial behaviour. Method: Analyses are based on data from the Mater University Study of Pregnancy, an on-going longitudinal investigation of womenās and childrenās health and development involving over 8000 participants. Five types of risk factors (child characteristics, perinatal factors, maternal/familial characteristics, maternal pre- and post-natal substance use and parenting practices) were included in analyses and were based on maternal reports, child assessments and medical records. Adolescent antisocial behaviour was measured when children were 14 years old, using the delinquency subscale of the Child Behaviour Checklist. Results: Based on a series of logistic regression models, significant risk factors for adolescent antisocial behaviour included childrenās prior problem behaviour (i.e. aggression and attention/restlessness problems at age 5 years) and marital instability, which doubled or tripled the odds of antisocial behaviour. Perinatal factors, maternal substance use, and parenting practices were relatively poor predictors of antisocial behaviour. Conclusions: Few studies have assessed early predictors of antisocial behaviour in Australia and the current results can be used to inform prevention programs that target risk factors likely to lead to problem outcomes for Australian youth
Can cohort data be treated as genuine panel data?
If repeated observations on the same individuals are not available it is not possible to capture unobserved individual characteristics in a linear model by using the standard fixed effects estimator. If large numbers of observations are available in each period one can use cohorts of individuals with common characteristics to achieve the same goal, as shown by Deaton (1985). It is tempting to analyze the observations on cohort averages as if they are observations on individuals which are observed in consecutive time periods. In this paper we analyze under which conditions this is a valid approach. Moreover, we consider the impact of the construction of the cohorts on the bias in the standard fixed effects estimator. Our results show that the effects of ignoring the fact that only a synthetic panel is available will be small if the cohort sizes are sufficiently large (100, 200 individuals) and if the true means within each cohort exhibit sufficient time variation
Which executive functioning deficits are associated with AD/HD, ODD/CD and comorbid AD/HD+ODD/CD?
Item does not contain fulltextThis study investigated (1) whether attention deficit/hyperactivity disorder (AD/HD) is associated with executive functioning (EF) deficits while controlling for oppositional defiant disorder/conduct disorder (ODD/CD), (2) whether ODD/CD is associated with EF deficits while controlling for AD/HD, and (3)~whether a combination of AD/HD and ODD/CD is associated with EF deficits (and the possibility that there is no association between EF deficits and AD/HD or ODD/CD in isolation). Subjects were 99~children ages 6ā12 years. Three putative domains of EF were investigated using well-validated tests: verbal fluency, working memory, and planning. Independent of ODD/CD, AD/HD was associated with deficits in planning and working memory, but not in verbal fluency. Only teacher rated AD/HD, but not parent rated AD/HD, significantly contributed to the prediction of EF task performance. No EF deficits were associated with ODD/CD. The presence of comorbid AD/HD accounts for the EF deficits in children with comorbid AD/HD+ODD/CD. These results suggest that EF deficits are unique to AD/HD and support the model proposed by R. A. Barkley (1997).17 p
Optimal portfolio choice with path dependent labor income: the infinite horizon case
We consider an infinite horizon portfolio problem with borrowing constraints, in which an agentreceives labor income which adjusts to financial market shocks in a path dependent way. Thispath-dependency is the novelty of the model, and leads to an infinite dimensional stochasticoptimal control problem. We solve the problem completely, and find explicitly the optimalcontrols in feedback form. This is possible because we are able to find an explicit solutionto the associated infinite dimensional Hamilton-Jacobi-Bellman (HJB) equation, even if stateconstraints are present. To the best of our knowledge, this is the first infinite dimensionalgeneralization of Mertonās optimal portfolio problem for which explicit solutions can be found.The explicit solution allows us to study the properties of optimal strategies and discuss theirfinancial implications
Expressive and Instrumental Offending: Reconciling the Paradox of Specialisation and Versatility
Although previous research into specialisation has been dominated by the debate over the existence of specialisation versus versatility, it is suggested that research needs to move beyond the restrictions of this dispute. The current study explores the criminal careers of 200 offenders based on their criminal records, obtained from a police database in the North West of England, aiming to understand the patterns and nature of specialisation by determining the presence of differentiation within their general offending behaviours and examining whether the framework of Expressive and Instrumental offending styles can account for any specialised tendencies that emerge. Fifty-eight offences were subjected to Smallest Space Analysis. Results revealed that a model of criminal differentiation could be identified and that any specialisation is represented in terms of Expressive and Instrumental offending styles
Integrating Biological and Social Processes in Relation to Early-Onset Persistent Aggression in Boys and Girls
This study examined the relationship between biological and social risk factors and aggressive behavior patterns in an Australian high-risk sample of 370 adolescents. Perinatal, temperamental, familial, sociodemographic, and behavioral data were collected during interviews completed during pregnancy, immediately postpartum, and when the children were 6 months old and 5, 14, and 15 years old. Youths were given tests of verbal and neuropsychological functioning at the age 5 and age 15 follow-ups. Youths were divided into early-onset persistent aggression, adolescent-onset aggression, and nonaggressive behavior groups. Results revealed that the interaction of biological and social risk factors was significantly related to early-onset persistent aggression. Gender and developmental phase of measurement moderated the relationship between biosocial risks and the outcomes of early-onset persistent aggression and adolescent-onset aggression
Identification of promoter elements in the Dolichospermum circinale AWQC131C saxitoxin gene cluster and the experimental analysis of their use for heterologous expression
Background
Dolichospermum circinale is a filamentous bloom-forming cyanobacterium responsible for biosynthesis of the paralytic shellfish toxins (PST), including saxitoxin. PSTs are neurotoxins and in their purified form are important analytical standards for monitoring the quality of water and seafood and biomedical research tools for studying neuronal sodium channels. More recently, PSTs have been recognised for their utility as local anaesthetics. Characterisation of the transcriptional elements within the saxitoxin (sxt) biosynthetic gene cluster (BGC) is a first step towards accessing these molecules for biotechnology.
Results
In D. circinale AWQC131C the sxt BGC is transcribed from two bidirectional promoter regions encoding five individual promoters. These promoters were identified experimentally using 5ā² RACE and their activity assessed via coupling to a lux reporter system in E. coli and Synechocystis sp. PCC 6803. Transcription of the predicted drug/metabolite transporter (DMT) encoded by sxtPER was found to initiate from two promoters, PsxtPER1 and PsxtPER2. In E. coli, strong expression of lux from PsxtP, PsxtD and PsxtPER1 was observed while expression from Porf24 and PsxtPER2 was remarkably weaker. In contrast, heterologous expression in Synechocystis sp. PCC 6803 showed that expression of lux from PsxtP, PsxtPER1, and Porf24 promoters was statistically higher compared to the non-promoter control, while PsxtD showed poor activity under the described conditions.
Conclusions
Both of the heterologous hosts investigated in this study exhibited high expression levels from three of the five sxt promoters. These results indicate that the majority of the native sxt promoters appear active in different heterologous hosts, simplifying initial cloning efforts. Therefore, heterologous expression of the sxt BGC in either E. coli or Synechocystis could be a viable first option for producing PSTs for industrial or biomedical purposes
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