157 research outputs found
Multifragmentation of a very heavy nuclear system (I): Selection of single-source events
A sample of `single-source' events, compatible with the multifragmentation of
very heavy fused systems, are isolated among well-measured 155Gd+natU 36AMeV
reactions by examining the evolution of the kinematics of fragments with Z>=5
as a function of the dissipated energy and loss of memory of the entrance
channel. Single-source events are found to be the result of very central
collisions. Such central collisions may also lead to multiple fragment emission
due to the decay of excited projectile- and target-like nuclei and so-called
`neck' emission, and for this reason the isolation of single-source events is
very difficult. Event-selection criteria based on centrality of collisions, or
on the isotropy of the emitted fragments in each event, are found to be
inefficient to separate the two mechanisms, unless they take into account the
redistribution of fragments' kinetic energies into directions perpendicular to
the beam axis. The selected events are good candidates to look for bulk effects
in the multifragmentation process.Comment: 39 pages including 15 figures; submitted to Nucl. Phys.
Multifragmentation of a very heavy nuclear system (II): bulk properties and spinodal decomposition
The properties of fragments and light charged particles emitted in
multifragmentation of single sources formed in central 36AMeV Gd+U collisions
are reviewed. Most of the products are isotropically distributed in the
reaction c.m. Fragment kinetic energies reveal the onset of radial collective
energy. A bulk effect is experimentally evidenced from the similarity of the
charge distribution with that from the lighter 32AMeV Xe+Sn system. Spinodal
decomposition of finite nuclear matter exhibits the same property in simulated
central collisions for the two systems, and appears therefore as a possible
mechanism at the origin of multifragmentation in this incident energy domain.Comment: 28 pages including 14 figures; submitted to Nucl. Phys.
A phase II study of irinotecan plus chronomodulated oxaliplatin, 5-fluorouracil and folinic acid in advanced colorectal cancer patients
Schedule-dependent activity of 5-fluorouracil and irinotecan combination in the treatment of human colorectal cancer: in vitro evidence and a phase I dose-escalating clinical trial
Several schedules of 5-fluorouracil (FU) and irinotecan (IRI) have been shown to improve overall survival in advanced colorectal cancer (CRC). Preclinical evidence suggests that the sequential administration of IRI and FU produces synergistic activity, although their clinical use has not been fully optimised. We investigated the interaction between short-term exposure to SN-38, the active metabolite of IRI, and prolonged exposure to FU in human CRC HT-29 cells and observed that the synergism of action between the two agents can be increased by extending the time of cell exposure to FU and reducing the interval between administration of the two agents. Based on these findings, we performed a phase I trial in 25 advanced CRC patients using a modified IRI/FU regimen as first-line therapy and evaluated three dose levels of IRI (150â300âmg/m2) and two of continuous infusion of FU (800â1000âmg/m2) in a 3-weekly schedule. The most severe grade IIIâIV toxicities were neutropoenia in four cycles and diarrhoea in three. One patient achieved complete response (4%), 12 a partial response (48%), the overall response rate was 52% (±20, 95% CI); seven of 25 patients had stable disease (28%), the overall disease control was 80% (±16, 95% CI). This modified IRI/FU schedule is feasible and exhibits potentially interesting clinical activity
Emission time scale of light particles in the system Xe+Sn at 50 AMeV. A probe for dynamical emission ?
Proton and deuteron correlation functions have been investigated with both
impact parameter and emission source selections. The correlations of the system
(129Xe + natSn) at 50 AMeV have been measured with the 4 pi INDRA which
provides a complete kinematical description of each event. The emission time
scale analyzed with a quantum model reveals the time sequence of the light
particles emitted by the projectile-like fragment. The short and constant
emission time of the proton, independent of the impact parameter, can be
attributed to a preequilibrium process.Comment: 20 pages, with 11 included figures; Accepted by European Physics
Journal
CUBES: a UV spectrograph for the future
In spite of the advent of extremely large telescopes in the UV/optical/NIR range, the current generation of 8-10m facilities is likely to remain competitive at ground-UV wavelengths for the foreseeable future. The Cassegrain U-Band Efficient Spectrograph (CUBES) has been designed to provide high-efficiency (>40%) observations in the near UV (305-400 nm requirement, 300-420 nm goal) at a spectral resolving power of R>20,000, although a lower-resolution, sky-limited mode of R ~ 7,000 is also planned. CUBES will offer new possibilities in many fields of astrophysics, providing access to key lines of stellar spectra: a tremendous diversity of iron-peak and heavy elements, lighter elements (in particular Beryllium) and light-element molecules (CO, CN, OH), as well as Balmer lines and the Balmer jump (particularly important for young stellar objects). The UV range is also critical in extragalactic studies: the circumgalactic medium of distant galaxies, the contribution of different types of sources to the cosmic UV background, the measurement of H2 and primordial Deuterium in a regime of relatively transparent intergalactic medium, and follow-up of explosive transients. The CUBES project completed a Phase A conceptual design in June 2021 and has now entered the Phase B dedicated to detailed design and construction. First science operations are planned for 2028. In this paper, we briefly describe the CUBES project development and goals, the main science cases, the instrument design and the project organization and management
Independence of fragment charge distributions of the size of heavy multifragmenting sources
International audienceCharged product multiplicities and Z distributions were measured for single multifragmenting sources produced in collisions between Full-size image (<1 K) and Full-size image (<1 K) at the same available energy per nucleon. Z distributions are found identical for both reactions while fragment multiplicities scale as the charge of the total systems. A complete dynamical simulation, in which multifragmentation originates in the spinodal decomposition of a finite piece of nuclear matter resulting from an incomplete fusion of projectile and target, well accounts for this experimental observation
Surveying the nuclear caloric curve
International audienceThe 4Ï array INDRA was used to detect nearly all charged products emitted in Ar + Ni collisions between 52 and 95 MeV/u. The charge, mass and excitation energy Eâ of the quasi-projectiles have been reconstructed event by event. Excitation energies up to 25 MeV per nucleon are reached
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