Image-based Recommendations on Styles and Substitutes

Humans inevitably develop a sense of the relationships between objects, some of which are based on their appearance. Some pairs of objects might be seen as being alternatives to each other (such as two pairs of jeans), while others may be seen as being complementary (such as a pair of jeans and a matching shirt). This information guides many of the choices that people make, from buying clothes to their interactions with each other. We seek here to model this human sense of the relationships between objects based on their appearance. Our approach is not based on fine-grained modeling of user annotations but rather on capturing the largest dataset possible and developing a scalable method for uncovering human notions of the visual relationships within. We cast this as a network inference problem defined on graphs of related images, and provide a large-scale dataset for the training and evaluation of the same. The system we develop is capable of recommending which clothes and accessories will go well together (and which will not), amongst a host of other applications.Comment: 11 pages, 10 figures, SIGIR 201

Mainstreaming ecosystem science in spatial planning practice : exploiting a hybrid opportunity space

This paper develops a framework for improved mainstreaming of ecosystem science in policy and decision-making within a spatial planning context. Ecosystem science is advanced as a collective umbrella to capture a body of work and approaches rooted in social-ecological systems thinking, spawning a distinctive ecosystem terminology: ecosystem approach, ecosystem services, ecosystem services framework and natural capital. The interface between spatial planning and ecosystem science is explored as a theoretical opportunity space to improve mainstreaming processes adapting Rogers’ (2003) diffusion model. We introduce the twin concepts of hooks (linking ecosystem science to a key policy or legislative term, duty or priority that relate to a particular user group) and ‘bridges’ (linking ecosystem science to a term, concept or policy priority that is used and readily understood across multiple groups and publics) as translational mechanisms in transdisciplinary mainstreaming settings. We argue that ecosystem science can be embedded into the existing work priorities and vocabularies of spatial planning practice using these hooks and bridges. The resultant framework for mainstreaming is then tested, drawing on research funded as part of the UK National Ecosystem Assessment Follow-On programme (2012-2014), within 4 case studies; each reflecting different capacities, capabilities, opportunities and barriers. The results reveal the importance of leadership, political buy in, willingness to experiment outside established comfort zones and social learning as core drivers supporting mainstreaming processes. Whilst there are still significant challenges in mainstreaming in spatial planning settings, the identification and use of hooks and bridges collectively, enables traction to be gained for further advances; moving beyond the status quo to generate additionality and potential behaviour change within different modes of mainstreaming practice. This pragmatic approach has global application to help improve the way nature is respected and taken account of in planning systems nationally and globally

Perfectionism and self-conscious emotions in British and Japanese students: Predicting pride and embarrassment after success and failure

Regarding self-conscious emotions, studies have shown that different forms of perfectionism show different relationships with pride, shame, and embarrassment depending on success and failure. What is unknown is whether these relationships also show cultural variations. Therefore, we conducted a study investigating how self-oriented and socially prescribed perfectionism predicted pride and embarrassment after success and failure comparing 363 British and 352 Japanese students. Students were asked to respond to a set of scenarios where they imagined achieving either perfect (success) or flawed results (failure). In both British and Japanese students, self-oriented perfectionism positively predicted pride after success and embarrassment after failure whereas socially prescribed perfectionism predicted embarrassment after success and failure. Moreover, in Japanese students, socially prescribed perfectionism positively predicted pride after success and self-oriented perfectionism negatively predicted pride after failure. The findings have implications for our understanding of perfectionism indicating that the perfectionism–pride relationship not only varies between perfectionism dimensions, but may also show cultural variations

Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model

AS (Apert syndrome) is a congenital disease composed of skeletal, visceral and neural abnormalities, caused by dominant-acting mutations in FGFR2 [FGF (fibroblast growth factor) receptor 2]. Multiple FGFR2 splice variants are generated through alternative splicing, including PTC (premature termination codon)-containing transcripts that are normally eliminated via the NMD (nonsense-mediated decay) pathway. We have discovered that a soluble truncated FGFR2 molecule encoded by a PTC-containing transcript is up-regulated and persists in tissues of an AS mouse model. We have termed this IIIa–TM as it arises from aberrant splicing of FGFR2 exon 7 (IIIa) into exon 10 [TM (transmembrane domain)]. IIIa–TM is glycosylated and can modulate the binding of FGF1 to FGFR2 molecules in BIAcore-binding assays. We also show that IIIa–TM can negatively regulate FGF signalling in vitro and in vivo. AS phenotypes are thought to result from gain-of-FGFR2 signalling, but our findings suggest that IIIa–TM can contribute to these through a loss-of-FGFR2 function mechanism. Moreover, our findings raise the interesting possibility that FGFR2 signalling may be a regulator of the NMD pathway

Automatically generating streamlined constraint models with ESSENCE and CONJURE

Streamlined constraint reasoning is the addition of uninferred constraints to a constraint model to reduce the search space, while retaining at least one solution. Previously, effective streamlined models have been constructed by hand, requiring an expert to examine closely solutions to small instances of a problem class and identify regularities. We present a system that automatically generates many conjectured regularities for a given Essence specification of a problem class by examining the domains of decision variables present in the problem specification. These conjectures are evaluated independently and in conjunction with one another on a set of instances from the specified class via an automated modelling tool-chain comprising of Conjure, Savile Row and Minion. Once the system has identified effective conjectures they are used to generate streamlined models that allow instances of much larger scale to be solved. Our results demonstrate good models can be identified for problems in combinatorial design, Ramsey theory, graph theory and group theory - often resulting in order of magnitude speed-ups.Postprin

Dispositional optimism as a correlate of decision-making styles in adolescence

Despite the numerous psychological areas in which optimism has been studied, including career planning, only a small amount of research has been done to investigate the relationship between optimism and decision-making styles. Consequently, we have investigated the role of dispositional optimism as a correlate of different decision-making styles, in particular, positive for effective styles and negative for ineffective ones (doubtfulness, procrastination, and delegation). Data were gathered through questionnaires administered to 803 Italian adolescents in their last 2 years of high schools with different fields of study, each at the beginning stages of planning for their professional future. A paper questionnaire was completed containing measures of dispositional optimism and career-related decision styles, during a vocational guidance intervention conducted at school. Data were analyzed using stepwise multiple regression. Results supported the proposed model by showing optimism to be a strong correlate of decision-making styles, thereby offering important intervention guidelines aimed at modifying unrealistically negative expectations regarding their future and helping students learn adaptive decision-making skills

Importance of heterogeneity in Porhyromonas gingivalis lipopolysaccharide lipid A in tissue specific inflammatory signaling

Lipopolysaccharide (LPS) of Porphyromonas gingivalis exists in at least two known forms, O-LPS and A-LPS. A-LPS shows heterogeneity in which two isoforms designated LPS1435/1449 and LPS1690 appear responsible for tissue specific immune signalingpathways activation and increased virulence. The modification of lipid A to tetra-acylated1435/1449 and/or penta-acylated1690 fatty acids indicates poor growth conditions and bioavailability of hemin. Hemin protects P. gingivalis from serum resistance and the lipid A serves as a site for its binding. The LPS1435/1449 and LPS1690 isoforms can produce opposite effects on the human Toll-like receptors (TLR) TLR 2 and TLR 4 activation. This enabless P. gingivalis to select the conditions for its entry, survival and that of its co-habiting species in the host, orchestrating its virulence to control innate immune pathway activation and biofilm dysbiosis. Thismini review describes a number of effects that LPS1435/1449 and LPS1690 can exert on the host tissues such as deregulation of the innate immune system, subversion of host cell autophagy, regulation of outer membrane vesicle production and adverse effects on pregnancy outcome. The ability to change its LPS1435/1449 and/or LPS1690 composition may enables P. gingivalis to paralyze local pro-inflammatory cytokine production, thereby gaining access to its primary location in periodontal tissue

Un paysage entièrement moderne : Artaud dans la Sierra Tarahumara

Un paysage entièrement moderne : Artaud dans la Sierra TarahumaraLes écrits surréalistes d'Antonin Artaud sur les Tarahumaras du nord-ouest du Mexique se conforment à certaines qualités contemporaines de l'ethnographie postmoderne : une impression que l'observation subjective est politiquement libératrice et une vision globale de l'humanité sans réelles distinctions culturelles. De récentes recherches sur le terrain dans la Sierra Tarahumara révèlent que l'ethnographie d'Artaud a été sérieusement déformée par le primitivisme romantique et par le mysticisme. Cependant, sa tendance à utiliser des métaphores du paysage pour décrire les conditions culturelles a été ( par inadvertance ) retenue par bon nombre de postmodernistes. Plus encore, malgré le fait que les postmodernes aient pour la plupart remplacé l'inconscient universel (et le mysticisme) par une union mondiale en évoquant les - droits •• de co-citoyenneté. ces deux genres d'ethnographie perpétuent le colonialisme culturel en imposant au monde des définitions euro-centriques de l'humanité.A Thorouahly Modem Landscape : Artaud in the Sierra TarahumaraArtaud's surrealist writings about the Tarahumara of Northwestern Mexico adhère to some contemporary qualities of postmodern ethnography : a sense that subjective observation is politically liberating and a global vision of humanity that dismisses cultural différence. Recent Tarahumara fieldwork reveals that Artaud's ethnography was seriously distorted by Romantic primitivism and mysticism. However. his tendency to use landscape metaphors to describe cultural conditions has been (inadvertently) retained by many postmodernists. Furthermore. although postmodernists hâve largely replaced the universal unconscious (and mysticism) with global union through the " rights " of co-citizenship. both types of ethnography continue cultural colonialism through global impositions of Euro-centric définitions of humanity