Introduction to SQL

This chapter provides a very brief introduction to the Structured Query Language (SQL) for getting information from relational databases. We make no pretense that this is a complete or comprehensive discussion of SQL. There are many aspects of the language the will be completely ignored in the presentation. The goal here is to provide enough background so that users understand the basic concepts involved in building and using relational databases. We also go through the steps involved in building a particular astronomical database used in some of the other presentations in this volume

El català uneix els ports de Balears, Tarragona i Barcelona per mitjà de les noves tecnologies

Abstract not availabl

Transcriptional control of the forkhead thyroid transcription factor TTF-2 by thyrotropin, insulin, and insulin-like growth factor I

The hormonal regulation of both thyroglobulin and thyroperoxidase promoter activity in FRTL-5 thyroid cells takes place, at least in part, through a hormone-responsive element to which the thyroid transcription factor TTF-2 binds. The TTF-2 cDNA, encoded by the titf2 locus, has recently been cloned and classified as a member of the forkhead transcription factor family. Here, we demonstrate that TTF-2 mRNA levels become undetectable in FRTL-5 thyroid cells cultured for 4 days in 0.2% serum and in the absent of thyrotropin (TSH) and insulin. Addition of TSH, insulin or insulin-like growth factor I (IGF-I) to the culture medium increases the levels of this transcription factor in a dose- and time-dependent manner and requires ongoing protein synthesis. The TSH effect is greater than that produced by insulin or IGF-I and is similar to the effect produced by the cAMP analog forskolin. The TSH and insulin effects are additive. In all cases, the mRNA levels increase is accompanied by an increase in transcription rate, as demonstrated by run-off assays. These data demonstrate that the TTF-2 mRNA is under tight hormonal control. This is consistent with an important role for TTF-2 as a mediator of the transcriptional activation of thyroid-specific genes (thyroglobulin and thyroperoxidase) by TSH via cAMP and by insulin through the IGF-I receptor

Hábitos de sueño saludable, melatonina y cáncer de mama

En la actualidad es conocido que un estilo de vida saludable (actividad física aeróbica, dieta mediterránea, minimización de hábitos tóxicos y equilibrio emocional o una vida con un nivel de estrés aceptable) reduce el riesgo de padecer cáncer, pudiendo prevenir el cáncer en general y el de mama en particular. Un ritmo sueño-vigilia adecuado es imprescindible para conseguir un descanso reparador, y la falta de sueño asociada a una disrupción de biorritmos circadianos se ha relacionado con un mayor riesgo de sufrir cáncer de mama (CM) en mujeres

El paleógeno del sector suroccidental de la Cuenca del Duero: nueva división estratigráfica y controles sobre su sedimentación

Como resultado de un detallado trabajo cartográfico, estratigráfico y sedimentológico, se propone la división del Paleógeno del sector suroccidental de la Cuenca del Duero en cuatro U.T.S. limitadas por discordancias. Estas D.T.S., que abarcan desde el tránsito Cretácico superior-Paleoceno hasta el Oligoceno, incluyen distintas unidades litoestratigráficas que sonreordenadas, modificando la sucesión estratigrática propuesta por los autores anteriores. Se asigna a la U.T.S. Me una edad Cretácico superior-Paleoceno. Se individualiza el Eoceno inferior (U.T.S. PI) en la zona de Salamanca. Se reinterpreta la relación existente entre los materiales del Eoceno mediosuperior y los del Eoceno superior-Oligoceno considerándolos en tránsito por lo que se asignan a una única U.T.S. (UT.S. P2, Eoceno medio Oligoceno inferior). Se incluyen en la U.T.S. P3 (Oligoceno superior) los sedimentos arcósicos anterionnente considerados como Vatlesienses. Así mismo, se considera que gran parte de los materiales asignados al mioceno inferior son sedimentos paleógenos afectados por un proceso de alteración de edad Miocena, lo que implica una variación en la extensión y límites de la cuenca neógena en su extremo SO. Se analiza la evolución de las distintas U.T.S. deduciendo un carácter tectónico para las megasecuencias propuestas relacionado con el progresivo levantamiento de las áreas fuente. El clima muestra un tránsito desde condiciones tropicales sin estaciones contrastadas (U,T.S. MC) hasta un clima mediterráneo árido (U.T.S. P3) con una estación seca muy marcada y una corta estación húmeda caracterizada por violentas avenidas. [ABSTRACT] A Paleogene four-fold stratigraphical division is proposed here as result fram the detailed studies carried out during the elaboration of 22 sheets of the Geological Map of Spain (E. 1 :50.000). This units (T.S.U.) are limited by regional discordances and they have a Upper Cretaceous to Oligocene ages. The previous stratigraphical schemes are rearranged due to the different stratigraphical relations observed between the lithostratigraphical units proposed by other workers (Jiménez, 1970; Corrochano, 1977; Alonso, 1981...). An Upper Cretaceous-Paleocene age is assumed to T.S.U. MC which is mainly composed by siliciclastic sediments strongly silicified forming a FU megasequence. It is intcrpretated as braided streams that flowed downslope filling paleovalleys erodcd onto Paleozoic materiaIs. Mineralogical features point to a tropical climate. Lower Eocene (T.S.U. P I ) is identified in the Salamanca area, where ir was considered as lacking. It is composed by arkosic sediments forming a CU megasequence. Fossil faunas of this T.S.U. record a subtropical clima te. It is observed a transition from high sinuosity streams to braided ones. T.S.U. P2 (Middle Eocene-Lower Oligocene) is composed of two lithostratigraphical units previously considered as bounded by a discordance (Alonso, 1981).It has a subarkosic to lithic nature and forms a CU megasequence. This unit records a subtropical climate with short arid periods and is interpretated as braided streams showing an increasing stability and enviromental energy to the topo T.S. U. P3 (Upper Oligocene) is composed by arkosic sediments previously considered of Vallesian (Middle to Upper Miocene) age. They form a CU megasequence that records braided streams prograding basinwardfrom higher arcas. Palinological associations and pedological features indicate an arid mediterranean climate with long arid periods and a short rainy season with strong floods. We consider that most of Lower Miocene sediments are of Paleogene age. They are afected by a widespread alteration profile developed along Lower Miocene that masked its more significative features. Sedimentological analysis of T.S.U. shows that its megasequentiality is related to the rates of tectonical uplift of source arcas whereas a distensive regime developed in the sedimentation basin

The Interaction between the Forkhead Thyroid Transcription Factor TTF-2 and the Constitutive Factor CTF/NF-1 Is Required for Efficient Hormonal Regulation of the Thyroperoxidase Gene Transcription

The forkhead thyroid-specific transcription factor TTF-2 is the main mediator of thyrotropin and insulin regulation of thyroperoxidase (TPO) gene expression. This function depends on multimerization and specific orientation of its DNA-binding site, suggesting that TTF-2 is part of a complex interaction network within the TPO promoter. This was confirmed by transfection experiments and by protein-DNA interaction studies, which demonstrated that CTF/NF1 proteins bind 10 base pairs upstream of the TTF-2- binding site to enhance its action in hormone-induced expression of the TPO gene. GST pull-down assays showed that TTF-2 physically interacts with CTF/NF1 proteins. In addition, we demonstrate that increasing the distance between both transcription factors binding sites by base pair insertion results in loss of promoter activity and in a drastic decrease on the ability of the promoter to respond to the hormones. CTF/NF1 is a family of transcription factors that contributes to constitutive and cell-type specific gene expression. Originally identified as factors implicated in the replication of adenovirus, this group of proteins (CTF/NF1-A, -B, -C, and - X) is now known to be involved in the regulation of several genes. In contrast to other reports regarding the involvement of these proteins in inducible gene expression, we show here that members of this family of transcription factors are regulated by hormones. With the use of specific CTF/NF1 DNA probes and antibodies we demonstrate that CTF/NF1-C is a thyrotropin-, cAMP-, and insulin-inducible protein. Thus CTF/NF1 proteins do not only mediate hormone-induced gene expression cooperating with TTF-2, but are themselves hormonally regulated. All these findings are clearly of important value in understanding the mechanisms governing the transcription regulation of RNA polymerase II promoters, which often contain binding sites for multiple transcription factors

Pneumonia Detection in Chest X-ray Images using Convolutional Neural Networks

Pneumonia is an infectious and deadly disease which strikes over millions of people. Usually, chest X-rays are used by radiotherapist to diagnose pneumonia. In this paper, a Computer- Aided Diagnosis (CAD) system for pneumonia detection in chest X-ray images is proposed. This system is based on Convolutional Neural Networks (CNNs) which are able to classify the image into two classes (pneumonia or normal). Experimental results show that the proposed system obtained an accuracy rate of 98.59%.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Nuevas faunas de roedores del Mioceno medio y del Mio-Plioceno en la cuenca del Cabriel (Valencia, España)

Five new localities with micromammal remains have been located in the Cabriel Basin. These localities are situated in the eastern area of the Cabriel Basin, in the Juan Vich ravine, where the oldest deposits of this basin crop out. The localities JV2, JV3 and JV6 are of Middle Miocene age, JVTLI1 of Middle Miocene or Late Miocene age and JVTS1 of Late Miocene or Early Pliocene age. The beginning of the sedimentary history of the basin was attributed to Late Turolian (Late Miocene). The new sedimentary record from the Juan Vich ravine and the mammalian findings extend the stratigraphic and paleontological knowledge of the Basin.Cinco nuevas localidades con restos de micromamíferos han sido localizadas en la cuenca del Cabriel. Estas localidades se sitúan en el sector este, en el conocido como barranco de Juan Vich, donde afloran los depósitos más antiguos de esta cuenca. Las localidades JV2, JV3 et JV6 son del Mioceno medio, del Mioceno medio o superior JVTLI1 y del Mioceno superior o Plioceno inferior JVTS1. El inicio de la sedimentación en esta cuenca se había datado en el Turoliense. El registro sedimentario del barranco de Juan Vich y la fauna de mamíferos hallada en él, amplían el conocimiento estratigráfico y paleontológico de esta cuenca