Consumption of Analeptics and Energizing Drinks to Improve Academic Performance in Students From First to Third Level of the Career of Medicine

Central nervous system stimulant drugs are frequently used by college students as factors to alleviate fatigue, maintain wakefulness, and stimulate cognitive abilities, which has become a problem because the physical or emotional consequences that may occur are not considered. produce. At the time of marketing these products they do not keep any type of control, it is freely distributed to the general public. Objective: to analyze how the consumption of analeptics and energy drinks affects the academic performance of students. Methods: An explanatory, cross-sectional, quantitative-qualitative study was carried out, to obtain data, the survey was applied to first to third level students of the Medicine School of the Polytechnic School of Chimborazo (ESPOCH). Results: From the compilation of the information it can be determined that 65% of the students use stimulants to increase their performance, without considering the consequences such as palpitations, insomnia, headache, tremor, vomiting, gastrointestinal discomfort as well as affections to different organs and body systems. Bottom Line: The cognitive effects of stimulants commonly bring about changes in performance by accelerating the production of dopamine in the brain, which is a neurotransmitter that is related to attention, pleasure, memory and performance. Adverse effects can vary from mild to very serious, causing irritability, headache, arrhythmias, hypertension, dizziness, and lesser degrees such as difficulty in bowel movement, itching or skin rash, among others. Keywords: analleptic, stimuli, effects, academic performance. Resumen Los estudiantes universitarios consumen con frecuencia los fármacos estimulantes del sistema nervioso central como factores para aliviar la fatiga, mantener la vigilia y estimular las capacidades cognitivas, lo cual se ha convertido en un problema, porque no se consideran las consecuencias físicas o emocionales que se pueden producir. Al momento de comercializar estos productos no guardan algún tipo de control, es de libre distribución al público general. Objetivo: analizar como el consumo de analépticos y bebidas energizantes incide en el rendimiento académico de los estudiantes. Métodos: Se realizó un estudio explicativo de corte transversal, de tipo cuanti- cualitativo, para la obtención de datos se aplicó la encuesta a los estudiantes de primer a tercer nivel de la Carrera de Medicina de la Escuela Superior Politécnica de Chimborazo (ESPOCH). Resultados: De la recopilación de la información se puede determinar que un 65% de los estudiantes utilizan los estimulantes para elevar su rendimiento, sin considerar las consecuencias como palpitaciones, insomnio, cefalea, temblor, vómito, molestias gastrointestinales así como afecciones a distintos órganos y sistemas del cuerpo. Conclusión: Los efectos cognitivos de los estimulantes, comúnmente aportan cambios en el rendimiento al acelerar la producción de dopamina en el cerebro, que es un neurotransmisor que se relaciona con la atención, el placer, la memoria y el rendimiento. Los efectos adversos pueden variar de leves a muy graves causando irritabilidad, dolor de cabeza, arritmias, hipertensión, mareos y los de menor grado como dificultad para la evacuación intestinal, picazón o erupción en la piel, entre otras. Palabras clave: analépticos, estímulos, efectos, rendimiento académico

Spatial distribution of Cydia fagiglandana (Zeller) in an exploited holm oak (Quercus ilex L.) forest.

Cydia fagiglandana (Zeller) (Lepidoptera: Tortricidae) is a carpophagous insect which affects the quality andviability of the fruits of beech, oak and chestnut trees. The majority of the works on this species in holm oak woodsdealt with assessing its damages. No investigations have yet been performed on the spatial distribution of this pest,although this element is one of the key features to take in account in order to develop proper integrated managementprograms. The present study, performed during a four years period in an exploited holm oak forest area in SouthernSpain, investigated the spatial distribution of C. fagiglandana integrating classic methods based on dispersion ratesand distribution fitting together with the elaboration of population density maps based on GIS. Our results showedthat the infestation rate progressively decreased from 0.339 in 2001 to 0.102 in 2004. Density maps for C. fagiglandanaalso show an heterogeneous and aggregated distribution of this insect and a spatio-temporal stability in this area. It isconcluded that during the four years of the study inter-specific competition with the weevil Curculio elephas was thefactor that most affected the spatial distribution of C. fagiglandana in the experimental plot

Intervención psicológica con corredores de maratón : características y valoración del programa aplicado en el maratón de Madrid

12 psicólogos del deporte participaron en un programa de intervención psicológica con los corredores del Maratón de Madrid. En los días anteriores al maratón, 1457 corredores recibieron asesoramiento a través de un folleto informativo con recomendaciones prácticas para preparar su participación en la carrera (incluyendo establecimiento de objetivos, planificación de la carrera, anticipación de dificultades, control de pensamientos negativos y control de la activación), información relacionada con sus puntuaciones en el cuestionario CSAI-2 (ansiedad somática, ansiedad cognitiva y autoconfianza) y atención de demandas concretas. Después de la carrera, los psicólogos proporcionaron apoyo psicológico a corredores que acudieron al servicio de Fisioterapia. Así mismo, antes de la prueba, el personal sanitario (fisioterapeutas y enfermeros) recibió algunas recomendaciones prácticas para optimizar su trabajo con los corredores. Unas semanas más tarde, 452 corredores contestaron a una encuesta valorando la eficacia de esta intervención psicológica, recogiéndose, también, los informes globales de los psicólogos participantes y de un reducido número de fisioterapeutas. Los datos senalan que el asesoramiento realizado antes de la carrera fue considerado útil por la mayoría de los corredores y bastante útil para un considerable número de ellos, sobre todo para aquellos que lograron el objetivo deportivo que habían establecido para este maratón, destacando la información recibida para el control de pensamientos negativos y en relación con la autoconfianza. Las valoraciones globales de corredores, psicólogos y fisioterapeutas también avalan la utilidad del apoyo psicológico proporcionado después de la carrera. En el artículo se explican las características de este programa de intervención psicológica con corredores populares de maratón, y se discute su aportación a la Psicología del Deporte, al papel de los psicólogos del deporte en equipos interdisciplinares y a la contribución de los psicólogos en los maratones populares.12 sport psychologists conducted a programme of psychological intervention with the participants at the Marathon of Madrid (Spain). In the days prior the marathon 1457 recreational runners were helped with psychological counselling using both a handout with practical recommendations to prepare for the race (including goal setting, planning for the race, anticipating main difficulties, preparing to control negative thoughts, and arousal control), information related to their scores in the CSAI-2 (somatic anxiety, cognitive anxiety and self-confidence), and attention to specific demands. After the race, psychologists provided psychological support to runners who attended the service of Physiotherapy to receive massage. Likewise, before the race, the medical personnel involved in te marathon (physiotherapists and nurses) received from sport psychologists practical guidelines to improve their work with the runners. Few weeks after the marathon, 452 runners answered to a survey to assess this programme. Data were also obtained through global reports from the sport psychologists and a reduced number of physiotherapists. Most runners found useful, and many of them very useful, the counselling provided before the race, especially runners who achieved their goals for the marathon, highlighting the information to control negative thoughts and related to selfconfidence. Global reports of runners, sport psychologists and physiotherapists, also supported the utility of psychological intervention after the race, especially to help runners to relax, to tolerate pain while receiving massage, to show their feelings and to gain control over the experience. The article explains all the characteristics of this programme and pinpoints its contribution to Sport Psychology, the role of sport psychologists within multidisciplinary teams, and the contribution of sport psychologists in recreational marathons

Identification of novel adipokines in the joint.Differential expression in healthy and osteoarthritis tissues

OBJECTIVES: Emerging data suggest that several metabolic factors, released mainly by white adipose tissue (WAT) and joint tissues, and collectively named adipokines, might have a role in the pathophysiology of OA. Recently, novel adipokines such as SERPINE2, WISP2, GPNMB and ITIH5 have been identified in WAT. The main goal of this study was to analyse the expression of these novel adipokines in synovium, infrapatellar fat pad and chondrocytes and to compare the expression of these molecules in healthy and OA tissues. METHODS: Synovial tissues, infrapatellar fat pad and chondrocytes were obtained from 36 OA patients (age 52-85; mean BMI 28.9) who underwent total knee replacement surgery. Healthy synovial tissues and infrapatellar fat pad were obtained from 15 traumatic knee patients (age 23-53; mean BMI 23.5). mRNA and protein expression were determined by qRT-PCR and western blot analysis respectively. RESULTS: All the novel adipokines, matter of our study, are expressed in OA synovium, infrapatellar fat pad and chondrocytes. Moreover, we detected a differential expression of SERPINE2 and ITIH5 in OA synovial tissues as compared to healthy samples. Finally, we also observed an increased expression of WISP2 in OA infrapatellar fat pad in comparison to healthy controls. CONCLUSIONS: In this study we demonstrated for the first time the expression of four novel adipokines in different joint tissues and how these molecules are differentially expressed in healthy and OA joint tissues.Xunta de Galicia/SERGASInstituto de Salud Carlos III (ISCIII)Fundación Ramón DomínguezMinisterio de Educación de Españ

Towards an ICF Core Set for functioning assessment in severe mental disorders: Commonalities in bipolar disorder, depression and schizophrenia

Background: The International Classification of Functioning, Disability and Health (ICF) offers an internationally accepted standard for describing and assessing functioning and disability in any health condition. A specific list of ICF categories, an ICF Core Set (CS), has been developed for bipolar disorder, depression and schizophrenia. The aim of this study was to determine commonalities in the ICF-CSs for these three disorders, and to identify relevant categories for the development of tentative ICFCSs for severe mental disorders in general. Methods: The ICF categories of all three mental health conditions were examined and compared. Results: Comparison of the Comprehensive ICF-CSs for the three mental health conditions revealed a set of 34 common categories (i.e., 10 from the Body functions component, 14 from the Activities and participation component, and 10 Environmental factors). These categories formed the proposed Comprehensive ICF-CS for severe mental disorders. A total of 11 categories were common to the Brief ICF-CSs of the three mental health conditions, and these formed the Brief ICF-CS for severe mental disorders (i.e., 3 from the Body functions component, 6 from the Activities and participation component, and 2 Environmental factors). All the categories included refer to key aspects of functioning for severe mental disorders. Conclusions: The proposed ICF-CSs for severe mental disorders may be applicable across a number of psychotic and affective disorders and they should prove useful for mental health services whose care remit covers a range of conditions

The association between subjective caregiver burden and depressive symptoms in carers of older relatives: a systematic review and meta-analysis

BackgroundFamily carers are an important source of care for older people. Although several studies have reported that subjective caregiver burden is related to depressive symptoms there are no systematic reviews quantifying this association.ObjectiveTo establish the extent to which subjective caregiver burden is associated with depressive symptoms and whether this association would vary by study or care characteristics.MethodsWe searched major databases such as PubMed, CINAHL, PsycINFO, Scopus and ISI Proceedings up to March 2018, and conducted a meta-analysis of included studies. Summary estimates of the association were obtained using a random-effects model to improve generalisation of findings.ResultsAfter screening of 4,688 articles, 55 studies were included providing a total of 56 independent comparisons with a total of 9,847 carers from data across 20 countries. There was a large, positive association between subjective caregiver burden and depressive symptoms ([Formula: see text] = 0.514; 95% CI = 0.486, 0.541), with very low heterogeneity amongst individual studies (I2 = 8.6%). Sensitivity analyses showed no differences between cross-sectional or repeated measures ([Formula: see text] = 0.521; 95% CI = 0.491, 0.550; 51 samples) and longitudinal studies ([Formula: see text] = 0.454; 95% CI = 0.398, 0.508; 6 samples). We found a higher effect size for those caring for people living with dementia compared to those caring for frail older people, and stroke survivors. Carer sex, age and kinship did not change the estimate of the effect.ConclusionsSubjective caregiver burden is a significant risk factor for depressive symptoms in carers of older people and may precipitate clinical depression. Those caring for people with dementia experience greater burden. There is a need for longitudinal evaluations examining the effects of potential mediators of the association of subjective burden and depressive symptoms. Future interventions should test whether minimizing subjective burden may modify the risk of developing depression in carers of older relatives

Inhibidores potenciales de monoaminooxidasa: 4-(1-arilimidazolil) metilhidracina

N-Acetyl-N'-[ 4-(1-arylimidazolyl) methylene] hydrazine (II) is synthetized by reaction of 1-aryl-4-forrnylimidazole (1) with acetylhydrazine. Reduction of 11 yield N-acetyl-N: [4 -(arylimidazolyl) methyl] hydrazine (III). This compound give 4-(1-arylimidazolyl) methylhydrazine (IV) by hydrolisis with hydrochloric acid. The configuration of 11 has been established by  H-NMR.Se prepara N-acetil-N'- [4-(1-arilimidazolil) metilén] hidracina (11) por reacción de 1-aril-4-formilimidazol (1) con acetilhidracina. La reducción de 11 produce N-acetil-N'-[ 4-(1-arilimidazolil) metil] hidracina (III). Este último compuesto se transforma en 4-(1-arilimidazolil) metilhidracina (IV) por hidrólisis con ácido clorhídrico. La configuración de 11 se estabece mediante  H-RMN