Clinical findings associated with a de novo partial trisomy 10p11.22p15.3 and monosomy 7p22.3 detected by chromosomal microarray analysis.

We present the case of an 18-month-old boy with dysmorphic facial features, developmental delay, growth retardation, bilateral clubfeet, thrombocytopenia, and strabismus, whose array CGH analysis revealed concurrent de novo trisomy 10p11.22p15.3 and monosomy 7p22.3. We describe the patient's clinical presentation, along with his cytogenetic analysis, and we compare the findings to those of similar case reports in the literature. We also perform a bioinformatic analysis in the chromosomal regions of segmental aneuploidy to find genes that could potentially explain the patient's phenotype

GIS-based models for the development of sustainable aquaculture of native fish species in central Mexico: a catchment level approach for the protection of biodiversity.

Over the last 3 decades, freshwater aquaculture has become one of the most important food industries. However the constant introduction of a reduced number of very successful species for aquaculture has been identified as one of the main activities related to the alarming decline of fish biodiversity worldwide. This issue has raised awareness amongst the scientific community, governmental authorities and the general public towards freshwater fish biodiversity. This new awareness has promoted the development of “green” markets and environmentally friendly strategies, aiming for a reliable production of protein sources. The development of native species aquaculture has been presented as a strong alternative for sustainable aquaculture and the protection of biodiversity. However, it seems clear that unplanned native species aquaculture developments can be as detrimental on local biodiversity as the introduction of exotic fish, if not more dangerous. Therefore, the advantages and disadvantages of native species aquaculture have to be clearly analysed before any aquaculture development. This study aimed to establish a philosophical background regarding the use of native fish species in aquaculture in contrast to the introduction of exotic species that may compete for a similar niche as food in local markets. The main ecological impacts that exotic fish species may have on natives, such as competition, predation, and hybridization were discussed. In addition, a well planned native species Aquaculture Strategy for the Protection of Biodiversity was produced, at catchment level, within a Geographic Information System (GIS). For the development of the native species aquaculture strategy in central Mexico, four species of Atherinids (Chirostoma estor, C. Jordani, C. promelas and Atherinella balsana) and two species of native Ictalurids (Ictalurus balsanus and Ictalurus dugesii) were included in this study. These six species are relatively new to aquaculture and they were selected on the basis of their importance in local fisheries and markets in their native basins of the Lerma-Santiago and Balsas rivers. Both of these basins are of great importance in central Mexico, not only because of their biodiversity but also because of their high human population densities and socio-economic status. The use of Geographic Information Systems was a fundamental factor in the development of the native species aquaculture strategy at catchment level, consisting of site suitability models (SSM) for each species in their corresponding native catchments. Overall, SSM identified 13,916 km2 and 11,178 km2 highly suitable for aquaculture of the studied Atherinids and Ictalurids respectively, based on Water, Soil and Terrain, Infrastructure and Risk sub-models. A set of predictive species distribution models (PSDM), which related ecological characteristics for each studied species with relevant environmental and topographic parameters into a GIS, were also produced. Such models were developed for the establishment of potential natural ranges of distribution for each species, as well as their potential to become exotic in new environments, as a potential for invasion model (PI). Based on a partial verification, both PSDM and PI models produced results that were satisfactorily consistent with the known distribution of each modelled species. The combination of SSM and PSDM produced an Aquaculture Strategy for the Protection of Biodiversity model (ASPB) which identified the most environmentally friendly suitable areas for aquaculture sites. In contrast, the combination of the SSM with PI models into an ASPB model identified the site suitability potential for non-native species that are genetically close to native ones, in an attempt to reduce the known impacts that exotic species have on local biodiversity. In this way the ASPB model identified 7,651 km2 suitable for aquaculture of I. balsanus in its native Balsas basin and 15,633 km¬2 suitable for aquaculture of the non-native I. dugesii. ASPB models were produced for all the studied species. The final results were used to produce a set of guidelines for the development of sustainable aquaculture of native species at catchment level that cover genetic and ecological implications, as well as a well planned decision making tool produced in a GIS

Common property: uncommon forms of prosocial organizing

As Adam Smith memorably observed, commerce is replete with positive externalities (Smith, 1776). Much good comes to societies in which profit-seeking entrepreneurship flourishes, including gainful employment and the generation of income for expenditure on life’s necessities and luxury goods and services. Alas, the externalities are not always positive and individuals, groups and societies also suffer from the negative externalities of commerce. Lately there has been heightened concern that left to its own self-interested devices, commerce is responsible for increasing social and environmental harm. Porter and Kramer (2011) remark that “business increasingly has been viewed as a major cause of social, environmental, and economic problems. Companies are widely perceived to be prospering at the expense of the broader community” (p. 62)

Najas flexilis (Hydrocharitaceae) in Alaska : a reassessment

Author Posting. © New England Botanical Club, 2015. This article is posted here by permission of New England Botanical Club for personal use, not for redistribution. The definitive version was published in Rhorora 117 (2015): 354-370, doi:10.3119/15-03.Fifteen Najas flexilis collections were made in Alaska during the summer of 2012, with 13 of the stations representing either new or formerly undocumented localities for this imperiled Alaskan species. These field collections characterize the Alaskan habitats of N. flexilis as shallow water sites (<1.5 m) with sand-dominated substrates (71% of sites) and have documented an additional 28 species associates (a 300% increase). However, the additional collections have not extended the elevational, latitudinal, or longitudinal extent of N. flexilis from the limits indicated by previous Alaskan collections. Najas flexilis remains rare in Alaska as evidenced by a low specimen recovery rate (10%) from potentially suitable sites, and a total of only 12 geographically distinct localities known across the entire state. The new collections have furnished valuable study material for morphological and genetic analyses, which have confirmed the identity of Alaskan populations as N. flexilis, rather than N. canadensis, a recently identified, cryptic, allotetraploid derivative. A synthesis of information indicates that N. flexilis is indigenous to Alaska, where it originated via past (versus recent) migrations from other North American rather than Old World populations.Portions of this work were funded by National Science Foundation grant DEB-0841658 to D.H.L

Nose velocity calculation for spatial analysis of habitat and environmental flow assessments

For the enviromental flow assesments, physical habitat simulation was applied with the 2-dimentional software River 2D. Habitat suistability criteria for depth, mean velocity, nose height and nose velocity were considered for the native brown trout. The WUA flow functions were calculated for two alternatives: based on both depth and mean velocity as well as depth and nose velocity at a fixed height above the river bed

Nose velocity calculation for spatial analysis of habitat and environmental flow assessments

For the enviromental flow assesments, physical habitat simulation was applied with the 2-dimentional software River 2D. Habitat suistability criteria for depth, mean velocity, nose height and nose velocity were considered for the native brown trout. The WUA flow functions were calculated for two alternatives: based on both depth and mean velocity as well as depth and nose velocity at a fixed height above the river bed

The effect of longitudinal flow on resonantly damped kink oscillations

The most promising mechanism acting towards damping the kink oscillations of coronal loops is resonant absorption. In this context most of previous studies neglected the effect of the obvious equilibrium flow along magnetic field lines. The flows are in general sub-Alfv\'enic and hence comparatively slow. Here we investigate the effect of an equilibrium flow on the resonant absorption of linear kink MHD waves in a cylindrical magnetic flux tube with the aim of determining the changes in the frequency of the forward and backward propagating waves and in the modification of the damping times due to the flow. A loop model with both the density and the longitudinal flow changing in the radial direction is considered. We use the thin tube thin boundary (TTTB) approximation in order to calculate the damping rates. The full resistive eigenvalue problem is also solved without assuming the TTTB approximation. Using the small ratio of flow and Alfv\'en speeds we derive simple analytical expressions to the damping rate. The analytical expressions are in good agreement with the resistive eigenmode calculations. Under typical coronal conditions the effect of the flow on the damped kink oscillations is small when the characteristic scale of the density layer is similar or smaller than the characteristic width of the velocity layer. However, in the opposite situation the damping rates can be significantly altered, specially for the backward propagating wave which is undamped while the forward wave is overdamped

New insights into the use and circulation of reindeer antler in northern Iberia during the Magdalenian (ca. 21-13 cal ka BP)

Interactions between prehistoric foragers and reindeer at the end of the Pleistocene are still poorly documented in northern Iberia, particularly the reasons and means by which their antlers were collected, processed and circulated. Here we review the main osseous industries dated to between 21 and 13 cal ka BP, focusing on the use and circulation of reindeer antler as a raw material for the production of weapons and tools by Magdalenian foragers. Thirty-six reindeer antler artefacts were identified from 11 Iberian sites that are located at either end of the Pyrenees: the Cantabrian region to the west, and to a lesser extent, in Catalonia to the east. Despite biases in the identification of production objectives (end-products), a detailed techno-typological, chronological and geographical analysis of these assemblages reveals both the existence of a consistent reindeer antler industry in northern Iberia and long-distance connections between the Cantabrian region and the Pyrenees. The integration of contemporary macrofaunal data makes it possible to explore the extension of the reindeer?s ecological niche in northern Iberia, as well as strategies for the acquisition and circulation of reindeer antler in the peninsula. Assuming that some reindeer assemblages result from the import of raw materials to supply manufacturing activities, we propose a scenario where the acquisition of reindeer antlers may have been organised at a local scale in the Basque region, and potentially in the neighbouring territories of Navarre, Cantabria and Asturias. On the other hand, in Catalonia, the combination of both faunal and technological data supports the hypothesis that reindeer antlers were imported (along with pelts) over longer distances, probably from the northern Pyrenees.This research was primarily financed by an international collaboration between the Spanish Ministry of Science and Innovation (MCIN/AEI/10.13039/501100011033) and the European Union (NextGenerationEU/PRTR) as part of the HumAntler project (PCI2021-122053-2 B) based at the Grupo I + D + i EvoAdapta (UC). Funding was also provided by the UMR-5608 TRACES laboratory of the University of Toulouse and PID2020-114462 GB-I00 of the Spanish Ministry of Science and Innovation (University of Salamanca)

Tuning and hybrid parallelization of a genetic-based multi-point statistics simulation code

One of the main difficulties using multi-point statistical (MPS) simulation based on annealing techniques or genetic algorithms concerns the excessive amount of time and memory that must be spent in order to achieve convergence. In this work we propose code optimizations and parallelization schemes over a genetic-based MPS code with the aim of speeding up the execution time. The code optimizations involve the reduction of cache misses in the array accesses, avoid branching instructions and increase the locality of the accessed data. The hybrid parallelization scheme involves a fine-grain parallelization of loops using a shared-memory programming model (OpenMP) and a coarse-grain distribution of load among several computational nodes using a distributed-memory programming model (MPI). Convergence, execution time and speed-up results are presented using 2D training images of sizes 100 × 100 × 1 and 1000 × 1000 × 1 on a distributed-shared memory supercomputing facility.Peer ReviewedPostprint (author's final draft