Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders

The bed nucleus of the stria terminalis (BNST) is a center of integration for limbic information and valence monitoring. The BNST, sometimes referred to as the extended amygdala, is located in the basal forebrain and is a sexually dimorphic structure made up of between 12 and 18 sub-nuclei. These sub-nuclei are rich with distinct neuronal subpopulations of receptors, neurotransmitters, transporters and proteins. The BNST is important in a range of behaviors such as: the stress response, extended duration fear states and social behavior, all crucial determinants of dysfunction in human psychiatric diseases. Most research on stress and psychiatric diseases has focused on the amygdala, which regulates immediate responses to fear. However, the BNST, and not the amygdala, is the center of the psychogenic circuit from the hippocampus to the paraventricular nucleus. This circuit is important in the stimulation of the hypothalamic-pituitary-adrenal axis. Thus, the BNST has been largely overlooked with respect to its possible dysregulation in mood and anxiety disorders, social dysfunction and psychological trauma, all of which have clear gender disparities. In this review, we will look in-depth at the anatomy and projections of the BNST, and provide an overview of the current literature on the relevance of BNST dysregulation in psychiatric diseases

Efficacy of alternative copper-based preservatives in protecting decking from biodegradation

The above-ground performance of decking treated with two alternative copper-based preservative formulations is being evaluated at a test site near Madison, Wisconsin, USA. Southern pine sapwood lumber specimens (38 mm by 140 mm by 910 mm) were pressure treated with 0,93 %, 1,40 % or 2,34 % (oxide basis) actives concentrations of a boron-copper formulation (BC) composed of 7,2 % copper hydroxide and 92,8 % sodium tetraborate decahydrate. Similar specimens were pressure-treated with 0,66 % or 1,32 % actives concentrations of a copper-zinc formulation (CZDP) composed of 18 % copper (CuO basis), 12 % zinc (ZnO basis), 14 % dimethylcocoamine and 56 % propanoic acid. In both cases untreated specimens and specimens treated with a 1% concentration of chromated copper arsenate Type C (CCA-C) were included for comparison.  The specimens were installed on racks approximately 760 mm above the ground and periodically evaluated for extent of fungal decay and surface microbial growth. After 18 years in test specimens treated with the lowest solution concentration of BC (0,93 %) suffered substantial degradation and all but three replicates have failed. Obvious decay has not yet been detected in specimens treated to the highest BC concentration (2,34 %), but decay is suspected in one of these specimens. Decking specimens treated with CZDP exhibited no evidence of decay until year 17 when a fruiting body was observed on one specimen treated with a 0,66 % solution concentration. There has been no evidence of decay in specimens treated with 1,32 % CZDP or in either set of specimens treated with 1 % CCA-C. Both BC and CZDP-treated specimens were at least as effective as 1 % CCA-C in minimizing noticeable surface microbial growth. These decking studies confirm that relatively low copper concentrations can provide substantial protection for decking exposed in a moderate climate, and that the CZDP formulation is potentially more effective than the BC formulation. However, caution is warranted in extrapolating these findings to more severe climates and to construction designs that are more likely to trap moisture

DURABILITY OF MASS TIMBER STRUCTURES: A REVIEW OF THE BIOLOGICAL RISKS

Mass timber structures have the potential to change wooden construction on a global scale. Numerous mass timber high-rise buildings are in planning, under development or already built and their performance will alter how architects and engineers view wood as a material. To date, the discussion of material durability and biodegradation in these structures has been limited. While all materials can be degraded by wetting, the potential for biodegradation of wood in a mass timber building requires special consideration. Identifying and eliminating the conditions that might lead to this degradation will be critical for ensuring proper performance of wood in these structures. This article reviews and contrasts potential sources of biodegradation that exist for traditional wood construction with those in mass timber construction and identifies methods for limiting the degradation risk. Finally, future research needs are outlined

The effect of pH on decomposition of Mylone (dazomet) and tridipam to fungitoxic methylisothiocyanate in wood

Mylone@ and tridipam are two solid chemicals that decompose to produce methylisothiocyanate (MIT), a highly effective wood fumigant. In this study, two techniques -- a rapid, test-tube method and small-scale, wood-block assay -- were used to determine the effect of the pH of various chemical buffers on the decomposition of Mylone@ and tridipam in Douglas-fir heartwood samples colonized by Poria carbonica. Both chemicals were sensitive to pH, and higher levels of MIT were produced as the pH of the buffers increased. In general, fungal survival was not affected 1 week after chemical treatment. Complete control of P. carbonica, however, resulted after 4 weeks of exposure to 50 mg Mylone@/block or 150 mg tridipam/block, when each chemical was combined with a pH-12 buffer. These results suggest that regulating fumigant treatments according to the degree of fungal attack can substantially improve the precision of decay control in wood maintenance programs.Keywords: wood decay, Mylone, tridipam, pH, methylisothiocyanate, Poria placenta, Poria carbonica, fumigants, Douglas-fir, buffers, utility pole

Patient-reported outcome data generated in a clinical intervention in community mental health care - psychometric properties

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Aesthetics of self-scaling: parallaxed transregionalism and Kutluğ Ataman's art practice

This article examines relations of ethnography, contemporary art-practice, globalisation and scalar geopolitics with particular reference to Kutluğ Ataman’s artworks. Having been shortlisted for the Turner Prize at the Tate and awarded the prestigious international Carnegie Prize in 2004 with his forty-screen video installation Küba (2004), Ataman became an extremely well-known, globally acclaimed artist and filmmaker. Self-conscious of their global travel and critically attentive to the contemporary ethnographic turn in the visual arts scene, Ataman’s video-works perform a conscientious failure of representing cultural alterity as indigeneity. Concentrating on the artist’s engagement with ethnography, this article contains three main parts. Analyses of the selection of videos in each part will give an account of different scalar aspects of Ataman’s artworks. It will first revisit a previous study (Çakirlar 2011) on the artist’s earlier work of video-portraits including Never My Soul! (2002) and Women Who Wear Wigs (1999). A detailed discussion of Küba follows, which may be taken as the ‘hinge - work’ in Ataman’s oeuvre that marks a scalar transition in his critical focus - from body and identity to community and geopolitics. The discussion will then move to a brief analysis of the series Mesopotamian Dramaturgies, including the screen-based sculptures Dome (2009), Column (2009), Frame (2009), English as a Second Language (2009), and The Complete Works of William Shakespeare (2009). Rather than addressing scale as a differential concept, this article aims to demonstrate the ways in which Ataman’s art-practice produces self-scaling, self-regioning subjects that unsettle the hierarchical constructions of scale and facilitates a critique of the scalar normativity within the global art world’s regionalisms and internationalisms

The use of interpretive phenomenological analysis in couple and family therapy research

This article proposes a research methodology that is newer to the field of couple and family therapy research called Interpretive Phenomenological Analysis (IPA). Researchers exploring couple and family therapy research continue to establish the efficacy of couple and family interventions in a context that favors a positivist view of phenomena. This research continues to be critical for establishing the role of couple and family therapy in the field of mental health as well as further clarifying which interventions are best for specific clinical issues and when. IPA offers researchers the opportunity to explore how couples and families make meaning of their experiences from an intersubjective perspective. Meaning making is central to understanding couples and families as well as part of the many clinical approaches to working with couples and families. Despite the importance of meaning, few research methodologies allow for this central concept in couple and family therapy to be the focus of exploration. The following article outlines one such methodology and the possible use of IPA in couple and family therapy research

A case study analysis of a constructionist knowledge building community with activity theory

This article investigates how activity theory can help research a constructionist community. We present a constructionist activity model called CONstructionism Through ACtivity Theory (CONTACT) model and explain how it can be used to analyse the constructionist activity in knowledge building communities. We then illustrate the model through its application to analysing the Wiki-supported community associated with a computer game. Our analysis focuses mainly on two perspectives: individual and collective actions, as well as individual and collective mediations. Experiences and challenges from the analysis are reported to demonstrate how CONTACT is helpful in analysing such communities