Ayurvedic mangement of Stroke - A Case Report

Stroke is one of the leading causes of adult neurological disability across the globe. Its prevalence ranges from 40 to 270 per 100,000 population. The timely management of stroke is so crucial so as to limit the upcoming disability. Stroke is the condition of sudden onset of weakness, numbness, paralysis, slurred speech, aphasia, problems with vision and other manifestations of a sudden interruption of blood flow to a specific anatomical area of the brain. Ayurvedic management is having results in this regard as per reported studies. The present article deals with a diagnosed case of subacute non-haemorrhagic infarct involving the right fronto parieto temporal region and the ganglio capsular region, presented as left sided hemiplegia. Stroke is quite clearly defined along with its symptoms, prognosis and management in Ayurveda in the context of Pakshaghata as a Vatavyadhi, affecting Madhyama Rogamarga, in which Sira and Snayu are mainly affected. Rookshana followed by Sneha-Sweda, Sodhana, Vasthi and Nasya along with selected Samana drugs were administered to the patient. Assessments were done before and after treatment using Motor Assessment Scale for Stroke. Supine to sitting over side of bed, balanced sitting, sitting to standing and walking are the main domains which got maximum improvement as per the assessment. The recovery was promising and worth detailing

2-Trifluoromethyl-10H-benzo4,5imidazo1,2-apyrimidin-4-one

In the molecule of the title compound, C11H6F3N3O, the three fused rings of the benzo4,5imidazo1,2-apyrimidine unit are essentially coplanar, the maximum deviation from the mean plane being 0.096 (2) à . In the crystal, N - Hâ¯O hydrogen bonds link the molecules into chains running along the b-axis direction

A Hybrid Approach to Cognition in Radars

In many engineering domains, cognition is emerging to play vital role. Cognition will play crucial role in radar engineering as well for the development of next generation radars. In this paper, a cognitive architecture for radars is introduced, based on hybrid cognitive architectures. The paper proposes deep learning applications for integrated target classification based on high-resolution radar range profile measurements and target revisit time calculation as case studies. The proposed architecture is based on the artificial cognitive systems concepts and provides a basis for addressing cognition in radars, which is inadequately explored for radar systems. Initial experimental studies on the applicability of deep learning techniques under this approach provided promising results

Correlation of micronutrient status with atherogenic index and oxidative stress markers in metabolic syndrome

The prognostication of cardiovascular events in people with metabolic syndrome (MetS) is paramount due to their heightened risk profile. MetS is typified by a cluster of medical conditions such as raised blood pressure, hyperglycemia, central adiposity, and anomalous levels of cholesterol or triglycerides, which collectively increase the likelihood of developing cardiovascular disease. Anticipating cardiovascular events in these individuals enables enhanced prevention approaches, more efficient management, and better patient results. The present investigation involved an examination of the correlation between a range of biomarkers, namely Lp-PLA2, Apo A1, Apo B, hs-CRP, OxLDL, MDA, and Vitamin C, and the atherogenic index in a population afflicted with MetS. The results indicated no statistically significant association between the markers mentioned above and the atherogenic index within the sample population. This suggests that these markers may not possess sufficient predictive value for cardiovascular events in this demographic. Nevertheless, it was noted that although there was no discernible correlation with the atherogenic index, the MetS cohort exhibited increased serum concentrations of Lp-PLA2, OxLDL, and MDA. The markers mentioned above are widely recognized as reliable indicators of inflammation and oxidative stress, two crucial processes in the development of atherosclerosis and subsequent cardiovascular events. As a result, the increased prevalence of MetS may indicate heightened susceptibility to cardiovascular disease, underscoring the importance of implementing a comprehensive approach to managing cardiovascular risk in affected individuals. In summary, although the markers analyzed in this investigation may not directly associate with the atherogenic index, their increased concentrations warrant prudence and emphasize the significance of vigilant management of cardiovascular risk in individuals diagnosed with MetS. Accurately forecasting cardiovascular events remains a multifaceted obstacle that necessitates the examination of numerous variables and persistent scholarly endeavors

Integrated Omics Profiling Reveals Novel Patterns of Epigenetic Programming in Cancer-Associated Myofibroblasts

There is increasing evidence that stromal myofibroblasts play a key role in tumour development, however the mechanisms by which they become reprogrammed to assist in cancer progression remain unclear. As cultured Cancer Associated Myofibroblasts (CAMs) retain an ability to enhance the proliferation and migration of cancer cells in vitro, it is possible that epigenetic reprogramming of CAMs within the tumour microenvironment may confer long-term pro-tumorigenic changes in gene expression. This study reports the first comparative multi-omics analysis of cancer-related changes in gene expression and DNA-methylation in primary myofibroblasts derived from gastric and oesophageal tumours. In addition, we identify novel CAM-specific DNA methylation signatures, which are not observed in patient-matched Adjacent Tissue-derived Myofibroblasts (ATMs), or corresponding Normal Tissue-derived Myofibroblasts (NTMs). Analysis of correlated changes in DNA methylation and gene expression show that different patterns of gene-specific DNA methylation have the potential to confer pro-tumourigenic changes in metabolism, cell signalling and differential responses to hypoxia. These molecular signatures provide new insights into potential mechanisms of stromal reprogramming in gastric and oesophageal cancer, while also providing a new resource to facilitate biomarker identification and future hypothesis driven studies into mechanisms of stromal reprogramming and tumour progression in solid tumours

Broodstock collection, Transportation and Maintenance of Marine finfishes

Wild collection and transportation of adult/sub-adults of marine finfish have a pivotal role in developing the broodstock in captive conditions. Physiological stress and physical injury of a brood fish while transportation and handling may have a more detrimental effect on spawning success than any other factor (Rottman et al., 1991). Mainly marine broodfishes are collected from the wild only. Wild collection can be done from Alappuzha, Vizhinjam, Kanyakumari, Tuticorin and Ramanathapuram areas along India’s southwest and southeast coast. The availability of broodfishes from a particular area can be assessed by a short-term market survey or by interviewing fishermen who target the particular fish. Experienced fishermen can confirm the presence of sub-adults of target fish around 200 meters from the high tide line during the post-monsoon period. Wild collection of fishes mainly done using Gill nets and Hook and line fishin

Forging the path to precision medicine in Qatar: a public health perspective on pharmacogenomics initiatives

Pharmacogenomics (PGx) is an important component of precision medicine that promises tailored treatment approaches based on an individual’s genetic information. Exploring the initiatives in research that help to integrate PGx test into clinical setting, identifying the potential barriers and challenges as well as planning the future directions, are all important for fruitful PGx implementation in any population. Qatar serves as an exemplar case study for the Middle East, having a small native population compared to a diverse immigrant population, advanced healthcare system, national genome program, and several educational initiatives on PGx and precision medicine. This paper attempts to outline the current state of PGx research and implementation in Qatar within the global context, emphasizing ongoing initiatives and educational efforts. The inclusion of PGx in university curricula and healthcare provider training, alongside precision medicine conferences, showcase Qatar’s commitment to advancing this field. However, challenges persist, including the requirement for population specific implementation strategies, complex genetic data interpretation, lack of standardization, and limited awareness. The review suggests policy development for future directions in continued research investment, conducting clinical trials for the feasibility of PGx implementation, ethical considerations, technological advancements, and global collaborations to overcome these barriers

Structural and optical properties of (In,Ga)As/GaP quantum dots and (GaAsPN/GaPN) diluted-nitride nanolayers coherently grown onto GaP and Si substrates for photonics and photovoltaics applications

San Francisco, California, United StatesInternational audienceLattice-matched GaP-based nanostructures grown on silicon substrates is a highly rewarded route for coherent integration of photonics and high-efficiency photovoltaic devices onto silicon substrates. We report on the structural and optical properties of selected MBE-grown nanostructures on both GaP substrates and GaP/Si pseudo-substrates. As a first stumbling block, the GaP/Si interface growth has been optimised thanks to a complementary set of thorough structural analyses. Photoluminescence and time-resolved photoluminescence studies of self-assembled (In,Ga)As quantum dots grown on GaP substrate demonstrate a proximity of two different types of optical transitions interpreted as a competition between conduction band states in X and Γ valleys. Structural properties and optical studies of GaAsP(N)/GaP(N) quantum wells coherently grown on GaP substrates and GaP/Si pseudo substrates are reported. Our results are found to be suitable for light emission applications in the datacom segment. Then, possible routes are drawn for larger wavelengths applications, in order to address the chip-to-chip and within-a-chip optical interconnects and the optical telecom segments. Finally, results on GaAsPN/GaP heterostructures and diodes, suitable for PV applications are reporte