86 research outputs found
Grandiose and vulnerable narcissism, identity integration and self-control related to criminal behavior
BACKGROUND: Although systematic research on narcissism has been conducted for over 100 years, researchers have only recently started to distinguish between grandiose and vulnerable narcissism in relation to criminal behavior. In addition, there is some evidence suggesting that identity integration and self-control may underlie this association. Therefore, the present study aimed to develop a theory-driven hypothetical model that investigates the complex associations between grandiose and vulnerable narcissism, identity integration, self-control, and criminal behavior using structural equation modeling (SEM). METHODS: The total sample (N = 222) included 65 (29.3%) individuals convicted of criminal behavior and 157 (70.7%) participants from the community, with a mean age of 37.71 years (SD = 13.25). Criminal behavior was a grouping variable used as a categorical outcome, whereas self-report questionnaires were used to assess grandiose and vulnerable narcissism, self-control, and identity integration. RESULTS: The overall SEM model yielded good fit indices. Grandiose narcissism negatively predicted criminal behavior above and beyond the influence of identity integration and self-control. In contrast, vulnerable narcissism did not have a direct significant effect on criminal behavior, but it was indirectly and positively associated with criminal behavior via identity integration and self-control. Moreover, grandiose narcissism was positively, whereas vulnerable narcissism was negatively associated with identity integration. However, identity integration did not have a direct significant effect on criminal behavior, but it was indirectly and negatively associated with criminal behavior via self-control. Finally, self-control was, in turn, negatively related to criminal behavior. CONCLUSIONS: We propose that both subtypes of narcissism should be carefully considered in clinical assessment and current intervention practices. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40359-021-00697-1
Calcified multilocular thymic cyst associated with thymoma: a case report
<p>Abstract</p> <p>Introduction</p> <p>There are few case reports of thymoma with a thymic cyst. Such an association renders it difficult for any pathologist to differentiate from other neoplasms, such as a cystic thymoma.</p> <p>Case presentation</p> <p>A 50-year-old Berber woman from Morocco was admitted with a chronic cough of more than 10 years duration. Her medical history and physical examination were normal. Anterior chest radiography demonstrated a calcified opacity in her right anterior mediastinum. A chest-computed tomogram revealed a round cystic tumor, with significant calcification in her right anterior mediastinum. A surgical exploration was performed. The tumor seemed to be a well-encapsulated and totally calcified lesion, arising from the right lobe of her thymus. It was removed by partial resection of her thymus. Through histology, the calcified tumor exhibited some areas of multilocular fibrous-wall cysts. These cysts were partially lined by small cuboidal cells with severe chronic inflammation and an AB thymoma that arose from the wall of the cyst.</p> <p>Conclusion</p> <p>Greater attention should be given to multilocular thymic cysts, to exclude the possibility of neoplasm, especially when the cyst wall is thickened.</p
Consumption patterns and living conditions inside Het Steen, the late medieval prison of Malines (Mechelen, Belgium)
Excavations at the Main Square (Grote Markt) of Malines (Mechelen, Belgium) have unearthed the building remains of a tower, arguably identifiable as the former town prison: Het Steen. When this assumption is followed, the contents of the fills of two cesspits dug out in the cellars of the building illustrate aspects of daily life within the early 14th-century prison. An integrated approach of all find categories, together with the historical context available, illuminates aspects of the material culture of the users of the cesspits, their consumption patterns and the living conditions within the building
Een 18de-eeuwse wraksite op de Buiten Ratel-zandbank (Belgische territoriale wateren): 1. Multidisciplinair onderzoek van het vondstenmateriaal
In 1996 werd op de Buiten Ratel-zandbank, op 9 mijl van de kust, ter hoogte van Koksijde, een houten scheepswrak gelokaliseerd. Het werd onderzocht door een groep sportduikers, met de naam NATA. Jarenlange verkenning van de wraksite leverde talrijke vondsten op. In 2003 zochten de duikers steun bij het toenmalige IAP (Instituut voor het Archeologisch Patrimonium), nu Vlaams Instituut voor het Onroerend Erfgoed (VIOE), om het onderzoek en de conservatie op wetenschappelijke basis verder te zetten. Het VIOE ontfermde zich over het onderzoek van de tot nu toe geborgen materiële resten van de wraksite.
Het eerste hoofdstuk van het artikel geeft een overzicht van de observaties van de wraksite via duikonderzoek en via gespecialiseerde technieken vanop een onderzoeksschip. In hoofdstuk 2 worden de objecten beschreven, hun betekenis aan boord van het schip besproken, evenals hun datering en herkomst. Hoofdstuk 3 brengt alle informatie samen en geeft aan wat er in de toekomst nog aan onderzoek kan gebeuren
MicroRNAs promote skeletal muscle differentiation of mesodermal iPSC-derived progenitors
Muscular dystrophies (MDs) are often characterized by impairment of both skeletal and cardiac muscle. Regenerative strategies for both compartments therefore constitute a therapeutic avenue. Mesodermal iPSC-derived progenitors (MiPs) can regenerate both striated muscle types simultaneously in mice. Importantly, MiP myogenic propensity is influenced by somatic lineage retention. However, it is still unknown whether human MiPs have in vivo potential. Furthermore, methods to enhance the intrinsic myogenic properties of MiPs are likely needed, given the scope and need to correct large amounts of muscle in the MDs. Here, we document that human MiPs can successfully engraft into the skeletal muscle and hearts of dystrophic mice. Utilizing non-invasive live imaging and selectively induced apoptosis, we report evidence of striated muscle regeneration in vivo in mice by human MiPs. Finally, combining RNA-seq and miRNA-seq data, we define miRNA cocktails that promote the myogenic potential of human MiPs
De visserskaai te Oostende (prov. West-Vlaanderen): archeologie van een in de 17de eeuw zwaar geteisterde stad
The Institute for the Archaeological Heritage of the Flemish Community (IAP) has, in close collaboration with the town of Ostend, carried out archaeological excavations during the construction works of the car park below the Visserskaai at Ostend from September 1998 till February 1999. This archaeological work mainly produced information on the eastern ramparts of Ostend and their evolution from the 16th century onwards together with information on the material culture of the inhabitants of Ostend during this same period. The town of Ostend had no defences until late in the 16th century as initial construction work for the defences only started in 1572 when the town came into northern hands. In the beginning of the 17th century Ostend managed to withstand successfully, with its newly built ramparts, for three years an overwhelming Spanish army siege. This was only possible thanks to the fact that the Spaniards never managed to seal of Ostend completely from the sea. As a result, victuals and soldiers arrived continuously at Ostend during the siege. It was only after the arrival of Spinola in the besieging camp, at the end of 1603, that Ostend was gradually forced to surrender. At the bottom of the excavated car park trench, some 4 m below the actual street level, wooden structures of the earthen ramparts were preserved (figs. 4-5). The presence of these con- firms historical data about the use of wood to strengthen the earthen ramparts. The excavations however documented mainly features from 2 bastions, the Peckels bastion and the Spanish bastion (fig. 2-3). Human burials and a gunpowder-magazine (figs. 7, 8, 10, 12) were uncovered in the Peckels bastion and human burials and an open-air rainwater reservoir were detected in the Spanish bastion. The human burials are studied elsewhere in this volume together with other post-medieval burials from Ostend recently discovered outside regular cemeteries. Archaeological material found in connection with the gunpowder-magazine in the Peckelf bastion dates from the 2nd half of the 16th /1st half of the 17th century (figs. 6,9,13-15) and suggests that the construction of this gunpowder-magazine? has to be situated somewhere in the middle of the 17th century, in other words in the period when the town defences of Ostend were adapted to new standards after the above- mentioned siege. A typical object related to the siege is a funnel-shaped gunpowder-flask in a copper-alloy (fig. 6). The inner wall of the gunpowder-magazine was erected on a framework of horizontal wooden beams, which were themselves resting on vertically placed and sharpened beams, mainly in oak (fig. 8). A dendrochronological analysis of the vertically placed beams produced a terminus post quem, which is far too early to be of any help in the discussion on the gunpowder-magazine. The technical differences between the inner and outer wall of the gunpowder-magazine suggest at least 2 phases for this building. The above-mentioned ceramics consist of redwares, Rhenish stone- wares a.o. Raeren, maiolicas, Weser slipwares, olive jars from Seville and some whitewares with green or yellow glaze. The archaeological material from the open- air rainwater reservoir in the Spanish bastion dates from the 2nd half of the 17th/1st half of the 19th century but mainly from the 18th century (figs. 16-32). The collection of ceramics from this context is largely dominated by tablewares. Among these stonewares are nearly missing and replaced by faience, china and industrial white- wares (pearl and cream wares). Maiolica has been nearly completely replaced by faience. Maiolicas remain in fact only important as wall-tiles. The collection contains some olive jars from Seville, a bowl from Dèsvres and a few products from Beauvais. The collection of china mainly consists of cups and small dishes in blue and white china. The china has been brought to Ostend in great quantities in the 18th century, first by the Ostend Company and later by mariners from Ostend in Foreign Service, mainly as ship's ballast. Besides ceramics this context also produced several finds in leather, glass, stone and metal. The leather finds mainly consist of shoes. The glass collection is largely dominated by cylindrical and globular bottles of which one was still intact including its cork (fig. 26: 1). Metal is represented by 22 cast iron cannon balls (fig. 28) and by a standard measure for bottles from an unidentified town inspector of measures and weights of Ostend with GS initials (fig. 27: 8). Small quantities of animal remains were found dispersed over many contexts within the site's stratigraphy. Only three of them are meaningful: a deposit found under the floor of the gunpowder-magazine (table 1: context A), an assemblage excavated in leveling layers within the Peckels bastion (table 1: context B), and material found in the water reservoir in the Spanish bastion (table 1: context C). All connections consisted of larger material; sieved samples did not yield meaningful numbers of smaller animal remains. Context A dates from the second half of the 16th to the first half of the 17th century and consists of consumption refuse: marine molluscs, marine fish bones, bird bone and the remains of cattle, sheep and pig. Context B is contemporaneous to context A and also represents consumption refuse with a similar composition. Remarkable are only a series of vertebrae of a large specimen of ling, a fish that must have been caught in northern waters, and a number of skeletal elements of a gurnard species. Context C has a younger date (second half of the 17th century to the first half of the 19th century) and has a mixed origin in terms of the taphonomy of the animal remains. Not only consumption refuse is present but also parts of the skeletons of at least four dogs and a horse. It is possible that all three contexts represent secondary refuse; in any case their provenance remains unknown. The material certainly has limited value for the interpretation of former consumption patterns. A feature of special interest is the presence of a few cowrie shells. Several aspects of the material culture reflect the maritime character of the town: the presence of several imports such as olive jars from Seville and specific objects as a token in lead (fig. 13: 16) probably used by skippers for the payment of fees and/or tolls. The presence of an important percentage of china and of some cowrie shells is probably related to the activities of the Ostend Company in the l8th century. The pottery discovered from both contexts (2nd half 16th century/ 1 st half 17th century and 2nd half 17th century/ 1st half 19th century) follows the general trends described for post-medieval Flanders
One-pot synthesis of nano-crystalline MCM-22
[EN] Nano-crystalline MCM-22 zeolite was synthesized in a one-pot procedure by the use of an organosilane (dimethyl-octadecyl-(3-trimethoxysilylpropyl)-ammonium chloride, TPOAC) in the zeolite synthesis gel. This crystal growth inhibition procedure introduced mesopores in the MCM-22 crystallites. The lower mechanical stability of the nano-crystalline MCM-22 zeolite compared with bulk MCM-22 can be countered to some extent by pillaring. The increased external surface of the microporous zeolite domains resulted in increased accessibility of the Bronsted acid sites, as followed from the better performance in liquid-phase benzene alkylation with propylene as compared with bulk MCM-22. The increased accessibility of the internal acid sites in Mo-loaded hierarchical MCM-22 was also evident from the improved benzene selectivity during methane aromatization. Silylation of hierarchical Mo/MCM-22 was detrimental for the catalytic performance in MDA. The nano-crystalline MCM-22 has physico-chemical and catalytic properties intermediate between those of MCM-22 and ITQ-2 with the benefit over ITQ-2 that it can be synthesized in a single step. (C) 2015 Elsevier Inc. All rights reserved.Funding from the 7th Framework Program of the European Commission through the Collaborative Project Next-GTL (agreement no 229183) and financial support by the Spanish Government-MINECO through "Severo Ochoa" (SEV 2012-0267), Consolider Ingenio 2010-Multicat (CSD2009-00050) and MAT2012-31657 are acknowledged. Marta E. Martinez Armero thanks MINECO for economical support through pre-doctoral fellowship for doctors training (BES-2013-066800). The authors thank B. Esparcia for technical assistance.Tempelman, CHL.; Portilla Ovejero, MT.; Martínez Armero, ME.; Mezari, B.; De Caluwe, NGR.; Martínez, C.; Hensen, EJM. (2016). One-pot synthesis of nano-crystalline MCM-22. Microporous and Mesoporous Materials. 220:28-38. https://doi.org/10.1016/j.micromeso.2015.08.018S283822
A Bayesian approach to modelling heterogeneous calcium responses in cell populations
Calcium responses have been observed as spikes of the whole-cell calcium concentration in numerous cell types and are essential for translating extracellular stimuli into cellular responses. While there are several suggestions for how this encoding is achieved, we still lack a comprehensive theory. To achieve this goal it is necessary to reliably predict the temporal evolution of calcium spike sequences for a given stimulus. Here, we propose a modelling framework that allows us to quantitatively describe the timing of calcium spikes. Using a Bayesian approach, we show that Gaussian processes model calcium spike rates with high fidelity and perform better than standard tools such as peri-stimulus time histograms and kernel smoothing. We employ our modelling concept to analyse calcium spike sequences from dynamically-stimulated HEK293T cells. Under these conditions, different cells often experience diverse stimuli time courses, which is a situation likely to occur in vivo. This single cell variability and the concomitant small number of calcium spikes per cell pose a significant modelling challenge, but we demonstrate that Gaussian processes can successfully describe calcium spike rates in these circumstances. Our results therefore pave the way towards a statistical description of heterogeneous calcium oscillations in a dynamic environmen
Diseño de un manual de detección de ansiedad social en adolescentes
Curso de Especial InterésEl objetivo de este trabajo de grado ha sido diseñar un manual dirigido a padres y docentes, en el que se establezcan técnicas de detección de ansiedad social en adolescentes; el diseño de este manual permite un aprendizaje significativo de una forma diferente, en un lenguaje claro y preciso, en formato digital para un fácil acceso y portabilidad del material, logrando de esta forma, que la población adolescente sea beneficiada a través de las acciones que se emprenderán por parte de los padres de familia, docentes y profesionales.142 p.RESUMEN
1. JUSTIFICACIÓN
2. OBJETIVOS
3. ESTUDIO DEL MERCADO
4. PRESENTACIÓN DEL PRODUCTO
5. CLIENTES – SEGMENTACIÓN
6. COMPETENCIA
7. CANALES DE DISTRIBUCIÓN
8. RESULTADOS DEL ESTUDIO DE MERCADO
9. DISCUSIÓN DEL ESTUDIO DE MERCADO
10. PRESUPUESTO
11. RESULTADOS
12. CONCLUSIONES
REFERENCIAS
APÉNDICESPregradoPsicólog
Impact of vascular calcification on cardiovascular mortality in hemodialysis patients: clinical significance, mechanisms and possible strategies for treatment
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