On Silicon Group Elements Ejected by Supernovae Type Ia

There is compelling evidence that the peak brightness of a Type Ia supernova is affected by the electron fraction Ye at the time of the explosion. The electron fraction is set by the aboriginal composition of the white dwarf and the reactions that occur during the pre explosive convective burning. To date, determining the makeup of the white dwarf progenitor has relied on indirect proxies, such as the average metallicity of the host stellar population. In this paper, we present analytical calculations supporting the idea that the electron fraction of the progenitor systematically influences the nucleosynthesis of silicon group ejecta in Type Ia supernovae. In particular, we suggest the abundances generated in quasi nuclear statistical equilibrium are preserved during the subsequent freezeout. This allows one to potential recovery of Ye at explosion from the abundances recovered from an observed spectra. We show that measurement of 28Si, 32S, 40Ca, and 54Fe abundances can be used to construct Ye in the silicon rich regions of the supernovae. If these four abundances are determined exactly, they are sufficient to recover Ye to 6 percent. This is because these isotopes dominate the composition of silicon-rich material and iron rich material in quasi nuclear statistical equilibrium. Analytical analysis shows that the 28Si abundance is insensitive to Ye, the 32S abundance has a nearly linear trend with Ye, and the 40Ca abundance has a nearly quadratic trend with Ye. We verify these trends with post-processing of 1D models and show that these trends are reflected in model synthetic spectra.Comment: Submitted to the Ap

Predictability of the quasi-biennial oscillation and its northern winter teleconnection on seasonal to decadal timescales

Journal ArticlePublished version used with permision of the publisher.The predictability of the quasi-biennial oscillation (QBO) is examined in initialized climate forecasts extending out to lead times of years. We use initialized retrospective predictions made with coupled ocean-atmosphere climate models that have an internally generated QBO. We demonstrate predictability of the QBO extending more than 3 years into the future, well beyond timescales normally associated with internal atmospheric processes. Correlation scores with observational analyses exceed 0.7 at a lead time of 12 months. We also examine the variation of predictability with season and QBO phase and find that skill is lowest in winter. An assessment of perfect predictability suggests that higher skill may be achievable through improved initialization and climate modeling of the QBO, although this may depend on the realism of gravity wave source parameterizations in the models. Finally, we show that skilful prediction of the QBO itself does not guarantee predictability of the extratropical winter teleconnection that is important for surface winter climate prediction. Key Points The QBO is skilfully predicted in seasonal-decadal forecast systems Further improvements in predictions of the QBO are possible The QBO winter surface teleconnection is reproduced with mixed succes

EZH2 is a sensitive marker of malignancy in salivary gland tumors

BACKGROUND: The immunohistochemical detection of Enhancer of zeste homologue 2 (EZH2) proved to be a useful tool to recognize the malignant nature of tumors in a wide variety of neoplasms. The histological diagnostics of salivary gland tumors is a challenging task, and a reliable marker of malignancy would be extremely helpful. METHODS: EZH2 expression was investigated in 54 malignant and 40 benign salivary gland tumors of various histological types by standard immunohistochemistry. RESULTS: The majority (n = 52) of the malignant tumors stained positively, while all the investigated benign tumors were negative for EZH2. CONCLUSIONS: EZH2 expression in salivary gland tumors, similarly to the tumors of other organs is not characteristic for any tumor type, but is a solid marker of the malignant nature of the tumors

14-3-3theta Protects against Neurotoxicity in a Cellular Parkinson's Disease Model through Inhibition of the Apoptotic Factor Bax

Disruption of 14-3-3 function by alpha-synuclein has been implicated in Parkinson's disease. As 14-3-3s are important regulators of cell death pathways, disruption of 14-3-3s could result in the release of pro-apoptotic factors, such as Bax. We have previously shown that overexpression of 14-3-3θ reduces cell loss in response to rotenone and MPP+ in dopaminergic cell culture and reduces cell loss in transgenic C. elegans that overexpress alpha-synuclein. In this study, we investigate the mechanism for 14-3-3θ's neuroprotection against rotenone toxicity. While 14-3-3s can inhibit many pro-apoptotic factors, we demonstrate that inhibition of one factor in particular, Bax, is important to 14-3-3s' protection against rotenone toxicity in dopaminergic cells. We found that 14-3-3θ overexpression reduced Bax activation and downstream signaling events, including cytochrome C release and caspase 3 activation. Pharmacological inhibition or shRNA knockdown of Bax provided protection against rotenone, comparable to 14-3-3θ's neuroprotective effects. A 14-3-3θ mutant incapable of binding Bax failed to protect against rotenone. These data suggest that 14-3-3θ's neuroprotective effects against rotenone are at least partially mediated by Bax inhibition and point to a potential therapeutic role of 14-3-3s in Parkinson's disease

Top-down estimates of European CH₄ and N₂O emissions based on four different inverse models

European CH4 and N2O emissions are estimated for 2006 and 2007 using four inverse modelling systems, based on different global and regional Eulerian and Lagrangian transport models. This ensemble approach is designed to provide more realistic estimates of the overall uncertainties in the derived emissions, which is particularly important for verifying bottom-up emission inventories. We use continuous observations from 10 European stations (including 5 tall towers) for CH4 and 9 continuous stations for N2O, complemented by additional European and global discrete air sampling sites. The available observations mainly constrain CH4 and N2O emissions from northwestern and eastern Europe. The inversions are strongly driven by the observations and the derived total emissions of larger countries show little dependence on the emission inventories used a priori. Three inverse models yield 26–56% higher total CH4 emissions from north-western and eastern Europe compared to bottom-up emissions reported to the UNFCCC, while one model is close to the UNFCCC values. In contrast, the inverse modelling estimates of European N2O emissions are in general close to the UNFCCC values, with the overall range from all models being much smaller than the UNFCCC uncertainty range for most countries. Our analysis suggests that the reported uncertainties for CH4 emissions might be underestimated, while those for N2O emissions are likely overestimated.JRC.H.2-Air and Climat

Modifiable risk factors associated with bone deficits in childhood cancer survivors

<p>Abstract</p> <p>Background</p> <p>To determine the prevalence and severity of bone deficits in a cohort of childhood cancer survivors (CCS) compared to a healthy sibling control group, and the modifiable factors associated with bone deficits in CCS.</p> <p>Methods</p> <p>Cross-sectional study of bone health in 319 CCS and 208 healthy sibling controls. Bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry (DXA). Generalized estimating equations were used to compare measures between CCS and controls. Among CCS, multivariable logistic regression was used to evaluate odds ratios for BMD Z-score ≤ -1.</p> <p>Results</p> <p>All subjects were younger than 18 years of age. Average time since treatment was 10.1 years (range 4.3 - 17.8 years). CCS were 3.3 times more likely to have whole body BMD Z-score ≤ -1 than controls (95% CI: 1.4-7.8; p = 0.007) and 1.7 times more likely to have lumbar spine BMD Z-score ≤ -1 than controls (95% CI: 1.0-2.7; p = 0.03). Among CCS, hypogonadism, lower lean body mass, higher daily television/computer screen time, lower physical activity, and higher inflammatory marker IL-6, increased the odds of having a BMD Z-score ≤ -1.</p> <p>Conclusions</p> <p>CCS, less than 18 years of age, have bone deficits compared to a healthy control group. Sedentary lifestyle and inflammation may play a role in bone deficits in CCS. Counseling CCS and their caretakers on decreasing television/computer screen time and increasing activity may improve bone health.</p

The Bolund Experiment, Part I: Flow Over a Steep, Three-Dimensional Hill

We present an analysis of data from a measurement campaign performed at the Bolund peninsula in Denmark in the winter of 2007–2008. Bolund is a small isolated hill exhibiting a significantly steep escarpment in the main wind direction. The physical shape of Bolund represents, in a scaled-down form, a typical wind turbine site in complex terrain. Because of its small size the effect of atmospheric stratification can be neglected, which makes the Bolund experiment ideal for the validation of neutral flow models and hence model scenarios most relevant to wind energy. We have carefully investigated the upstream conditions. With a 7-km fetch over water, the incoming flow is characterized as flow over flat terrain with a local roughness height based on the surface momentum flux. The nearly perfect upstream conditions are important in forming a meaningful quantitative description of the flow over the Bolund hill. Depending on the wind direction, we find a maximum speed-up of 30% at the hill top accompanied by a maximum 300% enhancement of turbulence intensity. A closer inspection reveals transient behaviour with recirculation zones. From the wind energy context, this implies that the best site for erecting a turbine based on resource constraints unfortunately also imposes a penalty of high dynamic loads. On the lee side of Bolund, recirculation occurs with the turbulence intensity remaining significantly enhanced even at one hill length downstream. Its transient behaviour and many recirculation zones place Bolund in a category in which the linear flow theory is not applicable