50 research outputs found
Early radiologic and metabolic tumour response assessment during combined chemo-radiotherapy for locally advanced NSCLC
Background: The role of early treatment response for patients with locally advanced non-small cell lung cancer (LA-NSCLC) treated with concurrent chemo-radiotherapy (cCRT) is unclear. The study aims to investigate the predictive value of response to induction chemotherapy (iCX) and the correlation with pattern of failure (PoF). Materials and methods: Patients with LA-NSCLC treated with cCRT were included for analyses (n = 276). Target delineations were registered from radiotherapy planning PET/CT to diagnostic PET/CT, in between which patients received iCX. Volume, sphericity, and SUVpeak were extracted from each scan. First site of failure was categorised as loco-regional (LR), distant (DM), or simultaneous LR+M (LR+M). Fine and Gray models for PoF were performed: a baseline model (including performance status (PS), stage, and histology), an image model for squamous cell carcinoma (SCC), and an image model for non-SCC. Parameters included PS, volume (VOL) of tumour, VOL of lymph nodes, ÎVOL, sphericity, SUVpeak, ÎSUVpeak, and oligometastatic disease. Results: Median follow-up was 7.6 years. SCC had higher sub-distribution hazard ratio (sHR) for LRF (sHR = 2.771 [1.577:4.87], p < 0.01) and decreased sHR for DM (sHR = 0.247 [0.125:0.485], p < 0.01). For both image models, high diagnostic SUVpeak increased risk of LRF (sHR = 1.059 [1.05:1.106], p < 0.01 for SCC, sHR = 1.12 [1.03:1.21], p < 0.01 for non-SCC). Patients with SCC and less decrease in VOL had higher sHR for DM (sHR = 1.025[1.001:1.048] pr. % increase, p = 0.038). Conclusion: Poor response in disease volume was correlated with higher sHR of DM for SCC, no other clear correlation of response and PoF was observed. Histology significantly correlated with PoF with SCC prone to LRF and non-SCC prone to DM as first site of failure. High SUVpeak at diagnosis increased the risk of LRF for both histologies
Quantum computing implementations with neutral particles
We review quantum information processing with cold neutral particles, that
is, atoms or polar molecules. First, we analyze the best suited degrees of
freedom of these particles for storing quantum information, and then we discuss
both single- and two-qubit gate implementations. We focus our discussion mainly
on collisional quantum gates, which are best suited for atom-chip-like devices,
as well as on gate proposals conceived for optical lattices. Additionally, we
analyze schemes both for cold atoms confined in optical cavities and hybrid
approaches to entanglement generation, and we show how optimal control theory
might be a powerful tool to enhance the speed up of the gate operations as well
as to achieve high fidelities required for fault tolerant quantum computation.Comment: 19 pages, 12 figures; From the issue entitled "Special Issue on
Neutral Particles
Density functional theory based screening of ternary alkali-transition metal borohydrides: A computational material design project
The dissociation of molecules, even the most simple hydrogen molecule, cannot be described accurately within density functional theory because none of the currently available functionals accounts for strong on-site correlation. This problem led to a discussion of properties that the local Kohn-Sham potential has to satisfy in order to correctly describe strongly correlated systems. We derive an analytic expression for the nontrivial form of the Kohn-Sham potential in between the two fragments for the dissociation of a single bond. We show that the numerical calculations for a one-dimensional two-electron model system indeed approach and reach this limit. It is shown that the functional form of the potential is universal, i.e., independent of the details of the two fragments.We acknowledge funding by the Spanish MEC (Grant No. FIS2007-65702-C02-01), âGrupos Consolidados UPV/EHU del Gobierno Vascoâ (Grant No. IT-319-07), and the European Community through e-I3 ETSF project (Grant Agreement No. 211956).Peer reviewe
Prompt K_short production in pp collisions at sqrt(s)=0.9 TeV
The production of K_short mesons in pp collisions at a centre-of-mass energy
of 0.9 TeV is studied with the LHCb detector at the Large Hadron Collider. The
luminosity of the analysed sample is determined using a novel technique,
involving measurements of the beam currents, sizes and positions, and is found
to be 6.8 +/- 1.0 microbarn^-1. The differential prompt K_short production
cross-section is measured as a function of the K_short transverse momentum and
rapidity in the region 0 < pT < 1.6 GeV/c and 2.5 < y < 4.0. The data are found
to be in reasonable agreement with previous measurements and generator
expectations.Comment: 6+18 pages, 6 figures, updated author lis
Different benefits of adaptive radiotherapy for different histologies of NSCLC
Background
Adenocarcinoma (AC) and squamous cell carcinoma (SCC) are the most frequent histological subtypes of non-small cell lung cancer (NSCLC). The aim of this study was to investigate how patients with AC and SCC benefit from image-guided adaptive radiotherapy (ART) with tumour match.
Material and methods
Consecutive patients diagnosed with AC or SCC of the lung treated with definitive chemo-radiotherapy before and after the implementation of ART and tumour match were retrospectively included for analyses. Data collection included baseline patient and treatment characteristics in addition to clinical data on radiation pneumonitis (RP), failure, and survival. Patients were divided into four categories based on their histology and treatment before (nâ=â173 [89 AC and 84 SCC]) and after implementation of ART (nâ=â240 [141 AC and 99 SCC]).
Results
Median follow-up was 5.7âyears for AC and 6.3âyears for SCC. Mean lung dose decreased for both histologies with ART, whereas mean heart dose only decreased for patients with AC. Incidences of grade 3 and 5âRP decreased for both histologies with ART. Loco-regional failure (LRF) rates decreased significantly for patients with SCC after ART (pâ=â.04), no significant difference was observed for AC. Overall survival (OS) increased significantly for SCC after ART (pâ<â.01): the 2-year OS increased from 31.0% (95% confidence interval [CI] [22.5â42.6]) to 54.5% (95% CI [45.6â65.3]). No significant effect on OS was observed for patients with AC.
Conclusion
ART and tumour match in the radiotherapeutic treatment of patients with locally advanced NSCLC primarily led to decreased LRF and improved OS for patients with SCC