Leistungs- und Kostenrechnung in der Datenverarbeitung:Am Beispiel der Hochschulrechenzentren in NRW

Für Hochschulrechenzentren wird eine Leistungs- und Kostenrechnung vorgeschlagen, die Dienstleistungen und ihre Qualitätsmerkmale neben eine Prozeßkostenrechnung stellt. Mit der Prozeßkostenrechnung entstehen Steuerungs- und Vergleichsmöglichkeiten in und zwischen Hochschulrechenzentren. Über "Kostentreiber" werden die Leistungen weitgehend mengenabhängig. Eine Zuordnung der Kosten zu ihren Verursachern wird möglich. Die Prozesse werden für ein Hochschulrechenzentrum definiert, die einzelnen Kostenfaktoren erläutert und zusammengestellt. Es wird ein Berechnungsschema vorgeschlagen, Ausführungshinweise werden gegeben und die Ergebnisse diskutiert. Als Fallstudien werden die Prozeßkosten eines kleinen und eines großen Rechenzentrums angesprochen

Quantitative estimates of discrete harmonic measures

A theorem of Bourgain states that the harmonic measure for a domain in $\R^d$ is supported on a set of Hausdorff dimension strictly less than $d$ \cite{Bourgain}. We apply Bourgain's method to the discrete case, i.e., to the distribution of the first entrance point of a random walk into a subset of $\Z ^d$, $d\geq 2$. By refining the argument, we prove that for all \b>0 there exists \rho (d,\b)N(d,\b), any $x \in \Z^d$, and any $A\subset \{1,..., n\}^d$ | \{y\in\Z^d\colon \nu_{A,x}(y) \geq n^{-\b} \}| \leq n^{\rho(d,\b)}, where $\nu_{A,x} (y)$ denotes the probability that $y$ is the first entrance point of the simple random walk starting at $x$ into $A$. Furthermore, $\rho$ must converge to $d$ as \b \to \infty.Comment: 16 pages, 2 figures. Part (B) of the theorem is ne

Hypersurface Bohm-Dirac models

We define a class of Lorentz invariant Bohmian quantum models for N entangled but noninteracting Dirac particles. Lorentz invariance is achieved for these models through the incorporation of an additional dynamical space-time structure provided by a foliation of space-time. These models can be regarded as the extension of Bohm's model for N Dirac particles, corresponding to the foliation into the equal-time hyperplanes for a distinguished Lorentz frame, to more general foliations. As with Bohm's model, there exists for these models an equivariant measure on the leaves of the foliation. This makes possible a simple statistical analysis of position correlations analogous to the equilibrium analysis for (the nonrelativistic) Bohmian mechanics.Comment: 17 pages, 3 figures, RevTex. Completely revised versio

Y Chromosomal Variation Tracks the Evolution of Mating Systems in Chimpanzee and Bonobo

The male-specific regions of the Y chromosome (MSY) of the human and the chimpanzee (Pan troglodytes) are fully sequenced. The most striking difference is the dramatic rearrangement of large parts of their respective MSYs. These non-recombining regions include ampliconic gene families that are known to be important for male reproduction,and are consequently under significant selective pressure. However, whether the published Y-chromosomal pattern of ampliconic fertility genes is invariable within P. troglodytes is an open but fundamental question pertinent to discussions of the evolutionary fate of the Y chromosome in different primate mating systems. To solve this question we applied fluorescence in situ hybridisation (FISH) of testis-specific expressed ampliconic fertility genes to metaphase Y chromosomes of 17 chimpanzees derived from 11 wild-born males and 16 bonobos representing seven wild-born males. We show that of eleven P. troglodytes Y-chromosomal lines, ten Y-chromosomal variants were detected based on the number and arrangement of the ampliconic fertility genes DAZ (deleted in azoospermia) and CDY (chromodomain protein Y)—a so-far never-described variation of a species' Y chromosome. In marked contrast, no variation was evident among seven Y-chromosomal lines of the bonobo, P. paniscus, the chimpanzee's closest living relative. Although, loss of variation of the Y chromosome in the bonobo by a founder effect or genetic drift cannot be excluded, these contrasting patterns might be explained in the context of the species' markedly different social and mating behaviour. In chimpanzees, multiple males copulate with a receptive female during a short period of visible anogenital swelling, and this may place significant selection on fertility genes. In bonobos, however, female mate choice may make sperm competition redundant (leading to monomorphism of fertility genes), since ovulation in this species is concealed by the prolonged anogenital swelling, and because female bonobos can occupy high-ranking positions in the group and are thus able to determine mate choice more freely

Encoding difficulty promotes postlearning changes in sleep spindle activity during napping

Learning-dependent increases in sleep spindle density have been reported during nocturnal sleep immediately after the learning session. Here, we investigated experience-dependent changes in daytime sleep EEG activity after declarative learning of unrelated word pairs. At weekly intervals, 13 young male volunteers spent three 24 h sessions in the laboratory under carefully controlled homeostatic and circadian conditions. At approximately midday, subjects performed either one of two word-pair learning tasks or a matched nonlearning control task, in a counterbalanced order. The two learning lists differed in the level of concreteness of the words used, resulting in an easier and a more difficult associative encoding condition, as confirmed by performance at immediate cued recall. Subjects were then allowed to sleep for 4 h; afterward, delayed cued recall was tested. Compared with the control condition, sleep EEG spectral activity in the low spindle frequency range and the density of low-frequency sleep spindles (11.25-13.75 Hz) were both significantly increased in the left frontal cortex after the difficult but not after the easy encoding condition. Furthermore, we found positive correlations between these EEG changes during sleep and changes in memory performance between pre-nap and post-nap recall sessions. These results indicate that, like during nocturnal sleep, daytime sleep EEG oscillations including spindle activity are modified after declarative learning of word pairs. Furthermore, we demonstrate here that the nature of the learning material is a determinant factor for sleep-related alterations after declarative learning

Saturation in Liquid/Gas Coalescence

The problem was to construct a mathematical model for a liquid/gas coalescer, in order that the model could be analyzed to find combinations of parameters that would minimize the effects of saturation. The team has developed three complementary models, each with different strengths and weaknesses so that, depending on the information desired, one model may be more useful than another. The three models are: 1. A continuum model giving a macroscopic description of the filter. The governing equations are derived from first-principle consider- ations of conservation of mass and momentum. Constitutive relations for this model are derived by considering the processes going on in the filter at a microscopic level. 2. A stochastic model based on a Markov Decision Process. Each droplet is modelled as a single entity that can merge or move stochastically. This leads to a Markov simulation of the filter and the computation of average quantities. 3. A Lattice-Boltzmann model. The droplets are modelled to interact with each other and with the filter, using a Boltzmann distribution for their speed. This simulates the hydrodynamic behaviour of the droplet inside the filter

Stationary solutions of driven fourth- and sixth-order Cahn-Hilliard type equations

New types of stationary solutions of a one-dimensional driven sixth-order Cahn-Hilliard type equation that arises as a model for epitaxially growing nano-structures such as quantum dots, are derived by an extension of the method of matched asymptotic expansions that retains exponentially small terms. This method yields analytical expressions for far-field behavior as well as the widths of the humps of these spatially non-monotone solutions in the limit of small driving force strength which is the deposition rate in case of epitaxial growth. These solutions extend the family of the monotone kink and antikink solutions. The hump spacing is related to solutions of the Lambert $W$ function. Using phase space analysis for the corresponding fifth-order dynamical system, we use a numerical technique that enables the efficient and accurate tracking of the solution branches, where the asymptotic solutions are used as initial input. Additionally, our approach is first demonstrated for the related but simpler driven fourth-order Cahn-Hilliard equation, also known as the convective Cahn-Hilliard equation

Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells

In patients with bile acid malabsorption, high concentrations of bile acids enter the colon and stimulate Cl− and fluid secretion, thereby causing diarrhoea. However, deoxycholic acid (DCA), the predominant colonic bile acid, is normally present at lower concentrations where its role in regulating transport is unclear. Thus, the current study set out to investigate the effects of physiologically relevant DCA concentrations on colonic epithelial secretory function. Cl− secretion was measured as changes in short-circuit current across voltage-clamped T84 cell monolayers. At high concentrations (0.5–1 mM), DCA acutely stimulated Cl− secretion but this effect was associated with cell injury, as evidenced by decreased transepithelial resistance (TER) and increased lactate dehydrogenase (LDH) release. In contrast, chronic (24 hrs) exposure to lower DCA concentrations (10–200 μM) inhibited responses to Ca2+ and cAMP-dependent secretagogues without altering TER, LDH release, or secretagogue-induced increases in intracellular second messengers. Other bile acids – taurodeoxycholic acid, chenodeoxycholic acid and cholic acid – had similar antisecretory effects. DCA (50 μM) rapidly stimulated phosphorylation of the epidermal growth factor receptor (EGFr) and both ERK and p38 MAPKs (mitogen-activated protein kinases). The EGFr inhibitor, AG1478, and the protein synthesis inhibitor, cycloheximide, reversed the antisecretory effects of DCA, while the MAPK inhibitors, PD98059 and SB203580, did not. In summary, our studies suggest that, in contrast to its acute prosecretory effects at pathophysiological concentrations, lower, physiologically relevant, levels of DCA chronically down-regulate colonic epithelial secretory function. On the basis of these data, we propose a novel role for bile acids as physiological regulators of colonic secretory capacity