ЭПИДЕМИОЛОГИЯ И ВЫЖИВАЕМОСТЬ БОЛЬНЫХ ЗЛОКАЧЕСТВЕННЫМИ НОВООБРАЗОВАНИЯМИ ПОЛОСТИ НОСА, СРЕДНЕГО УХА И ПРИДАТОЧНЫХ ПАЗУХ С УЧЕТОМ СТАДИИ ЗАБОЛЕВАНИЯ И ГИСТОЛОГИЧЕСКОЙ СТРУКТУРЫ ОПУХОЛИ

Introduction. The population-level survival analysis for cancer patients was not carried out in Russia due to the absence of population-based cancer registries, meeting the requirements of international Agency for Research on Cancer. This opportunity has appeared only with the establishment of the population-based cancer registry in St. Petersburg. Cancer survival estimation is possible only under conditions of strict adherence to the principles of the study. Analysis of survival of cancer patients is the main criterion of the objective assessment of the effectiveness of anticancer therapy. Malignant tumors of the nasal cavity, middle ear and accessory sinuses are classified by two ICD-10 diagnosis codes: С30 and С31 (С30: malignant tumors of the nasal cavity and middle ear; C31: malignant tumors of accessory sinuses). Database of the population-based cancer registry promotes the study of survival by any parameter including the fourth character of the ICD-10 code and histological type of the tumor.Purposes and objectives. To estimate the observed and relative survival rates in patients with malignant tumors of the nasal cavity, middle ear and accessory sinuses and to compare the results obtained with the EU average (according to the EuroCare program), as well as to estimate survival of this group of patients according to sex, age, stage of disease and histological type of the tumor.Material and methods. Between 1994 and 2009, 565 cases with malignant tumors of the nasal cavity, middle ear and accessory sinuses were selected from the population-based cancer registry. There were used the observed and relative survival rates calculated according to the international standards.Results. We estimated the 5-year observed and relative survival rates in patients with cancers of the nasal cavity, middle ear and sinuses, using ICD-10 codes С30 and 31 and taking into account sex, age, stage of disease and histological structure of tumors. A clear trend toward increase in the 5-year observed and relative survival rates in patients with malignant tumors of the nasal cavity, middle ear and accessory sinuses was observed.Введение. Расчеты выживаемости больных злокачественными новообразованиями (ЗНО) на популяционном уровне в России не проводились в связи с отсутствием системы популяционных раковых регистров (ПРР), работающих по международным стандартам. Такая возможность появилась только с созданием ПРР в г. Санкт-Петербурге. Расчет показателей выживаемости больных ЗНО возможен только при условии строгого соблюдения всех правил проведения исследования. Анализ выживаемости больных является основным критерием объективной характеристики эффективности проводимых противораковых мероприятий. ЗНО полости носа, среднего уха и придаточных пазух при расчетах заболеваемости рассматриваются вместе по двум рубрикам МКБ-10: С30 и 31 (С30 – ЗНО полости носа и среднего уха, С31 – ЗНО придаточных пазух). БД ПРР предоставляет возможность исследования выживаемости больных по любому параметру, в том числе и по четвертому знаку МКБ-10 и гистологическому типу опухоли.Цель исследования – исчислить показатели наблюдаемой и относительной выживаемости больных раком носа, среднего уха и придаточных пазух, сравнить полученные данные со среднеевропейскими показателями (по программе Eurocare). Провести расчеты выживаемости данной группы больных по полу, возрасту, стадии заболевания и гистологическому типу опухоли.Материал и методы. Для проведения исследования из БД ПРР отобрано 565 случаев ЗНО полости носа, среднего уха и придаточных пазух среди мужского и женского населения г. Санкт-Петербурга за 1994–2009 гг. Для расчета использованы показатели наблюдаемой и относительной выживаемости, исчисленные по международным стандартам (Eurocare).Результаты. Исчислен показатель наблюдаемой и относительной 5-летней выживаемости больных ЗНО по рубрикам МКБ-10 С30,31 с учетом пола, возраста, стадии заболевания и гистологической структуры опухолей. Установлен прогресс в динамике 5-летней наблюдаемой и относительной выживаемости больных ЗНО данной группы и сближение с аналогичными среднеевропейскими показателями.

Performance studies of the CMS strip tracker before installation

Peer reviewe

EPIDEMIOLOGY AND SURVIVAL OF PATIENTS WITH MALIGNANT TUMORS OF THE NASAL CAVITY, MIDDLE EAR AND ACCESSORY SINUSES ACCORDING TO THE STAGE OF DISEASE AND HISTOLOGICAL STRUCTURE OF TUMORS

Introduction. The population-level survival analysis for cancer patients was not carried out in Russia due to the absence of population-based cancer registries, meeting the requirements of international Agency for Research on Cancer. This opportunity has appeared only with the establishment of the population-based cancer registry in St. Petersburg. Cancer survival estimation is possible only under conditions of strict adherence to the principles of the study. Analysis of survival of cancer patients is the main criterion of the objective assessment of the effectiveness of anticancer therapy. Malignant tumors of the nasal cavity, middle ear and accessory sinuses are classified by two ICD-10 diagnosis codes: С30 and С31 (С30: malignant tumors of the nasal cavity and middle ear; C31: malignant tumors of accessory sinuses). Database of the population-based cancer registry promotes the study of survival by any parameter including the fourth character of the ICD-10 code and histological type of the tumor.Purposes and objectives. To estimate the observed and relative survival rates in patients with malignant tumors of the nasal cavity, middle ear and accessory sinuses and to compare the results obtained with the EU average (according to the EuroCare program), as well as to estimate survival of this group of patients according to sex, age, stage of disease and histological type of the tumor.Material and methods. Between 1994 and 2009, 565 cases with malignant tumors of the nasal cavity, middle ear and accessory sinuses were selected from the population-based cancer registry. There were used the observed and relative survival rates calculated according to the international standards.Results. We estimated the 5-year observed and relative survival rates in patients with cancers of the nasal cavity, middle ear and sinuses, using ICD-10 codes С30 and 31 and taking into account sex, age, stage of disease and histological structure of tumors. A clear trend toward increase in the 5-year observed and relative survival rates in patients with malignant tumors of the nasal cavity, middle ear and accessory sinuses was observed

Single excited dual band luminescent hybrid carbon dots-terbium chelate nanothermometer

The report introduces hybrid polyelectrolyte-stabilized colloids combining blue and green-emitting building blocks, which are citrate carbon dots (CDs) and [TbL]+ chelate complexes with 1,3-diketonate derivatives of calix[4]arene. The joint incorporation of green and blue-emitting blocks into the polysodium polystyrenesulfonate (PSS) aggregates is carried out through the solvent-exchange synthetic technique. The coordinative binding between Tb3+ centers and CD surface groups in initial DMF solutions both facilitates joint incorporation of [TbL]+ complexes and the CDs into the PSS-based nanobeads and affects fluorescence properties of [TbL]+ complexes and CDs, as well as their ability for temperature sensing. The variation of the synthetic conditions is represented herein as a tool for tuning the fluorescent response of the blue and green-emitting blocks upon heating and cooling. The revealed regularities enable developing either dual-band luminescent colloids for monitoring temperature changes within 25–50 °C through double color emission or transforming the colloids into ratiometric temperature sensors via simple concentration variation of [TbL]+ and CDs in the initial DMF solution. Novel hybrid carbon dots-terbium chelate PSS-based nanoplatform opens an avenue for a new generation of sensitive and customizable single excited dualband nanothermometers

Single Excited Dual Band Luminescent Hybrid Carbon Dots-Terbium Chelate Nanothermometer

The report introduces hybrid polyelectrolyte-stabilized colloids combining blue and green-emitting building blocks, which are citrate carbon dots (CDs) and [TbL]+ chelate complexes with 1,3-diketonate derivatives of calix[4]arene. The joint incorporation of green and blue-emitting blocks into the polysodium polystyrenesulfonate (PSS) aggregates is carried out through the solvent-exchange synthetic technique. The coordinative binding between Tb3+ centers and CD surface groups in initial DMF solutions both facilitates joint incorporation of [TbL]+ complexes and the CDs into the PSS-based nanobeads and affects fluorescence properties of [TbL]+ complexes and CDs, as well as their ability for temperature sensing. The variation of the synthetic conditions is represented herein as a tool for tuning the fluorescent response of the blue and green-emitting blocks upon heating and cooling. The revealed regularities enable developing either dual-band luminescent colloids for monitoring temperature changes within 25–50 °C through double color emission or transforming the colloids into ratiometric temperature sensors via simple concentration variation of [TbL]+ and CDs in the initial DMF solution. Novel hybrid carbon dots-terbium chelate PSS-based nanoplatform opens an avenue for a new generation of sensitive and customizable single excited dual-band nanothermometers

Alignment of the CMS silicon strip tracker during stand-alone commissioning

The results of the CMS tracker alignment analysis are presented using the data from cosmic tracks, optical survey information, and the laser alignment system at the Tracker Integration Facility at CERN. During several months of operation in the spring and summer of 2007, about five million cosmic track events were collected with a partially active CMS Tracker. This allowed us to perform first alignment of the active silicon modules with the cosmic tracks using three different statistical approaches; validate the survey and laser alignment system performance; and test the stability of Tracker structures under various stresses and temperatures ranging from +15C to -15C. Comparison with simulation shows that the achieved alignment precision in the barrel part of the tracker leads to residual distributions similar to those obtained with a random misalignment of 50 (80) microns in the outer (inner) part of the barrel.Comment: 41 pages, 63 postscript figures, submitted to JINS

Stand-alone cosmic muon reconstruction before installation of the CMS silicon strip tracker

The subsystems of the CMS silicon strip tracker were integrated and commissioned at the Tracker Integration Facility (TIF) in the period from November 2006 to July 2007. As part of the commissioning, large samples of cosmic ray data were recorded under various running conditions in the absence of a magnetic field. Cosmic rays detected by scintillation counters were used to trigger the readout of up to 15% of the final silicon strip detector, and over 4.7 million events were recorded. This document describes the cosmic track reconstruction and presents results on the performance of track and hit reconstruction as from dedicated analyses.Comment: Added missing LaTex command / no change in contents w.r.t. v

Improved measurement of B+->rho(+)rho(0) and determination of the quark-mixing phase angle alpha

We present improved measurements of the branching fraction B, the longitudinal polarization fraction f(L), and the direct CP asymmetry A(CP) in the B meson decay channel B+->rho(+)rho(0). The data sample was collected with the BABAR detector at SLAC. The results are B(B+->rho(+)rho(0))=(23.7 +/- 1.4 +/- 1.4)x10(-6), f(L)=0.950 +/- 0.015 +/- 0.006, and A(CP)=-0.054 +/- 0.055 +/- 0.010, where the uncertainties are statistical and systematic, respectively. Based on these results, we perform an isospin analysis and determine the Cabibbo-Kobayashi-Maskawa phase angle alpha=arg(-VtdVtb*/VudVub*) to be (92.4(-6.5)(+6.0))degrees