Data analysis and tools applied to modeling and simulation of a PV system in Ecuador

This paper presents a research was carried out for the management of a photovoltaic system in a Microgrid, with applications and the use of tools applied to modeling and computational simulation in the Microgrid laboratory implanted in the facilities of the University of Cuenca (Ecuador). Additionally, through the use of automatic learning techniques, the behavior of the photovoltaic system has been modeled in the study area based on radiation and temperature with very good results. In addition, several applications can be made in real engineering studies such as feasibility, performance analysis, energy estimation, educational models, etc

Los ensayos clínicos y su situación actual en Perú: Oportunidades para la acción

GEsTión es un grupo de sitios de investigación en la ciudad de Lima, que están dedicados exclusivamente a implementar ensayos clínicos auspiciados por la Industria Farmacéutica Internacional (IFI). Nos hemos asociado para divulgar, explorar y desarrollar procesos operativos consistentes en el marco de la investigación clínica y nuevas formas de reclutamiento de pacientes. Es nuestra intención difundir estos avances a la comunidad de investigadores y a todos aquellos que están involucrados de una u otro forma en procesos de investigación. Esta contribución tomará la forma de artículos publicados en medios sociales, publicaciones impresas, reuniones públicas de trabajo, eventos públicos, congresos, talleres y otros por definir.&nbsp

Especialización turística y rendimientos del capital humano de las regiones españolas en el sector de la hostelería

El objetivo de este trabajo es evaluar la existencia y el grado de especialización en la industria turística de las principales regiones españolas desde la perspectiva del stock de capital humano y de los rendimientos de la educación, centrándose en el subsector de la hostelería. Para ello, se ha utilizado una versión extendida de la ecuación de salarios de Mincer (1974) y datos procedentes de la Encuesta de Estructura Salarial para el año 2006. Todas las regiones analizadas muestran rendimientos de la educación más bajos en el sector de la hostelería que los que se presentan en otros servicios privados. Existen también diferencias significativas en los rendimientos de la educación entre regiones, especialmente en Cataluña y en las Islas Canarias.The aim of our study is to evaluate the existence and degree of specialization in tourism of the Spanish regions from the perspective of the human capital stock and the returns of their education, limiting the scope of study to the hospitality subsector. We use an expanded version of the Mincer wage equation (1974) and data from the 2006 Spanish Wage Structure Survey. All the regions under analysis show lower education returns (and other human capital variables) in the hospitality sector when compared to other private services. There are signifi cant differences in education returns between regions, especially in Catalonia and the Canary Islands

Effect of hyoscine butylbromide on cervical dilation during labor

To compare the effects of intravenous hyoscine butylbromide versus placebo on the duration of labor in term pregnancies. Materials and methods: 86 patients were selected and randomly assigned to receive intravenous hyoscine butylbromide (20 mg twice) (n = 43) or an intravenous placebo (saline solution 10 cc) (n = 43). We evaluated maternal adverse effects, effects on neonatal Apgar score, cervical dilatation 1 h after drug administration and the interval between the onset of labor and delivery. Results: No significant differences were observed in the duration of phases of labor between the two groups. No significant differences were found between the groups in Apgar scores at 1 and 5 min. No maternal adverse effects were observed or reported due to the use of hyoscine butylbromide or the placebo. On the first phase of primigravidas it shortens the first labor phase up to 159.1 ± 84 min vs. the control group (p = 0.002). Conclusion: Hyoscine butylbromide oxytocin shortens the duration of labor in term primigravida pregnancies. No side effects were reported

Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution

P. 1-14The relation between gestational age and foetal death risk in ovine toxoplasmosis is already known, but the mechanisms involved are not yet clear. In order to study how the stage of gestation influences these mechanisms, pregnant sheep of the same age and genetic background were orally dosed with 50 oocysts of Toxoplasma gondii (M4 isolate) at days 40 (G1), 90 (G2) and 120 (G3) of gestation. In each group, four animals were culled on the second, third and fourth week post infection (pi) in order to evaluate parasite load and distribution, and lesions in target organs. Ewes from G1 showed a longer period of hyperthermia than the other groups. Abortions occurred in all groups. While in G2 they were more frequent during the acute phase of the disease, in G3 they mainly occurred after day 20 pi. After challenge, parasite and lesions in the placentas and foetuses were detected from day 19 pi in G3 while in G2 or G1 they were only detected at day 26 pi. However, after initial detection at day 19 pi, parasite burden, measured through RT-PCR, in placenta or foetus of G3 did not increase significantly and, at in the third week pi it was lower than that measured in foetal liver or placenta from G1 to G3 respectively. These results show that the period of gestation clearly influences the parasite multiplication and development of lesions in the placenta and foetus and, as a consequence, the clinical course in ovine toxoplasmosis.S

Three-Dimensional Analysis of Spiny Dendrites Using Straightening and Unrolling Transforms

Current understanding of the synaptic organization of the brain depends to a large extent on knowledge about the synaptic inputs to the neurons. Indeed, the dendritic surfaces of pyramidal cells (the most common neuron in the cerebral cortex) are covered by thin protrusions named dendritic spines. These represent the targets of most excitatory synapses in the cerebral cortex and therefore, dendritic spines prove critical in learning, memory and cognition. This paper presents a new method that facilitates the analysis of the 3D structure of spine insertions in dendrites, providing insight on spine distribution patterns. This method is based both on the implementation of straightening and unrolling transformations to move the analysis process to a planar, unfolded arrangement, and on the design of DISPINE, an interactive environment that supports the visual analysis of 3D patterns

Peripheral and placental immune responses in sheep after experimental infection with "Toxoplasma gondii" at the three terms of gestation

P. 1-9Although it is known that gestation could infuence the clinical course of ovine toxoplasmosis, the precise efect of the term of gestation when sheep are infected are yet mostly unknown. The aim of this study was to evaluate the peripheral and placental immune responses developed in pregnant sheep after experimental infection with Toxoplasma gondiiat diferent times of gestation. Thirty‑six pregnant sheep were allocated in diferent groups, orally inocu‑lated with sporulated oocysts of T. gondiiat early, mid and late gestation and culled within 30 days post‑infection. The peripheral humoral and cytokine responses were evaluated, as well as the transcription of cytokines at the placenta. Serological analysis revealed that, regardless the term of gestation when infected, specifc IgG against T. gondiiwere detected from day 8 post‑infection and there was an early peripheral release of IFN‑γ at the frst week post‑infection followed by a short peak of IL10 and TNF‑α at the second week post‑infection. There were no signifcant diferences in this response between infected groups. At the placenta, a similar increase in transcription of IFN‑γ, and TNF‑α was found at the three terms of gestation, while IL‑4 increased mainly at the frst and second terms and IL‑10 transcription was higher at the last term. While these fndings show that both Th1 and Th2 cytokines play a key role in the patho‑genesis of ovine toxoplasmosis and that placental and peripheral immune responses do not closely correlate, there seems to be no clear modulation of these responses along the gestation.S

Haplotype analysis of the internationally distributed BRCA1 c.3331_3334delCAAG founder mutation reveals a common ancestral origin in Iberia

Background: TheBRCA1c.3331_3334delCAAG founder mutation has been reported in hereditary breast and ovarian cancer families from multiple Hispanic groups. We aimed to evaluateBRCA1c.3331_3334delCAAG haplotype diversity in cases of European, African, and Latin American ancestry. Methods: BC mutation carrier cases from Colombia (n = 32), Spain (n = 13), Portugal (n = 2), Chile (n = 10), Africa (n = 1), and Brazil (n = 2) were genotyped with the genome-wide single nucleotide polymorphism (SNP) arrays to evaluate haplotype diversity aroundBRCA1c.3331_3334delCAAG. Additional Portuguese (n = 13) and Brazilian (n = 18) BC mutation carriers were genotyped for 15 informative SNPs surroundingBRCA1. Data were phased using SHAPEIT2, and identical by descent regions were determined using BEAGLE and GERMLINE. DMLE+ was used to date the mutation in Colombia and Iberia. Results: The haplotype reconstruction revealed a shared 264.4-kb region among carriers from all six countries. The estimated mutation age was similar to 100 generations in Iberia and that it was introduced to South America early during the European colonization period. Conclusions: Our results suggest that this mutation originated in Iberia and later introduced to Colombia and South America at the time of Spanish colonization during the early 1500s. We also found that the Colombian mutation carriers had higher European ancestry, at the BRCA1 gene harboring chromosome 17, than controls, which further supported the European origin of the mutation. Understanding founder mutations in diverse populations has implications in implementing cost-effective, ancestry-informed screening

EpIG‐DB: A database of vascular epiphyte assemblages in the Neotropics

Vascular epiphytes are a diverse and conspicuous component of biodiversity in tropical and subtropical forests. Yet, the patterns and drivers of epiphyte assemblages are poorly studied in comparison with soil‐rooted plants. Current knowledge about diversity patterns of epiphytes mainly stems from local studies or floristic inventories, but this information has not yet been integrated to allow a better understanding of large‐scale distribution patterns. EpIG‐DB, the first database on epiphyte assemblages at the continental scale, resulted from an exhaustive compilation of published and unpublished inventory data from the Neotropics. The current version of EpIG‐DB consists of 463,196 individual epiphytes from 3,005 species, which were collected from a total of 18,148 relevés (host trees and ‘understory’ plots). EpIG‐DB reports the occurrence of ‘true’ epiphytes, hemiepiphytes and nomadic vines, including information on their cover, abundance, frequency and biomass. Most records (97%) correspond to sampled host trees, 76% of them aggregated in forest plots. The data is stored in a TURBOVEG database using the most up‐to‐date checklist of vascular epiphytes. A total of 18 additional fields were created for the standardization of associated data commonly used in epiphyte ecology (e.g. by considering different sampling methods). EpIG‐DB currently covers six major biomes across the whole latitudinal range of epiphytes in the Neotropics but welcomes data globally. This novel database provides, for the first time, unique biodiversity data on epiphytes for the Neotropics and unified guidelines for future collection of epiphyte data. EpIG‐DB will allow exploration of new ways to study the community ecology and biogeography of vascular epiphytes