Emotional modulation of visual cortex activity: A functional nearinfrared spectroscopy study

Functional neuroimaging and electroencephalography reveal emotional effects in early visual cortex. Here, we used fNIRS to examine haemodynamic responses evoked by neutral, positive and negative emotional pictures, matched for brightness, contrast, hue, saturation, spatial frequency and entropy. Emotion content modulated amplitude and latency of oxy-, deoxy- and total haemoglobin response peaks, and induced peripheral autonomic reactions. The processing of positive and negative pictures enhanced haemodynamic response amplitude, and this effect was paralleled by blood pressure changes. The processing of positive pictures was reflected in reduced haemodynamic response peak latency. Together these data suggest early visual cortex holds amplitude-dependent representation of stimulus salience and latency-dependent information regarding stimulus valence, providing new insight into affective interaction with sensory processing

Slow breathing and hypoxic challenge: cardiorespiratory consequences and their central neural substrates

Controlled slow breathing (at 6/min, a rate frequently adopted during yoga practice) can benefit cardiovascular function, including responses to hypoxia. We tested the neural substrates of cardiorespiratory control in humans during volitional controlled breathing and hypoxic challenge using functional magnetic resonance imaging (fMRI). Twenty healthy volunteers were scanned during paced (slow and normal rate) breathing and during spontaneous breathing of normoxic and hypoxic (13% inspired O2) air. Cardiovascular and respiratory measures were acquired concurrently, including beat-to-beat blood pressure from a subset of participants (N = 7). Slow breathing was associated with increased tidal ventilatory volume. Induced hypoxia raised heart rate and suppressed heart rate variability. Within the brain, slow breathing activated dorsal pons, periaqueductal grey matter, cerebellum, hypothalamus, thalamus and lateral and anterior insular cortices. Blocks of hypoxia activated mid pons, bilateral amygdalae, anterior insular and occipitotemporal cortices. Interaction between slow breathing and hypoxia was expressed in ventral striatal and frontal polar activity. Across conditions, within brainstem, dorsal medullary and pontine activity correlated with tidal volume and inversely with heart rate. Activity in rostroventral medulla correlated with beat-to-beat blood pressure and heart rate variability. Widespread insula and striatal activity tracked decreases in heart rate, while subregions of insular cortex correlated with momentary increases in tidal volume. Our findings define slow breathing effects on central and cardiovascular responses to hypoxic challenge. They highlight the recruitment of discrete brainstem nuclei to cardiorespiratory control, and the engagement of corticostriatal circuitry in support of physiological responses that accompany breathing regulation during hypoxic challenge

Acute tryptophan depletion attenuates conscious appraisal of social emotional signals in healthy female volunteers

Rationale: Acute tryptophan depletion (ATD) decreases levels of central serotonin. ATD thus enables the cognitive effects of serotonin to be studied, with implications for the understanding of psychiatric conditions, including depression. Objective: To determine the role of serotonin in conscious (explicit) and unconscious/incidental processing of emotional information. Materials and methods: A randomized, double-blind, cross-over design was used with 15 healthy female participants. Subjective mood was recorded at baseline and after 4 h, when participants performed an explicit emotional face processing task, and a task eliciting unconscious processing of emotionally aversive and neutral images presented subliminally using backward masking. Results: ATD was associated with a robust reduction in plasma tryptophan at 4 h but had no effect on mood or autonomic physiology. ATD was associated with significantly lower attractiveness ratings for happy faces and attenuation of intensity/arousal ratings of angry faces. ATD also reduced overall reaction times on the unconscious perception task, but there was no interaction with emotional content of masked stimuli. ATD did not affect breakthrough perception (accuracy in identification) of masked images. Conclusions: ATD attenuates the attractiveness of positive faces and the negative intensity of threatening faces, suggesting that serotonin contributes specifically to the appraisal of the social salience of both positive and negative salient social emotional cues. We found no evidence that serotonin affects unconscious processing of negative emotional stimuli. These novel findings implicate serotonin in conscious aspects of active social and behavioural engagement and extend knowledge regarding the effects of ATD on emotional perception

Fear from the heart: sensitivity to fear stimuli depends on individual heartbeats

Cognitions and emotions can be influenced by bodily physiology. Here, we investigated whether the processing of brief fear stimuli is selectively gated by their timing in relation to individual heartbeats. Emotional and neutral faces were presented to human volunteers at cardiac systole, when ejection of blood from the heart causes arterial baroreceptors to signal centrally the strength and timing of each heartbeat, and at diastole, the period between heartbeats when baroreceptors are quiescent. Participants performed behavioral and neuroimaging tasks to determine whether these interoceptive signals influence the detection of emotional stimuli at the threshold of conscious awareness and alter judgments of emotionality of fearful and neutral faces. Our results show that fearful faces were detected more easily and were rated as more intense at systole than at diastole. Correspondingly, amygdala responses were greater to fearful faces presented at systole relative to diastole. These novel findings highlight a major channel by which short-term interoceptive fluctuations enhance perceptual and evaluative processes specifically related to the processing of fear and threat and counter the view that baroreceptor afferent signaling is always inhibitory to sensory perception

Is the Stalk of the SARS-CoV-2 Spike Protein Druggable?

The spike protein is key to SARS-CoV-2 high infectivity because it facilitates the receptor binding domain (RBD) encounter with ACE2. As targeting subunit S1 has not yet delivered an ACE2-binding inhibitor, we have assessed the druggability of the conserved segment of the spike protein stalk within subunit S2 by means of an integrated computational approach that combines the molecular docking of an optimized library of fragments with high-throughput molecular dynamics simulations. The high propensity of the spike protein to mutate in key regions that are responsible for the recognition of the human angiotensin-converting enzyme 2 (hACE2) or for the recognition of antibodies, has made subunit S1 of the spike protein difficult to target. Despite the inherent flexibility of the stalk region, our results suggest two hidden interhelical binding sites, whose accessibility is only partially hampered by glycan residues

A Dtm Multi-Resolution Compressed Model for Efficient Data Storage and Network Transfer

In recent years the technological evolution of terrestrial, aerial and satellite surveying, has considerably increased the measurement accuracy and, consequently, the quality of the derived information. At the same time, the smaller and smaller limitations on data storage devices, in terms of capacity and cost, has allowed the storage and the elaboration of a bigger number of instrumental observations. A significant example is the terrain height surveyed by LIDAR (LIght Detection And Ranging) technology where several height measurements for each square meter of land can be obtained. The availability of such a large quantity of observations is an essential requisite for an in-depth knowledge of the phenomena under study. But, at the same time, the most common Geographical Information Systems (GISs) show latency in visualizing and analyzing these kind of data. This problem becomes more evident in case of Internet GIS. These systems are based on the very frequent flow of geographical information over the internet and, for this reason, the band-width of the network and the size of the data to be transmitted are two fundamental factors to be considered in order to guarantee the actual usability of these technologies. In this paper we focus our attention on digital terrain models (DTM's) and we briefly analyse the problems about the definition of the minimal necessary information to store and transmit DTM's over network, with a fixed tolerance, starting from a huge number of observations. Then we propose an innovative compression approach for sparse observations by means of multi-resolution spline functions approximation. The method is able to provide metrical accuracy at least comparable to that provided by the most common deterministic interpolation algorithms (inverse distance weighting, local polynomial, radial basis functions). At the same time it dramatically reduces the number of information required for storing or for transmitting and rebuilding a digital terrain model dataset. A brief description of the method is presented and comparisons about the accuracy and data-store compression obtained with respect to other interpolators are shown

Sound and the City: Multi-Layer Representation and Navigation of Audio Scenarios

IEEE 1599-2008 is an XML-based standard originally intended for the multi-layer representation of music information. Nevertheless, it is versatile enough to describe also information different from traditional scores written according to the Common Western Notation (CWN) rules. This paper will discuss the application of IEEE 1599-2008 to the audio description of paths and scenarios from the urban life or other landscapes. The standard we adopt allows the multilayer integration of textual, symbolical, structural, graphical, audio and video contents within a unique synchronized environment. Besides, for each kind of media, a number of digital objects is supported. As a consequence, thanks to the features of the format the produced description will be more than a mere audio track, a slideshow made of sonified static images or a movie. Finally, an ad hoc evolution of a standard viewer for IEEE 1599 documents will be presented, in order to enjoy the results of our efforts

A NEW MULTI-RESOLUTION ALGORITHM TO STORE AND TRANSMIT COMPRESSED DTM

WebGIS and virtual globes allow DTMs distribution and three dimensional representations to the Web users' community. In these applications, the database storage size represents a critical point. DTMs are obtained by some sampling or interpolation on the raw observations and typically are stored and distributed by data based models, like for example regular grids. A new approach to store and transmit DTMs is presented. The idea is to use multi-resolution bilinear spline functions to interpolate the observations and to model the terrain. More in detail, the algorithm performs the following actions. 1) The spatial distribution of the observations is investigated. Where few data are available, few levels of splines are activated while more levels are activated where the raw observations are denser: each new level corresponds to an halving of the spline support with respect to the previous level. 2) After the selection of the spline functions to be activated, the relevant coefficients are estimated by interpolating the observations. The interpolation is computed by batch least squares. 3) Finally, the estimated coefficients of the splines are stored. The model guarantees a local resolution consistent with the data density and can be defined analytical, because the coefficients of a given function are stored instead of a set of heights. The approach is discussed and compared with the traditional techniques to interpolate, store and transmit DTMs, considering accuracy and storage requirements. It is also compared with another multi-resolution technique. The research has been funded by the INTERREG HELI-DEM (Helvetia Italy Digital Elevation Model) project

An XML-based Format for Advanced Music Fruition

(Abstract to follow