Patterns of Early Urbanisation in Swat: A Reassessment of the Data from the Recent Excavations at Barikot

The study presents a set of new data, all coming from recent excavations in the ancient urban site of Barikot (Swat, Pakistan), which may allow a new look at phenomena hitherto considered certain, such as the delay of protohistoric phases, the so-called marginalization of Swat, and the beginning of urban phases seen in association with the Indo-Greek colonial power. In our reconstruction, the protohistoric phases end around 800 BCE, while, after a phase of negative interface, i.e. of significant abandonment, towards the middle of the first millennium, there are conditions for the establishment of an urban settlement in Barikot. At this stage, very significantly, for the first time, the local ceramic tradition is replaced by Gangetic and Iranian forms, which are interpreted as markers of a growing process of trans-regional trade relations. In this ongoing process of historical reconstruction, the silence of the archaeological component towards the so-called Mauryan phase, of which field archaeology has not yet managed to provide a clear picture, remains strident

Restauro conservativo e mobilizzazione sociale in siti archeologici della valle dello Swat (Pakistan)

The 60-year presence of the Italian Archaeological Mission in Swat, has built a substantial continuity among the skilled workers from one generation to the next resulting in a working experience that is unique in this field. This experience was transformed in 2011-2014 into a model of intervention, the ACT project. In view of this experience, a specific approach in conservative restoration was designed with special reference to the materials and skills of the local workers. The need was felt to come up with a low cost type of intervention based on clear-cut methodological concepts that would allow government agencies in future to plan maintenance and restoration cycles also on a large scale, that is with an order of magnitude that the administration of cultural heritage has to cope with in Swat and in Pakistan. This model of intervention is pictured through two test cases, i.e. the Main Stupa at the site of Saidu Sharif I, and the colossal rock-carving of Jahanabad.

Le cosiddette ‘croci di San Tommaso’. Una nota archeologica

The question of Christian presence in mainland South Asia, although historically certain, is not archaeologically attested for the period before the Portuguese contact phase. Elsewhere the archaeological evidence is clear: in the Iranian and Central Asian area, in the Karakoram‑Himalaya, but also along the Indian Ocean routes. The so‑called ‘St. Thomas crosses’, a traditional key point for the issue, can hardly be considered as supporting evidence for an early presence of Christian communities at least in South India. Research on these phases will have to move in other directions in the future, both by exploring the rich regional epigraphic corpus and by planning archaeological fieldwork

The value of transbronchial lung biopsy using jumbo forceps via rigid bronchoscope in diffuse lung disease.

Background. Transbronchial lung biopsy (TBLB) is a valuable procedure used to obtain a parenchymal specimen in the evaluation of diffuse lung infiltrates. Large forceps are expected to result in larger specimens and improve diagnostic yield. Aim. The objective of this study was to evaluate diagnostic yield of TBLB using large modified flexible gastroenterological forceps ("Jumbo forceps") compared with 'normal' flexible forceps via rigid bronchoscopy in patients with diffuse parenchymal lung disease (DPLD). Methods. The study was a prospective analysis of 95 patients who underwent fluoroscopy guided TBLB over a two year period. Patients with a lung mass or solitary lung nodule undergoing TBLB were excluded. The larger and small forceps were used in a random sequence to avoid a reduction in diagnostic yield of the second series of biopsies related to possible bleeding by first series of biopsies. To minimize the consequence of haemorrhage, we performed every rigid bronchoscopy, placing a non inflated Fogarty balloon and a rigid aspirator (diameter 4 mm) in lobar bronchus near the biopsy segment. The Fogarty balloon has been inflated in case of bleeding. After the bleeding was controlled we continued to operate up to the biopsy segment. Results. Diagnostic yield of TBLB using Jumbo forceps was significantly higher than using normal flexible forceps via rigid bronchoscopy in patients with DPLD (p=0.001). In 74 out of 95 patients (78%) the diagnosis was placed with Jumbo forcep while the smaller forcep was diagnostic in 62 out of 95 patients (65%). Large forceps obtained significantly more tissue than the small forceps; the biopsy specimen taken with normal forcep measured in average 1.4 x 1.0 mm and the larger biopsy taken with jumbo forcep measured in average 2.5 x 1.9 mm (p < 0.005). Conclusion. The use of large biopsy forceps to perform TBLB via rigid bronchoscope can significantly increase diagnostic yield in the pathological diagnosis of diffuse infiltrative lung disease

A Journey to the West: The Ancient Dispersal of Rice Out of East Asia.

Funder: Max Planck Institute for the Science of Human HistoryRice is one of the most culturally valued and widely grown crops in the world today, and extensive research over the past decade has clarified much of the narrative of its domestication and early spread across East and South Asia. However, the timing and routes of its dispersal into West Asia and Europe, through which rice eventually became an important ingredient in global cuisines, has remained less clear. In this article, we discuss the piecemeal, but growing, archaeobotanical data for rice in West Asia. We also integrate written sources, linguistic data, and ethnohistoric analogies, in order to better understand the adoption of rice outside its regions of origin. The human-mediated westward spread of rice proceeded gradually, while its social standing and culinary uses repeatedly changing over time and place. Rice was present in West Asia and Europe by the tail end of the first millennium BC, but did not become a significant crop in West Asia until the past few centuries. Complementary historical, linguistic, and archaeobotanical data illustrate two separate and roughly contemporaneous routes of westward dispersal, one along the South Asian coast and the other through Silk Road trade. By better understanding the adoption of this water-demanding crop in the arid regions of West Asia, we explore an important chapter in human adaptation and agricultural decision making

Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes

Type-2 Diabetes (T2D), diabetic complications, and their clinical risk factors harbor a substantial genetic component but the genetic factors contributing to overall diabetes mortality remain unknown. Here, we examined the association between genetic variants at 21 T2D-susceptibility loci and all-cause mortality in an elderly cohort of 542 Italian diabetic patients who were followed for an average of 12.08 years. Univariate Cox regression analyses detected age, waist-to-hip ratio (WHR), glycosylated haemoglobin (HbA1c), diabetes duration, retinopathy, nephropathy, chronic kidney disease (CKD), and anaemia as predictors of all-cause mortality. When Cox proportional hazards multivariate models adjusted for these factors were run, three erythropoietin (EPO) genetic variants in linkage disequilibrium (LD) with each other (rs1617640-T/G, rs507392-T/C and rs551238-A/C) were significantly (False Discovery Rate < 0.1) associated with mortality. Haplotype multivariate analysis revealed that patients carrying the G-C-C haplotype have an increased probability of survival, while an opposite effect was observed among subjects carrying the T-T-A haplotype. Our findings provide evidence that the EPO gene is an independent predictor of mortality in patients with T2D. Thus, understanding the mechanisms by which the genetic variability of EPO affects the mortality of T2D patients may provide potential targets for therapeutic interventions to improve the survival of these patients

Identification of backgrounds in the EDELWEISS-I dark matter search experiment

This paper presents our interpretation and understanding of the different backgrounds in the EDELWEISS-I data sets. We analyze in detail the several populations observed, which include gammas, alphas, neutrons, thermal sensor events and surface events, and try to combine all data sets to provide a coherent picture of the nature and localisation of the background sources. In light of this interpretation, we draw conclusions regarding the background suppression scheme for the EDELWEISS-II phase

Measurement of the response of heat-and-ionization germanium detectors to nuclear recoils

The heat quenching factor Q' (the ratio of the heat signals produced by nuclear and electron recoils of equal energy) of the heat-and-ionization germanium bolometers used by the EDELWEISS collaboration has been measured. It is explained how this factor affects the energy scale and the effective quenching factor observed in calibrations with neutron sources. This effective quenching effect is found to be equal to Q/Q', where Q is the quenching factor of the ionization yield. To measure Q', a precise EDELWEISS measurement of Q/Q' is combined with values of Q obtained from a review of all available measurements of this quantity in tagged neutron beam experiments. The systematic uncertainties associated with this method to evaluate Q' are discussed in detail. For recoil energies between 20 and 100 keV, the resulting heat quenching factor is Q' = 0.91+-0.03+-0.04, where the two errors are the contributions from the Q and Q/Q' measurements, respectively. The present compilation of Q values and evaluation of Q' represent one of the most precise determinations of the absolute energy scale for any detector used in direct searches for dark matter.Comment: 28 pages, 7 figures. Submitted to Phys. Rev.

Phylogenetic Position of a Copper Age Sheep (Ovis aries) Mitochondrial DNA

BACKGROUND: Sheep (Ovis aries) were domesticated in the Fertile Crescent region about 9,000-8,000 years ago. Currently, few mitochondrial (mt) DNA studies are available on archaeological sheep. In particular, no data on archaeological European sheep are available. METHODOLOGY/PRINCIPAL FINDINGS: Here we describe the first portion of mtDNA sequence of a Copper Age European sheep. DNA was extracted from hair shafts which were part of the clothes of the so-called Tyrolean Iceman or Ötzi (5,350-5,100 years before present). Mitochondrial DNA (a total of 2,429 base pairs, encompassing a portion of the control region, tRNA(Phe), a portion of the 12S rRNA gene, and the whole cytochrome B gene) was sequenced using a mixed sequencing procedure based on PCR amplification and 454 sequencing of pooled amplification products. We have compared the sequence with the corresponding sequence of 334 extant lineages. CONCLUSIONS/SIGNIFICANCE: A phylogenetic network based on a new cladistic notation for the mitochondrial diversity of domestic sheep shows that the Ötzi's sheep falls within haplogroup B, thus demonstrating that sheep belonging to this haplogroup were already present in the Alps more than 5,000 years ago. On the other hand, the lineage of the Ötzi's sheep is defined by two transitions (16147, and 16440) which, assembled together, define a motif that has not yet been identified in modern sheep populations

Postoperative Delirium after elective and emergency surgery: analysis and checking of risk factors. A study protocol

BACKGROUND: Delirum is common in hospitalized elderly patients and may be associated with increased morbidity, length of stay and patient care costs. Delirium (acute confusional state) is defined as an acute disorder of attention and cognition. In elderly patients, delirium is often an early indicator of patho-physiological disturbances. Despite landmark studies dating back to the 1940s, the pathogenesis of Delirium remains poorly understood. Early investigators noted that Delirium was characterized by global cortical dysfunction that was associated predominantly with specific electroencephalographic changes. It's important to understand the risk factors and incidence of Delirium. Some of the risk factors are already identified in literature and can be summarized in the word "VINDICATE" which stands for: Vascular, Infections, Nutrition, Drugs, Injury, Cardiac, Autoimmune, Tumors, Endocrine. Aims of this study are: to re-evaluate the above mentioned clinical risk factors, adding some others selected from literature, and to test, as risk factors, a pattern of some genes associated to cognitive dysfunction and inflammation possibly related to postoperative Delirium. DESIGN: All patients admitted to our Emergency Unit who are meet our inclusion/exclusion criteria will be recruited. The arising of postoperative Delirium will select incidentally two groups (Delirium/non Delirium) and the forward analysis of correlate risk factors will be performed. As in a typical observational case/control study we will consider all the exposure factors to which our population are submitted towards the outcome (presence of Delirium). Our exposures are the following: ASA, Pain (SVS; VAS), Blood gas analysis (pH; Hb; pO2; pCO2), Residence pharmacological therapy (BDZ; hypnotics; narcotic drugs; alcohol; nitrous derivates), Body temperature, Arterial pressure, Heart frequency, Breath frequency, Na, K, Creatinin, Glicemia, Albumin, Hct, White blood cells, Glasgow Coma Scale (GCS), Cognitive state (SPMSQ), Functional state (ADL and IADL), Psychological Distress (HADS), Cumulative Illness Rating Scale (CIRS), Hypotension (classified in: light; moderate and severe and duration), Blood loss (classified in: < 2 lt and > 2 lt), Blood transfusions (< 2 lt and > 2 lt), Quantity of red cells and plasma transfusions, Visual VAS / SVS (timing: I-II-III post-operative day), Red cells and Plasma transfusions, Blood count evaluation and Saturation (O(2)%), Postoperative analgesia (Emilia-Romagna protocol), Presence of malignant tumoral disease, APACHE Score II. Moreover the presence of some relevant genetic polymorphisms will be studied in different genes such as IL-6, IL-10, TNF-alpha, and IL-1 cluster