Sintomatologia depressiva e empowerment psicológico nos estudantes universitários

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Iniciativa de crescimento pessoal e satisfação com a vida em estudantes universitários

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Effects of resistive exercise and stretching on the soleus muscle of ovariectomized rats

O estudo analisou os efeitos do exercício resistido e/ou alongamento na morfologia muscular de ratas ovariectomizadas. Setenta e cinco ratas Wistar (218±22g) foram divididas em 8 grupos: Controle (CONTROLE, n=5); Ovariectomia/histerectomia (OH, n=10): foram submetidas à ovariectomia/histerectomia e aguardaram oito semanas para instalação de osteopenia; Alongamento (ALONG, n=10): alongamento manual do músculo sóleo (10 repetições de 60s), duas vezes por semana; Ovariectomia/histerectomia e Alongamento (OH+ALONG, n=10); Exercício Resistido (ER, n=10): 4 séries de 10 repetições, carga inicial de 50% do peso corporal, aumentando semanalmente até 70%, três vezes por semana; Exercício Resistido e Alongamento (ER+ALONG, n=10); Ovariectomia/histerectomia e Exercício Resistido (OH+PL, n=10); Ovariectomia/histerectomia, Exercício Resistido e Alongamento (OH+ER+Along, n=10). Alongamento e/ou Exercicio Resistido foram realizados durante 6 semanas. Após 14 semanas, as ratas foram submetidas à ortotanásia para remoção do sóleo. As seguintes variáveis foram avaliadas: peso corporal; peso e comprimento muscular; número e comprimento dos sarcômeros e área da secção transversa das fibras musculares (ASTFM). Comparação entre grupos foi realizada com ANOVA one way post hoc Tukey ou Kruskall-Wallis (pEl estudio analizó los efectos del ejercicio resistido y/o estiramiento en la morfología muscular de ratas ovarectomizadas. Se dividió setenta y cinco ratas Wistar (218±22g) en 8 grupos: Control (CONTROL, n=5); ovariectomía/histerectomía (OH, n=10): fueron sometidas a ovariectomía/histerectomía y esperaron ocho semanas para la instalación de osteopenia; Estiramiento (ESTIR, n=10): estiramiento manual del músculo sóleo (10 repeticiones de 60s), dos veces por semana; ovariectomía/histerectomía y estiramiento (OH + ESTIR, n=10), ejercicio resistido (ER, n=10): 4 series de 10 repeticiones, carga inicial de 50% del peso corporal, aumentando semanalmente hasta 70%, tres veces por semana; Ejercicio resistido y estiramiento (ER+ESTIR, n=10); ovariectomía/histerectomía y ejercicio resistido (OH + PL, n=10); ovariectomía/histerectomía, ejercicio resistido y estiramiento (OH + ER + ESTIR, n=10). Se realizó estiramiento y/o ejercicio resistido durante 6 semanas. Después de 14 semanas, las ratas fueron sometidas a ortotanasia para la remoción del sóleo. Las siguientes variables fueron evaluadas: peso corporal; peso y longitud muscular; número y longitud de los sarcómeros y área de la sección trasversa de las fibras musculares (ASTFM). Se realizó una comparación entre grupos con ANOVA one way post hoc Tukey o Kruskall-Wallis (pThis study analyzed the effects of resistive exercise and/or stretching in the muscle morphology of ovariectomized rats. Seventy-five female Wistar rats (218±22g) were divided into 8 groups: Control (CONTROL, n=5); Ovariectomy/Hysterectomy (OH, n=10): ovariectomized/hysterectomized and then waited 8 weeks for the onset of osteopenia. Stretching (STRET, n=10): manual stretching of the soleus muscle (10 repetitions of 60s), twice weekly; Ovariectomy/Hysterectomy and Stretching (OH+STRET, n=10); Progressive Loading (PL, n=10): 4 sets of 10 repetitions, initial load 50% of body weight, increasing weekly until 70%, three times a week. Progressive Loading and Stretching (PL+STRET, n=10); Ovariectomy/Hysterectomy and Progressive loading exercise (OH+PL, n=10); Ovariectomy/Hysterectomy, Progressive Loading and Stretching (OH+PL+STRET, n=10). Stretching and/or progressive loading were performed for 6 weeks. After 14 weeks, the female rats were euthanized to remove the soleus muscle. The following variables were assessed: body weight; muscle weight and length; number and length of sarcomeres and the muscle fiber cross-sectional area (MFCSA). Comparisons between the groups were performed with ANOVA one-way post hoc Tukey or Kruskall-Wallis (

Investigating information regarding functional capacity and quality of life in institutionalized elderly according to the ICF

Objetivo: Avaliar a funcionalidade por meio da capacidade funcional e qualidade de vida (QV), sob a ótica da CIF, de idosas institucionalizadas. Método: Foi realizado um estudo observacional transversal com 22 idosas (77,9 ± 9,41 anos) de uma instituição de longa permanência da cidade de Curitiba/Paraná. Foram aplicados os seguintes instrumentos de avaliação: Índice de Barthel, Questionário Perfil de Saúde de Nottingham e a Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF). A descrição dos dados foi feita por meio de medidas de tendência central (média) e dispersão (desvio-padrão). A CIF foi analisada de acordo com a distribuição de frequência relativa e absoluta. Resultados: A maioria das idosas apresentaram um médio estado cognitivo e dependência funcional leve. O domínio que mais interferiu a QV das idosas foi a habilidade física, nível energético, sono, dor, emocional e social, respectivamente. A distribuição de frequência da CIF evidenciou aspectos não observados na avaliação convencional das idosas, sobretudo, apresentou grande especificidade nas funções mentais, sensoriais e dor, sistema digestivo, metabólico e endócrino, psicomotora, movimento, cuidado pessoal, apoio e relacionamentos e atividades individuais. Conclusão: Espera-se que a CIF seja incorporada e utilizada em diversos setores da saúde, inclusive em instituições de longa permanência e equipes multidisciplinares, para que profissionais tenham ações de saúde que contemplem o indivíduo como um todoObjective: To evaluate the functional capacity and quality of life (QoL) of the institutionalized elderly from an ICF perspective. Method: A cross-sectional observational analytic study was conducted with 22 elderly residents (77.9 ± 9.41 years) of a long-stay care institution in Curitiba, Paraná. The following assessment instruments were applied: the Barthel Index, the Nottingham Health Profile Questionnaire, and the International Classification of Functioning, Disability, and Health (ICF). Analysis of the data was done by measures of central tendency (mean) and dispersion (standard deviation). The ICF was analyzed by the distribution of relative and absolute frequencies. Results: The majority of the sample had medium cognitive status and light functional dependency. The domain that most interfered with the elderly’s QOL was physical ability, energy level, sleep, and emotional and social pain, respectively. The ICF frequency distribution showed aspects not observed in the conventional assessment of the participants; in particular, it showed great specificity in the following functions: mental, sensory, and pain, the digestive, metabolic, and endocrine systems, psychomotor, movement, personal care, support and relationships, and individual activities. Conclusions: It is expected that the ICF will be adopted and used in various areas of health, including long-stay care facilities and multidisciplinary teams, so that professionals, through a unified and standard language, may intervene in the health of the individual as a whole

High-Fat Diet-Induced Obesity Model Does Not Promote Endothelial Dysfunction via Increasing Leptin/Akt/eNOS Signaling

Experimental studies show that the unsaturated high-fat diet-induced obesity promotes vascular alterations characterized by improving the endothelial L-arginine/Nitric Oxide (NO) pathway. Leptin seems to be involved in this process, promoting vasodilation via increasing NO bioavailability. The aim of this study was to test the hypothesis that unsaturated high-fat diet-induced obesity does not generate endothelial dysfunction via increasing the vascular leptin/Akt/eNOS signaling. Thirty-day-old male Wistar rats were randomized into two groups: control (C) and obese (Ob). Group C was fed a standard diet, while group Ob was fed an unsaturated high-fat diet for 27 weeks. Adiposity, hormonal and biochemical parameters, and systolic blood pressure were observed. Concentration response curves were performed for leptin or acetylcholine in the presence or absence of Akt and NOS inhibitor. Our results showed that an unsaturated high-fat diet promoted a greater feed efficiency (FE), elevation of body weight and body fat (BF), and an adiposity index, characterizing a model of obesity. However, comorbidities frequently associated with experimental obesity were not visualized, such as glucose intolerance, dyslipidemia and hypertension. The evaluation of the endothelium-dependent relaxation with acetylcholine showed no differences between the C and Ob rats. After NOS inhibition, the response was completely abolished in the Ob group, but not in the C group. Furthermore, Akt inhibition completely blunted vascular relaxation in the C group, but not in the Ob group, which was more sensitive to leptin-induced vascular relaxation. L-NAME incubation abolished the relaxation in both groups at the same level. Although Akt inhibitor pre-incubation reduced the leptin response, group C was more sensitive to its effect. In conclusion, the high-unsaturated fat diet-induced obesity improved the vascular reactivity to leptin and does not generate endothelial dysfunction, possibly by the increase in the vascular sensitivity to leptin and increasing NO bioavailability. Moreover, our results suggest that the increase in NO production occurs through the increase in NOS activation by leptin and is partially mediated by the Akt pathway

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability

Chromobacterium violaceum is one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. Its complete genome sequence reveals (i) extensive alternative pathways for energy generation, (ii) ≈500 ORFs for transport-related proteins, (iii) complex and extensive systems for stress adaptation and motility, and (iv) wide-spread utilization of quorum sensing for control of inducible systems, all of which underpin the versatility and adaptability of the organism. The genome also contains extensive but incomplete arrays of ORFs coding for proteins associated with mammalian pathogenicity, possibly involved in the occasional but often fatal cases of human C. violaceum infection. There is, in addition, a series of previously unknown but important enzymes and secondary metabolites including paraquat-inducible proteins, drug and heavy-metal-resistance proteins, multiple chitinases, and proteins for the detoxification of xenobiotics that may have biotechnological applications

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

O GMFM E SUA APLICAÇÃO NA AVALIAÇÃO MOTORA DE CRIANÇAS COM PARALISIA CEREBRAL

A avaliação do paciente neurológico é um processo contínuo de coleta de informações que ajuda no planejamento de um programa terapêutico. Elegeu-se para estudo o GMFM (Medição da Função Motora Grossa) que é um instrumento que avalia a motricidade ampla, de forma quantitativa, destinado inicialmente a crianças com PC (Paralisia Cerebral). O objetivo deste estudo foi apresentar uma revisão de literatura sobre o GMFM e a sua utilização na avaliação motora de crianças com PC em diferentes propostas de pesquisa. A metodologia deste trabalho constou de uma busca bibliográfica nas bases de dados Medline, Proquest e Ovid, bem como em artigos e livros, procurando encontrar referências relacionadas ao instrumento de avaliação. Dentro da população escolhida, observou-se que o GMFM vem sendo cada vez mais aplicado para comparar técnicas e procedimentos clínicos e fisioterapêuticos. Como o GMFM trata-se de uma avaliação funcional e quantitativa, terapeutas e familiares visualizam melhor o potencial motor funcional da criança. Porém, a avaliação qualitativa, ou seja, a qualidade com que a criança realiza as atividades não é descrita. Deve-se lembrar que cada instrumento tem suas particularidades e são considerados complementares um do outro para auxiliar na elaboração das metas terapêuticas. O uso de medidas de avaliação ainda não faz parte da rotina dos profissionais fisioterapeutas, isso pode ser devido ao tempo despendido para tais procedimentos ou ao próprio desconhecimento desses métodos de avaliação e de como aplicá-los, mas se faz de suma importância para que possamos ter uma abordagem baseada em evidências