Glissements pelliculaires sur versants rocheux, Côte-Nord du Saint-Laurent, Québec

Les glissements pelliculaires sont des décrochements superficiels affectant la mince couche de débris minéraux et la couche organique recouvrant les versants rocheux à pente raide (> 35°). Par suite d'une saturation en eau du matériel, un paquet de débris se détache du haut du versant et glisse brusquement vers le bas déblayant ainsi un étroit couloir dans le tapis végétal et mettant à nu le substrat rocheux. Les débris accumulés au pied du versant forment un amas correspondant au volume des débris arrachés au versant. Ce processus de denudation des versants rocheux joue un rôle dans leur évolution, le substrat rocheux mis à nu étant ainsi exposé différemment aux agents d'altération subaériens. Environ 500 glissements pelliculaires sur versant rocheux dans plus de 300 sites ont été cartographies dans l'arrière région côtière de la Côte-Nord du Saint-Laurent entre Godbout et Blanc-Sablon. Ce processus mal connu est brièvement décrit et son importance morphologique est soulignée.Skin slides or flows are surficial debris movements on rocky slopes. They occur in the thin mineral soil veneer and the organic cover on relatively steep slopes (> 35°). In the upper part of rocky slopes, water-saturated debris slide down suddenly, cutting through the vegetation cover. The ribbon-like stripe so formed exposes the underlying bedrock. Debris involved in the slide accumulates at the slope base forming a ridge varying in size according to the volume of slide debris. This process of denudation plays a role in the evolution of rocky slopes, since the bedrock is thus exposed to subaerial weathering. Over 500 skin slides on rocky slopes have been mapped in the inland area between Godbout and Blanc-Sablon on the North Shore of the Gulf of St. Lawrence. This poorly documented slope process is briefly described and its morphological significance is stressed

Taux de récurrence chez les enfants signalés à une direction de la protection de la jeunesse entre 1998 et 2002

L’application de la Loi sur la protection de la jeunesse repose sur le signalement d’une situation qui compromet la sécurité ou le développement d’un enfant. Depuis quelques années les intervenants des centres jeunesse constatent qu’un nombre élevé d’enfants font l’objet d’un nouveau signalement au fil des ans : on parle alors de récurrence. Les études menées sur ce sujet rapportent des taux de récurrence variant entre 18 % et 60 %. Or, une majorité d’études s’appuient sur de petits échantillons, et non sur des cohortes, pour établir les taux de récurrence. L’objectif de la présente étude est d’estimer la récurrence en s’appuyant sur cinq cohortes d’enfants (n = 8 738) dont le signalement a été analysé par la direction de la protection de la jeunesse d’un centre jeunesse entre 1998 et 2002. Les résultats indiquent que 24,5 % des enfants évalués avaient fait l’objet d’une enquête antérieurement et qu’un enfant sur six (15,8 %) avait reçu des services des centres jeunesse. Finalement, les prévalences les plus fortes s’observent chez les garçons, dans le groupe d’âge des 13-17 ans et chez ceux qui sont signalés pour une problématique d’abandon et de négligence.Over the past few years, caseworkers in Child Protection Centres in Quebec have noticed a recurrence of referrals for a significant number of children over time. Recent estimates of recurrence for children who received child protection services (CPS) range from 18 % to 60 %. Most studies base their rate on small samples or cases referred over a short period of time, and not on cohorts of CPS-evaluated children. The focus of this study is to estimate the recurrence rate using data from 5 cohorts of children referred and evaluated (n=8738) by a CPS between 1998 and 2002. Results show that 24.5 % of substantiated cases had been evaluated in the past by CPS, and one out of six children (15.8 %) had received CPS services. Boys, children in the 13-17 age group and cases referred for neglect or abandonment showed the highest recurrence rate

Human Parainfluenza Type 4 Infections, Canada

During the fall/winter season of 2004–05, we found 9 respiratory specimens positive for human parainfluenza virus type 4 (HPIV-4) in our laboratory (43% of all HPIVs) from patients with mild to moderate respiratory illnesses. Sequencing studies identified 8 different HPIV-4A strains and 1 HPIV-4B strain

Women's beliefs on early adherence to adjuvant endocrine therapy for breast cancer : a theory-based qualitative study to guide the development of community pharmacist interventions

Adjuvant endocrine therapy (AET) taken for a minimum of five years reduces the recurrence and mortality risks among women with hormone-sensitive breast cancer. However, adherence to AET is suboptimal. To guide the development of theory-based interventions to enhance AET adherence, we conducted a study to explore beliefs regarding early adherence to AET. This qualitative study was guided by the Theory of Planned Behavior (TPB). We conducted focus groups and individual interviews among women prescribed AET in the last two years (n = 43). The topic guide explored attitudinal (perceived advantages and disadvantages), normative (perception of approval or disapproval), and control beliefs (barriers and facilitating factors) towards adhering to AET. Thematic analysis was conducted. Most women had a positive attitude towards AET regardless of their medication-taking behavior. The principal perceived advantage was protection against a recurrence while the principal inconvenience was side effects. Almost everyone approved of the woman taking her medication. The women mentioned facilitating factors to encourage medication-taking behaviors and cope with side effects. For adherent women, having trouble establishing a routine was their main barrier to taking medication. For non-adherent women, it was side effects affecting their quality of life. These findings could inform the development of community pharmacy-based adherence interventions

Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia.

In a large scale screen for skin, hair, and nail abnormalities in null mice generated by The Jackson Laboratory\u27s KOMP center, homozygous mutant Far2tm2b(KOMP)Wtsi/2J (hereafter referrred to as Far2-/-) mice were found to develop focal areas of alopecia as they aged. As sebocytes matured in wildtype C57BL/NJ mice they became pale with fine, uniformly sized clear lipid containing vacuoles that were released when sebocytes disintegrated in the duct. By contrast, the Far2-/- null mice had sebocytes that were similar within the gland but become brightly eosinophilic when the cells entered the sebaceous gland duct. As sebocytes disintegrated, their contents did not readily dissipate. Scattered throughout the dermis, and often at the dermal hypodermal fat junction, were dystrophic hair follicles or ruptured follicles with a foreign body granulomatous reaction surrounding free hair shafts (trichogranuloma). The Meibomian and clitoral glands (modified sebaceous glands) of Far2-/- mice showed ducts dilated to various degrees that were associated with mild changes in the sebocytes as seen in the truncal skin. Skin surface lipidomic analysis revealed a lower level of wax esters, cholesterol esters, ceramides, and diacylglycerols compared to wildtype control mice. Similar changes were described in a number of other mouse mutations that affected the sebaceous glands resulting in primary cicatricial alopecia

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Impact of COVID-19 pandemic on mental health: An international study

Background The COVID-19 pandemic triggered vast governmental lockdowns. The impact of these lockdowns on mental health is inadequately understood. On the one hand such drastic changes in daily routines could be detrimental to mental health. On the other hand, it might not be experienced negatively, especially because the entire population was affected. Methods The aim of this study was to determine mental health outcomes during pandemic induced lockdowns and to examine known predictors of mental health outcomes. We therefore surveyed n = 9,565 people from 78 countries and 18 languages. Outcomes assessed were stress, depression, affect, and wellbeing. Predictors included country, sociodemographic factors, lockdown characteristics, social factors, and psychological factors. Results Results indicated that on average about 10% of the sample was languishing from low levels of mental health and about 50% had only moderate mental health. Importantly, three consistent predictors of mental health emerged: social support, education level, and psychologically flexible (vs. rigid) responding. Poorer outcomes were most strongly predicted by a worsening of finances and not having access to basic supplies. Conclusions These results suggest that on whole, respondents were moderately mentally healthy at the time of a population-wide lockdown. The highest level of mental health difficulties were found in approximately 10% of the population. Findings suggest that public health initiatives should target people without social support and those whose finances worsen as a result of the lockdown. Interventions that promote psychological flexibility may mitigate the impact of the pandemic

To Help or Not to Help? Prosocial Behavior, Its Association With Well-Being, and Predictors of Prosocial Behavior During the Coronavirus Disease Pandemic

Funding Information: This work was supported by grants from the Swiss National Science Foundation awarded to ATG (PP00P1_ 163716/1 and PP00P1_190082). The funder provided support in the form of salaries for authors (EH and ATG) but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: Copyright © 2022 Haller, Lubenko, Presti, Squatrito, Constantinou, Nicolaou, Papacostas, Aydın, Chong, Chien, Cheng, Ruiz, García-Martín, Obando-Posada, Segura-Vargas, Vasiliou, McHugh, Höfer, Baban, Dias Neto, da Silva, Monestès, Alvarez-Galvez, Paez-Blarrina, Montesinos, Valdivia-Salas, Ori, Kleszcz, Lappalainen, Ivanović, Gosar, Dionne, Merwin, Karekla, Kassianos and Gloster.The coronavirus disease (COVID-19) pandemic fundamentally disrupted humans’ social life and behavior. Public health measures may have inadvertently impacted how people care for each other. This study investigated prosocial behavior, its association well-being, and predictors of prosocial behavior during the first COVID-19 pandemic lockdown and sought to understand whether region-specific differences exist. Participants (N = 9,496) from eight regions clustering multiple countries around the world responded to a cross-sectional online-survey investigating the psychological consequences of the first upsurge of lockdowns in spring 2020. Prosocial behavior was reported to occur frequently. Multiple regression analyses showed that prosocial behavior was associated with better well-being consistently across regions. With regard to predictors of prosocial behavior, high levels of perceived social support were most strongly associated with prosocial behavior, followed by high levels of perceived stress, positive affect and psychological flexibility. Sociodemographic and psychosocial predictors of prosocial behavior were similar across regions.publishersversionPeer reviewe