2,027 research outputs found
Challenges of stroke management in resource-limited settings: A case- based reflection
A 19-year-old man presented with a 1-year history of headache, generalised body weakness, progressive memory loss, and disorientation. One month prior to admission, there was aggravation of the weakness of the right upper limb, with new-onset difficulty with mastication, speech impairment, apathy, and urinary incontinence. On clinical examination, the patient had a motor aphasia and a right-sided hemiparesis with increased muscle tone and hyperreflexia. A noncontrast computed tomography (CT) scan of the brain revealed large ischaemic strokes extending beyond the classical vascular territories. Cerebrospinal fluid analysis showed a mildly increased protein level. The electrocardiogram revealed an irregular sinus bradycardia. The remainder of the cardiovascular and laboratory workup was unremarkable. Considering a working diagnosis of central nervous system vasculitis, the patient was treated with aspirin, prednisolone, and physiotherapy. However, he died suddenly a few weeks later. Based on this case, we discuss the challenges of stroke management in resource-limited settings, provide practical tips for general practitioners, reflect on the potential avenues for short- and long-term action, and introduce the budding collaboration platform between the University College London, the University of Liverpool, the Queen Elizabeth Central Hospital, and the Malawi-Liverpool-Wellcome Trust Clinical Research Programme
Spectroscopy, MOST Photometry, and Interferometry of MWC 314: Is it an LBV or an interacting binary?
MWC 314 is a bright candidate luminous blue variable that resides in a fairly
close binary system, with an orbital period of 60.7530.003 d. We observed
MWC 314 with a combination of optical spectroscopy, broad-band ground- and
space-based photometry, as well as with long baseline, near-infrared
interferometry. We have revised the single-lined spectroscopic orbit and
explored the photometric variability. The orbital light curve displays two
minima each orbit that can be partially explained in terms of the tidal
distortion of the primary that occurs around the time of periastron. The
emission lines in the system are often double-peaked and stationary in their
kinematics, indicative of a circumbinary disc. We find that the stellar wind or
circumbinary disc is partially resolved in the K\prime-band with the longest
baselines of the CHARA Array. From this analysis, we provide a simple,
qualitative model in an attempt to explain the observations. From the
assumption of Roche Lobe overflow and tidal synchronisation at periastron, we
estimate the component masses to be M1 M and M2
M, which indicates a mass of the LBV that is extremely low. In addition
to the orbital modulation, we discovered two pulsational modes with the MOST
satellite. These modes are easily supported by a low-mass hydrogen-poor star,
but cannot be easily supported by a star with the parameters of an LBV. The
combination of these results provides evidence that the primary star was likely
never a normal LBV, but rather is the product of binary interactions. As such,
this system presents opportunities for studying mass-transfer and binary
evolution with many observational techniques.Comment: 26 pages, 7 figures, 5 tables, 2 appendices with 7 additional tables
and 2 additional figures. Accepted for publication in MNRA
Epidermoid cyst of the floor of the mouth: two case reports
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
The Atacama Cosmology Telescope: Galactic Dust Structure and the Cosmic PAH Background in Cross-correlation with WISE
We present a cross-correlation analysis between resolution total
intensity and polarization observations from the Atacama Cosmology Telescope
(ACT) at 150 and 220 GHz and 15 mid-infrared photometry from the Wide-field
Infrared Survey Explorer (WISE) over 107 12.512.5 patches
of sky. We detect a spatially isotropic signal in the WISEACT
cross power spectrum at 30 significance that we interpret as the
correlation between the cosmic infrared background at ACT frequencies and
polycyclic aromatic hydrocarbon (PAH) emission from galaxies in WISE, i.e., the
cosmic PAH background. Within the Milky Way, the Galactic dust spectra are
generally well-described by power laws in over the range 1010, but there is evidence both for variability in the power law index and
for non-power law behavior in some regions. We measure a positive correlation
between WISE total intensity and ACT -mode polarization at 10006000 at 3 in each of 35 distinct 100 deg regions
of the sky, suggesting alignment between Galactic density structures and the
local magnetic field persists to sub-parsec physical scales in these regions.
The distribution of amplitudes in this range across all 107 regions
is biased to positive values, while there is no evidence for such a bias in the
spectra. This work constitutes the highest- measurements of the
Galactic dust spectrum to date and indicates that cross-correlation with
high-resolution mid-infrared measurements of dust emission is a promising tool
for constraining the spatial statistics of dust emission at millimeter
wavelengths.Comment: 20 pages, 14 figures, submitted to Ap
Defective formation of IgA memory B cells, Th1 and Th17 cells in symptomatic patients with selective IgA deficiency
Objective: Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency in Western countries. Patients can suffer from recurrent infections and autoimmune diseases because of a largely unknown aetiology. To increase insights into the pathophysiology of the disease, we studied memory B and T cells and cytokine concentrations in peripheral blood. Methods: We analysed 30 sIgAD patients (12 children, 18 adults) through detailed phenotyping of peripheral B-cell, CD8+ T-cell and CD4+ T-cell subsets, sequence analysis of IGA and IGG transcripts, in vitro B-cell activation and blood cytokine measurements. Results: All patients had significantly decreased numbers of T-cell-dependent (TD; CD27+) and T-cell-independent (TI; CD27−) IgA memory B cells and increased CD21low B-cell numbers. IgM+IgD− memory B cells were decreased in children and normal in adult patients. IGA and IGG transcripts contained normal SHM levels. In sIgAD children, IGA transcripts more frequently used IGA2 than controls (58.5% vs. 25.1%), but not in adult patients. B-cell activation after in vitro stimulation was normal. However, adult sIgAD patients exhibited increased blood levels of TGF-β1, BAFF and APRIL, whereas they had decreased Th1 and Th17 cell numbers. Conclusion: Impaired IgA memory formation in sIgAD patients is not due to a B-cell activation defect. Instead, decreased Th1 and Th17 cell numbers and high blood levels of BAFF, APRIL and TGF-β1 might reflect disturbed regulation of IgA responses in vivo. These insights into B-cell extrinsic immune defects suggest the need for a broader immunological focus on genomics and functional analyses to unravel the pathogenesis of sIgAD
The Atacama Cosmology Telescope: Cosmology from cross-correlations of unWISE galaxies and ACT DR6 CMB lensing
We present tomographic measurements of structure growth using
cross-correlations of Atacama Cosmology Telescope (ACT) DR6 and Planck CMB
lensing maps with the unWISE Blue and Green galaxy samples, which span the
redshift ranges and , respectively. We improve on prior unWISE cross-correlations not just by
making use of the new, high-precision ACT DR6 lensing maps, but also by
including additional spectroscopic data for redshift calibration and by
analysing our measurements with a more flexible theoretical model. An extensive
suite of systematic and null tests within a blind analysis framework ensures
that our results are robust. We determine the amplitude of matter fluctuations
at low redshifts (), finding using the ACT cross-correlation alone and with a combination of Planck and ACT cross-correlations; these
measurements are fully consistent with the predictions from primary CMB
measurements assuming standard structure growth. The addition of Baryon
Acoustic Oscillation data breaks the degeneracy between and
, allowing us to measure from the
cross-correlation of unWISE with ACT and from the
combination of cross-correlations with ACT and Planck. These results also agree
with the expectations from primary CMB extrapolations in CDM
cosmology; the consistency of derived from our two redshift samples
at and provides a further check of our cosmological model.
Our results suggest that structure formation on linear scales is well described
by CDM even down to low redshifts .Comment: 73 pages (incl. 30 pages of appendices), 50 figures, 16 tables, to be
submitted to ApJ. Watch G. S. Farren and A. Krolewski discuss the analysis
and results under https://cosmologytalks.com/2023/09/11/act-unwis
Variational formulas and cocycle solutions for directed polymer and percolation models
We discuss variational formulas for the law of large numbers limits of certain models of motion in a random medium: namely, the limiting time constant for last-passage percolation and the limiting free energy for directed polymers. The results are valid for models in arbitrary dimension, steps of the admissible paths can be general, the environment process is ergodic under spatial translations, and the potential accumulated along a path can depend on the environment and the next step of the path. The variational formulas come in two types: one minimizes over gradient-like cocycles, and another one maximizes over invariant measures on the space of environments and paths. Minimizing cocycles can be obtained from Busemann functions when these can be proved to exist. The results are illustrated through 1+1 dimensional exactly solvable examples, periodic examples, and polymers in weak disorder
Impact of COVID-19 pandemic on mental health: An international study
Background
The COVID-19 pandemic triggered vast governmental lockdowns. The impact of these lockdowns on mental health is inadequately understood. On the one hand such drastic changes in daily routines could be detrimental to mental health. On the other hand, it might not be experienced negatively, especially because the entire population was affected.
Methods
The aim of this study was to determine mental health outcomes during pandemic induced lockdowns and to examine known predictors of mental health outcomes. We therefore surveyed n = 9,565 people from 78 countries and 18 languages. Outcomes assessed were stress, depression, affect, and wellbeing. Predictors included country, sociodemographic factors, lockdown characteristics, social factors, and psychological factors.
Results
Results indicated that on average about 10% of the sample was languishing from low levels of mental health and about 50% had only moderate mental health. Importantly, three consistent predictors of mental health emerged: social support, education level, and psychologically flexible (vs. rigid) responding. Poorer outcomes were most strongly predicted by a worsening of finances and not having access to basic supplies.
Conclusions
These results suggest that on whole, respondents were moderately mentally healthy at the time of a population-wide lockdown. The highest level of mental health difficulties were found in approximately 10% of the population. Findings suggest that public health initiatives should target people without social support and those whose finances worsen as a result of the lockdown. Interventions that promote psychological flexibility may mitigate the impact of the pandemic
To Help or Not to Help? Prosocial Behavior, Its Association With Well-Being, and Predictors of Prosocial Behavior During the Coronavirus Disease Pandemic
Funding Information: This work was supported by grants from the Swiss National Science Foundation awarded to ATG (PP00P1_ 163716/1 and PP00P1_190082). The funder provided support in the form of salaries for authors (EH and ATG) but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: Copyright © 2022 Haller, Lubenko, Presti, Squatrito, Constantinou, Nicolaou, Papacostas, Aydın, Chong, Chien, Cheng, Ruiz, García-Martín, Obando-Posada, Segura-Vargas, Vasiliou, McHugh, Höfer, Baban, Dias Neto, da Silva, Monestès, Alvarez-Galvez, Paez-Blarrina, Montesinos, Valdivia-Salas, Ori, Kleszcz, Lappalainen, Ivanović, Gosar, Dionne, Merwin, Karekla, Kassianos and Gloster.The coronavirus disease (COVID-19) pandemic fundamentally disrupted humans’ social life and behavior. Public health measures may have inadvertently impacted how people care for each other. This study investigated prosocial behavior, its association well-being, and predictors of prosocial behavior during the first COVID-19 pandemic lockdown and sought to understand whether region-specific differences exist. Participants (N = 9,496) from eight regions clustering multiple countries around the world responded to a cross-sectional online-survey investigating the psychological consequences of the first upsurge of lockdowns in spring 2020. Prosocial behavior was reported to occur frequently. Multiple regression analyses showed that prosocial behavior was associated with better well-being consistently across regions. With regard to predictors of prosocial behavior, high levels of perceived social support were most strongly associated with prosocial behavior, followed by high levels of perceived stress, positive affect and psychological flexibility. Sociodemographic and psychosocial predictors of prosocial behavior were similar across regions.publishersversionPeer reviewe
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