Cutting Through the Magnetic Tape: Collaborative Preservation of Endangered Videos

Many cultural heritage AV collections are owned by institutions with limited means to preserve them. This project involves the digitization of the Saline Historical Society's oral history collection and the creation of a practices and standards guide for other students to use in similar projects.University Library's Student Engagement Programhttp://deepblue.lib.umich.edu/bitstream/2027.42/122851/1/Lott_Adam_FinalReport_Poster.pdfDescription of Lott_Adam_FinalReport_Poster.pdf : Symposium presentation poste

Relative slow entropy

In 1997, Katok--Thouvenot and Ferenczi independently introduced a notion of ``slow entropy'' as a way to quantitatively compare measure-preserving systems with zero entropy. We develop a relative version of this theory for a measure-preserving system conditioned on a given factor. Our new definition inherits many desirable properties that make it a natural generalization of both the Katok--Thouvenot/Ferenczi theory and the classical conditional Kolmogorov--Sinai entropy. As an application, we prove a relative version of a result of Ferenczi that classifies isometric systems in terms of their slow entropy. We also introduce a new definition for the notion of a rigid extension and investigate its relationship to relative slow entropy.Comment: v2: 30 page

The Effect of Social Media Education in Preventing Smoking in Adolescents to Reduce the Incidence of COPD

Objective: Smoking is the leading cause of chronic obstructive pulmonary disease (COPD) and can lead to other health problems like cardiovascular disease, type two diabetes, and lung cancer (World Health Organization, 2024). The population chosen for the study is adolescents aged 10-19 because smokers normally start smoking on a routine basis before the age of twenty (Reitsma, 2021). The research question is: what is the effect of social media education in preventing smoking in adolescents to reduce the incidence of COPD? Methods: A literature review was conducted to explore evidence-based best practices for social media education using ProQuest and Google Scholar search engines. A boolean strategy was used with the word “AND” along with the following keywords: quantitative study, smoking prevention, adolescents, and using social media. The search results were narrowed using the following filters: meta-analysis, systematic reviews, full text, peer-reviewed, last five years, and evidence-based healthcare. Results: Four articles were chosen based on the highest levels of evidence. Two systematic review articles and two randomized control trials were reviewed. One systematic review focused on social media education in adults, which is shown to be an effective tool for smoking prevention. The second systematic review found that a school-based smoking prevention education program was successful for adolescent education. The remaining two randomized control trials supported social media education in adolescents to prevent smoking. Conclusion: The literature revealed social media interventions are cost-effective that can reach larger target audiences. The literature review provides supporting evidence that social media education programs about smoking prevention in adolescents should be adopted. However, additional research is recommended to examine how social media education impacts smoking patterns in the long term and its relationship to the possible development of COPD, as well as to determine the best social media platform to use for education

The Inverse Gamma Distribution and Benford's Law

According to Benford's Law, many data sets have a bias towards lower leading digits (about 30% are 1's). The applications of Benford's Law vary: from detecting tax, voter and image fraud to determining the possibility of match-fixing in competitive sports. There are many common distributions that exhibit such bias, i.e. they are almost Benford. These include the exponential and the Weibull distributions. Motivated by these examples and the fact that the underlying distribution of factors in protein structure follows an inverse gamma distribution, we determine the closeness of this distribution to a Benford distribution as its parameters change

More on axial anomalies of Lifshitz fermions

We show that the gauge and metric field contribution to the axial anomaly of a four-dimensional massless Lifshitz fermion theory with anisotropy scaling exponent z is identical to the relativistic case, hereby extending the results found in arXiv:1103.5693 to arbitrary values of z. This is in accordance with the fact that the axial anomaly is an infra-red phenomenon in disguise. We also provide some new models that realize baryon and lepton number violation in non-relativistic theories of gravity. In all cases, the volume of space exhibits a lower bound that is fixed by the gravitational coupling parameters.Comment: 1+26 pages; a typo corrected and a small paragraph added in the appendix in v

The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology.

INTRODUCTION: Adults with Down syndrome (DS) are at exceptionally high risk for Alzheimer's disease (AD), with virtually all individuals developing key neuropathological features by age 40. Identifying biomarkers of AD progression in DS can provide valuable insights into pathogenesis and suggest targets for disease modifying treatments. METHODS: We describe the development of a multi-center, longitudinal study of biomarkers of AD in DS. The protocol includes longitudinal examination of clinical, cognitive, blood and cerebrospinal fluid-based biomarkers, magnetic resonance imaging and positron emission tomography measures (at 16-month intervals), as well as genetic modifiers of AD risk and progression. RESULTS: Approximately 400 individuals will be enrolled in the study (more than 370 to date). The methodological approach from the administrative, clinical, neuroimaging, omics, neuropathology, and statistical cores is provided. DISCUSSION: This represents the largest U.S.-based, multi-site, biomarker initiative of AD in DS. Findings can inform other multidisciplinary networks studying AD in the general population

Gene Annotation and Drug Target Discovery in Candida albicans with a Tagged Transposon Mutant Collection

Candida albicans is the most common human fungal pathogen, causing infections that can be lethal in immunocompromised patients. Although Saccharomyces cerevisiae has been used as a model for C. albicans, it lacks C. albicans' diverse morphogenic forms and is primarily non-pathogenic. Comprehensive genetic analyses that have been instrumental for determining gene function in S. cerevisiae are hampered in C. albicans, due in part to limited resources to systematically assay phenotypes of loss-of-function alleles. Here, we constructed and screened a library of 3633 tagged heterozygous transposon disruption mutants, using them in a competitive growth assay to examine nutrient- and drug-dependent haploinsufficiency. We identified 269 genes that were haploinsufficient in four growth conditions, the majority of which were condition-specific. These screens identified two new genes necessary for filamentous growth as well as ten genes that function in essential processes. We also screened 57 chemically diverse compounds that more potently inhibited growth of C. albicans versus S. cerevisiae. For four of these compounds, we examined the genetic basis of this differential inhibition. Notably, Sec7p was identified as the target of brefeldin A in C. albicans screens, while S. cerevisiae screens with this compound failed to identify this target. We also uncovered a new C. albicans-specific target, Tfp1p, for the synthetic compound 0136-0228. These results highlight the value of haploinsufficiency screens directly in this pathogen for gene annotation and drug target identification

Attribution: how is it relevant for loss and damage policy and practice?

Attribution has become a recurring issue in discussions about Loss and Damage (L&D). In this highly-politicised context, attribution is often associated with responsibility and blame; and linked to debates about liability and compensation. The aim of attribution science, however, is not to establish responsibility, but to further scientific understanding of causal links between elements of the Earth System and society. This research into causality could inform the management of climate-related risks through improved understanding of drivers of relevant hazards, or, more widely, vulnerability and exposure; with potential benefits regardless of political positions on L&D. Experience shows that it is nevertheless difficult to have open discussions about the science in the policy sphere. This is not only a missed opportunity, but also problematic in that it could inhibit understanding of scientific results and uncertainties, potentially leading to policy planning which does not have sufficient scientific evidence to support it. In this chapter, we first explore this dilemma for science-policy dialogue, summarising several years of research into stakeholder perspectives of attribution in the context of L&D. We then aim to provide clarity about the scientific research available, through an overview of research which might contribute evidence about the causal connections between anthropogenic climate change and losses and damages, including climate science, but also other fields which examine other drivers of hazard, exposure, and vulnerability. Finally, we explore potential applications of attribution research, suggesting that an integrated and nuanced approach has potential to inform planning to avert, minimise and address losses and damages. The key messages are In the political context of climate negotiations, questions about whether losses and damages can be attributed to anthropogenic climate change are often linked to issues of responsibility, blame, and liability. Attribution science does not aim to establish responsibility or blame, but rather to investigate drivers of change. Attribution science is advancing rapidly, and has potential to increase understanding of how climate variability and change is influencing slow onset and extreme weather events, and how this interacts with other drivers of risk, including socio-economic drivers, to influence losses and damages. Over time, some uncertainties in the science will be reduced, as the anthropogenic climate change signal becomes stronger, and understanding of climate variability and change develops. However, some uncertainties will not be eliminated. Uncertainty is common in science, and does not prevent useful applications in policy, but might determine which applications are appropriate. It is important to highlight that in attribution studies, the strength of evidence varies substantially between different kinds of slow onset and extreme weather events, and between regions. Policy-makers should not expect the later emergence of conclusive evidence about the influence of climate variability and change on specific incidences of losses and damages; and, in particular, should not expect the strength of evidence to be equal between events, and between countries. Rather than waiting for further confidence in attribution studies, there is potential to start working now to integrate science into policy and practice, to help understand and tackle drivers of losses and damages, informing prevention, recovery, rehabilitation, and transformation

Gamma-ray and radio properties of six pulsars detected by the fermi large area telescope

We report the detection of pulsed γ-rays for PSRs J0631+1036, J0659+1414, J0742-2822, J1420-6048, J1509-5850, and J1718-3825 using the Large Area Telescope on board the Fermi Gamma-ray Space Telescope (formerly known as GLAST). Although these six pulsars are diverse in terms of their spin parameters, they share an important feature: their γ-ray light curves are (at least given the current count statistics) single peaked. For two pulsars, there are hints for a double-peaked structure in the light curves. The shapes of the observed light curves of this group of pulsars are discussed in the light of models for which the emission originates from high up in the magnetosphere. The observed phases of the γ-ray light curves are, in general, consistent with those predicted by high-altitude models, although we speculate that the γ-ray emission of PSR J0659+1414, possibly featuring the softest spectrum of all Fermi pulsars coupled with a very low efficiency, arises from relatively low down in the magnetosphere. High-quality radio polarization data are available showing that all but one have a high degree of linear polarization. This allows us to place some constraints on the viewing geometry and aids the comparison of the γ-ray light curves with high-energy beam models

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised