Between Times and Spaces: Polyglotism and Polychronism in Yuri Lotman

Even if Lotman\u2019s theory has often been presented as a semiotic theory based on categories of space, temporal categories are crucial as well. And as we can speak of polyglotism as one of the main features of culture, we should speak of polychronism as well. In each state of culture, in fact, we find many temporal codes, and the internal dialogue is not only based on codes coming from different spaces (in the normal sense of polyglotism), but also as coming from different times (in the sense of a sort of polychronism). Lotman\u2019s reflections about this aspect of culture could be very useful in order to understand some aspects of our society, where we find a form of presentism, the temporal dimension corresponding to localism within the spatial dimension, which globalization has produced

Le tribunal d’Internet : réseaux sociaux, culture de l’annulation et discours de haine

The contribution aims to reflect on some specificities of the sanctioning methods on social networks, transformed in today’s post-truth regime into real courts of summary justice. In particular, four aspects will be taken into consideration: i) the lack of an institutional dimension; ii) the punctual and extemporaneous character on the temporal level; iii) the absence of a probative logic on the argumentative level; iv) the strongly phatic characterization. Particularly important will be the reflection on the actantial role of the sender and on the recourse to assumption of a communicative community of destination

Use of Selected Lactic Acid Bacteria and Quinoa Flour for Manufacturing Novel Yogurt-Like Beverages

This study aimed at investigating the suitability of quinoa for making yogurt-like beverages. After the selection of the adequate technological parameters, the fermentation was carried out by using different lactic acid bacteria strains: a probiotic (Lactobacillus rhamnosus SP1), an exopolysaccharides (EPS)-producing (Weissella confusa DSM 20194), and one isolated from quinoa (Lactobacillus plantarum T6B10). During the 20 h of fermentation, W. confusa caused the highest viscosity increase. All the strains had improved concentration of free amino acids and γ-Aminobutyric acid (GABA), polyphenols availability, antioxidant activity (up to 54%), and protein digestibility. The nutritional index (NI) was the highest when L. rhamnosus SP1 was used. The starch hydrolysis index in vitro ranged from 52 to 60. During storage at 4 °C, viscosity and water holding capacity decreased with the exception of the beverage fermented with W. confusa, while all the nutritional characteristics remained stable or slightly increased. Sensory analyses showed that beverages had good textural and organoleptic profiles. Besides the well-known positive properties of the raw matrix, fermentation allowed the obtainment of beverages with different features. Due to the nutritional and functional characteristics conferred to the quinoa beverages, the use of the probiotic and EPS-producing strains showed adequate potential for the industrial application

Italie

Centres et groupes de recherche Centro internazionale di studi umanistici Umberto Eco (CUE – Unibo) Dirigé par Patrizia Violi, le but principal du centre est de promouvoir la recherche, l’étude, la documentation, la diffusion et les études approfondies, au niveau national et international, sur des questions liées au travail et aux intérêts d’Umberto Eco. En outre, le Centre organise chaque année des dizaines d’initiatives sémiotiques et accueille des cycles de conférences, des journées d’étud..

Nassirya: una serie italiana entre ficción y realidad histórica

Las autoras realizan un análisis de Nassirya, miniserie televisiva que ficcionaliza y conmemora un evento trágico de la historia: la muerte de un contingente de soldados italianos en la guerra de Irak. La memoria del hecho se convierte en recreación y celebración de la identidad italiana, la italianidad, a través de un relato del heroísmo de unos hombres cualesquiera. La ficción transforma a los italianos en fuerzas de paz y opone su sensible humanidad a la corrupción e inhumanidad de los norteamericanos, antagonistas que toman el lugar de un enemigo iraquí, imposible en un relato de paz. El espectador es puesto ante el momento en que la historia se escribe. Y en la construcción de la memoria, realidad y ficción se superponen e intercambian sus lugares

A phase I dose-escalation study of TAK-733, an investigational oral MEK inhibitor, in patients with advanced solid tumors.

Purpose TAK-733, an investigational, selective, allosteric MEK1/2 inhibitor, has demonstrated antitumor effects against multiple cancer cell lines and xenograft models. This first-in-human study investigated TAK-733 in patients with solid tumors. Methods Patients received oral TAK-733 once daily on days 1-21 in 28-day treatment cycles. Adverse events (AEs) were graded using the Common Terminology Criteria for AEs version 3.0. Response was assessed using RECIST v1.1. Blood samples for TAK-733 pharmacokinetics and pharmacodynamics (inhibition of ERK phosphorylation) were collected during cycle 1. Results Fifty-one patients received TAK-733 0.2-22 mg. Primary diagnoses included uveal melanoma (24 %), colon cancer (22 %), and cutaneous melanoma (10 %). Four patients had dose-limiting toxicities of dermatitis acneiform, plus fatigue and pustular rash in one patient, and stomatitis in one patient. The maximum tolerated dose was 16 mg. Common drug-related AEs included dermatitis acneiform (51 %), diarrhea (29 %), and increased blood creatine phosphokinase (20 %); grade ≥ 3 AEs were reported in 27 (53 %) patients. Median Tmax was 3 h; systemic exposure increased less than dose-proportionally over the dose range 0.2-22 mg. On day 21 maximum inhibition of ERK phosphorylation in peripheral blood mononuclear cells of 46-97 % was seen in patients receiving TAK-733 ≥ 8.4 mg. Among 41 response-evaluable patients, 2 (5 %) patients with cutaneous melanoma (one with BRAF L597R mutant melanoma) had partial responses. Conclusions TAK-733 had a generally manageable toxicity profile up to the maximum tolerated dose, and showed the anticipated pharmacodynamic effect of sustained inhibition of ERK phosphorylation. Limited antitumor activity was demonstrated. Further investigation is not currently planned

Learning and Using Abstract Words: Evidence from Clinical Populations

Lorusso ML, Burigo M, Tavano A, et al. Learning and Using Abstract Words: Evidence from Clinical Populations. BioMed Research International. 2017;2017:1-8