106 research outputs found
Head Start Comprehensive Services: A Key Support for Early Learning for Poor Children
This policy brief, the fourth in the Head Start Series, describes the comprehensive services Head Start children receive. It presents data from Head Start Program Information Reports (PIR) from the most recent program year, 20012002, and compares them, when possible, to national data on the services low-income children and families receive
Industrial Symbiosis in Action
Report on the Third International Industrial Symbiosis Research Symposium Birmingham, England, August 5-6, 200
Estimating photometric redshifts with artificial neural networks
A new approach to estimating photometric redshifts - using Artificial Neural
Networks (ANNs) - is investigated. Unlike the standard template-fitting
photometric redshift technique, a large spectroscopically-identified training
set is required but, where one is available, ANNs produce photometric redshift
accuracies at least as good as and often better than the template-fitting
method. The Bayesian priors on the underlying redshift distribution are
automatically taken into account. Furthermore, inputs other than galaxy colours
- such as morphology, angular size and surface brightness - may be easily
incorporated, and their utility assessed.
Different ANN architectures are tested on a semi-analytic model galaxy
catalogue and the results are compared with the template-fitting method.
Finally the method is tested on a sample of ~ 20000 galaxies from the Sloan
Digital Sky Survey. The r.m.s. redshift error in the range z < 0.35 is ~ 0.021.Comment: Submitted to MNRAS, 9 pages, 9 figures, substantial improvements to
paper structur
Volume 07
Introduction from Interim Dean Dr. Jennifer Apperson
Spatial Analysis of Potential Risk Factors Associated with Addition of Atlantic Coast Pipeline Through Virginia by Rachel C. Lombardi
Delicate Matters with No Speaking, Hope and Nothing, Mono Duality by Ben Osterhout
Connect Graphic Design Senior Project by Lindsay Graybill
Phenolic Acids in Brassicaceae Plants: Ovipositional Stimulants or Deterrents for Cabbage White Butterfly, Pieris Rapae? by Rebecca E. Dey And Skyler T. Carpenter
Abecedarian Cards by Emma Beckett, Jason Ware, And Mollie Andrews
Helvetica: A Type Specimen Book by James Bates, Landon Cooper, Tiffani Jeffries, And Maria Wheaton
âThings Left Behindâ by Dallas Price
Heretic Adornment by Laura Kahler
Photography by Sarah Charlton
Revisiting Longfellow: Expressing Universality through Accessibility by Anna Bultrowicz
Magazine Spreads from âWhat Dreams May Come: Marriage Across Culturesâ by Emily Spittle
Magazine Spreads From âLive on The Street: A Naked Look at Human Sex Traffickingâ by Erin Godwin
Lasting Light by Eamon Brokenbroug
Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages
The salt-inducible kinases (SIKs) control a novel molecular switch regulating macrophage polarization. Pharmacological inhibition of the SIKs induces a macrophage phenotype characterized by the secretion of high levels of anti-inflammatory cytokines, including interleukin (IL)-10, and the secretion of very low levels of pro-inflammatory cytokines, such as tumour necrosis factor α. The SIKs, therefore, represent attractive new drug targets for the treatment of macrophage-driven diseases, but which of the three isoforms, SIK1, SIK2 or SIK3, would be appropriate to target remains unknown. To address this question, we developed knock-in (KI) mice for SIK1, SIK2 and SIK3, in which we introduced a mutation that renders the enzymes catalytically inactive. Characterization of primary macrophages from the single and double KI mice established that all three SIK isoforms, and in particular SIK2 and SIK3, contribute to macrophage polarization. Moreover, we discovered that inhibition of SIK2 and SIK3 during macrophage differentiation greatly enhanced the production of IL-10 compared with their inhibition in mature macrophages. Interestingly, macrophages differentiated in the presence of SIK inhibitors, MRT199665 and HG-9-91-01, still produced very large amounts of IL-10, but very low levels of pro-inflammatory cytokines, even after the SIKs had been reactivated by removal of the drugs. Our data highlight an integral role for SIK2 and SIK3 in innate immunity by preventing the differentiation of macrophages into a potent and stable anti-inflammatory phenotype
Conceptualising sustainability in UK urban Regeneration: a discursive Formation
Despite the wide usage and popular appeal of the concept of sustainability in UK policy, it does not appear to have challenged the status quo in urban regeneration because policy is not leading in its conceptualisation and therefore implementation. This paper investigates how sustainability has been conceptualised in a case-based research study of the regeneration of Eastside in Birmingham, UK, through policy and other documents, and finds that conceptualisations of sustainability are fundamentally limited. The conceptualisation of sustainability operating within urban regeneration schemes should powerfully shape how they make manifest (or do not) the principles of sustainable development. Documents guide, but people implement regenerationâand the disparate conceptualisations of stakeholders demonstrate even less coherence than policy. The actions towards achieving sustainability have become a policy âfixâ in Eastside: a necessary feature of urban policy discourse that is limited to solutions within market-based constraints
LSST: from Science Drivers to Reference Design and Anticipated Data Products
(Abridged) We describe here the most ambitious survey currently planned in
the optical, the Large Synoptic Survey Telescope (LSST). A vast array of
science will be enabled by a single wide-deep-fast sky survey, and LSST will
have unique survey capability in the faint time domain. The LSST design is
driven by four main science themes: probing dark energy and dark matter, taking
an inventory of the Solar System, exploring the transient optical sky, and
mapping the Milky Way. LSST will be a wide-field ground-based system sited at
Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m
effective) primary mirror, a 9.6 deg field of view, and a 3.2 Gigapixel
camera. The standard observing sequence will consist of pairs of 15-second
exposures in a given field, with two such visits in each pointing in a given
night. With these repeats, the LSST system is capable of imaging about 10,000
square degrees of sky in a single filter in three nights. The typical 5
point-source depth in a single visit in will be (AB). The
project is in the construction phase and will begin regular survey operations
by 2022. The survey area will be contained within 30,000 deg with
, and will be imaged multiple times in six bands, ,
covering the wavelength range 320--1050 nm. About 90\% of the observing time
will be devoted to a deep-wide-fast survey mode which will uniformly observe a
18,000 deg region about 800 times (summed over all six bands) during the
anticipated 10 years of operations, and yield a coadded map to . The
remaining 10\% of the observing time will be allocated to projects such as a
Very Deep and Fast time domain survey. The goal is to make LSST data products,
including a relational database of about 32 trillion observations of 40 billion
objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures
available from https://www.lsst.org/overvie
Appraising infrastructure for new towns in Ireland
Copyright © 2013 ICE Publishing Ltd. Permission is granted by ICE Publishing to print one copy for personal use. Any other use of these PDF files is subject to reprint fees.Over a 20 year period 1996â2016, a new 223 ha town is being developed 10 miles west of Dublin's city centre on the south side of Lucan, County Dublin, in the Republic of Ireland (ROI). This âŹ4 billion âAdamstownâ development is the first of four planning schemes in ROI to be approved as a strategic development zone â an integrated planning framework deemed suitable for creating sustainable neighbourhoods in sites of strategic economic or social importance to the state. The creation of sustainable neighbourhoods in ROI is facilitated through the implementation of a checklist of 60 indicators. This paper critically examines the attempts being made to consider sustainability within the development's overall infrastructure plan, specifically: transport, energy and water services, information technology and waste. Inadequacies in the existing development are linked to shortfalls in the sustainability checklist, by way of a comparison of infrastructure-related indicators from the ROI checklist with those derived for the UK and exemplar European projects (i.e. Bedzed, UK and Freiberg, Germany). The subsequent legacy for future residents of Adamstown is then considered in the context of âwhat ifâ scenarios
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