Experiential Learning Through the Transformational Incubation Programme: A Case Study from Accra, Ghana

This topical new book provides an illuminating overview of enterprise education, and poses the question as to whether current establishments have adequate systems in place to prepare students for the world of work

Isolation and characterization of the full-length cDNA encoding a member of a novel cytochrome p450 family (CYP320A1) from the tropical freshwater snail, Biomphalaria glabrata, intermediate host for Schistosoma mansoni

Cytochrome p450s (cyp450s) are a family of structurally related proteins, with diverse functions, including steroid synthesis and breakdown of toxins. This paper reports the full-length sequence of a novel cyp450 gene, the first to be isolated from the tropical freshwater snail Biomphalaria glabrata, an important intermediate host of Schistosoma mansoni. The nucleotide sequence is 2291 bp with a predicted amino acid sequence of 584aa. The sequence demonstrates conserved cyp450 structural motifs, but is sufficiently different from previously reported cyp450 sequences to be given a new classification, CYP320A1. Initially identified as down-regulated in partially resistant snails in response to S. mansoni infection, amplification of this gene using RT-PCR in both totally resistant or susceptible snail lines when exposed to infection, and all tissues examined, suggests ubiquitous expression. Characterization of the first cyp450 from B. glabrata is significant in understanding the evolution of these metabolically important proteins

Stretched exponential relaxation in the mode-coupling theory for the Kardar-Parisi-Zhang equation

We study the mode-coupling theory for the Kardar-Parisi-Zhang equation in the strong-coupling regime, focusing on the long time properties. By a saddle point analysis of the mode-coupling equations, we derive exact results for the correlation function in the long time limit - a limit which is hard to study using simulations. The correlation function at wavevector k in dimension d is found to behave asymptotically at time t as C(k,t)\simeq 1/k^{d+4-2z} (Btk^z)^{\gamma/z} e^{-(Btk^z)^{1/z}}, with \gamma=(d-1)/2, A a determined constant and B a scale factor.Comment: RevTex, 4 pages, 1 figur

Transmission through optically generated inductive grid arrays

A technique is developed for generating pseudometallic plasma inductive grid arrays within a semiconductor wafer. The induced plasma elements are defined by a surface impedance which is discussed. Results of an investigation into the transmission properties of a variety of array designs between 16 and 40 GHz are presented. Measurements are performed on a silicon wafer illuminated by an external optical source via a negative image mas

A comparison of systems for measuring methane emissions from sheep

Two experiments were conducted, at ADAS Drayton in the autumn and winter 1996/1997, to compare methane (CH4) emissions from sheep housed either in a polytunnel system or in open-circuit respiration chambers. In each system, the sheep received maintenance levels of either cut grass or high temperature dried grass pellets (HTDG). All experiments in the tunnel were conducted on concrete to avoid any interactions of the CH4 with the soil/plant environment. The results suggested that CH4 production from the open-circuit chambers was greater than from the tunnel system (26·9±0·46 v. 31·7±0·35 l/kg dry matter intake (±S.E.) for open circuit respiration chambers and tunnel, respectively). Recovery tests gave similar results for both systems (95·5–97·9% for tunnels and 89·2–96·7% for chambers), and confirmed that both methods give good quantitative recovery of added CH4, and can therefore be assumed to provide reliable estimates of emissions from animals. There is no technical explanation, therefore, for the different estimates of emissions provided by the two systems. Further studies are required to understand the reasons for the differences and in particular, the possible links between animal behaviour induced by the two systems and CH4 emission rates

Close coupled resonant aperture inserts for waveguide filtering applications

A two-layer frequency selective surface (FSS) is used as a very compact and lightweight transverse waveguide filter element. A narrow-band transmission response is produced from two layers, which, otherwise, in isolation would exhibit a broadband response. Measured results are compared with theoretical data obtained from a Transmission Line Matrix (TLM) based modeling method. Reduction in the passband bandwidth of a factor of four has been achieved using the proposed structure

The Nuclear Receptors of Biomphalaria glabrata and Lottia gigantea : Implications for Developing New Model Organisms

Funding: This work was funded by the National Centre for the Replacement, Refinement and Reduction of Animals in Research, Grant Ref:G0900802 to CSJ, LRN, SJ & EJR [www.nc3rs.org.uk]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

The Birmingham Boron Neutron Capture Therapy (BNCT) project : developments towards selective internal particle therapy

This paper will review progress on two aspects of the Birmingham BNCT project. Firstly on evaluation of the effects of high and low LET radiations when delivered simultaneously, and secondly on attempts to optimise delivery of the boron carrier compound BPA through pharmacokinetic studies. Simultaneous or non-simultaneous irradiations of V79 cells with alpha-particle and X-ray irradiations were performed. Alpha doses of 2 and 2.5 Gy were chosen and the impact on survival when delivered separately or simultaneously with variable doses of X-rays was evaluated. The pharmacokinetics of the delivery of a new formulation of BPA (BPA-mannitol) are being investigated in brain tumour patients through a study with 2 × 2 design featuring intravenous and intracarotid artery infusion of BPA, with or without a mannitol bolus. On the combined effect of low and high LET radiations, a synergistic effect was observed when alpha and X-ray doses are delivered simultaneously. The effect is only present at the 2.5 Gy alpha dose and is a very substantial effect on both the shape of the survival curve and the level of cell killing. This indicates that the alpha component may have the effect of inhibiting the repair of damage from the low LET radiation dose delivered simultaneously. On the pharmacokinetics of BPA, data on the first three cohorts indicate that bioavailability of BPA in brain ECF is increased substantially through the addition of a mannitol bolus, as well as by the use of intracarotid artery route of infusion. In both cases, for some patients the levels after infusion approach those seen in blood, whereas the ECF levels for intravenous infusion without mannitol are typically less than 10% of the blood values

A 64-pixel Positron-Sensitive Surgical Probe

We report on the continued development of a 64-pixel positron-sensitive surgical probe with a dual-layer detector and multi-anode PMT. An 8 x 8 array of this plastic scintillators in teh first layer detects positrons and a matched GSO crystal array in the second layer detects annihilation 511 keV gammas, which are required to be in coincidence with the detected positrons. Also, the 64 PMT anode signals are differentiated and an overshoot threshold is applied to separate the fast decay plastic anode signals from the slower GSO signals. Finally, an energy threshold is applied to the summed anode signal to distinguish 511 keV gammas from the 140 keV gammas commonly used in sentinel lymph node (SLN) surgery. Previously we reported on how these signal selection criteria were individually tested and optimized based on 9 channels of prototype electronics [1-2]. Currently the electronics shave been upgraded to Xilinx® programmable components, allowing on-the-fly alteration of signal selection criteria, and all 64 channels are operational. Initial measurements of the complete 64-pixel probe were conducted using 18F-FDG positron sources and 18F-FDG and 99mTcphantoms (background 511 keV and 140 keV gammas), simulating lesions in the SLN surgery environment. The average positron sensitivity is measured to be 3.0-7.0 kcps/µCi at different signal selection criteria. The lower bound on sensitivity corresponds to settings optimized for high image resolution and high background rejection ability. The upper bound on sensitivity corresponds to settings optimized for high sensitivity at the cost of lower image resolution and lower background rejection ability. The measured true-to-background contrast in the presence of clinically observed levels of 511 keV and 140 keV background gammas is ~3:1 for a tumor-to-background uptake ratio of 5:1. Performance measurements of the complete 64-pixel probe including sensitivity, true-to-background ratio, and the pixel separation ability are presented

An evaluation of the capability of data conversion of impression creep test

High temperature power plant components are now working far beyond their operative designed life. Establishing their in-service material properties has become a matter of significant concern for power generation companies. Advantages for the assessment of creep material properties may come from miniature specimen creep testing techniques, like impression creep testing method, which can be treated as a quasistatic non-destructive technique and requires a small volume of material that can be scooped from in-service critical components, and can produce reliable secondary creep data. This paper presents an overview of impression creep testing method to highlight the capability in determining the minimum creep strain rate data by use of conversion relationships that relates uniaxial creep test data and impression creep test data. Stepped-load and stepped-temperature impression creep tests are also briefly described. Furthermore, the paper presents some new impression creep test data and their correlation with uniaxial data, obtained from P91, P92 and ½CrMoV steels at different stresses and temperatures. The presented data, in terms of creep strain rate against the reference uniaxial stress, are useful for calibration of impression creep testing technique and provide further comparative results for the evaluation of the reliability of the method in determining secondary creep properties