Los Juegos Olímpicos aplicados a conocimientos de las Ciencias Sociales en Educación Infantil

Los Juegos Olímpicos modernos no son solo un tema de interés deportivo, cultural o social, cuentan además con un espíritu y una filosofía de vida que les da un valor educativo y pedagógico interesante para una educación global. Por la atención que despiertan se destacan como herramienta de motivación, también en infantil. En este Trabajo Fin de Grado he querido explorar el estudio de las Ciencias Sociales, es decir, trabajar distintas áreas como el espacio, el tiempo, la historia, la cultura,…, en las edades más tempranas que son las que abarca la educación infantil a través de un proyecto basado en los Juegos Olímpicos, teniendo en cuenta lo contenido en este currículo. Con este propósito, he realizado un trabajo en el que se puede ver la importancia de las Ciencias Sociales en la Educación Infantil y cómo trabajarlo de la mejor forma posible.The modern Olympic Games are not only a topic of sports, cultural or social interest, they also have a spirit and a philosophy of life that gives them an interesting educational and pedagogical value for a global education. Because of the attention they awaken they stand out as a motivation tool, also in children. In this Final Degree Project I wanted to explore the study of Social Sciences, that is, work different areas such as space, time, history, culture,..., in the earliest ages that are included in early childhood education through a project based on the Olympic Games, taking into account what is contained in the Early Childhood Education curriculum.Grado en Educación Infanti

Implementación de una aplicación para almacenamiento y visualización de imágenes utilizando tecnologías cloud computing

Los sistemas de información son elementos básicos para la gestión de empresas y organizaciones. Cuando el número de estos sistemas y su complejidad son elevados los costes pueden incrementarse de forma drástica. En los últimos años, algunas organizaciones han optado por soluciones basadas en las tecnologías cloud computing con las que han mejorado la calidad del servicio y han ahorrado costes. El objetivo de este proyecto es diseñar e implementar una aplicación web sencilla para gestionar fotografías similar a Flickr empleado dichas tecnologías. Para ello se utilizarán diversos servicios en la nube como la plataforma Heroku donde se ejecutará la aplicación y los servicios auxiliares Amazon S3, MongoHQ y Google Image Charts que facilitan alojamiento masivo de archivos, almacenamiento de datos estructurados y generación de gráficos respectivamente. Finalmente, se realizan una serie de pruebas bajo diferentes condiciones para evaluar su rendimiento utilizando las herramientas Siege y New Relic. ___________________________________________________________________________________________________________Information systems are basic elements for business and corporation management. As the number and complexity of these systems increase, the cost of managing them might get too high to be a ffordable. During the last years, some corporations have adopted solutions based on cloud computing technologies which provide better quality service and cost savings. The main purpose of this project is to design and implement a simple web application similar to Flickr that allows a user to manage and view photographies taking advantage of such technologies. In order to do it, several cloud services are used such as Heroku platform on which the application will be deployed and executed and complementary services such as Amazon S3, MongoHQ and Google Image Charts which provide file storage, structured data storage and graphics generation respectively. Finally, application will be benchmarked under di fferent scenarios to check its performance by means of the tools Siege and New Relic.Ingeniería en Informátic

On the effect of thin film growth mechanisms on the specular reflectance of aluminum thin films deposited via filtered cathodic vacuum arc

The optimisation of the specular reflectance of solar collectors is a key parameter to increase the global yield of concentrated solar power (CSP) plants. In this work, the influence of filtered cathodic vacuum arc deposition parameters, particularly working pressure and deposition time, on the specular and diffuse reflectance of aluminium thin films, was studied. Changes in specular reflectance, measured by ultraviolet–visible and near-infrared spectroscopy (UV-vis-NIR) spectro photometry, were directly correlated with thin film elemental concentration depth profiles, obtained by Rutherford backscattering spectrometry (RBS), and surface and cross-sectional morphologies as measured by scanning electron microscopy (SEM) and profilometry. Finally, atomic force microscopy (AFM) provided information on the roughness and growth mechanism of the films. The two contributions to the total reflectance of the films, namely diffuse and specular reflectance, were found to be deeply influenced by deposition conditions. It was proven that working pressure and deposition time directly determine the predominant factor. Specular reflectance varied from 12 to 99.8% of the total reflectance for films grown at the same working pressure of 0.1 Pa and with different deposition times. This transformation could not be attributed to an oxidation of the films as stated by RBS, but was correlated with a progressive modification of the roughness, surface, and bulk morphology of the samples over the deposition time. Hence, the evolution in the final optical properties of the films is driven by different growth mechanisms and the resulting microstructures. In addition to the originally addressed CSP applications the potential of the developed aluminium films for other application rather than CSP, such as, for example, reference material for spectroscopic diffuse reflectance measurements, is also discussed

Low-density lipoprotein receptor-related protein 1 (LRP1) as a modulator of the vascular inflammatory response to modified LDL

Low density lipoprotein receptor-related protein 1 (LRP1) is a ubiquitously expressed cell surface receptor that mediates the internalization of more than 40 different ligands and participates in cell signaling. LRP1 plays a key pathophysiological role in the onset, development and thrombotic resolution of the atherosclerotic process due to its role in the intracellular lipid accumulation of vascular smooth muscle cells (VSMCs). During last years, LRP1 has also been proposed as a modulator of the inflammatory phenomenon in atherosclerosis. However, the investigations have obviated the function of LRP1 as a binding receptor of modified-lipids. In addition, the studies that analysed the relation between inflammation and LRP1 are focused on immunological cells from mice models. Whether LRP1 can respond to its modified-LDL ligands developing an inflammatory response in human VSMCs is unknown. Further investigations are, thus, necessary

Shimura correspondence for level p^2 and the central values of L-series

Given a weight 2 and level p^2 modular form f, we construct two weight 3/2 modular forms (possibly zero) of level 4p^2 and non trivial character mapping to f via the Shimura correspondence. Then we relate the coefficients of the constructed forms to the central value of the L-series of certain imaginary quadratic twists of f. Furthermore, we give a general framework for our construction that applies to any order in definite quaternion algebras, with which one can, in principle, construct weight 3/2 modular forms of any level, provided one knows how to compute ideal classes representatives.Comment: 17 page

Departamento Rosario Vera Peñaloza: un camino de organización y articulación popular

EEA La RiojaFil: Llorente, Gonzalo. Cáritas; ArgentinaFil: Moyano, María Ester. Asociación Kölping Argentina; ArgentinaFil: Mena, Ramiro. Asociación de Emprendedores Chepes La Rioja (A.E.Che.La.R.); ArgentinaFil: Mendez, Carla Rebeca. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Rioja. Agencia de Extensión Rural Chepes; Argentin

Sensitivity of fire weather index to different reanalysis products in the Iberian Peninsula

Wildfires are a major concern on the Iberian Peninsula, and the establishment of effective prevention and early warning systems are crucial to reduce impacts and losses. Fire weather indices are daily indicators of fire danger based upon meteorological information. However, their application in many studies is conditioned to the availability of sufficiently large climatological time series over extensive geographical areas and of sufficient quality. Furthermore, wind and relative humidity, important for the calculation of fire spread and fuel flammability parameters, are relatively scarce data. For these reasons, different reanalysis products are often used for the calculation of surrogate fire danger indices, although the agreement with those derived from observations remains as an open question to be addressed. In this study, we analyze this problem focusing on the Canadian Fire Weather Index (FWI) ? and the associated Seasonal Severity Rating (SSR) ? and considering three different reanalysis products of varying resolutions on the Iberian Peninsula: NCEP, ERA-40 and ERA-Interim. Besides the inter-comparison of the resulting FWI/SSR values, we also study their correspondence with observational data from 7 weather stations in Spain and their sensitivity to the input parameters (precipitation, temperature, relative humidity and wind velocity). As a general result, ERA-Interim reproduces the observed FWI magnitudes with better accuracy than NCEP, with lower/higher correlations in the coast/inland locations. For instance, ERA-Interim summer correlations are above 0.5 in inland locations ? where higher FWI magnitudes are attained ? whereas the corresponding values for NCEP are below this threshold. Nevertheless, departures from the observed distributions are generally found in all reanalysis, with a general tendency to underestimation, more pronounced in the case of NCEP. In spite of these limitations, ERA-Interim may still be useful for the identification of extreme fire danger events. (e.g. those above the 90th percentile value) and for the definition of danger levels/classes (with level thresholds adapted to the observed/reanalysis distributions).We are grateful to the Spanish Meteorological Agency (AEMET) for providing the observational data used in this study and to Jes´us Fern´andez for useful comments that helped to improve the original manuscript. The research leading to these results has received funding from the European Union’s Seventh Framework Programme (FP7/2007–2013) under grant agreement 243888 (FUME Project) and 265192 (CLIMRUN Project), and from the CICYT project CGL2010-21869

Circulating non-coding RNAs in biomarker-guided cardiovascular therapy : A novel tool for personalized medicine?

Current clinical guidelines emphasize the unmet need for technological innovations to guide physician decision-making and to transit from conventional care to personalized cardiovascular medicine. Biomarker-guided cardiovascular therapy represents an interesting approach to inform tailored treatment selection and monitor ongoing efficacy. However, results from previous publications cast some doubts about the clinical applicability of biomarkers to direct individualized treatment. In recent years, the non-coding human transcriptome has emerged as a new opportunity for the development of novel therapeutic strategies and biomarker discovery. Non-coding RNA (ncRNA) signatures may provide an accurate molecular fingerprint of patient phenotypes and capture levels of information that could complement traditional markers and established clinical variables. Importantly, ncRNAs have been identified in body fluids and their concentrations change with physiology and pathology, thus representing promising non-invasive biomarkers. Previous publications highlight the translational applicability of circulating ncRNAs for diagnosis and prognostic stratification within cardiology. Numerous independent studies have also evaluated the potential of the circulating non-coding transcriptome to predict and monitor response to cardiovascular treatment. However, this field has not been reviewed in detail. Here, we discuss the state-of-the-art research into circulating ncRNAs, specifically microRNAs and long non-coding RNAs, to support clinical decision-making in cardiovascular therapy. Furthermore, we summarize current methodological and conceptual limitations and propose future steps for their incorporation into personalized cardiology. Despite the lack of robust population-based studies and technical barriers, circulating ncRNAs emerge as a promising tool for biomarker-guided therapy

LRP1-Mediated AggLDL Endocytosis Promotes Cholesteryl Ester Accumulation and Impairs Insulin Response in HL-1 Cells

The cardiovascular disease (CVD) frequently developed during metabolic syndrome and type-2 diabetes mellitus is associated with increased levels of aggregation-prone small LDL particles. Aggregated LDL (aggLDL) internalization is mediated by low-density lipoprotein receptor-related protein-1 (LRP1) promoting intracellular cholesteryl ester (CE) accumulation. Additionally, LRP1 plays a key function in the regulation of insulin receptor (IR) and glucose transporter type 4 (GLUT4) activities. Nevertheless, the link between LRP1, CE accumulation, and insulin response has not been previously studied in cardiomyocytes. We aimed to identify mechanisms through which aggLDL, by its interaction with LRP1, produce CE accumulation and affects the insulin-induced intracellular signaling and GLUT4 trafficking in HL-1 cells. We demonstrated that LRP1 mediates the endocytosis of aggLDL and promotes CE accumulation in these cells. Moreover, aggLDL reduced the molecular association between IR and LRP1 and impaired insulin-induced intracellular signaling activation. Finally, aggLDL affected GLUT4 translocation to the plasma membrane and the 2-NBDG uptake in insulin-stimulated cells. We conclude that LRP1 is a key regulator of the insulin response, which can be altered by CE accumulation through LRP1-mediated aggLDL endocytosis