Multi-omic analyses in Abyssinian cats with primary renal amyloid deposits

The amyloidoses constitute a group of diseases occurring in humans and animals that are characterized by abnormal deposits of aggregated proteins in organs, affecting their structure and function. In the Abyssinian cat breed, a familial form of renal amyloidosis has been described. In this study, multi-omics analyses were applied and integrated to explore some aspects of the unknown pathogenetic processes in cats. Whole-genome sequences of two affected Abyssinians and 195 controls of other breeds (part of the 99 Lives initiative) were screened to prioritize potential disease-associated variants. Proteome and miRNAome from formalin-fixed paraffin-embedded kidney specimens of fully necropsied Abyssinian cats, three affected and three non-amyloidosis-affected were characterized. While the trigger of the disorder remains unclear, overall, (i) 35,960 genomic variants were detected; (ii) 215 and 56 proteins were identified as exclusive or overexpressed in the affected and control kidneys, respectively; (iii) 60 miRNAs were differentially expressed, 20 of which are newly described. With omics data integration, the general conclusions are: (i) the familial amyloid renal form in Abyssinians is not a simple monogenic trait; (ii) amyloid deposition is not triggered by mutated amyloidogenic proteins but is a mix of proteins codified by wild-type genes; (iii) the form is biochemically classifiable as AA amyloidosis.Peer reviewe

Convening on the Future of Black Thriving & Joy

This co-creation event aims to be an asset-based intergenerational, inter-ideological, and intercultural opportunity for listening, shared learning, and recognition of points of synergy and opportunity across the rich complexity of the black community in our area -- resulting in a shared agenda and momentum for action. This affinity/identity based/closed event focuses on the black community and is part of a series of conversations with the different BIPOC communities as stated in the Time to Act plan created as a result of the October 2020 Time to Act summit. As a result of these conversations, Portland State University is seeking to discover the priorities and opportunities of our BIPOC communities and where those opportunities intersect with the assets and mission of the university and its partners. In the fall, an open macro BIPOC event presented the unique themes from each conversation, as well as the themes across communities. Allies and agents of change are invited to this macro fall event to partner with our communities, Portland State University, Meyer Memorial Trust\u27s Justice Oregon for Black Lives, our steering committee members and other critical stakeholders to advance efforts that will ensure the thriving of our communities. Steering Committee and Advisors: D\u27Artagnan Caliman, Supporting Partner, Executive Committee Michael Alexander, Executive Committee Sharon Gary Smith, NAACP Joe McFerrin, POIC Marcus Mundy, Coalition of Communities of Color Kali Thorne Ladd, The Children\u27s Institute Cobi Lewis, Meso Ed Washington, Portland State University Lisa Bates, Portland State University Facilitators: Tracy Smith, lnhance, LLC Ernest Stephens, Morant McLeod Contributing Advisor: Pastor Leroy Haynes Student Participation Sponsor: Oregon Community Foundation Black Student Success Related Materials: Five affinity-based convenings: Latiné Futures Convening Convening on the Future of Black Thriving & Joy Convening for a Thriving Future for Pacific Islander, Native Hawaiian, Asian, and Asian American Communities (PIAA) Convening for a Prosperous Future for Middle East, North African and South Asian Community (MENASA) Native Leaders Roundtable Time to Act Events:The Future and Thriving of BIPOC Communities: A Time to Act Macroconvening(Affinity groups met in-person November 2022)Time 2 Act: Continuing Action for a Just and Equitable PSU(Video - Winter Symposium 2021) Time to Act: Envisioning and Creating a Just and Equitable PSU(Video - Virtual Equity Summit, October 30, 2020) Equity Plan: Time to Act: Plan for Equity & Racial Justice 2021 - 2024 (PDF - Report, 2021

The Profile of Young Offenders in the City of Maputo, Mozambique

The present study describes the profile of 172 young people who were attending their prison sentences in three Maputo prisons. We examined their Certificates of Judgment and Execution of Sentence based on descriptive statistics and statistical tests. Most participants were male. Young people, especially men, committed a large number of crimes against property. There was higher prevalence of women committing crimes against people’s physical integrity and health. The number of young people charged increased as they progressed in age. The major part of the sample received correctional penalties, were convicted for the first time, had no occupation or worked in the informal sector, and came from the suburban neighborhoods of Maputo City. Our results show the need for focusing on the prevention of criminal acts in young people and in the monitoring of this population during and after incarceration

Persistent short-term imprisonment: belonging as a lens to understand its shifting meanings over the life course

This article takes a life-course perspective to the meaning of persistent short-term imprisonment and introduces the significance of ‘penal careers’. Examining a total of 62 interviews with men and women in Scotland with long careers of (progression through) criminal punishment, it uses to the concept of belonging as a lens to interpret their experiences. While some participants already felt early on in their career that they belonged in prison because of their shared characteristics with other prisoners, the repetition of imprisonment meant that they increasingly felt displaced from life outside and saw life in prison as ‘easier’ and ‘safer’. Nevertheless, looking back on their many sentences, they felt their cumulative meaning was ‘a waste of life’. The article concludes by considering steps towards tackling the conditions that create this sense of belonging in a place of punishment

What next for Shared Lives? Family-based support as a potential option for older people

With an ageing population and limited resources the challenge for policy makers and practitioners is how best to provide for the care and support needs of older people. This article draws on findings from two studies, a scoping study of the personalisation of care services and another which aimed to generate evidence about the potential use of family-based support schemes (Shared Lives, SL) for certain groups of older people. Forty-three schemes participated in a survey to gather information about services provided and the extent to which this included older people and their carers, and six staffs were interviewed across two schemes about issues for expanding provision for older people in their local areas. It was evident that SL schemes were already supporting a number of older people and there was support for expansion from both schemes and local authorities. Adequate resources, awareness raising, management commitment, and a pool of suitable carers would be needed to support any expansion effort. There is also still a need for SL to be more widely known and understood by care managers if it is to be considered part of mainstream provision for older people

Educación y aprendizaje: resultados iniciales de la quinta ronda de encuestas (2016) de Niños del Milenio - Perú

A los 15 años, el 37% de los integrantes de la cohorte menor tenían edad avanzada para el año normativo —es decir, extraedad—, en comparación con el 49% de los participantes en la cohorte mayor cuando tenían la misma edad. Así, se observa que los jóvenes de la cohorte menor están avanzando mejor en su educación que los de la cohorte mayor. Sin embargo, entre ambas cortes existen grandes diferencias asociadas con la pobreza, el origen étnico, el área de residencia y la educación materna. A pesar de las mejoras en el rendimiento, la mayoría de jóvenes de 15 años de la cohorte menor no pueden resolver problemas matemáticos simples. El rendimiento en las pruebas de los jóvenes que han vivido siempre en áreas urbanas se encuentra entre 13 y 9 puntos porcentuales por encima del rendimiento de sus pares que siempre han vivido en áreas rurales. El rendimiento de los jóvenes que han migrado de las áreas rurales a las urbanas se encuentra en el medio. Para la cohorte más joven, se puede observar una gran brecha —de casi 25 puntos porcentuales— en el vocabulario entre grupos de niños de 5 años. A los 15 años, esta brecha disminuye ligeramente, a 16 puntos porcentuales

Between crime and colony: Interrogating (im)mobilities aboard the convict ship

Recent literature in carceral geography has attended to the importance of mobilities in interrogating the experience and control of spaces of imprisonment, detention and confinement. Scholars have explored the paradoxical nature of incarcerated experience as individuals oscillate between moments of fixity and motion as they are transported to/from carceral environments. This paper draws upon the convict ship – an example yet to gain attention within these emerging discussions – which is both an exemplar of this paradox and a lens through which to complicate understandings of carceral (im)mobilities. The ship is a space of macro-movement from point A to B, whilst simultaneously a site of apparent confinement for those aboard who are unable to move beyond its physical parameters. Yet, we contend that all manner of mobilities permeate the internal space of the ship. Accordingly, we challenge the binary thinking that separates moments of fixity from motion and explore the constituent parts that shape movement. In paying attention to movements in motion on the ship, we argue that studies of carceral mobility must attend to both methods of moving in the space between points A and B; as micro, embodied and intimate (im)mobilities are also played out within large-scale regimes of movement

Intergenerational Transmission of Poverty and Inequality: Young Lives

Parents play major roles in determining the human capital of children, and thus the income of children when they become adults. Models of investments in children’s human capital posit that these investments are determined by parental resources (financial and human capital) and child endowments within particular market and policy environments. Many empirical studies are consistent with significant associations between parental resources and investments in their children. And there is considerable emphasis in the scholarly and the policy literatures on the degree of intergenerational mobility and the intergenerational transmission of economic opportunities, and therefore the intergenerational transmission of poverty – or of affluence. Therefore policies or other developments that affect the extent of poverty and/or inequality in the parents’ generation are likely to have impacts on the extent of poverty and/or inequality in the children’s generation. However the extent of these intergenerational effects is an empirical question that this paper explores using the Young Lives data to estimate intergenerational associations between parental resources and investments in human capital of children and then, under the assumption that these associations reflect causal effects, to simulate what impacts changes in poverty and inequality in the parents’ generation have on poverty and inequality in the children’s generation. The results suggest that reductions in poverty and in inequality in the parents’ generation reduce poverty and inequality in the children’s generation some, but not much