Application of High-Frequency Oscillations on Scalp EEG in Infant Spasm: A Prospective Controlled Study

ObjectiveWe quantitatively analyzed high-frequency oscillations (HFOs) using scalp electroencephalography (EEG) in patients with infantile spasms (IS).MethodsWe enrolled 60 children with IS hospitalized from January 2019 to August 2020. Sixty healthy age-matched children comprised the control group. Time–frequency analysis was used to quantify γ, ripple, and fast ripple (FR) oscillation energy changes.Resultsγ, ripple, and FR oscillations dominated in the temporal and frontal lobes. The average HFO energy of the sleep stage is lower than that of the wake stage in the same frequency bands in both the normal control (NC) and IS groups (P < 0.05). The average HFO energy of the IS group was significantly higher than that of the NC group in γ band during sleep stage (P < 0.01). The average HFO energy of S and Post-S stage were higher than that of sleep stage in γ band (P < 0.05). In the ripple band, the average HFO energy of Pre-S, S, and Post-S stage was higher than that of sleep stage (P < 0.05). Before treatment, there was no significant difference in BASED score between the effective and ineffective groups. The interaction of curative efficacy × frequency and the interaction of curative efficacy × state are statistically significant. The average HFO energy of the effective group was lower than that of the ineffective group in the sleep stage (P < 0.05). For the 16 children deemed “effective” in the IS group, the average HFO energy of three frequency bands was not significantly different before compared with after treatment.SignificanceScalp EEG can record HFOs. The energy of HFOs can distinguish physiological HFOs from pathological ones more accurately than frequency. On scalp EEG, γ oscillations can better detect susceptibility to epilepsy than ripple and FR oscillations. HFOs can trigger spasms. The analysis of average HFO energy can be used as a predictor of the effectiveness of epilepsy treatment

WMAPping out Neutrino Masses

Recent data from from the Wilkinson Microwave Anisotropy Probe (WMAP) place important bounds on the neutrino sector. The precise determination of the baryon number in the universe puts a strong constraint on the number of relativistic species during Big-Bang Nucleosynthesis. WMAP data, when combined with the 2dF Galaxy Redshift Survey (2dFGRS), also directly constrain the absolute mass scale of neutrinos. These results impinge upon a neutrino oscillation interpretation of the result from the Liquid Scintillator Neutrino Detector (LSND). We also note that the Heidelberg--Moscow evidence for neutrinoless double beta decay is only consistent with the WMAP+2dFGRS data for the largest values of the nuclear matrix element.Comment: 5 pages, 2 figures. v2:Streamlined discussion of thermalization; improved discussion of large lepton asymmetry. v3: Added References. v4: More conservative treatment of bia

The Impact of an Extra Background of Relativistic Particles on the Cosmological Parameters derived from Microwave Background Anisotropies

Recent estimates of cosmological parameters derived from Cosmic Microwave Background (CMB) anisotropies are based on the assumption that we know the precise amount of energy density in relativistic particles in the universe, $\omega_{rel}$, at all times. There are, however, many possible mechanisms that can undermine this assumption. In this paper we investigate the effect that removing this assumption has on the determination of the various cosmological parameters. We obtain fairly general bounds on the redshift of equality, $z_{eq}= \omega_{m}/\omega_{rel}=3100_{-400}^{+600}$. We show that $\omega_{rel}$ is nearly degenerate with the amount of energy in matter, $\omega_m$, and that its inclusion in CMB parameter estimation also affects the present constraints on other parameters such as the curvature or the scalar spectral index of primordial fluctuations. This degeneracy has the effect of limiting the precision of parameter estimation from the MAP satellite, but it can be broken by measurements on smaller scales such as those provided by the Planck satellite mission.Comment: 9 pages, 6 figures, Submitted to MNRAS. High resolution colour pictures can be obtained on request from the author

Single crystal growth and superconductivity in RbNi2_2Se2_2

We report the synthesis and characterization of RbNi$_2$Se$_2$, an analog of the iron chalcogenide superconductor Rb$_x$Fe$_2$Se$_2$, via transport, angle resolved photoemission spectroscopy, and density functional theory calculations. A superconducting transition at $T_{c}$ = 1.20 K is identified. In normal state, RbNi$_2$Se$_2$ shows paramagnetic and Fermi liquid behaviors. A large Sommerfeld coefficient yields a heavy effective electron mass of $m^{*}\approx6m_{e}$. In the superconducting state, zero-field electronic specific-heat data $C_{es}$ can be described by a two-gap BCS model, indicating that RbNi$_2$Se$_2$ is a multi-gap superconductor. Our density functional theory calculations and angle resolved photoemission spectroscopy measurements demonstrate that RbNi$_2$Se$_2$ exhibits relatively weak correlations and multi-band characteristics, consistent with the multi-gap superconductivity.Comment: 7 pages, 4 figure

Multiple Apoptotic Caspase Cascades Are Required in Nonapoptotic Roles for Drosophila Spermatid Individualization

Spermatozoa are generated and mature within a germline syncytium. Differentiation of haploid syncytial spermatids into single motile sperm requires the encapsulation of each spermatid by an independent plasma membrane and the elimination of most sperm cytoplasm, a process known as individualization. Apoptosis is mediated by caspase family proteases. Many apoptotic cell deaths in Drosophila utilize the REAPER/HID/GRIM family proapoptotic proteins. These proteins promote cell death, at least in part, by disrupting interactions between the caspase inhibitor DIAP1 and the apical caspase DRONC, which is continually activated in many viable cells through interactions with ARK, the Drosophila homolog of the mammalian death-activating adaptor APAF-1. This leads to unrestrained activity of DRONC and other DIAP1-inhibitable caspases activated by DRONC. Here we demonstrate that ARK- and HID-dependent activation of DRONC occurs at sites of spermatid individualization and that all three proteins are required for this process. dFADD, the Drosophila homolog of mammalian FADD, an adaptor that mediates recruitment of apical caspases to ligand-bound death receptors, and its target caspase DREDD are also required. A third apoptotic caspase, DRICE, is activated throughout the length of individualizing spermatids in a process that requires the product of the driceless locus, which also participates in individualization. Our results demonstrate that multiple caspases and caspase regulators, likely acting at distinct points in time and space, are required for spermatid individualization, a nonapoptotic process

Neutrino physics from cosmological observations

We review the current status of neutrino cosmology, focusing mainly on the question of the absolute values of neutrino masses and the possibility of a cosmological neutrino lepton asymmetry.Comment: 7 pages, 3 figures, Invited talk at the XXth Internat. Conf. on Neutrino Physics and Astrophysics (Neutrino 2002), Munich, Germany, May 25-30, 200

Quantifying uncertainties in primordial nucleosynthesis without Monte Carlo simulations

We present a simple method for determining the (correlated) uncertainties of the light element abundances expected from big bang nucleosynthesis, which avoids the need for lengthy Monte Carlo simulations. Our approach helps to clarify the role of the different nuclear reactions contributing to a particular elemental abundance and makes it easy to implement energy-independent changes in the measured reaction rates. As an application, we demonstrate how this method simplifies the statistical estimation of the nucleon-to-photon ratio through comparison of the standard BBN predictions with the observationally inferred abundances.Comment: 22 pages (RevTeX) incl. 8 figures (epsf); Changes: Figs. 5 & 6 combined + typo in Footnote 1 corrected + several stylistic changes; to appear in Phys. Rev.