The Inflatino Problem in Supergravity Inflationary Models

We consider the potential problems due to the production of inflatinos and gravitinos after inflation. Inflationary models with a single scale set by the microwave background anisotropies have a low enough reheat temperature to avoid problems with the thermal production of gravitinos. Moreover, the nonthermal production of gravitinos has been shown to be sufficiently small if the sector ultimately responsible for supersymmetry breaking is coupled only gravitationally to the inflationary sector. Still, in some models, inflatinos can be created during preheating with a substantial abundance. The main contribution to the gravitino abundance may thus come from their decay into the inflaton, or into its scalar partner, as well as from the inverse processes. We show that this production needs to be strongly suppressed. This suppression can be realized in the simplest scenarios which typically have a sufficiently high inflationary scale.Comment: 18 page

6-PACK programme to decrease fall injuries in acute hospitals: Cluster randomised controlled trial

Objective: To evaluate the effect of the 6-PACK programme on falls and fall injuries in acute wards. Design: Cluster randomised controlled trial. Setting: Six Australian hospitals. Participants: All patients admitted to 24 acute wards during the trial period. Interventions: Participating wards were randomly assigned to receive either the nurse led 6-PACK programme or usual care over 12 months. The 6-PACK programme included a fall risk tool and individualised use of one or more of six interventions: “falls alert” sign, supervision of patients in the bathroom, ensuring patients’ walking aids are within reach, a toileting regimen, use of a low-low bed, and use of a bed/chair alarm. Main outcome measures: The co-primary outcomes were falls and fall injuries per 1000 occupied bed days. Results: During the trial, 46 245 admissions to 16 medical and eight surgical wards occurred. As many people were admitted more than once, this represented 31 411 individual patients. Patients’ characteristics and length of stay were similar for intervention and control wards. Use of 6-PACK programme components was higher on intervention wards than on control wards (incidence rate ratio 3.05, 95% confidence interval 2.14 to 4.34; P<0.001). In all, 1831 falls and 613 fall injuries occurred, and the rates of falls (incidence rate ratio 1.04, 0.78 to 1.37; P=0.796) and fall injuries (0.96, 0.72 to 1.27; P=0.766) were similar in intervention and control wards. Conclusions: Positive changes in falls prevention practice occurred following the introduction of the 6-PACK programme. However, no difference was seen in falls or fall injuries between groups. High quality evidence showing the effectiveness of falls prevention interventions in acute wards remains absent. Novel solutions to the problem of in-hospital falls are urgently needed

PRAXIS: low thermal emission high efficiency OH suppressed fibre spectrograph

PRAXIS is a second generation instrument that follows on from GNOSIS, which was the first instrument using fibre Bragg gratings for OH background suppression. The Bragg gratings reflect the NIR OH lines while being transparent to light between the lines. This gives a much higher signal-noise ratio at low resolution but also at higher resolutions by removing the scattered wings of the OH lines. The specifications call for high throughput and very low thermal and detector noise so that PRAXIS will remain sky noise limited. The optical train is made of fore-optics, an IFU, a fibre bundle, the Bragg grating unit, a second fibre bundle and a spectrograph. GNOSIS used the pre-existing IRIS2 spectrograph while PRAXIS will use a new spectrograph specifically designed for the fibre Bragg grating OH suppression and optimised for 1470 nm to 1700 nm (it can also be used in the 1090 nm to 1260 nm band by changing the grating and refocussing). This results in a significantly higher transmission due to high efficiency coatings, a VPH grating at low incident angle and low absorption glasses. The detector noise will also be lower. Throughout the PRAXIS design special care was taken at every step along the optical path to reduce thermal emission or stop it leaking into the system. This made the spectrograph design challenging because practical constraints required that the detector and the spectrograph enclosures be physically separate by air at ambient temperature. At present, the instrument uses the GNOSIS fibre Bragg grating OH suppression unit. We intend to soon use a new OH suppression unit based on multicore fibre Bragg gratings which will allow increased field of view per fibre. Theoretical calculations show that the gain in interline sky background signal-noise ratio over GNOSIS may very well be as high as 9 with the GNOSIS OH suppression unit and 17 with the multicore fibre OH suppression unit.Comment: SPIE conference proceedings 915

Constraints from Inflation and Reheating on Superpartner Masses

Flat directions in the Minimal Supersymmetric Standard Model (MSSM) can become unstable due to radiative corrections, and the global minimum of the (zero temperature) potential can lie at large values of the squark and/or slepton fields. Here we show that, in inflationary models of early cosmology, the universe is very likely to be in the domain of attraction of this global minimum at the end of inflation. While the minimum at the origin of field space is global at sufficiently high temperatures, depending on details of the model, the universe may be trapped in the non-zero minimum until it becomes the global minimum at low temperatures. Parameter values leading to this scenario are therefore ruled out.Comment: 14 pages in LaTeX + 2 postscript figures, uses epsf.sty; revised version, effect of Yukawa couplings added, figure modified, one figure added, references altere

The gravitino coupling to broken gauge theories applied to the MSSM

We consider gravitino couplings in theories with broken gauge symmetries. In particular, we compute the single gravitino production cross section in W+ W- fusion processes. Despite recent claims to the contrary, we show that this process is always subdominant to gluon fusion processes in the high energy limit. The full calculation is performed numerically; however, we give analytic expressions for the cross section in the supersymmetric and electroweak limits. We also confirm these results with the use of the effective theory of goldstino interactions.Comment: 26 pages, 4 figure

Effects of Unstable Particles on Light-Element Abundances: Lithium versus Deuterium and He3

We reconsider the effects of unstable particles on the production and destruction of the primordial light elements, with a view to reconciling the high primordial Li7 abundance deduced from Big Bang Nucleosynthesis (BBN), as implied by the baryon-to-photon ratio now inferred from the anisotropies of the Cosmic Microwave Background (CMB), with the lower abundance of Li7 observed in halo stars. The potential destruction of Li7 is strongly constrained by observations of Deuterium (D), He3 and Li6. We identify ranges for the unstable particle abundance and lifetime which would deplete Li7 while remaining consistent with the abundance of Li6. However, in these regions either the D abundance is unacceptably low or the ratio He3/D is unacceptably large. We conclude that late particle decay is unable to explain both the discrepancy of the calculated Li7 abundance and the observed Li7 plateau. In the context of supersymmetric theories with neutralino or gravitino dark matter, we display the corresponding light-element constraints on the model parameters.Comment: 19 pages, 13 eps figure

US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report

This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages + reference

Delineation of the Innate and Adaptive T-Cell Immune Outcome in the Human Host in Response to Campylobacter jejuni Infection

BACKGROUND: Campylobacter jejuni is the most prevalent cause of bacterial gastroenteritis worldwide. Despite the significant health burden this infection presents, molecular understanding of C. jejuni-mediated disease pathogenesis remains poorly defined. Here, we report the characterisation of the early, innate immune response to C. jejuni using an ex-vivo human gut model of infection. Secondly, impact of bacterial-driven dendritic cell activation on T-cell mediated immunity was also sought. METHODOLOGY: Healthy, control paediatric terminal ileum or colonic biopsy tissue was infected with C. jejuni for 8-12 hours. Bacterial colonisation was followed by confocal microscopy and mucosal innate immune responses measured by ELISA. Marked induction of IFNγ with modest increase in IL-22 and IL-17A was noted. Increased mucosal IL-12, IL-23, IL-1β and IL-6 were indicative of a cytokine milieu that may modulate subsequent T-cell mediated immunity. C. jejuni-driven human monocyte-derived dendritic cell activation was followed by analyses of T cell immune responses utilising flow cytometry and ELISA. Significant increase in Th-17, Th-1 and Th-17/Th-1 double-positive cells and corresponding cytokines was observed. The ability of IFNγ, IL-22 and IL-17 cytokines to exert host defence via modulation of C. jejuni adhesion and invasion to intestinal epithelia was measured by standard gentamicin protection assay. CONCLUSIONS: Both innate and adaptive T cell-immunity to C. jejuni infection led to the release of IFNγ, IL-22 and IL-17A; suggesting a critical role for this cytokine triad in establishing host anti-microbial immunity during the acute and effectors phase of infection. In addition, to their known anti-microbial functions; IL-17A and IL-17F reduced the number of intracellular C. jejuni in intestinal epithelia, highlighting a novel aspect of how IL-17 family members may contribute to protective immunity against C. jejuni

Updated Nucleosynthesis Constraints on Unstable Relic Particles

We revisit the upper limits on the abundance of unstable massive relic particles provided by the success of Big-Bang Nucleosynthesis calculations. We use the cosmic microwave background data to constrain the baryon-to-photon ratio, and incorporate an extensively updated compilation of cross sections into a new calculation of the network of reactions induced by electromagnetic showers that create and destroy the light elements deuterium, he3, he4, li6 and li7. We derive analytic approximations that complement and check the full numerical calculations. Considerations of the abundances of he4 and li6 exclude exceptional regions of parameter space that would otherwise have been permitted by deuterium alone. We illustrate our results by applying them to massive gravitinos. If they weigh ~100 GeV, their primordial abundance should have been below about 10^{-13} of the total entropy. This would imply an upper limit on the reheating temperature of a few times 10^7 GeV, which could be a potential difficulty for some models of inflation. We discuss possible ways of evading this problem.Comment: 40 pages LaTeX, 18 eps figure