A sensitivity analysis of the prediction of the nitrogen fertilizer requirement of cauliflower crops using the HRI WELL_N computer model

HRI WELL_N is an easy to use computer model, which has been used by farmers and growers since 1994 to predict crop nitrogen (N) requirements for a wide range of agricultural and horticultural crops. A sensitivity analysis was carried out to investigate the model predictions of the N fertilizer requirement of cauliflower crops, and, at that rate, the yield achieved, yield response to the fertilizer applied, N uptake, NO3-N leaching below 30 and 90 cm and mineral N at harvest. The sensitivity to four input factors – soil mineral N before planting, mineralization rate of soil organic matter, expected yield and duration of growth – was assessed. Values of these were chosen to cover ranges between 40% and 160% of values typical for field crops of cauliflowers grown in East Anglia. The assessments were made for three soils – sand, sandy loam and silt – and three rainfall scenarios – an average year and years with 144% or 56% of average rainfall during the growing season. The sensitivity of each output variable to each of the input factors (and interactions between them) was assessed using a unique ‘sequential' analysis of variance approach developed as part of this research project. The most significant factors affecting N fertilizer requirement across all soil types/rainfall amounts were soil mineral N before planting and expected yield. N requirement increased with increasing yield expectation, and decreased with increasing amounts of soil mineral N before planting. The responses to soil mineral N were much greater when higher yields were expected. Retention of N in the rooting zone was predicted to be poor on light soils in the wettest conditions suggesting that to maximize N use, plants needed to grow rapidly and have reasonable yield potential. Assessment of the potential impacts of errors in the values of the input factors indicated that poor estimation of, in particular, yield expectation and soil mineral N before planting could lead to either yield loss or an increased level of potentially leachable soil mineral N at harvest. The research demonstrates the benefits of using computer simulation models to quantify the main factors for which information is needed in order to provide robust N fertilizer recommendations

The performance of the EU-Rotate_N model in predicting the growth and nitrogen uptake of rotations of field vegetable crops in a Mediterranean environment

The EU-Rotate_N model was developed as a tool to estimate the growth and nitrogen (N) uptake of vegetable crop rotations across a wide range of European climatic conditions and to assess the economic and environmental consequences of alternative management strategies. The model has been evaluated under field conditions in Germany and Norway and under greenhouse conditions in China. The present work evaluated the model using Italian data to evaluate its performance in a warm and dry environment. Data were collected from four 2-year field rotations, which included lettuce (Lactuca sativa L.), fennel (Foeniculum vulgare Mill.), spinach (Spinacia oleracea L.), broccoli (Brassica oleracea L. var. italica Plenck) and white cabbage (B. oleracea convar. capitata var. alba L.); each rotation used three different rates of N fertilizer (average recommended N1, assumed farmer's practice N2=N1+0·3×N1 and a zero control N0). Although the model was not calibrated prior to running the simulations, results for above-ground dry matter biomass, crop residue biomass, crop N concentration and crop N uptake were promising. However, soil mineral N predictions to 0·6 m depth were poor. The main problem with the prediction of the test variables was the poor ability to capture N mineralization in some autumn periods and an inappropriate parameterization of fennel. In conclusion, the model performed well, giving results comparable with other bio-physical process simulation models, but for more complex crop rotations. The model has the potential for application in Mediterranean environments for field vegetable production

Chemical Weapons and public health: assessing impact and responses.

BACKGROUND: The recent use of Chemical Weapons (CWs) in armed conflicts and terror attacks highlights the importance of understanding their full impact in order to inform an effective response. This article argues that while the consequences of CWs on individual health have dominated our understanding of the impact of these weapons, far less attention has been directed to their impact on public health. METHODS: A review of the literature on the health impact of CWs was conducted, and two case studies of their use in urban settings were explored - Halabja in northern Iraq in 1988 and throughout Syria's ongoing conflict. RESULTS: The importance of considering the long-term health consequences of CW use and their impact on healthcare and health systems was demonstrated. CONCLUSIONS: This article highlights the importance of supporting future research on the topic and proposes a framework for assessing the public health impact of CW use

EU-Rotate_N – a decision support system – to predict environmental and economic consequences of the management of nitrogen fertiliser in crop rotations

A model has been developed which assesses the economic and environmental performance of crop rotations, in both conventional and organic cropping, for over 70 arable and horticultural crops, and a wide range of growing conditions in Europe. The model, though originally based on the N_ABLE model, has been completely rewritten and contains new routines to simulate root development, the mineralisation and release of nitrogen (N) from soil organic matter and crop residues, and water dynamics in soil. New routines have been added to estimate the effects of sub-optimal rates of N and spacing on the marketable outputs and gross margins. The model provides a mechanism for generating scenarios to represent a range of differing crop and fertiliser management strategies which can be used to evaluate their effects on yield, gross margin and losses of nitrogen through leaching. Such testing has revealed that nitrogen management can be improved and that there is potential to increase gross margins whilst reducing nitrogen losses

'What vision?': experiences of Team members in a community service for adults with intellectual disabilities.

BACKGROUND: In the UK, the closure of 'long-stay' hospitals was accompanied by the development of community teams (CTs) to support people with intellectual disabilities (IDs) to live in community settings. The self-reported experiences of staff working in such teams have been neglected. METHODS: Focusing on a single county-wide service, comprising five multi-disciplinary and inter-agency CTs, we measured perceptions among the health care and care management Team members of (1) their personal well-being; (2) the functioning of their team; and (3) the organisation's commitment to quality, and culture. RESULTS: Almost three-quarters of the questionnaires were returned (73/101; 72%). The scores of health care practitioners and care managers were very similar: (1) the MBI scores of more than half the respondents were 'of concern'; (2) similarly, almost four in ten respondents' scores on the Vision scale of the TCI were 'of concern'; (3) the perceived commitment to quality (QIIS-II Part 2) was uncertain; and (4) the organisational culture (QIIS-II, Part 1) was viewed as primarily hierarchical. DISCUSSION: The perceived absence of a vision for the service, combined with a dominant culture viewed by its members as strongly focussed on bureaucracy and process, potentially compromises the ability of these CTs to respond proactively to the needs of people with IDs. Given the changes in legislation, policy and practice that have taken place since CTs were established, it would be timely to revisit their role and purpose.We are grateful to all our participants in the IDP, without whom the study could not have taken place, to Professor Eivor Oborn (Warwick Business School) for her insights in the development of the study. Funding was provided by the NIHR’s Collaboration for Health Research & Care (CLAHRC) for Cambridgeshire & Peterborough. The preparation of the paper was funded by the NIHR’s CLAHRC East of England (ICHC, KAW, AJH, AL, EJ, APW). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.This is the author accepted manuscript. The final version is available from Wiley via https://doi.org/10.1111/jir.1231

Manganese-enhanced magnetic resonance imaging depicts brain activity in models of acute and chronic pain: a new window to study experimental spontaneous pain?

Application of functional imaging techniques to animal models is vital to understand pain mechanisms, but is often confounded by the need to limit movement artefacts with anaesthesia, and a focus on evoked responses rather than clinically relevant spontaneous pain and related hyperalgesia. The aim of the present study was to investigate the potential of manganese-enhanced magnetic resonance imaging (MEMRI) to measure neural responses during on-going pain that underpins hyperalgesia in pre-clinical models of nociception. As a proof of concept that MEMRI is sensitive to the neural activity of spontaneous, intermittent behaviour, we studied a separate positive control group undergoing a voluntary running wheel experiment. In the pain models, pain behaviour (weight bearing asymmetry and hindpaw withdrawal thresholds (PWTs)) was measured at baseline and following either intra-articular injection of nerve growth factor (NGF, 10 µg/50 µl; acute pain model, n=4 rats per group), or the chondrocyte toxin monosodium iodoacetate (MIA, 1 mg/50 µl; chronic model, n=8 rats per group), or control injection. Separate groups of rats underwent a voluntary wheel running protocol (n=8 rats per group). Rats were administered with paramagnetic ion Mn2+ as soluble MnCl2 over seven days (subcutaneous osmotic pump) to allow cumulative activity-dependent neural accumulation in the models of pain, or over a period of running. T1-weighted MR imaging at 7 T was performed under isoflurane anaesthesia using a receive-only rat head coil in combination with a 72 mm volume coil for excitation. The pain models resulted in weight bearing asymmetry (NGF: 20.0 ± 5.2%, MIA: 15 ± 3%), and a reduction in PWT in the MIA model (8.3 ± 1.5 g) on the final day of assessment before undergoing MR imaging. Voxel-wise and region-based analysis of MEMRI data did not identify group differences in T1 signal. However, MnCl2 accumulation in the VTA, right Ce amygdala, and left cingulate was negatively correlated with pain responses (greater differences in weight bearing), similarly MnCl2 accumulation was reduced in the VTA in line with hyperalgesia (lower PWTs), which suggests reduced regional activation as a result of the intensity and duration of pain experienced during the 7 days of MnCl2 exposure. Motor cortex T1-weighted signal increase was associated with the distance ran in the wheel running study, while no between group difference was seen. Our data suggest that on-going pain related signal changes identified using MEMRI offers a new window to study the neural underpinnings of spontaneous pain in rats

(μ-Piperazine-1,4-dicarbodithio­ato-κ4 S 1,S 1′:S 4,S 4′)bis­[bis­(triphenyl­phos­phane-κP)gold(I)] chloro­form disolvate

In the title compound, [Au2(C6H8N2S4)(C18H15P)4]·2CHCl3, the digold complex resides on a crystallographic inversion center and co-crystallizes with two mol­ecules of chloro­form solvent. The piperazine-1,4-dicarbodithio­ate linker has an almost ideal chair conformation. The geometry about the gold atoms is severely distorted tetra­hedral punctuated by a very acute S—Au—S bite angle

Evaluating sustainability: a retrospective cohort analysis of the Oxfordshire therapeutic community

Background: Therapeutic communities (TCs) could reduce the health care use of people with personality disorder (Davies S, Campling P and Ryan K, Psychiatrist 23:79–83, 1999; Barr W, Kirkcaldy A, Horne A, Hodge S, Hellin K and Göpfert M, J Ment Health 19:412–421, 2010) and in turn reduce the financial and environmental costs of services. Our hypothesis is that 3 years following entry to a TC service, patients have reduced subsequent health care use and associated reductions in financial costs and carbon footprint. Methods: A retrospective 4-year cohort study examined changes in health care use following entry to the Oxfordshire TC service. Comparative analysis was undertaken on a treated (n = 40) and a control group (referred but who declined treatment; n = 45). Financial costs and carbon footprint of health care use were calculated using national tariffs and standard carbon conversion factors. Mean changes in these outcomes were compared over 1, 2 and 3 years and adjusted for costs and carbon footprints in the year prior to joining the TC service. Results: Compared to baseline, the group receiving TC care had greater reductions in financial costs and carbon footprint associated with A&E attendances (p = 0.04) and crisis mental health appointments (p = 0.04) than the control group. There were significantly greater reductions in carbon footprint for all secondary health care use, both physical and mental health care, after 3 years (p = 0.04) in the TC group. Conclusions: TC services may have the potential to reduce the financial cost and carbon footprint of health car

Consequences of converting graded to action potentials upon neural information coding and energy efficiency

Information is encoded in neural circuits using both graded and action potentials, converting between them within single neurons and successive processing layers. This conversion is accompanied by information loss and a drop in energy efficiency. We investigate the biophysical causes of this loss of information and efficiency by comparing spiking neuron models, containing stochastic voltage-gated Na+ and K+ channels, with generator potential and graded potential models lacking voltage-gated Na+ channels. We identify three causes of information loss in the generator potential that are the by-product of action potential generation: (1) the voltage-gated Na+ channels necessary for action potential generation increase intrinsic noise and (2) introduce non-linearities, and (3) the finite duration of the action potential creates a ‘footprint’ in the generator potential that obscures incoming signals. These three processes reduce information rates by ~50% in generator potentials, to ~3 times that of spike trains. Both generator potentials and graded potentials consume almost an order of magnitude less energy per second than spike trains. Because of the lower information rates of generator potentials they are substantially less energy efficient than graded potentials. However, both are an order of magnitude more efficient than spike trains due to the higher energy costs and low information content of spikes, emphasizing that there is a two-fold cost of converting analogue to digital; information loss and cost inflation

Is Aquatic Life Correlated with an Increased Hematocrit in Snakes?

Background: Physiological adaptations that allow air-breathing vertebrates to remain underwater for long periods mainly involve modifications of the respiratory system, essentially through increased oxygen reserves. Physiological constraints on dive duration tend to be less critical for ectotherms than for endotherms because the former have lower mass-specific metabolic rates. Moreover, comparative studies between marine and terrestrial ectotherms have yet to show overall distinct physiological differences specifically associated with oxygen reserves. Methodology/Principal Findings: We used phylogenetically informed statistical models to test if habitat affects hematocrit (an indicator of blood oxygen stores) in snakes, a lineage that varies widely in habitat use. Our results indicate that both phylogenetic position (clade) and especially habitat are significant predictors of hematocrit. Our analysis also confirms the peculiar respiratory physiology of the marine Acrochordus granulatus. Conclusion/Significance: Contrary to previous findings, marine snakes have significantly–albeit slightly–elevated hematocrit, which should facilitate increased aerobic dive times. Longer dives could have consequences for foraging, mate searching, and predation risks. Alternatively, but not exclusively, increased Hct in marine species might also help t