209 research outputs found
On the influence of noise on chaos in nearly Hamiltonian systems
The simultaneous influence of small damping and white noise on Hamiltonian
systems with chaotic motion is studied on the model of periodically kicked
rotor. In the region of parameters where damping alone turns the motion into
regular, the level of noise that can restore the chaos is studied. This
restoration is created by two mechanisms: by fluctuation induced transfer of
the phase trajectory to domains of local instability, that can be described by
the averaging of the local instability index, and by destabilization of motion
within the islands of stability by fluctuation induced parametric modulation of
the stability matrix, that can be described by the methods developed in the
theory of Anderson localization in one-dimensional systems.Comment: 10 pages REVTEX, 9 figures EP
Risk stratification of individuals with low-risk colorectal adenomas using clinical characteristics: A pooled analysis
Objective For individuals with 1-2 small (<1 cm) low-risk colorectal adenomas, international guidelines range from no surveillance to offering surveillance colonoscopy in 5-10 years. We hypothesised that the risks for metachronous advanced neoplasia (AN) among patients with low-risk adenomas differ based on clinical factors distinct from those currently used. Design We pooled data from seven prospective studies to assess the risk of metachronous AN. Two groups with 1-2 small adenomas were defined based on guidelines from the UK (n=4516) or the European Union (EU)/US (n=2477). Results Absolute risk of metachronous AN ranged from a low of 2.9% to a high of 12.2%, depending on specific risk factor and guideline used. For the UK group, the highest absolute risks for metachronous AN were found among individuals with a history of prior polyp (12.2%), villous histology (12.2%), age ≥70 years (10.9%), high-grade dysplasia (10.9%), any proximal adenoma (10.2%), distal and proximal adenoma (10.8%) or two adenomas (10.1%). For the EU/US group, the highest absolute risks for metachronous AN were among individuals with a history of prior polyp (11.5%) or the presence of both proximal and distal adenomas (11.0%). In multivariate analyses, strong associations for increasing age and history of prior polyps and odds of metachronous AN were observed, whereas more modest associations were shown for baseline proximal adenomas and those with villous features. Conclusions Risks of metachronous AN among individuals with 1-2 small adenomas vary according to readily available clinical characteristics. These characteristics may be considered for recommending colonoscopy surveillance and require further investigation
Causação do comportamento humano: acesso à história passada como determinante na explicação do comportamento humano
TREE COMMUNITY COMPOSITION AND ABOVEGROUND BIOMASS IN A SECONDARY ATLANTIC FOREST, SERRA DO MAR STATE PARK, SÃO PAULO, BRAZIL
Structure and dynamics of a Cariniana estrellensis (Lecythidaceae) population in a fragment of Atlantic Forest in Minas Gerais, Brazil
Age at first birth in women is genetically associated with increased risk of schizophrenia
Prof. Paunio on PGC:n jäsenPrevious studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.Peer reviewe
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Diagnóstico florístico-estrutural do componente arbóreo da floresta da Serra de São José, Tiradentes, MG, Brasil
Diferenças florísticas e estruturais entre duas cotas altiduninais da Floresta Ombrófila Densa Submontana Atlântica, do Parque Estadual da Serra do Mar, município de Ubatuba/SP, Brasil
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