The monsters of my Father ... They are also my monsters

En el año 2012 mi padre es diagnosticado como enfermo de cáncer de próstata. Después de este mal augurio, los monstruos se dejan ver en las resonancias magnéticas. Invaden el cuerpo de mi padre, tomando partes de su interior, realizando transformaciones, rompiendo así el equilibrio del cuerpo y llevándolo a su muerte. Mi proceso de investigación - creación parte de la observación de las imágenes de la resonancia magnética realizada a mi padre el 23 de abril del 2012 para detectar si el cáncer había invadido algún otro miembro del cuerpo cercano a la próstata, la cual ya se encontraba afectada por la enfermedad. Al mirar las imágenes de las resonancias magnéticas unas figuras muy particulares comienzo a descubrir plasmándolas en dibujo, encontrando así tres personajes fantásticos y monstruosos, los cuales comienzo a imaginar sus características físicas, para después escribir la historia donde aparecerán dichos personajes acompañando a una niña que se interna en el mundo de los monstruos. Así comienza el recorrido de esta historia, pasando por mi infancia, mis miedos y la muerte. Para identificarme en una búsqueda interior, personal, para entender la perspectiva de mi propia vida, de mi existencia. Para que la búsqueda que emprendo me ayude a disipar mis miedos.In 2012 my father was diagnosed as having prostate cancer. After this bad omen, the monsters are seen in the magnetic resonances. They invade my father's body, taking parts of his interior, making transformations, breaking the balance of the body and taking him to his death. My research process – start the creation and observation of the images of the MRI performed on my father on April 23, 2012 to take into account if the cancer has invaded elsewhere in the body near the prostate, which was already affected because of the disease. The images of the magnetic resonances become the drawing; the drawing, the history, the drawing, the history, the characters, the fantasy, the monsters, the theme, the story. It goes into the world of monsters. Thus begins the journey of this story, going through my childhood, my fears and death. To identify in an interior, personal search, to understand the perspective of my own life, of my existence. So that the search that I undertake helps me to dissipate my fears

Flavonoid biosynthesis in tomato fruit cuticles after in vivo incorporation of 3H-phenylalanine precursor. Physiol Plant

throughout fruit ripening. Confocal microscopy, together with Radiolabelling of epicuticular waxes and cutin of isolated experimental estimation of the mobility (diffusion coefficient, tomato fruit cuticles were determined after fruit surface appli-D) and affinity (partition coefficient, K) of the flavonoids cation of 3 H-phenylalanine precursor. During fruit ripening, naringenin and chalconaringenin for the different cuticular the precursor is incorporated in different phenolic components: components, indicate that these compounds are extruded to the flavanone naringenin was found to be the major compound the outer surface of tomato fruits, forming molecular clusters. in the epicuticular waxes, while the amount of the labelled flavonoid in the cutin matrix was progressively increase

Características en la producción del habla en niños y niñas de 5 años y 6 meses a 6 años y 6 meses pertenecientes a la institución educativa Fe y Alegría N° 2 - Condevilla - SMP, UGEL 02

Investigación de tipo transaccional descriptivo y diseño descriptivo simple, cuyo objetivo principal fue identificar las características en la producción del habla en 100 niños con edades comprendidas entre los 5 años 6 meses a 6 años 6 meses, pertenecientes a la Institución Educativa Fe y Alegría N° 2 Condevilla – SMP UGEL 02. El instrumento utilizado fue el Protocolo de Evaluación Miofuncional de la Dra. Irene Queiroz Marchesan (MBGR, 2011). Se obtuvieron los siguientes resultados: El 53% de los niños evaluados presenta alteraciones en la producción del habla, presentándose con mayor frecuencia las alteraciones de origen musculoesquelético. El tipo de alteraciones de mayor incidencia fueron las distorsiones, siendo los fones más alterados los vibrantes simples y múltiples. Otro tipo de alteraciones más frecuentes fueron las omisiones, siendo también los fones vibrantes s imples y múltiples los de mayor dificultad para producirse en el habla de los niños. Entre las alteraciones asociadas en la producción del habla son la posición habitual de la lengua baja, la articulación trabada, el acúmulo de saliva en las comisuras y un habla con loudness más débil y velocidad lenta que fueron las características más frecuentes que se observaron en los niños con alteraciones en su habla.Research of descriptive transactional and descriptive, simple design, whose main objective was to identify characteristics in the production of speech in 100 children aged between 5 years 6 months to 6 years 6 months, belonging to the educational institution of Fe y Alegría No. 2 Condevilla - SMP UGEL 02. The instrument used was the Protocol of evaluation Myofunctional de la DRA. Irene Queiroz Marchesan (MBGR, 2011). The following results were obtained: 53% of evaluated children present alterations in the production of speech, presenting most often musculoskeletal alterations. The types of alterations of higher incidence were distortions, being the phones altered over the vibrant simple and multiple. Another type of frequent alterations were omissions, being also the simple and multiple vibrant phones of greater difficulty to occur in the speech of children. Among the alterations associated with speech production are the usual position of the low tongue, locked joint, the accumulation of saliva in the mouth and a speaking with weaker loudness and speed which were the most common characteristics that were observed in children with speech disorders. Keywords: production of speech, speech disorders, evaluation of myofunctional, default replacement, distortion, inaccuracy.Tesi

Verifying goal-oriented specifications used in model-driven development processes

[EN] Goal-oriented requirements engineering promotes the use of goals to elicit, elaborate, structure, specify, analyze, negotiate, document, and modify requirements. Thus, goal-oriented specifications are essential for capturing the objectives that the system to be developed should achieve. However, the application of goal oriented specifications into model-driven development (MDD) processes is still handcrafted, not aligned in the automated flow from models to code. In other words, the experience of analysts and designers is necessary to manually transform the input goal-oriented models into system models for code generation (models compilation). Some authors have proposed guidelines to facilitate and partially automate this translation, but there is a lack of techniques to assess the adequacy of goal-oriented models as starting point of MDD processes. In this paper, we present and evaluate a verification approach that guarantees the automatic, correct, and complete transformation of goal-oriented models into design models used by specific MDD solutions. In particular, this approach has been put into practice by adopting a well-known goal-oriented modeling approach, the i* framework, and an industrial MDD solution called Integranova.This work has been developed with the support of FONDECYT under the projects AMoDDI 11130583 and TESTMODE 11121395.This work is also supported by EOSSAC project, funded by the Ministry of Economy and Competitiveness of the Spanish government (TIN2013-44641-P).Giachetti Herrera, GA.; Marín, B.; López, L.; Franch, X.; Pastor López, O. (2017). Verifying goal-oriented specifications used in model-driven development processes. Information Systems. 64:41-62. https://doi.org/10.1016/j.is.2016.06.011S41626

FACTORS THAT DETERMINATE THE TEENAGE MATERNITY. CASE: MATERNAL PERINATAL NATIONAL INSTITUTE

In the present work we identified the factors that affect in the teenager maternity in patients of the service of set accommodation of the Instituto Nacional Materno Perinatal (INMP) of Lima using of the theory of multiple logistic regression (Hosmer y Lemeshow, 2000; Uriel, 2005). We made a questionnaire and consider questions with respect to the features of the teenager mothers: education level, age of the union, knowledge of sex education and family planning, and so on. Features home: structure of the household, marital status of parents, union of parents, educational level of parents, number of brothers and sisters, and so on. The final data was taken from October the 2007 to March the 2008, with the application of the final instrument to mothers hospitalized in the services of set accommodation of the INMP. (Solano et. Al, 2007). For the calculus of the size of the samplc we used the proposed Freeman (1987); the mother were select at random until completed the size of the sample of two hundred forty two

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Síntesis y estudio de receptores dipodales de aniones mediante enlace halógeno e hidrógeno : procesos de reconocimiento y formación de polímeros supramoleculres

El objetivo principal de esta Tesis Doctoral consiste en la síntesis y estudio comparativo en la habilidad de nuevos receptores dipodales para el reconocimiento de aniones mediante la utilización de interacciones de enlace de halógeno o de enlace de hidrógeno, así como el estudio pormenorizado de modo de enlace receptor-anión. Como unidad de reconocimiento de aniones se ha utilizado el anillo de 1,2,3-triazolio. Con el fin de estudiar como afecta al proceso de reconocimiento de aniones la incorporación de sustituyentes con diferentes características electrónicas, se han incorporado sustituyentes electrodadores, electroretiradores y neutros en la posición 4 del anillo de 1,2,3-triazolio. La incorporación de espaciadores de diferentes tamaños: naftaleno, fenilo y binaftol han permitido determinar como afecta el tamaño de la cavidad en el reconocimiento de aniones. Durante la realización de esta Tesis Doctoral se ha prestado especial atención al modo de enlace de los receptores con los aniones. A parte de las interacciones de enlace de halógeno o enlace de hidrógeno más evidentes se han detectado otro tipo de interacciones no covalentes entre los receptores y los aniones, entre las que destacamos: * Interacciones de enlaces de hidrógeno Csp2-H····A-. * Interacciones Csp3-H···A-. * Interacciones Anión-π. Por último se ha demostrado una de las hipótesis iniciales de la Tesis Doctoral en la que se postulaba que los receptores de enlace halógeno polidentados pueden formar polímeros supramoleculares mediante la formación de complejos intermoleculares consecutivos a través de interacciones monómero-anión mediante enlace de halógeno preferentemente al reconocimiento por un solo receptor. Las moléculas sintetizadas, se han caracterizado y estudiado mediante espectrometría de masas, punto de fusión, 1H-RMN y 13C-RMN, Fluorescencia, UV-Vis, Electroquímicas. En el caso de los polímeros supramoleculares también se han empleado la Microscopía Electrónica, Difracción de Rayos X, Dynamic Light Scattering y Dicroismo Circular entre otras. The main objective of this PhD is the synthesis and the comparative study of new dipodal receptors in the anion recognition process by hydrogen or halogen bonding interactions, as well as a detailed study of the anion binding mode. The 1,2,3-triazolium ring was used as anion binging site. In order to study how affects the incorporation of substituents with different electronic characteristics in the anion recognition process, electron-donor, electron-acceptor and neutral substituents have been incorporated in the 4-position of the 1,2,3-triazolium ring. The incorporation of bridges with different sizes: naphthalene, phenol and binaphthol have allowed to determine how the size of the cavity affects in the anion recognition process. During this PhD, we have paid special attention to the binding mode between the receptors and anions. In addition to the more obvious halogen or hydrogen bond interactions, other non-covalent interactions have been detected, among which we highlight: * Csp2-H····A- hydrogen bonds interactions. * Csp3-H···A- interactions * Anion-π interactions. Finally, we have demonstrated one of the initial hypotheses of this PhD, which is that polydentate halogen-bond receptors can form supramolecular polymers by the formation of consecutive intermolecular complexes through monomer-anion interactions by halogen bond, preferably to the recognition by a single receptor. The molecules synthesized, have been characterized and studied by mass spectrometry, melting point, 1H-NMR, 13C-NMR, Fluorescence, UV-Vis and Electrochemical. In the case of supramolecular polymers, we have also been used Electron Microscopy, X-Ray Diffraction, Dynamic Light Scattering and Circular Dichroism among others

Hydrolysis reaction of 2,4-dichlorophenoxyacetic acid. A kinetic and computational study

International audienceThe degradation of the 2,4-dichlorophenoxyacetic acid in aqueous solution is an hydrolysis reaction. Two products are identified: 2,4-dichlorophenol and glycolic acid. Reaction is investigated as a function of pH and temperature, and it is first-order kinetics and pH-dependent. Reaction is modeled in gas phase, where a proton catalyses the reaction. Critical points of PES are calculated at B3LYP/6-311++G(3df,2p), and aug-cc-pvqz//6-311++G(3df,2p) levels plus ZPE at 6-311++G(3df,2p) level. The activation barrier is 21.2 kcal/mol. Theoretical results agree with the experimental results. A second mechanism related with a Cl2Ph-O-CH2-COOH center dot center dot center dot H2O complex is found, but with a rate limiting step of 38.4 kcal/mol. (C) 2015 Elsevier B.V. All rights reserved

Plan de negocio de una central de compras de insumos para el cultivo de caña de azucar y otros cultivos en el Valle Huaura - Sayan

El Valle Huaura-Sayán abarca una extensión de 4,770 km², donde predomina el cultivo de la caña de azúcar. Actualmente, existen un total de 7,737 agricultores con un total de 28,098 Has de cultivo y alrededor de 108 tipos de cultivo. Asimismo, el 53% del área cultivada está dominada por tres cultivos: caña de azúcar, maíz y palto en sus distintas variedades. El fracaso de la Reforma Agraria propició la parcelación de las tierras dando origen a una atomización de pequeños agricultores. Esta situación conlleva a que los agricultores carezcan de capacidad de negociación y asociación que les permita proveerse de insumos a precios menores, así como acceder a una retribución justa del valor de su producción frente a los ingenios azucareros. Esta realidad motiva el desarrollo de un trabajo de investigación que evalúe la viabilidad y factibilidad de implementar una Central de Compras para atender a los agricultores suministrándoles insumos a precios competitivos (debido al poder negociador de las economía de escala a través de la estrategia de importación directa), brindando asesoría técnica para la mejora de la productividad y ofreciéndoles un control de la calidad mediante la medición de la sacarosa, permitiéndoles contar con una herramienta de negociación frente al ingenio. El análisis de los resultados económicos muestra que la Central de Compras es una importante oportunidad de negocio. Con un VAN de S/ 430,751, una TIR de 68.64% y un periodo de recupero de las inversiones de dos años, se concluye que es un modelo rentable y sostenible.The Huaura-Sayan Valley covers an area of 4,770 km² and has agriculture as its main economic activity, where sugarcane predominates. Currently, there are a total of 7,737 farmers with a total of 28,098 hectares of crops and around 108 types of crops. Likewise, 53% of the cultivated area is dominated by three crops: sugarcane, corn and avocado in its different varieties. The failure of the Agrarian Reform led to the division of land giving rise to the atomization of small farmers. This situation leads farmers to lack the capacity for negotiation and association that allows them to provide themselves with inputs at lower prices, as well as access to a fair retribution of the value of their production in front of the sugar mills. Furthermore, this reality brings the opportunity for the implementation of a Supplies Center that in addition to offering products at competitive prices, provides technical advice to the farmer, improving their productivity as well as allowing them access to quality control through the measurement of sucrose, which will allow them to have a negotiation tool in front of the mill. Under a conservative analysis, the economic results of the proposed business model are favorable. With a NPV of S / 430,751, an IRR of 68.64% and a recovery period of two years, it is concluded that it is a profitable and sustainable model.Trabajo de investigació