The Total Syntheses of JBIR-94 and Two Synthetic Analogs and Their Cytotoxicities Against A549 (CCL-185) Human Small Lung Cancer Cells

We here disclose the total syntheses of the natural polyphenol JBIR-94 and two nonnatural analogs, whose structures are of interest for their bioactivity potential as radical scavengers. Although we initially attempted this by dually acylating both of putrecine’s amine nitrogens in a single pot, our endeavors with this method (which has been successfully reported by other groups) proved ineffectual. We accordingly opted for the lengthier approach of acylating each amine individually, which gratuitously prevailed and also aligns with separate literature precedent. Moreover, we here share our analysis of these target compounds’ cytotoxicities and IC50 values against A549 (CCL-185) human small lung cancer cells

The Total Syntheses of JBIR-94 and Two Synthetic Analogs and Their Cytotoxicities Against A549 (CCL-185) Human Small Lung Cancer Cells

We here disclose the total syntheses of the natural polyphenol JBIR-94 and two nonnatural analogs, whose structures are of interest for their bioactivity potential as radical scavengers. Although we initially attempted this by dually acylating both of putrecine’s amine nitrogens in a single pot, our endeavors with this method (which has been successfully reported by other groups) proved ineffectual. We accordingly opted for the lengthier approach of acylating each amine individually, which gratuitously prevailed and also aligns with separate literature precedent. Moreover, we here share our analysis of these target compounds’ cytotoxicities and IC50 values against A549 (CCL-185) human small lung cancer cells

The value and opportunities of community-and citizen-based approaches to tropical forest biodiversity monitoring

The biodiversity sourcebook is accessible in pdf format for free from:•GOFC-GOLD Land Cover Office website: http://www.gofcgold.wur.nl/sites/gofcgold-geobon_biodiversitysourcebook.php•GEO BON website:http://geobon.org

Floristics, stand structure and aboveground biomass of a 25 ha rainforest plot in the Wet Tropics of Australia

Australian wet tropical rainforests are both floristically diverse and high in endemism, and their restricted distribution sees them particularly vulnerable to climate change and other anthropogenic influences. Historically, there are no large-scale studies of the dynamics and drivers of these systems in Australia. We established a 25 ha rainforest plot in the Wet Tropics bioregion of Australia to undertake intensive collection of floristic, structural and ecosystem measurements. An initial census of all stems ≥10 cm diameter at breast height (DBH) recorded 23416 stems from 208 species in 128 genera and 53 families; Lauraceae, Rutaceae, Proteaceae and Elaeocarpaceae were dominant. Endemism was high with 80.3% of species of stems ≥10 cm DBH found on the plot endemic to Australia and 45.2% endemic to the Wet Tropics bioregion. We provide the first measured estimate of basal area (52.0 m2 ha-1) and above ground living biomass (418.5 Mg ha-1) for a large area of Australian rainforest. The data collected from the 25 ha plot provides a baseline description of floristics and stand structure that will facilitate and encourage long term ecological research of forest dynamics and allow direct comparisons to be made with similar plots at a global scale