Non-verbal Communication across Cultures: a Case Study of Chinese, Polish, Turkish and (Yemeni) Arabic Cultures

To establish for a further study examining the degree of similarity and dissimilarity across cultures through four selected cultures (Chinese, Polish, Turkish and Yemeni) in fifteen identified paralanguage features. A non-experimental study was conducted where four participants from the four different countries took part in the study. Each was either interviewed or engaged in a guided discussion towards collecting the required data. Both reliability and validity within the qualitative research framework - credibility, transferability, dependability and confirmability have meet the basic requirement

CitySpec with Shield: A Secure Intelligent Assistant for Requirement Formalization

An increasing number of monitoring systems have been developed in smart cities to ensure that the real-time operations of a city satisfy safety and performance requirements. However, many existing city requirements are written in English with missing, inaccurate, or ambiguous information. There is a high demand for assisting city policymakers in converting human-specified requirements to machine-understandable formal specifications for monitoring systems. To tackle this limitation, we build CitySpec, the first intelligent assistant system for requirement specification in smart cities. To create CitySpec, we first collect over 1,500 real-world city requirements across different domains (e.g., transportation and energy) from over 100 cities and extract city-specific knowledge to generate a dataset of city vocabulary with 3,061 words. We also build a translation model and enhance it through requirement synthesis and develop a novel online learning framework with shielded validation. The evaluation results on real-world city requirements show that CitySpec increases the sentence-level accuracy of requirement specification from 59.02% to 86.64%, and has strong adaptability to a new city and a new domain (e.g., the F1 score for requirements in Seattle increases from 77.6% to 93.75% with online learning). After the enhancement from the shield function, CitySpec is now immune to most known textual adversarial inputs (e.g., the attack success rate of DeepWordBug after the shield function is reduced to 0% from 82.73%). We test the CitySpec with 18 participants from different domains. CitySpec shows its strong usability and adaptability to different domains, and also its robustness to malicious inputs.Comment: arXiv admin note: substantial text overlap with arXiv:2206.0313

Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics.

Progress in the management of patients with myelodysplastic syndromes (MDS) has been hampered by the inability to detect cytogenetic abnormalities in 40-60% of cases. We prospectively analyzed matched pairs of bone marrow and buccal cell (normal) DNA samples from 51 MDS patients by single nucleotide polymorphism (SNP) arrays, and identified somatically acquired clonal genomic abnormalities in 21 patients (41%). Among the 33 patients with normal bone marrow cell karyotypes, 5 (15%) had clonal, somatically acquired aberrations by SNP array analysis, including 4 with segmental uniparental disomies (UPD) and 1 with three separate microdeletions. Each abnormality was detected more readily in CD34+ cells than in unselected bone marrow cells. Paired analysis of bone marrow and buccal cell DNA from each patient was necessary to distinguish true clonal genomic abnormalities from inherited copy number variations and regions with apparent loss of heterozygosity. UPDs affecting chromosome 7q were identified in two patients who had a rapidly deteriorating clinical course despite a low-risk International Prognostic Scoring System score. Further studies of larger numbers of patients will be needed to determine whether 7q UPD detected by SNP array analysis will identify higher risk MDS patients at diagnosis, analogous to those with 7q cytogenetic abnormalities

Identification of the Red Supergiant Progenitor of Supernova 2005cs: Do the Progenitors of Type II-P Supernovae Have Low Mass?

The stars that end their lives as supernovae (SNe) have been directly observed in only a handful of cases, due mainly to the extreme difficulty in identifying them in images obtained prior to the SN explosions. Here we report the identification of the progenitor for the recent Type II-plateau (core-collapse) SN 2005cs in pre-explosion archival images of the Whirlpool Galaxy (M51) obtained with the Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS). From high-quality ground-based images of the SN from the Canada-France-Hawaii Telescope, we precisely determine the position of the SN and are able to isolate the SN progenitor to within 0".04 in the HST/ACS optical images. We further pinpoint the SN location to within 0".005 from HST/ACS ultraviolet images of the SN, confirming our progenitor identification. From photometry of the SN progenitor obtained with the pre-SN ACS images, and also limits to its brightness in pre-SN HST/NICMOS images, we infer that the progenitor is a red supergiant star of spectral type K0--M3, with initial mass 7--9 Msun. We also discuss the implications of the SN 2005cs progenitor identification and its mass estimate. There is an emerging trend that the most common Type II-plateau SNe originate from low-mass supergiants 8--15 Msun.Comment: Submitted to ApJ. A high resolution version can be found at http://astron.berkeley.edu/~weidong/sn05cs.p

Modelling the Interfacial Flow of Two Immiscible Liquids in Mixing Processes

This paper presents an interface tracking method for modelling the flow of immiscible metallic liquids in mixing processes. The methodology can provide an insight into mixing processes for studying the fundamental morphology development mechanisms for immiscible interfaces. The volume-of-fluid (VOF) method is adopted in the present study, following a review of various modelling approaches for immiscible fluid systems. The VOF method employed here utilises the piecewise linear for interface construction scheme as well as the continuum surface force algorithm for surface force modelling. A model coupling numerical and experimental data is established. The main flow features in the mixing process are investigated. It is observed that the mixing of immiscible metallic liquids is strongly influenced by the viscosity of the system, shear forces and turbulence. The numerical results show good qualitative agreement with experimental results, and are useful for optimisating the design of mixing casting processes

Overview of AC microgrid controls with inverter-interfaced generations

Distributed generation (DG) is one of the key components of the emerging microgrid concept that enables renewable energy integration in a distribution network. In DG unit operation, inverters play a vital role in interfacing energy sources with the grid utility. An effective interfacing can successfully be accomplished by operating inverters with effective control techniques. This paper reviews and categorises different control methods (voltage and primary) for improving microgrid power quality, stability and power sharing approaches. In addition, the specific characteristics of microgrids are summarised to distinguish from distribution network control. Moreover, various control approaches including inner-loop controls and primary controls are compared according to their relative advantages and disadvantages. Finally, future research trends for microgrid control are discussed pointing out the research opportunities. This review paper will be a good basis for researchers working in microgrids and for industry to implement the ongoing research improvement in real systems

Non-catalytic Roles of Tet2 Are Essential to Regulate Hematopoietic Stem and Progenitor Cell Homeostasis

The Ten-eleven translocation (TET) enzymes regulate gene expression by promoting DNA demethylation and partnering with chromatin modifiers. TET2, a member of this family, is frequently mutated in hematological disorders. The contributions of TET2 in hematopoiesis have been attributed to its DNA demethylase activity, and the significance of its nonenzymatic functions has remained undefined. To dissect the catalytic and non-catalytic requirements of Tet2, we engineered catalytically inactive Tet2 mutant mice and conducted comparative analyses of Tet2 mutant and Tet2 knockout animals. Tet2 knockout mice exhibited expansion of hematopoietic stem and progenitor cells (HSPCs) and developed myeloid and lymphoid disorders, while Tet2 mutant mice predominantly developed myeloid malignancies reminiscent of human myelodysplastic syndromes. HSPCs from Tet2 knockout mice exhibited distinct gene expression profiles, including downregulation of Gata2. Overexpression of Gata2 in Tet2 knockout bone marrow cells ameliorated disease phenotypes. Our results reveal the non-catalytic roles of TET2 in HSPC homeostasis

Multi-wavelength analysis of the dust emission in the Small Magellanic Cloud

We present an analysis of dust grain emission in the diffuse interstellar medium of the Small Magellanic Cloud (SMC). This study is motivated by the availability of 170 microns ISOPHOT data covering a large part of the SMC, with a resolution enabling to disentangle the diffuse medium from the star forming regions. After data reduction and subtraction of Galactic foreground emission, we used the ISOPHOT data together with HiRes IRAS data and ATCA/Parkes combined HI column density maps to determine dust properties for the diffuse medium. We found a far infrared emissivity per hydrogen atom 30 times lower than the Solar Neighborhood value. The modeling of the spectral energy distribution of the dust, taking into account the enhanced interstellar radiation field, gives a similar conclusion for the smallest grains (PAHs and very small grains) emitting at shorter wavelength. Assuming Galactic dust composition in the SMC, this result implies a difference in the gas-to-dust ratio (GDR) 3 times larger than the difference in metallicity. This low depletion of heavy elements in dust could be specific of the diffuse ISM and not apply for the whole SMC dust if it results from efficient destruction of dust by supernovae explosions.Comment: 11 pages, 10 figures. Accepted for publication in Astronomy & Astrophysic

Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors.

BackgroundIn 31 solid tumor patients treated with the demethylating agent decitabine, we performed tumor biopsies before and after the first cycle of decitabine and used immunohistochemistry (IHC) to assess whether decitabine increased expression of various membrane transporters. Resistance to chemotherapy may arise due to promoter methylation/downregulation of expression of transporters required for drug uptake, and decitabine can reverse resistance in vitro. The endocytosis regulator RhoA, the folate carriers FOLR1 and RFC1, and the glucose transporter GLUT4 were assessed.ResultsPre-decitabine RhoA was higher in patients who had received their last therapy >3 months previously than in patients with more recent prior therapy (P = 0.02), and varied inversely with global DNA methylation as assessed by LINE1 methylation (r = -0.58, P = 0.006). Tumor RhoA scores increased with decitabine (P = 0.03), and RFC1 also increased in patients with pre-decitabine scores ≤150 (P = 0.004). Change in LINE1 methylation with decitabine did not correlate significantly with change in IHC scores for any transporter assessed. We also assessed methylation of the RFC1 gene (alias SLC19A1). SLC19A1 methylation correlated with tumor LINE1 methylation (r = 0.45, P = 0.02). There was a small (statistically insignificant) decrease in SLC19A1 methylation with decitabine, and there was a trend towards change in SLC19A1 methylation with decitabine correlating with change in LINE1 methylation (r = 0.47, P <0.15). While SLC19A1 methylation did not correlate with RFC1 scores, there was a trend towards an inverse correlation between change in SLC19A1 methylation and change in RFC1 expression (r = -0.45, P = 0.19).ConclusionsIn conclusion, after decitabine administration, there was increased expression of some (but not other) transporters that may play a role in chemotherapy uptake. Larger patient numbers will be needed to define the extent to which this increased expression is associated with changes in DNA methylation