497 research outputs found
Preface: Stuck in motion? Capturing the dialectics of movement and stasis in an era of containment
In this special section we rethink the role of movement and stasis in an age of globalization from an existential perspective. We suggest that this theoretical avenue is particularly well suited to move beyond the dualistic binaries that have haunted much writing on mobilities. Rather than fixating movement and stasis into two opposite poles, this perspective allows us to productively work with the overlaps and paradoxes as they appear in the everyday, thereby carving out a dialectics of im/mobility. We argue that exploring the interplay of movement and stasis has become particularly important in the current global political climate, where the mobilities of people and groups deemed troublesome are violently cut short or obstructed in ways that keep them “stuck” in continuous loops of “motion”. By zooming in on the vectorial metaphors migrants and refugees seemingly stuck in immovable conditions deploy to make sense of their situations, we conceptualize both the existential orientation of migratory projects and the wider social and political coordinates impinging on these inner quests for (forward) movement and/or stillness
PTH analoga: vergelijkbaar of verschillend?
Momenteel bestaan er 2 verschillende PTH-analoga: PTH 1-34 (teriparatide) en PTH 1-84. Teriparatide is in Nederland vanaf
februari 2005 verkrijgbaar; inmiddels is sinds januari 2007 ook PTH 1-84 beschikbaar. Teriparatide is geregistreerd voor de
behandeling van vastgestelde osteoporose bij postmenopauzale vrouwen en bij mannen met een verhoogd risico op
botbreuken, PTH 1-84 voor de behandeling van postmenopauzale vrouwen met een verhoogd fractuurrisico.
Teriparatide bestaat uit de eerste 34 aminozuren van het humane parathormoon, op recombinante wijze geproduceerd, het
actieve gedeelte van dit hormoon. De resterende 50 aminozuren staan te boek als het “inactieve” gedeelte van het
parathormoon. PTH 1-84 daarentegen bestaat uit 84 aminozuren, het “volledige” parathormoon; ook dit wordt recombinant
gesynthetiseerd.
In dit artikel zal worden ingegaan op de overeenkomsten en de eventuele verschillen in effectiviteit en veiligheid van
teriparatide en PTH 1-84. Wat betreft de effectiviteit is voor beide middelen een overtuigende reductie van wervelfracturen
aangetoond; alleen voor teriparatide is reductie van niet-wervelfracturen aangetoond. Een andere belangrijke overeenkomst
is dat beide middelen sterk anabool werkzaam zijn, het werkingsmechanisme is essentieel verschillend van bisfosfonaten en
van strontiumranelaat. Beide middelen zijn daarmee voor oudere patiënten met ernstige osteoporose een welkome
aanvulling van het therapeutisch arsenaal. Dit betreft vooral patiënten die ondanks behandeling met bisfosfonaten of
raloxifen of strontiumranelaat na twee wervelinzakkingen opnieuw één of meerdere fracturen krijgen (“inadequate response”),
dan wel bovengenoemde drie middelen niet verdragen. Het is hierbij van belang dat beide middelen voorgeschreven dienen
te worden door de behandelend medisch specialist, bijvoorbeeld de klinisch geriater. Vanwege de hoge kosten van deze
medicamenten, worden deze middelen alleen vergoed bij patiënten die aan bovenstaande criteria voldoen
Analysis of Spatial Distribution of Canada Thistle (Cirsium Arvense) in Notill Soybean (Glycine Max)
The nonuniform spatial distribution of weeds across a field landscape complicates sampling and modeling, but allows site specific rather than broadcast management of weed populations. Where weeds are aggregated, densities measured at random locations are not independent, but rather spatially related or autocorrelated. Geostatistical methods were used to describe and map nonrandom distribution and variation of shoot density across ten well established patches of Canada thistle, a perennial weed, in a 65 hectare notillage soybean field in Moody county, South Dakota in 1996. Canada thistle densities were determined by counting the number of shoots present in a 20 by 50 cm (0.1m2 ) rectangle. Shoot densities were recorded at 3.04 m increments in 8 .directions from the center of each patch using adaptive sampling. The boundary of the thistle patch on each axis was arbitrarily defined as having 2 consecutive measurements of 0 shoots per 0.1 m2 . Contour maps of weed densities were generated and overlaid on field topography maps. A contour map was generated to estimate the size and density of each thistle patch. Generally, the highest densities of Canada thistle appear in the center of the patches. Shoot density within the patches declined as the distance from the center of the patch increased. Near infrared images were generated with a digital camera and compared to weed maps produced with ground scouting
Knee joint stabilization therapy in patients with osteoarthritis of the knee and knee instability: Subgroup analyses in a randomized, controlled trial
Growth rules based on the modularity of the Canarian Aeonium (Crassulaceae) and their phylogenetic value
Decrease of muscle strength is associated with increase of activity limitations in early knee osteoarthritis: 3-year results from the check study
Objective To determine whether a decrease in muscle strength over 3 years is associated with an increase in activity limitations in persons with early symptomatic knee osteoarthritis (OA), and to examine whether the longitudinal association between muscle strength and activity limitations is moderated by knee joint proprioception and laxity
SCOPE: a scorecard for osteoporosis in Europe
Summary
The scorecard summarises key indicators of the burden of osteoporosis and its management in each of the member states of the European Union. The resulting scorecard elements were then assembled on a single sheet to provide a unique overview of osteoporosis in Europe.
Introduction
The scorecard for osteoporosis in Europe (SCOPE) is an independent project that seeks to raise awareness of osteoporosis care in Europe. The aim of this project was to develop a scorecard and background documents to draw attention to gaps and inequalities in the provision of primary and secondary prevention of fractures due to osteoporosis.
Methods
The SCOPE panel reviewed the information available on osteoporosis and the resulting fractures for each of the 27 countries of the European Union (EU27). The information researched covered four domains: background information (e.g. the burden of osteoporosis and fractures), policy framework, service provision and service uptake e.g. the proportion of men and women at high risk that do not receive treatment (the treatment gap).
Results
There was a marked difference in fracture risk among the EU27. Of concern was the marked heterogeneity in the policy framework, service provision and service uptake for osteoporotic fracture that bore little relation to the fracture burden. For example, despite the wide availability of treatments to prevent fractures, in the majority of the EU27, only a minority of patients at high risk receive treatment for osteoporosis even after their first fracture. The elements of each domain in each country were scored and coded using a traffic light system (red, orange, green) and used to synthesise a scorecard. The resulting scorecard elements were then assembled on a single sheet to provide a unique overview of osteoporosis in Europe.
Conclusions
The scorecard will enable healthcare professionals and policy makers to assess their country’s general approach to the disease and provide indicators to inform future provision of healthcare
Biomechanical mechanisms underlying treatment effects of exercise therapy in patients with knee osteoarthritis: data from a randomized controlled trial
The aim of this paper is to briefly show the importance of the spatial organisation and of the temporal evolution of road transport in Belgium (freight, passengers). Attention is particularly put on the negative externalities produced by this transportation mode type (pollution, road damages, road accidents).L'objectif de cet article est de montrer brièvement l'importance de l'organisation spatiale et de l'évolution temporelle du transport routier de marchandises et de passagers en Belgique. Une attention particulière est portée aux externalités négatives produites par ce mode de transport (pollution, dégradations routières, accidents de la route).Het opzet van deze bijdrage bestaat erin om op een beknopte wijze het belang aan te tonen van de ruimtelijke organisatie en evolutie doorheen de tijd van het wegtransport in België (perso-nen zowel als vracht). Er is ook aandacht besteed aan negatieve externaliteiten veroorzaakt door dit type van transportmodus.Thomas Isabelle, Verhetsel Ann. Transport routier et mobilité durable : un état de la question pour la Belgique. In: Hommes et Terres du Nord, 1999/3. La Belgique. pp. 198-204
Synovitis associated with quadriceps weakness in persons with osteoarthritis of the knee: results from the AM-OA cohort
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