Design of Fe3–xO4 raspberry decorated graphene nanocomposites with high performances in lithium-ion battery

Fe3–xO4 raspberry shaped nanostructures/graphene nanocomposites were synthesized by a one-step polyol-solvothermal method to be tested as electrode materials for Li-ion battery (LIB). Indeed, Fe3–xO4 raspberry shaped nanostructures consist of original oriented aggregates of Fe3–xO4 magnetite nanocrystals, ensuring a low oxidation state of magnetite and a hollow and porous structure, which has been easily combined with graphene sheets. The resulting nanocomposite powder displays a very homogeneous spatial distribution of Fe3–xO4 nanostructures at the surface of the graphene sheets. These original nanostructures and their strong interaction with the graphene sheets resulted in very small capacity fading upon Li+ ion intercalation. Reversible capacity, as high as 660 mAh/g, makes this material promising for anode in Li-ion batteries application

Sustained Progression-Free Survival Benefit of Rituximab Maintenance in Patients With Follicular Lymphoma : Long-Term Results of the PRIMA Study

PURPOSE The PRIMA study (ClinicalTrials.gov identifier: NCT00140582) established that 2 years of rituximab maintenance after first-line immunochemotherapy significantly improved progression-free survival (PFS) in patients with follicular lymphoma compared with observation. Here, we report the final PFS and overall survival (OS) results from the PRIMA study after 9 years of follow-up and provide a final overview of safety. METHODS Patients (> 18 years of age) with previously untreated high-tumor-burden follicular lymphoma were nonrandomly assigned to receive one of three immunochemotherapy induction regimens. Responding patients were randomly assigned (stratified by induction regimen, response to induction treatment, treatment center, and geographic region) 1:1 to receive 2 years of rituximab maintenance (375 mg/m(2), once every 8 weeks), starting 8 weeks after the last induction treatment, or observation (no additional treatment). All patients in the extended follow-up provided their written informed consent (data cutoff: December 31, 2016). RESULTS In total, 1,018 patients completed induction treatment and were randomly assigned to rituximab maintenance (n = 505) or observation (n = 513). Consent for the extended follow-up was provided by 607 patients (59.6%) of 1,018 (rituximab maintenance, n = 309; observation, n = 298). After data cutoff, median PFS was 10.5 years in the rituximab maintenance arm compared with 4.1 years in the observation arm (hazard ratio, 0.61; 95% CI, 0.52 to 0.73; P <.001). No OS difference was seen in patients randomly assigned to rituximab maintenance or observation (hazard ratio, 1.04; 95% CI, 0.77 to 1.40; P = .7948); 10-year OS estimates were approximately 80% in both study arms. No new safety signals were observed. CONCLUSION Rituximab maintenance after induction immunochemotherapy provides a significant long-term PFS, but not OS, benefit over observation.Peer reviewe

Environmental Factors Influence Language Development in Children with Autism Spectrum Disorders

International audienc

Autoantibodies against type I IFNs in patients with critical influenza pneumonia

In an international cohort of 279 patients with hypoxemic influenza pneumonia, we identified 13 patients (4.6%) with autoantibodies neutralizing IFN-alpha and/or -omega, which were previously reported to underlie 15% cases of life-threatening COVID-19 pneumonia and one third of severe adverse reactions to live-attenuated yellow fever vaccine. Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-alpha 2 alone (five patients) or with IFN-omega (eight patients) from a cohort of 279 patients (4.7%) aged 6-73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-alpha 2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-omega. The patients' autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients 70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-alpha 2 and IFN-omega (OR = 11.7, P = 1.3 x 10(-5)), especially those <70 yr old (OR = 139.9, P = 3.1 x 10(-10)). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for similar to 5% of cases of life-threatening influenza pneumonia in patients <70 yr old

L'AEROSOLTHERAPIE PAR NEBULISATION (INCOMPATIBILITES MEDICAMENTEUSES)

RENNES1-BU Santé (352382103) / SudocSudocFranceF

La Strange Animal Situation, test appliqué aux enfants avec autisme : mise en évidence de compétences sociales particulières

International audienceLe syndrome autistique est caractérisé par des interactions sociales altérées. Des anecdotes rapportent cependant un lien fort avec les animaux. Afin de mieux appréhender ces questions, de nombreux chercheurs soulignent le besoin d'observations. Afin de comprendre les comportements d'enfants en présence d'un animal non familier, nous avons utilisé une approche éthologique grâce à une grille comportementale à codage simple. La Strange Animal Situation se déroule dans le milieu de vie quotidien de l'enfant, en présence d'un parent et d'un observateur. Nous avons étudié les comportements spontanés d'approche de l'animal par 27 enfants avec autisme comparés à 59 enfants typiques, âgés de 6 à 12 ans. Contrairement aux enfants typiques, les enfants avec autisme se sont peu intéressés à l'animal et ont présenté trois profils comportementaux différents. Le premier concerne des enfants "autocentrés", non intéressés par l'animal et présentant des stéréotypies (n=9). Le second concerne des enfants "confiants", allant droit vers l'animal et le caressant (n=7), profil comparable à la majorité des enfants typiques. Le dernier concerne des enfants "tournés vers l'homme" (n=11) qui, plutôt que d'interagir avec l'animal, ont regardé leur parent et l'observateur, profil non observé chez les enfants typiques. L'expression de certains comportements des enfants avec autisme - dits altérés dans des situations contraintes - semble dépendre en partie du contexte d'étude. Il apparait ici que si certains enfants expriment des comportements propres au syndrome autistique, d'autres se comportent comme des enfants typiques. L'animal ne semble pas aussi attractif que les anecdotes le rapportent. Nous supposons qu'il puisse alors jouer le rôle de catalyseur social permettant à certains enfants de se tourner préférentiellement vers l'homme. Notre étude permet des applications pour les interventions assistées par l'animal et montre l'intérêt des approches éthologiques pour révéler les capacités particulières des enfants avec autisme

Autistic children and pets: What types of interactions? A parent survey

International audiencePeople and pets are able to establish bonds. These bonds are currently used in animal-assistedtherapies to improve social skills of people with communicative difficulties as autismspectrums disorders (ASD; a cognitive disorder, with social withdrawal). However, clearscientific bases proving such effects are still lacking. As a first step, the present studydescribes the interactions between 186 subjects with ASD and their pets, and investigates thepossible influence of the subject's age and of the pet species. On the one hand, only parents ofadults with ASD reported visual interactions with dogs. They never talked about play betweentheir 6-to-9-years-old children and the dogs. The 6-to-12-years-old children are described asinteracted by physical contacts with the cats. On the other hand, some environmental factorsand pet characteristics seemed to modulate the relation described; for example, the relationbetween 6-to-9 year-old children with ASD and their dog seemed to be related to dog size andthe purchase’s reason. Such study could be considered as a first characterisation of therelation that subjects with ASD could develop with their pets. Pet’s adoption could beconsidered in the light of some factors (i.e. purchase for subjects with ASD, subjects’ age,pets’ characteristics). We hypothesize these bonds with pets might be extended by subjectswith ASD to their peers