Perfil do consumidor e oscilações de preços de produtos agroecológicos.

Em todo o mundo, o consumo de alimentos naturais tem aumentado significativamente, e o termo “orgânico” tem se destacado. Em face disto, buscou-se conhecer o perfil do consumidor de alimentos orgânicos, no município de Goiânia (GO), bem como saber quais são as principais dificuldades por ele encontradas, na aquisição destes produtos. Fez-se, também, um levantamento de preços, a fim de serem comparados alimentos orgânicos e convencionais. O principal problema apontado pelos entrevistados, quanto à dificuldade no consumo, foi o fator preço, seguido pela disponibilidade de produtos. Abóbora(Curcubita moschata), berinjela (Solanum melongena), beterraba (Beta vulgaris L.), cenoura (Daucus carota L.), jiló (Solanum gilo Raddi) e pepino (Cucumis sativus) foram os produtos que mais apresentaram variação percentual no preço (convencional x orgânico)

Porous titanium for biomedical applications : an experimental study on rabbits

Objective: The aim of this study was to carry out an in vivo assessment of bone ingrowth in two different types of porous titanium -the first being completely porous, and the second with a porous surface and dense nucleus, manufactured by powder metallurgy- and to evaluate their mechanical properties. Study design: Ten scaffolds from each group were submitted to metallographic analysis and compression tests. Next, two scaffolds of each type were inserted into 14 rabbits, which were sacrificed 8 weeks after surgery. The samples were submitted for histological examination. Results: Metallographic analysis revealed interconnected pores, and the average interconnected pore diameter was about 360 mm, with 36% total porosity. The totally porous titanium samples and the titanium samples with porous surface and dense nucleus showed an average compressive strength of 16.19 MPa and 69.27 MPa, respectively. After 8 weeks, the animals showed bone ingrowth, even into the most internal pores. Conclusions: The pore morphology was effective in permitting bone ingrowth in both groups. Titanium scaffolds with a porous surface and dense nucleus showed the best mechanical properties and most adequate interface

Management and treatment of decompensated hepatic fibrosis and severe refractory Schistosoma mansoni ascites with transjugular intrahepatic portosystemic shunt

This study aimed to report the first case of a patient with hepatosplenic schistosomiasis mansoni, refractory ascites and portal vein thrombosis treated with a transjugular intrahepatic portosystemic shunt (TIPS), at the Instituto de Radiologia, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Brazil. After the procedure, the patient recovered favorably and progressed with portal pressure reduction and no deterioration of the liver function. Endovascular shunt modification is a conservative medical approach that often helps in reducing symptoms significantly, making it a less invasive and a safer alternative to liver transplantation for the treatment of schistosomiasis with portal hypertension

ZONEAMENTO AMBIENTAL DA MICROBACIA HIDROGRÁFICA DO AÇUDE DA CACHOEIRA – CEARÁ, BRASIL

ENVIRONMENTAL ZONING OF MICRO WATERSHED AÇUDE DA CACHOEIRA – CEARÁ, BRAZILZONIFICACIÓN AMBIENTAL DE LA MICRO CUENCA HIDROGRÁFICA DEL AÇUDE DA CACHOEIRA – CEARÁ, BRASILRESUMOA bacia hidrográfica, considerada como um conjunto de terras drenadas por um corpo d’água principal e seus afluentes, representa a unidade mais apropriada para o estudo qualitativo e quantitativo dos recursos hídricos, sendo uma unidade ambiental que possibilita tratar dos componentes e da dinâmica das inter-relações necessárias ao planejamento e à gestão ambiental. Os impactos de degradação em bacias hidrográficas são advindos dos múltiplos usos, má gestão e ações antrópicas, sendo necessários o controle e a regulação de ocupação do solo visando à manutenção da qualidade, quantidade e regularidade da água para seus diversos usos. Dessa forma, o presente estudo teve por objetivo realizar a delimitação da Microbacia Açude da Cachoeira – MAC, localizada em maior parte no município de Aurora, estado do Ceará, bem como identificar e discutir dados gerais sobre a rede de drenagem, os parâmetros morfométricos, carta temática hidrográfica, relevo e Áreas de Preservação Permanente – APP’s. Os dados foram obtidos por meio do software gratuito QGIS com auxílio da ferramenta Google Earth Pro para a determinação da microbacia e rede de drenagem, além da delimitação das APP’s dos corpos hídricos e análise das potencialidades. Como resultados, constatou-se que a rede de drenagem da MAC apresenta baixa distribuição do escoamento, no qual oferece um menor risco a enchentes em picos de intensidades chuvosas. Além disso, seus canais de drenagem dispõem de um ordenamento hídrico de quarta ordem e seu escoamento global a classifica como uma bacia endorreica.Palavras-chave: Análise Morfométrica; Rede de Drenagem; Semiárido Brasileiro.ABSTRACTThe watershed, considered as a set of lands drained by a main body of water and its tributaries, represents the most appropriate unit for the qualitative and quantitative study of water resources, being an environmental unit that allows to treat the components and use the necessary interrelationships for environmental planning and management. The impacts of degradation in watersheds are the result of multiple uses, mismanagement and anthropic actions, requiring the control and regulation of land occupation in order to maintain the quality, quantity and regularity of water for its various uses. Thus, the present study aimed to delineate the Açude da Cachoeira watershed - ACMW, located mostly in the municipality of Aurora, Ceará state, as well as to identify and discuss general data about the drainage network, the morphometric parameters, hydrographic thematic chart, relief and Permanent Preservation Areas – PPA’s. The data were obtained through the free software QGIS with the aid of the Google Earth Pro tool for the determination of the micro watershed and drainage network, as well as the delimitation of water bodies PPA’s and potentiality analysis. As a result, it was found that the ACMW drainage network has low runoff distribution, which offers a lower risk of flooding at rainy peak. In addition, its drainage channels have a fourth order water structure and its global flow classifies it as an endorheic basin.Keywords: Morphometric Analysis; Drainage Network; Brazilian Semiarid.RESUMENLa cuenca hidrográfica, considerada como un conjunto de tierras drenadas por un cuerpo principal de agua y sus afluentes, representa la unidad más apropiada para el estudio cualitativo y cuantitativo de los recursos hídricos, siendo una unidad ambiental que permite tratar dos componentes de las interrelaciones dinámicas necesarias para la planificación y gestión ambiental. Los impactos de la degradación en las cuencas hidrográficas son el resultado de múltiples usos, mala gestión y acciones antrópicas, que requieren el control y la regulación de la ocupación de la tierra para mantener la calidad, cantidad y regularidad del agua para sus diversos usos. Por lo tanto, el presente estudio tuvo como objetivo delinear la micro cuenca hidrográfica del Açude da cachoeira- MHAC, ubicada principalmente en el municipio de Aurora, estado de Ceará, así como identificar y discutir datos generales sobre la red de drenaje, los parámetros morfométricos, carta temática hidrográfica, relieve y áreas de preservación permanente - APP's. Los datos se obtuvieron a través del software gratuito QGIS con la ayuda de la herramienta Google Earth Pro para la determinación de la red de micro cuencas y drenaje, además de la delimitación de las aplicaciones de los cuerpos de agua y el análisis de las potencialidades. Como resultado, se descubrió que la red de drenaje MHAC tiene una baja distribución de escorrentía, lo que ofrece un menor riesgo de inundación en el pico lluvioso. Además, sus canales de drenaje tienen un ordenamiento hidrico de cuarto orden y su flujo global lo clasifica como una microcuenca endorreica.Palabras clave: Análisis Morfométrico; Red de Drenaje; Semiárido Brasileño

Utilização do conceito “Milk Run” para redução dos custos logísticos em uma indústria automobilística

O presente trabalho apresenta um estudo de caso sobre a implementação de uma rota “Milk Run” e mostra como esta ferramenta pode ajudar a diminuir os custos e desperdícios resultantes da operação de entrega de componentes em uma montadora de veículos, com base nas premissas estabelecidas na filosofia “Lean”. Além disso, apresenta um roteiro com  os passos utilizados para o planejamento e operacionalização de uma rota de distribuição e transporte de peças. O estudo analisa a situação dos fornecedores que utilizam o centro de consolidação de carga como apoio a seus processos de entrega e, somente para eles, foram realizados os estudos de viabilidade de implementação da ferrament

Gestational malaria associated to Plasmodium vivax and Plasmodium falciparum placental mixed-infection followed by foetal loss: a case report from an unstable transmission area in Brazil

Gestational malaria is a multi-factorial syndrome leading to poor outcomes for both the mother and foetus. Although an unusual increasing in the number of hospitalizations caused by Plasmodium vivax has been reported in Brazil, mortality is rarely observed. This is a report of a gestational malaria case that occurred in the city of Manaus (Amazonas State, Brazil) and resulted in foetal loss. The patient presented placental mixed-infection by Plasmodium vivax and Plasmodium falciparum after diagnosis by nested-PCR, however microscopic analysis failed to detect P. falciparum in the peripheral blood. Furthermore, as the patient did not receive proper treatment for P. falciparum and hospitalization occurred soon after drug treatment, it seems that P. falciparum pathology was modulated by the concurrent presence of P. vivax. Collectively, this case confirms the tropism towards the placenta by both of these species of parasites, reinforces the notion that co-existence of distinct malaria parasites interferes on diseases' outcomes, and opens discussions regarding diagnostic methods, malaria treatment during pregnancy and prenatal care for women living in unstable transmission areas of malaria, such as the Brazilian Amazon

O financiamento da Atenção Básica no Brasil: um balanço de duas décadas (2000-2020)

This article analyzes the primary healthcare financing in Brazil between 2000 and 2020. We conducted an integrative review of the scientific productions available in the electronic scientific databases BVS, Scielo, and MEDLINE in December 2020. After including articles undertaken in Brazil, with free access, and excluding duplicates and non-scientific texts, ten articles were selected. Those articles were submitted to Thematic Content Analysis and organized into two categories (1) “Municipal differences in the financing of Primary Care” and (2) “Tripartite Financing of Primary Care”. The results of this review pointed out several inequalities in the financing of primary healthcare. Although federal participation in the budget has grown during the analyzed period, the transfers occurred due to incentives for the adoption of federal programs that did not reach the municipalities homogeneously. Compared to the South and Southeast, small municipalities in the North and Northeast regions had greater dependence on federal transfers. In addition, there was lower state participation in the overall financing in the North and Northeast regions. The main limitation of our review was not including studies published since 2021 analyzing the impacts of recent policies that aggravated the underfunding of primary healthcare in Brazil, which could have potentially worsened the results presented in this study and put primary healthcare quality and preservation even more at risk.Este artigo analisa o financiamento da Atenção Básica do Brasil entre 2000 e 2020 a partir de uma revisão integrativa das produções científicas disponíveis nas bases científicas eletrônicas BVS, SciELO e MEDLINE. Foram elegíveis artigos com acesso gratuito e situados no Brasil, excluindo duplicados e textos não científicos. Após aplicados os critérios de inclusão e exclusão, foram selecionados dez artigos, os quais foram submetidos à análise de conteúdo temática e organizados em duas categorias: (1) “Diferenças municipais no financiamento da Atenção Básica” e (2) “Financiamento tripartite da Atenção Básica”. Os resultados apontam para diversas desigualdades no financiamento desse nível de atenção. Apesar do crescimento da participação federal, as transferências ocorreram por incentivos à adoção de programas federais que não alcançaram os municípios homogeneamente. Houve maior dependência das transferências federais em municípios pequenos e nas regiões Norte e Nordeste, além de baixa participação estadual no financiamento. Um dos limites do estudo foi não alcançar, pelo recorte temporal, estudos analisando os impactos das atuais políticas que agravaram o desfinanciamento da Atenção Básica, que provavelmente tem piorado o contexto apresentado e colocado ainda mais em risco a qualidade e preservação dela

Efficacy and Safety of Oral Midazolam Sedation Compared with its Combination with Hydroxyzine Use in Pediatric Dentistry: A Systematic Review

Objective: To assess the efficacy and safety of the use of midazolam as monotherapy, compared to the associated use of midazolam and hydroxyzine for minimum and moderate sedation of children in dental offices, using data obtained from clinical trials. Material and Methods: A systematic review protocol was developed and registered on PROSPERO (CR42020208633). An electronic search was carried out in Pubmed, Lilacs, Science Direct, Open Gray, Web of Science, and central Cochrane Library. No language restrictions were included. Clinical trials were carried out with children aged 0-12 years, using midazolam as monotherapy compared to the use of midazolam associated with hydroxyzine to verify the effectiveness and safety of oral sedation. The quality of the studies was individually assessed and grouped using the RoB 2 (Revised Cochrane risk-of-bias tool for randomized trials) and GRADE (Grading of Recommendations Assessment, Development and Evaluation) systems, respectively. Results: A total of 749 studies were found. After analyzing the inclusion and removal of duplicates, two studies were analyzed for the quality of evidence. Through this analysis, it was possible to verify the very low level of scientific evidence on the superiority of the efficacy and safety of the combined use of midazolam and hydroxyzine for oral sedation in children in dental offices. Conclusion: The conflicting results and limitations of the studies enabled to establish that there is insufficient evidence to support the use of these drugs combined. There is only evidence for the use of midazolam as monotherapy

Novel homologous lactate transporter improves l‑lactic acid production from glycerol in recombinant strains of Pichia pastoris

Background: Crude glycerol is the main byproduct of the biodiesel industry. Although it can have different applications, its purification is costly. Therefore, in this study a biotechnological route has been proposed for further utilization of crude glycerol in the fermentative production of lactic acid. This acid is largely utilized in food, pharmaceutical, textile, and chemical industries, making it the hydroxycarboxylic acid with the highest market potential worldwide. Currently, industrial production of lactic acid is done mainly using sugar as the substrate. Thus here, for the first time, Pichia pastoris has been engineered for heterologous l-lactic acid production using glycerol as a single carbon source. For that, the Bos taurus lactate dehydrogenase gene was introduced into P. pastoris. Moreover, a heterologous and a novel homologous lactate transporter have been evaluated for l-lactic acid production. Results: Batch fermentation of the P. pastoris X-33 strain producing LDHb allowed for lactic acid production in this yeast. Although P. pastoris is known for its respiratory metabolism, batch fermentations were performed with different oxygenation levels, indicating that lower oxygen availability increased lactic acid production by 20 %, pushing the yeast towards a fermentative metabolism. Furthermore, a newly putative lactate transporter from P. pastoris named PAS has been identified by search similarity with the lactate transporter from Saccharomyces cerevisiae Jen1p. Both heterologous and homologous transporters, Jen1p and PAS, were evaluated in one strain already containing LDH activity. Fed-batch experiments of P. pastoris strains carrying the lactate transporter were performed with the batch phase at aerobic conditions followed by an aerobic oxygen-limited phase where production of lactic acid was favored. The results showed that the strain containing PAS presented the highest lactic acid titer, reaching a yield of approximately 0.7 g/g. Conclusions: We showed that P. pastoris has a great potential as a fermentative organism for producing l-lactic acid using glycerol as the carbon source at limited oxygenation conditions (below 0.05 % DO in the bioreactor). The best strain had both the LDHb and the homologous lactate transporter encoding genes expressed, and reached a titer 1.5 times higher than the strain with the S. cerevisiae transporter. Finally, it was also shown that increased lactic acid production was concomitant to reduction of acetic acid formation by half

Perfil nutricional e consumo de suplemento alimentar de atletas de futebol em um clube profissional de São Luís-MA

A nutrição adequada não pode compensar a falta de habilidade ou condicionamento físico deficiente, mas pode ajudar o jogador a potencializar sua habilidade e rendimento. Um atleta bem nutrido rende mais, se recupera mais rápido e consegue melhores resultados. O presente estudo tem como objetivo avaliar o perfil nutricional e o consumo de suplementos de atletas em um clube de futebol de São Luís-MA. A população do estudo foi constituída por 26 atletas do naipe masculino com idade entre 18 a 35 anos, entretanto apenas 21 atletas foram recrutados de acordo com os critérios de seleção. Para coleta de dados fora aplicado o recordatório de 24h, para a mensuração da massa corporal total e a estatura foi utilizada a balança com estadiomêtro (Welmy – modelo W300).  As variáveis foram avaliadas através do software BioEstat 5.0. Para definição do o perfil nutricional foi utilizado o Software Avanutri 9.0. Os atletas apresentaram idade de 25,67 ±3,83 anos, estatura de 1,76± 0,08 metros; massa corporal de 74,86 ± 6,53 Kg; IMC de 24,07 ± 1,08 Kg/ m, os atletas apresentaram um déficit na proporção entre gasto energético total e o valor energético Gasto Energético total de 3.574,35 ± 505,99 Kcal; Valor Energético Total de 2.926,86 ± 420,59 Kcal. O consumo de suplementos alimentares é significante chegando a 100%, os suplementos mais utilizados pela amostra foram: Whey Protein e Maltodextrina. ABSTRACTNutritional profile and food supplement intake of football athletes in a professional club of São Luís-MAProper nutrition can not compensate lack of skill or poor physical conditioning, but can help the player to potentiate his ability and performance. A well-nourished athlete earns more, recovers faster, and gets better results. The present study aims to evaluate the nutritional profile and consumption of athlete supplements in a football club in São Luís-MA. The study population consisted of 26 male athletes from 18 to 35 years of age, but only 21 athletes were recruited according to the selection criteria. For the data collection, the 24h recall was used to measure the total body mass and stature. The scale was used with Weli - W300 model. The variables were evaluated using BioEstat 5.0 software. To define the nutritional profile, the Avanutri 9.0 Software was used. The athletes had an age of 25.67 ± 3.83 years, height of 1.76 ± 0.08 meters; Body mass of 74.86 ± 6.53 kg; BMI of 24.07 ± 1.08 kg / m, the athletes presented a deficit in the proportion between total energy expenditure and the energy value. Total Energy Expenditure of 3,574.35 ± 505.99 Kcal; Total Energy Value of 2,926.86 ± 420.59 Kcal. The consumption of food supplements is significant reaching 100%, the supplements most used by the sample were: Whey Protein and Maltodextrin