Fabrication and characterization of porous metal emitters for electrospray applications

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2008.Includes bibliographical references (leaves 137-140).Electrospray thrusters provide small, precise thrust with high power efficiencies and variable specific impulses from less than 1000s to over 4000s. The miniaturization and clustering of many emitters together is essential to increase the thrust density of electrospray devices in order to increase their domain of applicability in space. Electrospray emitter arrays have many advantages over existing electric propulsion devices including much lower mass per unit thrust and much lower volume per unit thrust than conventional ion and hall devices. Additionally, with emitter clustering, the thrust density can meet and even exceed that of hall or ion thrusters. A method of micro-fabricating electrospray emitter arrays using modified conventional microfabrication technology is presented. The method is adaptable to different emitter materials and can be used to create ultra dense emitter arrays with microfabrication precision down to the micron level. One-dimensional linear emitter arrays with emitter separation as low as 500 [mu]m have been fabricated out of porous tungsten and preliminary tests show that dense two-dimensional emitter arrays can be fabricated with emitter separations down to 300[mu]m. Experimental research that was conducted to characterize emitter array performance is also presented. Time of flight mass spectrometry was used to identify the emitted ion species from the device, which showed that the device operates in the ion emission regime. Current was collected as a function of applied voltage to show that the devices were able to operate with emitted current levels of 0.5 - 1.5 [mu]A per emitter, even for dense arrays. Direct thrust measurements were performed to show that the amount of thrust attainable is on the order of 0.1 [mu]N per [mu]A of emitted current for extraction voltages of around 1900 V.(cont.) A normalization scheme was implemented to compare performance of emitter arrays of different density and initial results from a numerical model has shown that the emitters might be limited by fluid transport.by Robert S. Legge Jr.S.M

TID Tolerance of Popular CubeSat Components

In this paper we report total dose test results of COTS components commonly used on CubeSats. We investigate a variety of analog integrated circuits, a popular microcontroller (PIC24) as well as SD memory card

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

publisher: Elsevier articletitle: Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes journaltitle: Cell articlelink: https://doi.org/10.1016/j.cell.2018.05.046 content_type: article copyright: © 2018 Elsevier Inc

Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies

Optimization and valuation of recongurable satellite constellations under uncertainty/

Thesis: Ph. D., Massachusetts Institute of Technology, Department of Aeronautics and Astronautics, 2014.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 303-320).Space-based persistent surveillance provides decision makers with information necessary to effectively respond to both natural and man-made crises. This thesis investigates a reconfigurable constellation strategy that utilizes on-demand, maneuverable satellites to provide focused regional coverage with short revisit times at greatly decreased cost when compared to traditional static satellite constellations. The thesis develops and demonstrates a general framework to guide the design and optimization of recongurable satellite constellations specifically tailored to stakeholder objectives while considering requirement uncertainty. The framework is novel in that it avoids many of the assumptions and simplifications of past research by: 1. explicitly considering uncertainty in future operating conditions; 2. concurrently optimizing constellation pattern design, satellite design, and operations design; and, 3. investigating layered and asymmetric patterns. The framework consists of three elements: a detailed simulation model to compute constellation performance and cost for a variety of architectures and patterns, Monte Carlo simulation to determine how well each design performs under uncertain future conditions, and a parallel multi-objective evolutionary algorithm developed from the [epsilon]-NSGA-II genetic algorithm to nd designs that maximize performance while simultaneously minimizing cost. Additionally, a new performance metric is developed to measure directly how well a design meets desired temporal and spatial sampling requirements and a decision model and optimal assignment process is developed to determine how to employ the option of reconfigurability to respond to specific regional events. The framework was used to perform 85 optimization runs selected to compare the cost-effectiveness of several constellation architectures over varied operating conditions and coverage requirements. All optimization runs were performed in less than three months, demonstrating that parallel computing coupled with sophisticated optimization routines enable rapid spiral development of satellite constellations. Results show that recongurable constellations cost 20 to 70% less than similarly performing static constellations for the scenarios studied. The cost savings grows with increasingly demanding coverage requirements. Results from optimizing a fully asymmetric constellation pattern led to two the development of new 'quasi'-asymmetric patterns that were found to significantly outperform symmetric patterns for providing discontinuous coverage. Additionally, results show that the sun-synchronous and rapid launch architectures are the least cost-eective approaches.by Robert Scott Legge Jr.Ph. D

Public Opinion, Risk Assessment, and Biotechnology: Lessons from Attitudes toward Genetically Modified Foods in the European Union

Proponents of biotechnology argue that citizens' opposition to innovations such as genetically modified (GM) foods is rooted in emotionalism, media and nongovernmental organizations' distortions of good science, and scientific ignorance. Critics charge that this "risk management discursive" is too reductionist, exaggerates scientific capacity, inappropriately privileges scientific values over social and political values, and inaccurately captures how citizens evaluate biotechnology. This article uses ordered logit analysis applied to the responses of Europeans to a 2005 Eurobarometer survey to test the validity of these competing perspectives in the area of GM foods. Our analysis supports the arguments of those calling for the inclusion of broader discursive social, political, and cultural elements in deliberations over GM foods. Analysis also shows that citizens are less emotional in evaluating GM foods than proponents claim and supports this "new politics of knowledge" perspective, but citizens also cling more tightly to hopes that science can resolve debates with objective analysis. Copyright 2010 by The Policy Studies Organization.

Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans

Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn's disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1–V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obstacle by applying a centralized analysis pipeline to a SCZ cohort of 21,094 cases and 20,227 controls. A global enrichment of CNV burden was observed in cases (odds ratio (OR) = 1.11, P = 5.7 x 10(-15)), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 x 10(-6)). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 x 10(-11)) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 x 10(-5)). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination