472 research outputs found
First inappropriate implantable cardioverter defibrillator therapy is often due to inaccurate device programming: analysis of the French OPERA registry
AIMS:Inappropriate therapy delivered by implantable cardioverter defibrillators (ICDs) remains a challenge. The OPERA registry measured the times to, and studied the determinants of, first appropriate (FAT) and inappropriate (FIT) therapies delivered by single-, dual- and triple-chamber [cardiac resynchronization therapy defibrillator (CRT-D)] ICD. METHODS AND RESULTS: We entered 636 patients (mean age = 62.0 ± 13.5 years; 88% men) in the registry, of whom 251 received single-, 238 dual-, and 147 triple-chamber ICD, for primary (30.5%) or secondary (69.5%) indications. We measured times to FAT and FIT as a function of multiple clinical characteristics, examined the effects of various algorithm components on the likelihood of FAT and FIT delivery, and searched for predictors of FAT and FIT. Over 22.8 ± 8.8 months of observation, 184 patients (28.9%) received FAT and 70 (11.0%) received FIT. Ventricular tachycardia (VT) was the trigger of 88% of FAT, and supraventricular tachycardia was the trigger of 91% of FIT. The median times to FIT (90 days; range 49-258) and FAT (171 days; 50-363) were similar. The rate of FAT was higher (P <0.001) in patients treated for secondary than primary indications, while that of FIT were similar in both groups. Out of 57 analysable FIT, 27 (47.4%) could have been prevented by fine tuning the device programming like the sustained rate duration or the VT discrimination algorithm. CONCLUSIONS: First inappropriate therapy occurred in 11% of 636 ICD recipients followed for âŒ2 years. Nearly 50% of FIT could have been prevented by improving device programming
Three-body correlations in Borromean halo nuclei
Three-body correlations in the dissociation of two-neutron halo nuclei are
explored using a technique based on intensity interferometry and Dalitz plots.
This provides for the combined treatment of both the n-n and core-n
interactions in the exit channel. As an example, the breakup of 14Be into
12Be+n+n by Pb and C targets has been analysed and the halo n-n separation
extracted. A finite delay between the emission of the neutrons in the reaction
on the C target was observed and is attributed to 13Be resonances populated in
sequential breakup.Comment: 5 pages, 4 figures, submitted to PR
Nomenclature and semantic description of vascular lesions in small bowel capsule endoscopy: an international Delphi consensus statement
Background and study aims \u2002Nomenclature and descriptions of small bowel (SB) vascular lesions in capsule endoscopy (CE) are scarce in the medical literature. They are mostly based on the reader's opinion and thus differ between experts, with a potential negative impact on clinical care, teaching and research regarding SBCE. Our aim was to better define a nomenclature and to give a description of the most frequent vascular lesions in SBCE. Methods \u2002A panel of 18 European expert SBCE readers was formed during the UEGW 2016 meeting. Three experts constructed an Internet-based four-round Delphi consensus, but did not participate in the voting process. They built questionnaires that included various still frames of vascular lesions obtained with a third-generation SBCE system. The 15 remaining participants were asked to rate different proposals and description of the most common SB vascular lesions. A 6-point rating scale (varying from 'strongly disagree' to 'strongly agree') was used successive rounds. The consensus was reached when at least 80\u200a% voting members scored the statement within the 'agree' or 'strongly agree'. Results \u2002Consensual terms and descriptions were reached for angiectasia/angiodysplasia, erythematous patch, red spot/dot, and phlebectasia. A consensual description was reached for more subtle vascular lesions tentatively named "diminutive angiectasia" but no consensus was reached for this term. Conclusion \u2002An international group has reached a consensus on the nomenclature and descriptions of the most frequent and relevant SB vascular lesions in CE. These terms and descriptions are useful in daily practice, for teaching and for medical research purposes
Ventricular fibrillation treated by cryotherapy to the right ventricular outflow tract: a case report.
BACKGROUND: Arrhythmias originating from the right ventricular outflow tract are generally considered benign but cases of cardiac arrest have been described, usually associated with polymorphic ventricular tachycardia or extrasystoles with short coupling intervals. CASE PRESENTATION: We report the case of a 54-year-old Caucasian woman with symptomatic right ventricular outflow tract arrhythmias without structural heart disease who suffered a ventricular fibrillation arrest without prior malignant clinical features. Cryoablation was performed and an implantable cardioverter defibrillator was implanted. She has since been free of arrhythmia for 7 years and has asked that the implantable cardioverter defibrillator not be replaced when the battery becomes depleted. CONCLUSIONS: Although usually benign, right ventricular outflow tract tachycardia can be life-threatening. Even the most malignant cases can be cured by ablation
Crossing the Dripline to 11N Using Elastic Resonance Scattering
The level structure of the unbound nucleus 11N has been studied by 10C+p
elastic resonance scattering in inverse geometry with the LISE3 spectrometer at
GANIL, using a 10C beam with an energy of 9.0 MeV/u. An additional measurement
was done at the A1200 spectrometer at MSU. The excitation function above the
10C+p threshold has been determined up to 5 MeV. A potential-model analysis
revealed three resonance states at energies 1.27 (+0.18-0.05) MeV (Gamma=1.44
+-0.2 MeV), 2.01(+0.15-0.05) MeV, (Gamma=0.84 +-$0.2 MeV) and 3.75(+-0.05) MeV,
(Gamma=0.60 +-0.05 MeV) with the spin-parity assignments I(pi) =1/2+, 1/2- and
5/2+, respectively. Hence, 11N is shown to have a ground state parity inversion
completely analogous to its mirror partner, 11Be. A narrow resonance in the
excitation function at 4.33 (+-0.05) MeV was also observed and assigned
spin-parity 3/2-.Comment: 14 pages, 9 figures, twocolumn Accepted for publication in PR
The detection of neutron clusters
A new approach to the production and detection of bound neutron clusters is
presented. The technique is based on the breakup of beams of very neutron-rich
nuclei and the subsequent detection of the recoiling proton in a liquid
scintillator. The method has been tested in the breakup of 11Li, 14Be and 15B
beams by a C target. Some 6 events were observed that exhibit the
characteristics of a multineutron cluster liberated in the breakup of 14Be,
most probably in the channel 10Be+4n. The various backgrounds that may mimic
such a signal are discussed in detail.Comment: 11 pages, 12 figures, LPCC 01-1
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