Symmetric generation of finite homomorphic images?

The purpose of this thesis was to present the technique of double coset enumeration and apply it to construct finite homomorphic images of infinite semidirect products. Several important homomorphic images include the classical groups, the Projective Special Linear group and the Derived Chevalley group were constructed

Managerial Ability and the Quality of Firms’ Information Environment

In this study, we examine the relation between managerial ability and the quality of a firm’s information environment. An emerging stream of research has identified managerial ability as an important determinant of accruals quality and management forecast quality. However, our understanding of the impact of managerial ability on a firm’s broader information environment is incomplete because it captures more than these specific financial reporting disclosures. Using a composite index based on various proxies for a firm’s information environment, we find a positive relation between managerial ability and a firm’s information environment. Consistent with our argument that managers’ equity incentives improve disclosure quality, we find that the quality of a firm’s information environment improves when managers have higher levels of equity incentives. We contribute to the literature by providing more complete and conclusive evidence about the impact of managerial ability on a firm’s broader information environment

The relation between the diagonal entries and the eigenvalues of a symmetric matrix, based upon the sign pattern of its off-diagonal entries

It is known that majorization is a complete description of the relationships between the eigenvalues and diagonal entries of real symmetric matrices. However, for large subclasses of such matrices, the diagonal entries impose much greater restrictions on the eigenvalues. Motivated by previous results about Laplacian eigenvalues, we study here the additional restrictions that come from the off-diagonal sign-pattern classes of real symmetric matrices. Each class imposes additional restrictions. Several results are given for the all nonpositive and all nonnegative classes and for the third class that appears when n = 4. Complete description of the possible relationships are given in low dimensions. (C) 2012 Elsevier Inc. All rights reserved

Nonpositive Eigenvalues of the Adjacency Matrix and Lower Bounds for Laplacian Eigenvalues

Let $NPO(k)$ be the smallest number $n$ such that the adjacency matrix of any undirected graph with $n$ vertices or more has at least $k$ nonpositive eigenvalues. We show that $NPO(k)$ is well-defined and prove that the values of $NPO(k)$ for $k=1,2,3,4,5$ are $1,3,6,10,16$ respectively. In addition, we prove that for all $k \geq 5$, $R(k,k+1) \ge NPO(k) > T_k$, in which $R(k,k+1)$ is the Ramsey number for $k$ and $k+1$, and $T_k$ is the $k^{th}$ triangular number. This implies new lower bounds for eigenvalues of Laplacian matrices: the $k$-th largest eigenvalue is bounded from below by the $NPO(k)$-th largest degree, which generalizes some prior results.Comment: 23 pages, 12 figure

Influence of rural-urban migration on the fertility of migrants in developing

노트 : Final repor

Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice

<p>Abstract</p> <p>Background</p> <p>The identification of novel genes is critical to understanding the molecular basis of body weight. Towards this goal, we have identified secretogranin V (<it>Scg5</it>; also referred to as <it>Sgne1</it>), as a candidate gene for growth traits.</p> <p>Results</p> <p>Through a combination of DNA microarray analysis and quantitative PCR we identified a strong expression quantitative trait locus (eQTL) regulating <it>Scg5 </it>expression in two mouse chromosome 2 congenic strains and three additional F2 intercrosses. More importantly, the eQTL was coincident with a body weight QTL in congenic mice and <it>Scg5 </it>expression was negatively correlated with body weight in two of the F2 intercrosses. Analysis of haplotype blocks and genomic sequencing of <it>Scg5 </it>in high (C3H/HeJ, DBA/2J, BALB/cByJ, CAST/EiJ) and low (C57BL/6J) expressing strains revealed mutations unique to C57BL/6J and possibly responsible for the difference in mRNA abundance. To evaluate the functional consequence of <it>Scg5 </it>overexpression we measured the pituitary levels of 7B2 protein and PCSK2 activity and found both to be increased. In spite of this increase, the level of pituitary α-MSH, a PCSK2 processing product, was unaltered.</p> <p>Conclusion</p> <p>Together, these data support a role for <it>Scg5 </it>in the modulation of body weight.</p

Sexual stage-specific expression of a third calcium-dependent protein kinase from Plasmodium falciparum.

A third calcium-dependent protein kinase (CDPK) gene has been isolated from the human malaria parasite Plasmodium falciparum by vectorette technology. The gene consists of five exons and four introns. The open reading frame resulting from removal of the four introns encodes a protein of 562 amino acid residues with a predicted molecular mass of 65.3 kDa. The encoded protein, termed PfCDPK3, consists of four distinct domains characteristic of a member of the CDPK family and displays the highest homology (46% identity and 69% similarity) to PfCDPK2, the second CDPK of P. falciparum. The N-terminal variable domain is rich in serine/threonine and lysine and contains multiple consensus phosphorylation sites for a range of protein kinases. The catalytic domain possesses all conserved motifs of the protein kinase family except for the highly conserved glutamic acid residue in subdomain VIII, which is replaced by a glutamine residue. The sequence of the junction domain comprising 31 amino acid residues is less conserved. The calmodulin-like regulatory domain contains four EF-hand calcium-binding motifs, each consisting of a loop of 12 amino acid residues which is flanked by two alpha-helices. Southern blotting of genomic DNA digests showed that the Pfcdpk3 gene is present as a single copy per haploid genome. A 2900 nucleotide transcript of this gene is expressed specifically in the sexual erythrocytic stage, indicating that PfCDPK3 is involved in sexual stage-specific events. It is proposed that PfCDPK3 may serve as a link between calcium and gametogenesis of P. falciparum

COMPUTER TECHNIQUE IN RAILWAY CONSTRUCTION AND OPERATION

Laboratory mice develop populations of circulating memory CD4+ T cells in the absence of overt infection. We have previously shown that these populations are replenished from naive precursors at high levels throughout life (Gossel et al., 2017). However, the nature, relative importance and timing of the forces generating these cells remain unclear. Here, we tracked the generation of memory CD4+ T cell subsets in mice housed in facilities differing in their 'dirtiness'. We found evidence for sequential naive to central memory to effector memory development, and confirmed that both memory subsets are heterogeneous in their rates of turnover. We also inferred that early exposure to self and environmental antigens establishes persistent memory populations at levels determined largely, although not exclusively, by the dirtiness of the environment. After the first few weeks of life, however, these populations are continuously supplemented by new memory cells at rates that are independent of environment