11,240 research outputs found
Confidentiality and public protection: ethical dilemmas in qualitative research with adult male sex offenders
This paper considers the ethical tensions present when engaging in in-depth interviews with convicted sex offenders. Many of the issues described below are similar to those found in other sensitive areas of research. However, confidentiality and public protection are matters that require detailed consideration when the desire to know more about men who have committed serious and harmful offences is set against the possibility of a researcher not disclosing previously unknown sensitive information that relates to the risk of someone being harmed.</p
Real-time Visual Representations for Mixed Reality Remote Collaboration
We present a prototype Mixed Reality (MR) system with a hybrid interface to support remote collaboration between a local
worker and a remote expert in a large-scale work space. By combining a low-resolution 3D point-cloud of the environment
surrounding the local worker with a high-resolution real-time view of small focused details, the remote expert can see a virtual
copy of the local workspace with an independent viewpoint control. Meanwhile, the export can also check the current actions
of the local worker through a real-time feedback view. We conducted a pilot study to evaluate the usability of our system by
comparing the performance of three different interface designs (showing the real-time view in forms of 2D first-person view, a
2D third-person view and a 3D point cloud view). We found no difference in average task performance time between the three
interfaces, but there was a difference in user preference
The mediating role of individual-level social capital among worries, mental health and subjective well-being among adults in Hong Kong during the COVID-19 pandemic
The COVID-19 pandemic has substantially induced worries and affected individual mental health and subjective well-being. Nonetheless, a high level of social capital could potentially protect individuals who suffer from mental health problems and thus promote their subjective well-being, especially under the social distancing policies during the pandemic. To this end, based on a random sample of 1053 Hong Kong adults, structural equation modeling was applied to study the path relationships between the worries of COVID-19, social capital, mental health problems, and subjective well-being. The study found that worries during the pandemic were associated with mental health and subjective well-being, through social capital as a mediator. Moreover, social capital exhibited a stronger influence on mental health and subjective well-being in the economically inactive group than in the economically active group. This study highlights the important role of social capital during the COVID-19 pandemic. While Hong Kong’s COVID-19 response has primarily focused on disease prevention, it must be noted that social services and mutual-help activities are also crucial for people to withstand the crisis
Locally applied Simvastatin improves fracture healing in mice
<p>Abstract</p> <p>Background</p> <p>HMG-CoA reductase inhibitors, statins, are widely prescribed to lower cholesterol. High doses of orally administered simvastatin has previously been shown to improve fracture healing in a mouse femur fracture model. In this study, simvastatin was administered either subcutaneously or directly to the fracture area, with the goal of stimulating fracture repair at acceptable doses.</p> <p>Methods</p> <p>Femur fractures were produced in 70 mature male Balb-C mice and stabilized with marrow-nailing. Three experiments were performed. Firstly, 20 mice received subcutaneous injections of either simvastatin (20 mg) or vehicle. Secondly, 30 mice were divided into three groups of 10 mice receiving continuous subcutaneous delivery of the vehicle substance, the vehicle with 5 mg or with 10 mg of simvastatin per kg bodyweight per day. Finally, in 20 mice, a silicone tube was led from an osmotic mini-pump to the fracture area. In this way, 10 mice received an approximate local dose of simvastatin of 0.1 mg per kg per day for the duration of the experiment and 10 mice received the vehicle compound. All treatments lasted until the end of the experiment. Bilateral femurs were harvested 14 days post-operative. Biomechanical tests were performed by way of three-point bending. Data was analysed with ANOVA, Scheffé's post-hoc test and Student's unpaired t-test.</p> <p>Results</p> <p>With daily simvastatin injections, no effects could be demonstrated for any of the parameters examined. Continuous systemic delivery resulted in a 160% larger force at failure. Continuous local delivery of simvastatin resulted in a 170% larger force at failure as well as a twofold larger energy uptake.</p> <p>Conclusion</p> <p>This study found a dramatic positive effect on biomechanical parameters of fracture healing by simvastatin treatment directly applied to the fracture area.</p
Observation of contemporaneous optical radiation from a gamma-ray burst
The origin of gamma-ray bursts (GRBs) has been enigmatic since their
discovery. The situation improved dramatically in 1997, when the rapid
availability of precise coordinates for the bursts allowed the detection of
faint optical and radio afterglows - optical spectra thus obtained have
demonstrated conclusively that the bursts occur at cosmological distances. But,
despite efforts by several groups, optical detection has not hitherto been
achieved during the brief duration of a burst. Here we report the detection of
bright optical emission from GRB990123 while the burst was still in progress.
Our observations begin 22 seconds after the onset of the burst and show an
increase in brightness by a factor of 14 during the first 25 seconds; the
brightness then declines by a factor of 100, at which point (700 seconds after
the burst onset) it falls below our detection threshold. The redshift of this
burst, approximately 1.6, implies a peak optical luminosity of 5 times 10^{49}
erg per second. Optical emission from gamma-ray bursts has been generally
thought to take place at the shock fronts generated by interaction of the
primary energy source with the surrounding medium, where the gamma-rays might
also be produced. The lack of a significant change in the gamma-ray light curve
when the optical emission develops suggests that the gamma-rays are not
produced at the shock front, but closer to the site of the original explosion.Comment: 10 pages, 2 figures. Accepted for publication in Nature. For
additional information see http://www.umich.edu/~rotse
Beyond the caveman: Rethinking masculinity in relation to men’s help-seeking
publication-status: Publishedtypes: ArticleStatistically, men make less use of health-care services than women. This has been
interpreted as the result of the ‘hegemonic’ masculine code in which ‘real’ men are
understood to be physically fit, uninterested in their health and self-reliant. However,
less attention has been paid to understanding how hegemonic masculinity intersects
with the wider western socio-cultural contexts of men’s help-seeking, particularly
the valorization of health as a form of social achievement. This article presents the
results of interviews with 14 higher socio-economic status (SES) men to uncover their
‘interpretive repertoires’ in relation to health and illness, help-seeking and masculinity.
Although many interviewees drew on the stereotype of the ‘Neanderthal Man’ who
avoids the doctors to explain help-seeking by men ‘in general’, they constructed their
own experiences of help-seeking in terms of being responsible, problem-solving and in
control. It is argued that the framing of help-seeking in terms of ‘taking action’ chimes
with an increasingly pro-active ‘expert patient’ approach within western health-care.
This conceptual reconstruction of the dominant masculine code in relation to helpseeking,
from ‘Neanderthal Man’ to ‘Action Man’, may lead to greater gender equality
in terms of accessing health-care. However, it has the potential to exacerbate social
inequalities between men from different SES groups
Delayed self-recognition in children with autism spectrum disorder.
This study aimed to investigate temporally extended self-awareness (awareness of one’s place in and continued existence through time) in autism spectrum disorder (ASD), using the delayed self-recognition (DSR) paradigm (Povinelli et al., Child Development 67:1540–1554, 1996). Relative to age and verbal ability matched comparison children, children with ASD showed unattenuated performance on the DSR task, despite showing significant impairments in theory-of-mind task performance, and a reduced propensity to use personal pronouns to refer to themselves. The results may indicate intact temporally extended self-awareness in ASD. However, it may be that the DSR task is not an unambiguous measure of temporally extended self-awareness and it can be passed through strategies which do not require the possession of a temporally extended self-concept
Evaluating the importance of metamorphism in the foundering of continental crust
The metamorphic conditions and mechanisms required to induce foundering in deep arc crust are assessed using an example of representative lower crust in SW New Zealand. Composite plutons of Cretaceous monzodiorite and gabbro were emplaced at ~1.2 and 1.8 GPa are parts of the Western Fiordland Orthogneiss (WFO); examples of the plutons are tectonically juxtaposed along a structure that excised ~25 km of crust. The 1.8 GPa Breaksea Orthogneiss includes suitably dense minor components (e.g. eclogite) capable of foundering at peak conditions. As the eclogite facies boundary has a positive dP/dT, cooling from supra-solidus conditions (T > 950 ºC) at high-P should be accompanied by omphacite and garnet growth. However, a high monzodioritic proportion and inefficient metamorphism in the Breaksea Orthogneiss resulted in its positive buoyancy and preservation. Metamorphic inefficiency and compositional relationships in the 1.2 GPa Malaspina Pluton meant it was never likely to have developed densities sufficiently high to founder. These relationships suggest that the deep arc crust must have primarily involved significant igneous accumulation of garnet–clinopyroxene (in proportions >75%). Crustal dismemberment with or without the development of extensional shear zones is proposed to have induced foundering of excised cumulate material at P > 1.2 GPa
Phase transitions in biological membranes
Native membranes of biological cells display melting transitions of their
lipids at a temperature of 10-20 degrees below body temperature. Such
transitions can be observed in various bacterial cells, in nerves, in cancer
cells, but also in lung surfactant. It seems as if the presence of transitions
slightly below physiological temperature is a generic property of most cells.
They are important because they influence many physical properties of the
membranes. At the transition temperature, membranes display a larger
permeability that is accompanied by ion-channel-like phenomena even in the
complete absence of proteins. Membranes are softer, which implies that
phenomena such as endocytosis and exocytosis are facilitated. Mechanical signal
propagation phenomena related to nerve pulses are strongly enhanced. The
position of transitions can be affected by changes in temperature, pressure, pH
and salt concentration or by the presence of anesthetics. Thus, even at
physiological temperature, these transitions are of relevance. There position
and thereby the physical properties of the membrane can be controlled by
changes in the intensive thermodynamic variables. Here, we review some of the
experimental findings and the thermodynamics that describes the control of the
membrane function.Comment: 23 pages, 15 figure
An SU(N) Mott insulator of an atomic Fermi gas realized by large-spin Pomeranchuk cooling
The Hubbard model, containing only the minimum ingredients of nearest
neighbor hopping and on-site interaction for correlated electrons, has
succeeded in accounting for diverse phenomena observed in solid-state
materials. One of the interesting extensions is to enlarge its spin symmetry to
SU(N>2), which is closely related to systems with orbital degeneracy. Here we
report a successful formation of the SU(6) symmetric Mott insulator state with
an atomic Fermi gas of ytterbium (173Yb) in a three-dimensional optical
lattice. Besides the suppression of compressibility and the existence of charge
excitation gap which characterize a Mott insulating phase, we reveal an
important difference between the cases of SU(6) and SU(2) in the achievable
temperature as the consequence of different entropy carried by an isolated
spin. This is analogous to Pomeranchuk cooling in solid 3He and will be helpful
for investigating exotic quantum phases of SU(N) Hubbard system at extremely
low temperatures.Comment: 20 pages, 6 figures, to appear in Nature Physic
- …