Colegio ecoeficiente de alto rendimiento académico, deportivo y artístico en la provincia de Ambo, departamento de Huánuco

La presente tesis tiene como objetivo desarrollar el diseño de la nueva infraestructura ecoeficiente del servicio educativo de alto rendimiento de la región de Huánuco, en el distrito de Conchamarca, para que los estudiantes de alto desempeño (EAD) a nivel regional fortalezcan sus competencias personales, académicas, artísticas y deportivas. Para lograr dicha meta se tomó en cuenta información acerca de los colegios de alto rendimiento existentes en el país, datos estadísticos, entrevistas a estudiantes y profesores. Se seleccionó el terreno a través de informes de la Municipalidad Distrital de Conchamarca, en dicha documentación se encuentran establecidos los requisitos previos para el funcionamiento óptimo del colegio de alto rendimiento (COAR) Huánuco. El proyecto permite integrar de manera armónica, eficiente y funcional un eje organizacional-social entre las zonas que lo conforman, que en este caso según la Guía Pedagógica para la Implementación del Modelo de Servicio Educativo para la Atención de Estudiantes de Alto Desempeño del Ministerio de Educación (MINEDU) se denomina MUNDOS, Mundo YACHAY (Aprendizaje), Mundo TINKUY (Convivencia), Mundo WASI (Residencial) y Mundo PUJLLAY (Expresión corporal), junto con el entorno y la comunidad. De esta manera lograr la eficiente aplicación del modelo educativo especializado con una arquitectura innovadora y ecoeficiente

Topological Magnon Bands in a Kagome Lattice Ferromagnet

There is great interest in finding materials possessing quasiparticles with topological properties. Such materials may have novel excitations that exist on their boundaries which are protected against disorder. We report experimental evidence that magnons in an insulating kagome ferromagnet can have a topological band structure. Our neutron scattering measurements further reveal that one of the bands is flat due to the unique geometry of the kagome lattice. Spin wave calculations show that the measured band structure follows from a simple Heisenberg Hamiltonian with a Dzyaloshinkii-Moriya interaction. This serves as the first realization of an effectively two-dimensional topological magnon insulator—a new class of magnetic material that should display both a magnon Hall effect and protected chiral edge modes.United States. Dept. of Energy. Office of Basic Energy Sciences (Grant DE-FG02-07ER46134)National Science Foundation (U.S.) (Grant CHE 1041863

A Cu2+ (S = 1/2) Kagom\'e Antiferromagnet: MgxCu4-x(OH)6Cl2

Spin-frustrated systems are one avenue for inducing macroscopic quantum states in materials. However, experimental realization of this goal has been difficult because of the lack of simple materials and, if available, the separation of the unusual magnetic properties arising from exotic magnetic states from behavior associated with chemical disorder, such as site mixing. Here we report the synthesis and magnetic properties of a new series of magnetically frustrated materials, MgxCu4-x(OH)6Cl2. Because of the substantially different ligand-field chemistry of Mg2+ and Cu2+, site disorder within the kagom\'e layers is minimized, as directly measured by X-ray diffraction. Our results reveal that many of the properties of these materials and related systems are not due to disorder of the magnetic lattice but rather reflect an unusual ground state.Comment: Accepted for publication in J. Am. Chem. Soc

Redes y alianzas para el fortalecimiento de los emprendimientos de subsistencia de las mujeres de la Corporación Fresia en la localidad de Usaquén.

Proponer una estrategia de redes y alianzas para el fortalecimiento de los emprendimientos de subsistencia de los hogares con jefatura femenina de la Corporación de Mujeres Fresia de la localidad de UsaquénColombia no es indiferente a las condiciones socioeconómicas actuales, las cuales se han agudizado a raíz de la llegada del Covid-19, las circunstancias producidas por la pandemia, ha obligado a las mujeres cabeza de hogar a mantener sus unidades de negocio como la única fuente de recursos para el sostenimiento de su núcleo familiar. Estas mujeres de la Corporación Fresia han encontrado su autonomía económica y de autoempleo, generando espacios y oportunidades de poder contar con recursos que les permitan la subsistencia no solo en el ámbito económico, sino también contrarrestar los efectos generados por esta situación. Es por esto que los emprendimientos se deben fortalecer y potencializar a través de las redes y alianzas que les permitan alcanzar la sostenibilidad y un verdadero potencial de crecimiento para sus negociosColombia is not indifferent to current socioeconomic conditions, which have worsened as a result of the arrival of Covid-19, the circumstances produced by the pandemic, have forced women heads of households to maintain their business units as the only source of resources for the support of his family nucleus. These women of the Fresia Corporation have found their economic autonomy and self-employment, generating spaces and opportunities to have resources that allow them to survive not only in the economic sphere, but also to counteract the effects generated by this situation. This is why ventures must be strengthened and empowered through networks and alliances that allow them to achieve sustainability and true growth potential for their businesses

Redes y alianzas para el fortalecimiento de los emprendimientos de subsistencia de las mujeres de la Corporación Fresia en la localidad de Usaquén.

Proponer una estrategia de redes y alianzas para el fortalecimiento de los emprendimientos de subsistencia de los hogares con jefatura femenina de la Corporación de Mujeres Fresia de la localidad de UsaquénColombia no es indiferente a las condiciones socioeconómicas actuales, las cuales se han agudizado a raíz de la llegada del Covid-19, las circunstancias producidas por la pandemia, ha obligado a las mujeres cabeza de hogar a mantener sus unidades de negocio como la única fuente de recursos para el sostenimiento de su núcleo familiar. Estas mujeres de la Corporación Fresia han encontrado su autonomía económica y de autoempleo, generando espacios y oportunidades de poder contar con recursos que les permitan la subsistencia no solo en el ámbito económico, sino también contrarrestar los efectos generados por esta situación. Es por esto que los emprendimientos se deben fortalecer y potencializar a través de las redes y alianzas que les permitan alcanzar la sostenibilidad y un verdadero potencial de crecimiento para sus negociosColombia is not indifferent to current socioeconomic conditions, which have worsened as a result of the arrival of Covid-19, the circumstances produced by the pandemic, have forced women heads of households to maintain their business units as the only source of resources for the support of his family nucleus. These women of the Fresia Corporation have found their economic autonomy and self-employment, generating spaces and opportunities to have resources that allow them to survive not only in the economic sphere, but also to counteract the effects generated by this situation. This is why ventures must be strengthened and empowered through networks and alliances that allow them to achieve sustainability and true growth potential for their businesses

Circular Polymerase Extension Cloning of Complex Gene Libraries and Pathways

High-throughput genomics and the emerging field of synthetic biology demand ever more convenient, economical, and efficient technologies to assemble and clone genes, gene libraries and synthetic pathways. Here, we describe the development of a novel and extremely simple cloning method, circular polymerase extension cloning (CPEC). This method uses a single polymerase to assemble and clone multiple inserts with any vector in a one-step reaction in vitro. No restriction digestion, ligation, or single-stranded homologous recombination is required. In this study, we elucidate the CPEC reaction mechanism and demonstrate its usage in demanding synthetic biology applications such as one-step assembly and cloning of complex combinatorial libraries and multi-component pathways

Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.

An acute increase in the circulating concentration of glucocorticoid hormones is essential for the survival of severe somatic stresses. Circulating concentrations of GDF15, a hormone that acts in the brain to reduce food intake, are frequently elevated in stressful states. We now report that GDF15 potently activates the hypothalamic-pituitary-adrenal (HPA) axis in mice and rats. A blocking antibody to the GDNF-family receptor α-like receptor completely prevented the corticosterone response to GDF15 administration. In wild-type mice exposed to a range of stressful stimuli, circulating levels of both corticosterone and GDF15 rose acutely. In the case of Escherichia coli or lipopolysaccharide injections, the vigorous proinflammatory cytokine response elicited was sufficient to produce a near-maximal HPA response, regardless of the presence or absence of GDF15. In contrast, the activation of the HPA axis seen in wild-type mice in response to the administration of genotoxic or endoplasmic reticulum toxins, which do not provoke a marked rise in cytokines, was absent in Gdf15 -/- mice. In conclusion, consistent with its proposed role as a sentinel hormone, endogenous GDF15 is required for the activation of the protective HPA response to toxins that do not induce a substantial cytokine response. In the context of efforts to develop GDF15 as an antiobesity therapeutic, these findings identify a biomarker of target engagement and a previously unrecognized pharmacodynamic effect, which will require monitoring in human studies