14 research outputs found
Validating a novel web-based method to capture disease progression outcomes in multiple sclerosis
The Expanded Disability Status Scale (EDSS) is the current ‘gold standard’ for monitoring disease severity in multiple sclerosis (MS). The EDSS is a physician-based assessment. A patient-related surrogate for the EDSS may be useful in remotely capturing information. Eighty-one patients (EDSS range 0–8) having EDSS as part of clinical trials were recruited. All patients carried out the web-based survey with minimal assistance. Full EDSS scores were available for 78 patients. The EDSS scores were compared to those generated by the online survey using analysis of variance, matched pair test, Pearson’s coefficient, weighted kappa coefficient, and the intra-class correlation coefficient. The internet-based EDSS scores showed good correlation with the physician-measured assessment (Pearson’s coefficient = 0.85). Weighted kappa for full agreement was 0.647. Full agreement was observed in 20 patient
Reliability, validity, and ability to identify fall status of the Balance Evaluation Systems Test, Mini–Balance Evaluation Systems Test, and Brief–Balance Evaluation systems est in Older people Living in the Community
To assess the reliability, validity, and ability to identify fall status of the Balance Evaluation Systems Test (BESTest), Mini-BESTest, and Brief-BESTest, compared with the Berg Balance Scale (BBS), in older people living in the community. Design Cross-sectional. Setting Community centers. Participants Older adults (N=122; mean age ± SD, 76±9y). Interventions Not applicable. Main Outcome Measures Participants reported on falls history in the preceding year and completed the Activities-Specific Balance Confidence (ABC) Scale. The BBS, BESTest, and the Five Times Sit-To-Stand Test were administered. Interrater (2 physiotherapists) and test-retest relative (48–72h) and absolute reliabilities were explored with the intraclass correlation coefficient (ICC) equation (2,1) and the Bland and Altman method. Minimal detectable changes at the 95% confidence level (MDC95) were established. Validity was assessed by correlating the balance tests with each other and with the ABC Scale (Spearman correlation coefficients–ρ). Receiver operating characteristics assessed the ability of each balance test to differentiate between people with and without a history of falls. Results All balance tests presented good to excellent interrater (ICC=.71–.93) and test-retest (ICC=.50–.82) relative reliability, with no evidence of bias. MDC95 values were 4.6, 9, 3.8, and 4.1 points for the BBS, BESTest, Mini-BESTest, and Brief-BESTest, respectively. All tests were significantly correlated with each other (ρ=.83–.96) and with the ABC Scale (ρ=.46–.61). Acceptable ability to identify fall status (areas under the curve,.71–.78) was found for all tests. Cutoff points were 48.5, 82, 19.5, and 12.5 points for the BBS, BESTest, Mini-BESTest, and Brief-BESTest, respectively. Conclusions All balance tests are reliable, valid, and able to identify fall status in older people living in the community. Therefore, the choice of which test to use will depend on the level of balance impairment, purpose, and time availability