Generalised simulation environment for software testing

International audienceThe cost of the verification process is certainly one of the major engineering issue in the domain of embedded safety-sensitive systems such as avionis. Test environments, made up of dedicated software and hardware means, are among the most significantly contributing factors. This paper reports about an alternative approach where test environments are totally simulated for all test phases. Simulation is not per se a new approach, the expected positive gap is expected from its generalisation. test phases coverage. Our works on this generalised simulation approach are part the ongoing RNTL/ATLAS research project

Déterminer l'impact d'une évolution dans les processus métiers

National audienceAvec l'augmentation de la taille et de la complexité des systèmes à bases de services, la tâche du concepteur dans l'évolution des processus métiers est devenue ardue. Une simple modification localisée du processus peut entrainer une dégradation des propriétés non fonc- tionnelles (temps de réponse, sécurité, taille des messages, etc.) de l'application toute entière. Pouvoir déterminer l'impact d'une évolution sur l'ensemble du système aiderait le concepteur à se rendre compte a priori des conséquences potentielles de l'évolution. Nous proposons de construire un canevas de conception et d'évolution à base de modèles pour aider le concepteur à déterminer l'effet d'une évolution sur le système en s'appuyant sur des analyses d'impact

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)

(2011)&quot; Undoing Event-Driven Adaptation of Business Processes

Abstract—As business processes continue to gain relevance in different domains, dynamicity is becoming a great concern. Static processes no longer cover the actual needs of constantly changing environments, and process adaptation is a must in order to maintain competitive levels. While creating dynamically adaptable business processes can be a challenging task, undoing these adaptations is a natural functionality that has not been studied in depth. Straight forward approaches for unadaptation can easily end up with corrupted processes, bringing uncertainty to the whole business logic. In this paper we bring forward a solution for efficiently undoing a business process adaptation in event-driven environments, considering also the correlated adaptations that happened afterwards. Keywords-Event Driven Approach; Business Process; Adaptation; I

Patients with systemic lupus erythematosus display an altered B-cell regulation of them T-cell populations.

International audienc

Personal exposure of children and adults to airborne benzene in four French cities

International audienceAtmospheric concentrations of and personal exposure to benzene have been measured in four French metropolitan areas for 210 subjects over two seasons. Half of the volunteers were 6-13-year-old children. The adult subjects were nonsmokers, not occupationally exposed and they live and work in the monitored areas. Measurements were performed using diffusive samplers followed by GC-FID analysis. The average values for ambient air concentrations (mu gm(-3)) were: Rouen: 1.5; Ile de France (Paris area): 1.6; Grenoble: 2.3 and Strasbourg: 2.6, showing that benzene concentrations in the ambient air of the four cities satisfy the requirements of the European Directive 2000/69 EC of the European Parliament which stipulates a limit value of 5 mu gm(-3). However, the 48h exposures measured were found to be between 2.7 and 3.5 times higher than ambient air concentrations. As a consequence, 60% of the subjects investigated, including children, were exposed to concentrations higher than the ambient air limit value. This work confirms that air monitoring data collected by fixed stations should be used with caution when assessing population exposure to benzene, especially given the influence of indoor sources and other polluted microenvironments where people spend part of their time

Autonomous aerial swarm robotics for the management of the environmental and health impact in a post-accident situation

International audienc

Autonomous aerial swarm robotics for the management of the environmental and health impact in a post-accident situation

International audienc