Contact-less measurements of Shubnikov-de Haas oscillations in the magnetically ordered state of CeAgSb2_2 and SmAgSb2_2 single crystals

Shubnikov - de Haas oscillations were measured in single crystals of highly metallic antiferromagnetic SmAgSb$_{2}$ and ferromagnetic CeAgSb$_{2}$ using a tunnel diode resonator. Resistivity oscillations as a function of applied magnetic field were observed via measurements of skin depth variation. The effective resolution of $\Delta\rho\simeq20$ p$\Omega$ allows a detailed study of the SdH spectra as a function of temperature. The effects of the Sm long - range magnetic ordering as well as its electronic structure ($4f$-electrons) on the Fermi surface topology is discussed

The Factory and the Beehive III: PTFEB132.707+19.810, a Low-Mass Eclipsing Binary in Praesepe Observed by PTF and K2

Theoretical models of stars constitute a fundamental bedrock upon which much of astrophysics is built, but large swaths of model parameter space remain uncalibrated by observations. The best calibrators are eclipsing binaries in clusters, allowing measurement of masses, radii, luminosities, and temperatures, for stars of known metallicity and age. We present the discovery and detailed characterization of PTFEB132.707+19.810, a P=6.0 day eclipsing binary in the Praesepe cluster ($\tau$~600--800 Myr; [Fe/H]=0.14$\pm$0.04). The system contains two late-type stars (SpT$_P$=M3.5$\pm$0.2; SpT$_S$=M4.3$\pm$0.7) with precise masses ($M_p=0.3953\pm0.0020$~$M_{\odot}$; $M_s=0.2098\pm0.0014$~$M_{\odot}$) and radii ($R_p=0.363\pm0.008$~$R_{\odot}$; $R_s=0.272\pm0.012$~$R_{\odot}$). Neither star meets the predictions of stellar evolutionary models. The primary has the expected radius, but is cooler and less luminous, while the secondary has the expected luminosity, but is cooler and substantially larger (by 20%). The system is not tidally locked or circularized. Exploiting a fortuitous 4:5 commensurability between $P_{orb}$ and $P_{rot,prim}$, we demonstrate that fitting errors from the unknown spot configuration only change the inferred radii by <1--2%. We also analyze subsets of data to test the robustness of radius measurements; the radius sum is more robust to systematic errors and preferable for model comparisons. We also test plausible changes in limb darkening, and find corresponding uncertainties of ~1%. Finally, we validate our pipeline using extant data for GU Boo, finding that our independent results match previous radii to within the mutual uncertainties (2--3%). We therefore suggest that the substantial discrepancies are astrophysical; since they are larger than for old field stars, they may be tied to the intermediate age of PTFEB132.707+19.810.Comment: Accepted to ApJ; 36 pages, 19 figures, 8 tables in two-column AASTEX6 forma

How might improved estimates of HIV programme outcomes influence practice? A formative study of evidence, dissemination and response

BACKGROUND: While HIV programmes have started millions of persons on life-saving antiretroviral therapy in Africa, longitudinal health information systems are frail and, therefore, data about long-term survival is often inaccurate or unknown to HIV programmes. The \u27Better Information for Health in Zambia\u27 (BetterInfo) Study - a regional sampling-based survey to assess retention and mortality in HIV programmes in Zambia - found both retention and mortality to be higher than prevailing estimates from national surveillance systems. We sought to understand how Zambian health decision-makers at different health system levels would respond to these new data, with a view to informing research translation. METHODS: We interviewed 25 purposefully sampled health decision-makers from community, facility, district, provincial and national levels. During the interviews, we shared retention and mortality estimates from both routine programme surveillance and those generated by the study. Transcripts were analysed for inductive and deductive themes, the latter drawing on Weiss\u27s framework that policy-makers interpret and apply evidence as \u27warning\u27, \u27guidance\u27, \u27reconceptualisation\u27 or \u27mobilisation of support\u27. FINDINGS: All decision-makers found study findings relevant and important. Decision-makers viewed the underestimates of mortality to be a warning about the veracity and informativeness of routine data systems. Decision-makers felt guided by the findings to improve data monitoring and, acknowledging limitations of routine data, utilised episodic patient tracing to support improved data accuracy. Findings catalysed renewed motivation and mobilisation by national level decision-makers for differentiated models of HIV care to improve patient outcomes and also improved data management systems to better capture patient outcomes. Inductive analysis highlighted a programmatic application data interpretation, in which study findings can influence facility and patient-level decision-making, quality of care and routine data management. CONCLUSIONS: New epidemiological data on patient outcomes were widely seen as informative and relevant and can potentially catalyse health system action such as using evaluations to supplement electronic medical record data to improve HIV programmes. Formative evidence suggests that targeting research dissemination at different levels of the health system will elicit different responses. Researchers supporting the translation of evidence to action should leverage all relevant levels of the health system to facilitate both policy and programmatic action

How might improved estimates of HIV programme outcomes influence practice? A formative study of evidence, dissemination and response

Background While HIV programmes have started millions of persons on life-saving antiretroviral therapy in Africa, longitudinal health information systems are frail and, therefore, data about long-term survival is often inaccurate or unknown to HIV programmes. The 'Better Information for Health in Zambia' (BetterInfo) Study - a regional sampling-based survey to assess retention and mortality in HIV programmes in Zambia - found both retention and mortality to be higher than prevailing estimates from national surveillance systems. We sought to understand how Zambian health decision-makers at different health system levels would respond to these new data, with a view to informing research translation. Methods We interviewed 25 purposefully sampled health decision-makers from community, facility, district, provincial and national levels. During the interviews, we shared retention and mortality estimates from both routine programme surveillance and those generated by the study. Transcripts were analysed for inductive and deductive themes, the latter drawing on Weiss's framework that policy-makers interpret and apply evidence as 'warning', 'guidance', 'reconceptualisation' or 'mobilisation of support'. Findings All decision-makers found study findings relevant and important. Decision-makers viewed the underestimates of mortality to be a warning about the veracity and informativeness of routine data systems. Decision-makers felt guided by the findings to improve data monitoring and, acknowledging limitations of routine data, utilised episodic patient tracing to support improved data accuracy. Findings catalysed renewed motivation and mobilisation by national level decision-makers for differentiated models of HIV care to improve patient outcomes and also improved data management systems to better capture patient outcomes. Inductive analysis highlighted a programmatic application data interpretation, in which study findings can influence facility and patient-level decision-making, quality of care and routine data management. Conclusions New epidemiological data on patient outcomes were widely seen as informative and relevant and can potentially catalyse health system action such as using evaluations to supplement electronic medical record data to improve HIV programmes. Formative evidence suggests that targeting research dissemination at different levels of the health system will elicit different responses. Researchers supporting the translation of evidence to action should leverage all relevant levels of the health system to facilitate both policy and programmatic action

Longitudinal Fluctuations of National Help-Seeking Reports for Domestic Violence Before, During, and After the Financial Crisis in Cyprus

Although many studies generally agree that unemployment may affect domestic violence, little is known about these effects in small nations. The relationship between unemployment and domestic violence in large and small nations may be different. This is because small nations have more expensive public sectors and limited employment opportunities in comparison with larger nations. We examined how longitudinal rates of national help-seeking domestic violence contacts (DVCs) from the only nongovernmental domestic violence support agency in Cyprus (a small nation) fluctuated in relation to national unemployment data between 1996 and 2016. This period included an economic crisis which commenced in 2011 and showed signs of recovery in 2015. We analyzed whether the fluctuations in unemployment registrations could predict changes in DVCs. Our analysis included 5,103,120 unemployment registrations and 21,774 DVCs. Findings supported our hypothesis and revealed unemployment predicted and correlated with DVCs. There were significant changes to DVCs when Cyprus plunged into economic crisis, meaning that when unemployment increased, DVCs also increased. Cyprus does not deviate from larger societies in help-seeking behavior in the form of people contacting a national helpline when exposed to economic crises. This study provides evidence of the link between economic hardship and increased help-seeking behaviors in small nations. Societies at risk of an economic crisis need to consider the potential impact on domestic violence rates and on demand for support services

Insight Into the Formation of the Milky Way Through Cold Halo Substructure. I. The ECHOS of Milky Way Formation

We identify ten -- seven for the first time -- elements of cold halo substructure (ECHOS) in the volume within 17.5 kpc of the Sun in the inner halo of the Milky Way. Our result is based on the observed spatial and radial velocity distribution of metal-poor main sequence turnoff (MPMSTO) stars in 137 Sloan Extension for Galactic Understanding and Exploration (SEGUE) lines of sight. We point out that the observed radial velocity distribution is consistent with a smooth stellar component of the Milky Way's inner halo overall, but disagrees significantly at the radial velocities that correspond to our detections. We show that all of our detections are statistically significant and that we expect no false positives. We also use our detections and completeness estimates to infer a formal upper limit of 0.34 +/- 0.02 on the fraction of the MPMSTO population in the inner halo that belong to ECHOS. Our detections and completeness calculations suggest that there is a significant population of low fractional overdensity ECHOS in the inner halo, and we predict that 1/3 of the inner halo (by volume) harbors ECHOS with MPMSTO star number densities n ~ 15 kpc^-3. ECHOS are likely older than known surface brightness substructure, so our detections provide us with a direct measure of the accretion history of the Milky Way in a region and time interval that has yet to be fully explored. In concert with previous studies, our result suggests that the level of merger activity has been roughly constant over the past few Gyr and that there has been no accretion of single stellar systems more massive than a few percent of a Milky Way mass in that interval. (abridged)Comment: 47 pages, 23 figures, and 6 tables in emulaetapj format; accepted for publication in Ap

p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis.

The role of apoptosis in melanoma pathogenesis and chemoresistance is poorly characterized. Mutations in TP53 occur infrequently, yet the TP53 apoptotic pathway is often abrogated. This may result from alterations in TP53 family members, including the TP53 homologue TP63. Here we demonstrate that TP63 has an antiapoptotic role in melanoma and is responsible for mediating chemoresistance. Although p63 was not expressed in primary melanocytes, up-regulation of p63 mRNA and protein was observed in melanoma cell lines and clinical samples, providing the first evidence of significant p63 expression in this lineage. Upon genotoxic stress, endogenous p63 isoforms were stabilized in both nuclear and mitochondrial subcellular compartments. Our data provide evidence of a physiological interaction between p63 with p53 whereby translocation of p63 to the mitochondria occurred through a codependent process with p53, whereas accumulation of p53 in the nucleus was prevented by p63. Using RNA interference technology, both isoforms of p63 (TA and ΔNp63) were demonstrated to confer chemoresistance, revealing a novel oncogenic role for p63 in melanoma cells. Furthermore, expression of p63 in both primary and metastatic melanoma clinical samples significantly correlated with melanoma-specific deaths in these patients. Ultimately, these observations provide a possible explanation for abrogation of the p53-mediated apoptotic pathway in melanoma, implicating novel approaches aimed at sensitizing melanoma to therapeutic agents

Hypothyroidism among military infants born in countries of varied iodine nutrition status

<p>Abstract</p> <p>Background</p> <p>Iodine deficiency is a global problem representing the most common preventable cause of mental retardation. Recently, the impact of subtle deficiencies in iodine intake on children and pregnant women has been questioned. This study was designed to compare hypothyroidism among infants born to US military families in countries of varied iodine nutrition status.</p> <p>Methods</p> <p>A cohort design was used to analyze data from the Department of Defense Birth and Infant Health Registry for infants born in 2000-04 (<it>n </it>= 447,691). Hypothyroidism was defined using ICD-9-CM codes from the first year of life (<it>n </it>= 698). The impact of birth location on hypothyroidism was assessed by comparing rates in Germany, Japan, and US territories with the United States, while controlling for infant gender, plurality, gestational age, maternal age, maternal military status, and military parent's race/ethnicity.</p> <p>Results</p> <p>Hypothyroidism did not vary by birth location with adjusted odds ratios (OR) as follows: Germany (OR 0.82, [95% CI 0.50, 1.35]), Japan (OR 0.67, [95% CI 0.37, 1.22]), and US territories (OR 1.29, [95% CI 0.57, 2.89]). Hypothyroidism was strongly associated with preterm birth (OR 5.44, [95% CI 4.60, 6.42]). Hypothyroidism was also increased among infants with civilian mothers (OR 1.24, [95% CI 1.00, 1.54]), and older mothers, especially ages 40 years and older (OR 2.09, [95% CI 1.33, 3.30]).</p> <p>Conclusions</p> <p>In this study, hypothyroidism in military-dependent infants did not vary by birth location, but was associated with other risk factors, including preterm birth, civilian maternal status, and advanced maternal age.</p

Can computer-aided diagnosis assist in the identification of prostate cancer on prostate MRI? a multi-center, multi-reader investigation.

For prostate cancer detection on prostate multiparametric MRI (mpMRI), the Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2) and computer-aided diagnosis (CAD) systems aim to widely improve standardization across radiologists and centers. Our goal was to evaluate CAD assistance in prostate cancer detection compared with conventional mpMRI interpretation in a diverse dataset acquired from five institutions tested by nine readers of varying experience levels, in total representing 14 globally spread institutions. Index lesion sensitivities of mpMRI-alone were 79% (whole prostate (WP)), 84% (peripheral zone (PZ)), 71% (transition zone (TZ)), similar to CAD at 76% (WP, p=0.39), 77% (PZ, p=0.07), 79% (TZ, p=0.15). Greatest CAD benefit was in TZ for moderately-experienced readers at PI-RADSv2 <3 (84% vs mpMRI-alone 67%, p=0.055). Detection agreement was unchanged but CAD-assisted read times improved (4.6 vs 3.4 minutes, p<0.001). At PI-RADSv2 ≥ 3, CAD improved patient-level specificity (72%) compared to mpMRI-alone (45%, p<0.001). PI-RADSv2 and CAD-assisted mpMRI interpretations have similar sensitivities across multiple sites and readers while CAD has potential to improve specificity and moderately-experienced radiologists' detection of more difficult tumors in the center of the gland. The multi-institutional evidence provided is essential to future prostate MRI and CAD development