Le chemin de l'Agence -- Pointillés de synchronisations

National audiencePerspective d'Inria à l'occasion des 20 ans de l'ABE

Effects of Different Training Intensity Distributions Between Elite Cross-Country Skiers and Nordic-Combined Athletes During Live High-Train Low

Purpose: To analyze the effects of different training strategies (i.e., mainly intensity distribution) during living high – training low (LHTL) between elite cross-country skiers and Nordic-combined athletes.Methods: 12 cross-country skiers (XC) (7 men, 5 women), and 8 male Nordic combined (NC) of the French national teams were monitored during 15 days of LHTL. The distribution of training at low-intensity (LIT), below the first ventilatory threshold (VT1), was 80% and 55% in XC and NC respectively. Daily, they filled a questionnaire of fatigue, and performed a heart rate variability (HRV) test. Prior (Pre) and immediately after (Post), athletes performed a treadmill incremental running test for determination of V˙O2max and V˙O2 at the second ventilatory threshold (V˙O2V T2), a field roller-skiing test with blood lactate ([La-]) assessment.Results: The training volume was in XC and NC, respectively: at LIT: 45.9 ± 6.4 vs. 23.9 ± 2.8 h (p < 0.001), at moderate intensity: 1.9 ± 0.5 vs. 3.0 ± 0.4 h, (p < 0.001), at high intensity: 1.2 ± 0.9 vs. 1.4 ± 02 h (p = 0.05), in strength (and jump in NC): 7.1 ± 1.5 vs. 18.4 ± 2.7 h, (p < 0.001). Field roller-skiing performance was improved (-2.9 ± 1.6%, p < 0.001) in XC but decreased (4.1 ± 2.6%, p < 0.01) in NC. [La-] was unchanged (-4.1 ± 14.2%, p = 0.3) in XC but decreased (-27.0 ± 11.1%, p < 0.001) in NC. Changes in field roller-skiing performance and in [La-] were correlated (r = -0.77, p < 0.001). V˙O2max increased in both XC and NC (3.7 ± 4.2%, p = 0.01 vs. 3.7 ± 2.2%, p = 0.002) but V˙O2V T2 increased only in XC (7.3 ± 5.8%, p = 0.002). HRV analysis showed differences between XC and NC mainly in high spectral frequency in the supine position (HFSU). All NC skiers showed some signs of overreaching at Post.Conclusion: During LHTL, despite a higher training volume, XC improved specific performance and aerobic capacities, while NC did not. All NC skiers showed fatigue states. These findings suggest that a large amount of LIT with a moderate volume of strength and speed training is required during LHTL in endurance athletes

Solar and proxy-sensitivity imprints on paleohydrological records for the last millennium in west-central Europe

International audienceThis paper presents a lake-level record established for the last millennium at Lake Saint-Point in the French Jura Mountains. A comparison of this lake-level record with a solar irradiance record supports the hypothesis of a solar forcing of variations in the hydrological cycle linked to climatic oscillations over the last millennium in west-central Europe, with higher lake levels during the solar minimums of Oort (around AD 1060), Wolf (around AD 1320), Spörer (around AD 1450), Maunder (around AD 1690), and Dalton (around AD 1820). Further comparisons of the Saint-Point record with the fluctuations of the Great Aletsch Glacier (Swiss Alps) and a record of Rhône River floods from Lake Bourget (French Alps) give evidence of possible imprints of proxy sensitivity on reconstructed paleohydrological records. In particular, the Great Aletsch record shows an increasing glacier mass from AD 1350 to 1850, suggesting a cumulative effect of the Little Ice Age cooling and/or a possible reflection of a millennial-scale general cooling until the mid-19th century in the Northern Hemisphere. In contrast, the Saint-Point and Bourget records show a general trend toward a decrease in lake levels and in flood magnitude anti-correlated with generally increasing solar irradiance

Prooxidant/Antioxidant Balance in Hypoxia: A Cross-Over Study on Normobaric vs. Hypobaric “Live High-Train Low”

“Live High-Train Low” (LHTL) training can alter oxidative status of athletes. This study compared prooxidant/antioxidant balance responses following two LHTL protocols of the same duration and at the same living altitude of 2250 m in either normobaric (NH) or hypobaric (HH) hypoxia. Twenty-four well-trained triathletes underwent the following two 18-day LHTL protocols in a cross-over and randomized manner: Living altitude (PIO2 = 111.9 ± 0.6 vs. 111.6 ± 0.6 mmHg in NH and HH, respectively); training “natural” altitude (~1000–1100 m) and training loads were precisely matched between both LHTL protocols. Plasma levels of oxidative stress [advanced oxidation protein products (AOPP) and nitrotyrosine] and antioxidant markers [ferric-reducing antioxidant power (FRAP), superoxide dismutase (SOD) and catalase], NO metabolism end-products (NOx) and uric acid (UA) were determined before (Pre) and after (Post) the LHTL. Cumulative hypoxic exposure was lower during the NH (229 ± 6 hrs.) compared to the HH (310 ± 4 hrs.; P<0.01) protocol. Following the LHTL, the concentration of AOPP decreased (-27%; P<0.01) and nitrotyrosine increased (+67%; P<0.05) in HH only. FRAP was decreased (-27%; P<0.05) after the NH while was SOD and UA were only increased following the HH (SOD: +54%; P<0.01 and UA: +15%; P<0.01). Catalase activity was increased in the NH only (+20%; P<0.05). These data suggest that 18-days of LHTL performed in either NH or HH differentially affect oxidative status of athletes. Higher oxidative stress levels following the HH LHTL might be explained by the higher overall hypoxic dose and different physiological responses between the NH and HH.The study was funded by grants from the Ministère des Sports, de la Jeunesse, de l’Education Populaire et de la Vie Associative (MSJEPVA; France; to L.S. and G.P.M.), Institut National du Sport, de l’Expertise et de la Performance (INSEP; France; to L.S. and G.P.M.) and Institut Universitaire de France (IUF; France; to V.P.)

Similar Hemoglobin Mass Response in Hypobaric and Normobaric Hypoxia in Athletes

Purpose: To compare hemoglobin mass (Hbmass) changes during an 18-day live high-train low (LHTL) altitude training camp in normobaric hypoxia (NH) and hypobaric hypoxia (HH). Methods: Twenty-eight well-trained male triathletes were split into three groups (NH: n = 10, HH: n = 11, control (CON): n = 7) and participated in an 18-day LHTL camp. NH and HH slept at 2250 m while CON slept and all groups trained at altitudes 0.08) and remained unchanged in CON (+0.2%, P = 0.89). Conclusion: HH and NH evoked similar Hbmass increases for the same hypoxic dose and after 18-day LHTL. The wide variability in individual Hbmass responses in HH and NH emphasize the importance of individual Hbmass evaluation of altitude training.This study was financially supported by the Federal Office of Sport (FOSPO; Switzerland) and by the Ministère des Sports, de la Jeunesse, de l’Education Populaire et de la Vie Associative (MSJEPVA)/Institut National du Sport, de l’Expertise et de la Performance (INSEP, France)

Episciences IAM: un projet éditorial entre rupture et continuité

International audienceWith the launch of two scientific journals, Episciences IAM (Informatics and Applied Mathematics) is moving towards Overlay Journals. The idea is to publish scientific results labeled by the best journals. This contributes to Open Access publishing, for free and fair access. Within a technical platform, scientific contributions already in open archives are submitted to a process of evaluation and scientific validation. Designed as an inter-institutional research infrastructure, Episciences IAM project builds on the Episciences platform, developed and hosted by the CCSD of CNRSAvec le lancement de deux revues scientifiques, Episciences IAM (Informatics and Applied Mathematics) s'engage dans la voie des épi-journaux. Le principe est de publier des résultats scientifiques labellisés par des revues du meilleur niveau. Il s’agit de contribuer à l’édition en Open Access pour un accès libre plus équitable. Au moyen d’une plateforme technique, des contributions scientifiques déjà en archive ouverte sont soumises à un processus d'évaluation et de validation scientifiques. Conçu à terme comme une infrastructure de recherche inter-établissements, le projet Episciences IAM s'appuie sur la plateforme Épisciences, développée et hébergée par le CCSD du CNRS

Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor γ activity

Colitis involves immune cell–mediated tissue injuries, but the contribution of epithelial cells remains largely unclear. Vanin-1 is an epithelial ectoenzyme with a pantetheinase activity that provides cysteamine/cystamine to tissue. Using the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-colitis model we show here that Vanin-1 deficiency protects from colitis. This protection is reversible by administration of cystamine or bisphenol A diglycidyl ether, a peroxisome proliferator-activated receptor (PPAR)γ antagonist. We further demonstrate that Vanin-1, by antagonizing PPARγ, licenses the production of inflammatory mediators by intestinal epithelial cells. We propose that Vanin-1 is an epithelial sensor of stress that exerts a dominant control over innate immune responses in tissue. Thus, the Vanin-1/pantetheinase activity might be a new target for therapeutic intervention in inflammatory bowel disease