Investigation of reliability attributes and accelerated stress factors on terrestrial solar cells

Major effort during this reporting period was devoted to two tasks: improvement of the electrical measurement instrumentation through the design and construction of a microcomputer controlled short interval tester, and better understanding of second quadrant behavior by developing a mathematical model relating cell temperature to electrical characteristics. In addition, some preliminary work is reported on an investigation into color changes observed after stressing

Azimuthal velocity profiles in Rayleigh-stable Taylor-Couette flow and implied axial angular momentum transport

We present azimuthal velocity profiles measured in a Taylor-Couette apparatus, which has been used as a model of stellar and planetary accretion disks. The apparatus has a cylinder radius ratio of $\eta = 0.716$, an aspect-ratio of $\Gamma = 11.74$, and the plates closing the cylinders in the axial direction are attached to the outer cylinder. We investigate angular momentum transport and Ekman pumping in the Rayleigh-stable regime. The regime is linearly stable and is characterized by radially increasing specific angular momentum. We present several Rayleigh-stable profiles for shear Reynolds numbers $Re_S \sim O(10^5) \,$, both for $\Omega_i > \Omega_o > 0$ (quasi-Keplerian regime) and $\Omega_o > \Omega_i > 0$ (sub-rotating regime) where $\Omega_{i,o}$ is the inner/outer cylinder rotation rate. None of the velocity profiles matches the non-vortical laminar Taylor-Couette profile. The deviation from that profile increased as solid-body rotation is approached at fixed $Re_S$. Flow super-rotation, an angular velocity greater than that of both cylinders, is observed in the sub-rotating regime. The velocity profiles give lower bounds for the torques required to rotate the inner cylinder that were larger than the torques for the case of laminar Taylor-Couette flow. The quasi-Keplerian profiles are composed of a well mixed inner region, having approximately constant angular momentum, connected to an outer region in solid-body rotation with the outer cylinder and attached axial boundaries. These regions suggest that the angular momentum is transported axially to the axial boundaries. Therefore, Taylor-Couette flow with closing plates attached to the outer cylinder is an imperfect model for accretion disk flows, especially with regard to their stability.Comment: 22 pages, 10 figures, 2 tables, under consideration for publication in Journal of Fluid Mechanics (JFM

Algorithm engineering for optimal alignment of protein structure distance matrices

Protein structural alignment is an important problem in computational biology. In this paper, we present first successes on provably optimal pairwise alignment of protein inter-residue distance matrices, using the popular Dali scoring function. We introduce the structural alignment problem formally, which enables us to express a variety of scoring functions used in previous work as special cases in a unified framework. Further, we propose the first mathematical model for computing optimal structural alignments based on dense inter-residue distance matrices. We therefore reformulate the problem as a special graph problem and give a tight integer linear programming model. We then present algorithm engineering techniques to handle the huge integer linear programs of real-life distance matrix alignment problems. Applying these techniques, we can compute provably optimal Dali alignments for the very first time

Universality in fully developed turbulence

We extend the numerical simulations of She et al. [Phys.\ Rev.\ Lett.\ 70, 3251 (1993)] of highly turbulent flow with $15 \le$ Taylor-Reynolds number $Re_\lambda\le 200$ up to $Re_\lambda \approx 45000$, employing a reduced wave vector set method (introduced earlier) to approximately solve the Navier-Stokes equation. First, also for these extremely high Reynolds numbers $Re_\lambda$, the energy spectra as well as the higher moments -- when scaled by the spectral intensity at the wave number $k_p$ of peak dissipation -- can be described by {\it one universal} function of $k/k_p$ for all $Re_\lambda$. Second, the ISR scaling exponents $\zeta_m$ of this universal function are in agreement with the 1941 Kolmogorov theory (the better, the large $Re_\lambda$ is), as is the $Re_\lambda$ dependence of $k_p$. Only around $k_p$ viscous damping leads to slight energy pileup in the spectra, as in the experimental data (bottleneck phenomenon).Comment: 14 pages, Latex, 5 figures (on request), 3 tables, submitted to Phys. Rev.

On parameters of the Levi-Civita solution

The Levi-Civita (LC) solution is matched to a cylindrical shell of an anisotropic fluid. The fluid satisfies the energy conditions when the mass parameter $\sigma$ is in the range $0 \le \sigma \le 1$. The mass per unit length of the shell is given explicitly in terms of $\sigma$, which has a finite maximum. The relevance of the results to the non-existence of horizons in the LC solution and to gauge cosmic strings is pointed out.Comment: Latex, no figure

Perfect-fluid cylinders and walls - sources for the Levi-Civita space-time

The diagonal metric tensor whose components are functions of one spatial coordinate is considered. Einstein's field equations for a perfect-fluid source are reduced to quadratures once a generating function, equal to the product of two of the metric components, is chosen. The solutions are either static fluid cylinders or walls depending on whether or not one of the spatial coordinates is periodic. Cylinder and wall sources are generated and matched to the vacuum (Levi--Civita) space--time. A match to a cylinder source is achieved for -\frac{1}{2}<\si<\frac{1}{2}, where \si is the mass per unit length in the Newtonian limit \si\to 0, and a match to a wall source is possible for |\si|>\frac{1}{2}, this case being without a Newtonian limit; the positive (negative) values of \si correspond to a positive (negative) fluid density. The range of \si for which a source has previously been matched to the Levi--Civita metric is 0\leq\si<\frac{1}{2} for a cylinder source.Comment: 22 pages, LaTeX, one included figure. Revised version: three (non-perfect-fluid) interior solutions are added, one of which falsifies the original conjecture in Sec. 4, and the circular geodesics of the Levi-Civita space-time are discussed in a footnot

Immunoseq: the identification of functionally relevant variants through targeted capture and sequencing of active regulatory regions in human immune cells

$\textbf{BACKGROUND}$: The observation that the genetic variants identified in genome-wide association studies (GWAS) frequently lie in non-coding regions of the genome that contain cis-regulatory elements suggests that altered gene expression underlies the development of many complex traits. In order to efficiently make a comprehensive assessment of the impact of non-coding genetic variation in immune related diseases we emulated the whole-exome sequencing paradigm and developed a custom capture panel for the known DNase I hypersensitive site (DHS) in immune cells - "Immunoseq". $\textbf{RESULTS}$: We performed Immunoseq in 30 healthy individuals where we had existing transcriptome data from T cells. We identified a large number of novel non-coding variants in these samples. Relying on allele specific expression measurements, we also showed that our selected capture regions are enriched for functional variants that have an impact on differential allelic gene expression. The results from a replication set with 180 samples confirmed our observations. $\textbf{CONCLUSIONS}$: We show that Immunoseq is a powerful approach to detect novel rare variants in regulatory regions. We also demonstrate that these novel variants have a potential functional role in immune cells.This work was supported by grants from the Canadian Institute of Health Research (CIHR), the UK Medical Research Council (G1100125), the Swedish Research Council (DO283001) and Knut and Alice Wallenberg Foundation (KAW). We also acknowledge the use of subjects from the Cambridge BioResource and the support of the Cambridge NIHR Biomedical Research Centre. AM was supported by the Fond de Recherche Santé Québec Doctoral training award. TP and CL holds a Canada Research Chair